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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: PTGES3 (spascer ID:10728)

Gene summary for PTGES3

check button Gene summary
Gene information
SpeciesHuman
Gene symbol

PTGES3

Gene ID

10728

Gene nameprostaglandin E synthase 3
SynonymsP23|TEBP|cPGES
Cytomap12q13.3|12
Type of geneprotein-coding
Descriptionprostaglandin E synthase 3Hsp90 co-chaperonecytosolic prostaglandin E synthasecytosolic prostaglandin E2 synthaseprogesterone receptor complex p23prostaglandin E synthase 3 (cytosolic)telomerase-binding protein p23unactive progesterone receptor, 23
Modification date20220513
UniProtAcc

Q15185


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
PTGES3

GO:0001516

prostaglandin biosynthetic process

21873635

Process
PTGES3

GO:0005634

nucleus

21873635

Component
PTGES3

GO:0005829

cytosol

21873635

Component
PTGES3

GO:0006457

protein folding

21873635

Process
PTGES3

GO:0007004

telomere maintenance via telomerase

21873635

Process
PTGES3

GO:0050220

prostaglandin-E synthase activity

21873635

Function
PTGES3

GO:0051087

chaperone binding

21873635

Function
PTGES3

GO:0051131

chaperone-mediated protein complex assembly

21873635

Process
PTGES3

GO:0051879

Hsp90 protein binding

21873635

Function
PTGES3

GO:1905323

telomerase holoenzyme complex assembly

21873635

Process

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Spatial pattern events for PTGES3

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
PTGES3HumanBrainrep_7 335586952.35e-11
PTGES3HumanBrainrep_9 335586952.16e-08
PTGES3HumanBrainrep_10 335586953.23e-15
PTGES3HumanBrainrep_11 335586951.12e-14
PTGES3HumanBrainrep_12 335586951.11e-12
PTGES3HumanBladderrep_2 343854565.63e-08
PTGES3HumanIntestinerep_colon1 344172251.95e-15
PTGES3HumanIntestinerep_colon2 344172258.12e-16
PTGES3HumanIntestinerep_colon3 344172251.01e-15
PTGES3HumanIntestinerep_colon4 344172251.14e-15
PTGES3HumanLiverrep_liver1 344172251.08e-15
PTGES3HumanLiverrep_liver2 344172256.98e-16
PTGES3HumanLiverrep_liver4 344172257.71e-16
PTGES3HumanIntestineA2 334064092.36e-08
PTGES3HumanUterusrep_2 348579541.74e-07
PTGES3HumanUterusrep_3 348579541.66e-15
PTGES3HumanUterusrep_4 348579545.99e-12
PTGES3HumanBreast1160920F 344938724.71e-13
PTGES3HumanBreastCID4290 344938723.79e-14
PTGES3HumanBreastCID44971 344938721.76e-15
PTGES3HumanBreastCID4535 344938724.99e-09
PTGES3HumanSkinP2_rep2 329467851.55e-06
PTGES3HumanSkinmel1_rep1 301541488.04e-07
PTGES3HumanLungrep_1 353550184.99e-15
PTGES3HumanLungrep_2 353550185.64e-12

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_7_H&E
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Brain_rep_9_H&E
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Brain_rep_10_H&E
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Brain_rep_11_H&E
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Brain_rep_12_H&E
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Bladder_rep_2_H&E
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Intestine_rep_colon1_H&E
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Intestine_rep_colon2_H&E
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Intestine_rep_colon3_H&E
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Intestine_rep_colon4_H&E
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Liver_rep_liver1_H&E
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Liver_rep_liver2_H&E
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Liver_rep_liver4_H&E
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Intestine_A2_H&E
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Uterus_rep_2_H&E
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Uterus_rep_3_H&E
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Uterus_rep_4_H&E
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Breast_1160920F_H&E
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Breast_CID4290_H&E
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Breast_CID44971_H&E
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Breast_CID4535_H&E
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Lung_rep_1_H&E
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Lung_rep_2_H&E
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Spatial pattern pathway has PTGES3 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
PTGES3GOBP_Lipid_Metabolic_ProcessHumanBrainrep_1 2.8e-23
PTGES3GOBP_Positive_Regulation_Of_Catalytic_ActivityHumanBrainrep_1 8.7e-71
PTGES3GOBP_Positive_Regulation_Of_Molecular_FunctionHumanBrainrep_1 8.7e-71
PTGES3GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_ProcessHumanBrainrep_1 2.8e-23
PTGES3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessHumanBrainrep_1 7.4e-34
PTGES3GOBP_Regulation_Of_Response_To_StressHumanBrainrep_1 4.6e-05
PTGES3GOBP_Lipid_Metabolic_ProcessHumanLiverrep_1 1.0e-70
PTGES3GOBP_Positive_Regulation_Of_Catalytic_ActivityHumanLiverrep_1 2.1e-52
PTGES3GOBP_Positive_Regulation_Of_Molecular_FunctionHumanLiverrep_1 2.1e-52
PTGES3GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_ProcessHumanLiverrep_1 1.0e-70
PTGES3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessHumanLiverrep_1 1.0e-70
PTGES3GOBP_Regulation_Of_Response_To_StressHumanLiverrep_1 5.3e-67
PTGES3GOBP_Positive_Regulation_Of_Catalytic_ActivityHumanIntestinerep_colon2 2.3e-37
PTGES3GOBP_Positive_Regulation_Of_Molecular_FunctionHumanIntestinerep_colon2 2.3e-37
PTGES3GOBP_Regulation_Of_Response_To_StressHumanIntestinerep_colon4 2.2e-52
PTGES3GOBP_Cellular_Response_To_HeatHumanIntestineA3 2.1e-21
PTGES3GOBP_Chaperone_Cofactor_Dependent_Protein_RefoldingHumanIntestineA3 6.6e-15
PTGES3GOBP_Chaperone_Mediated_Protein_Complex_AssemblyHumanIntestineA3 6.3e-11
PTGES3GOBP_Chaperone_Mediated_Protein_FoldingHumanIntestineA3 1.1e-14
PTGES3GOBP_Chromosome_OrganizationHumanIntestineA3 2.5e-13
PTGES3GOBP_De_Novo_Protein_FoldingHumanIntestineA3 3.9e-13
PTGES3GOBP_Dna_Biosynthetic_ProcessHumanIntestineA3 9.4e-13
PTGES3GOBP_Dna_Metabolic_ProcessHumanIntestineA3 1.2e-09
PTGES3GOBP_Homeostatic_ProcessHumanIntestineA3 8.7e-10
PTGES3GOBP_Lipid_Biosynthetic_ProcessHumanIntestineA3 5.0e-07
PTGES3GOBP_Positive_Regulation_Of_Catalytic_ActivityHumanIntestineA3 7.7e-16
PTGES3GOBP_Positive_Regulation_Of_Dna_Metabolic_ProcessHumanIntestineA3 3.1e-07
PTGES3GOBP_Positive_Regulation_Of_Molecular_FunctionHumanIntestineA3 2.1e-13
PTGES3GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessHumanIntestineA3 5.1e-13
PTGES3GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_ProcessHumanIntestineA3 7.8e-15
PTGES3GOBP_Positive_Regulation_Of_Transferase_ActivityHumanIntestineA3 2.1e-11
PTGES3GOBP_Protein_FoldingHumanIntestineA3 3.4e-14
PTGES3GOBP_Protein_StabilizationHumanIntestineA3 5.9e-13
PTGES3GOBP_Regulation_Of_Cellular_Response_To_StressHumanIntestineA3 7.7e-17
PTGES3GOBP_Regulation_Of_Dna_Metabolic_ProcessHumanIntestineA3 2.8e-10
PTGES3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessHumanIntestineA3 1.5e-11
PTGES3GOBP_Regulation_Of_Protein_StabilityHumanIntestineA3 9.7e-11
PTGES3GOBP_Regulation_Of_Response_To_StressHumanIntestineA3 1.1e-10
PTGES3GOBP_Regulation_Of_Transferase_ActivityHumanIntestineA3 3.9e-10
PTGES3GOBP_Response_To_Abiotic_StimulusHumanIntestineA3 5.3e-18
PTGES3GOBP_Response_To_HeatHumanIntestineA3 7.0e-22
PTGES3GOBP_Response_To_Temperature_StimulusHumanIntestineA3 4.2e-20
PTGES3GOBP_Response_To_Xenobiotic_StimulusHumanIntestineA3 2.5e-09
PTGES3GOBP_Ribonucleoprotein_Complex_Subunit_OrganizationHumanIntestineA3 1.6e-07
PTGES3GOBP_Arachidonic_Acid_Metabolic_ProcessHumanIntestineA8 4.4e-09
PTGES3GOBP_Cellular_Lipid_Metabolic_ProcessHumanIntestineA8 3.8e-13
PTGES3GOBP_Fatty_Acid_Metabolic_ProcessHumanIntestineA8 7.3e-13
PTGES3GOBP_Icosanoid_Metabolic_ProcessHumanIntestineA8 9.6e-13
PTGES3GOBP_Lipid_Metabolic_ProcessHumanIntestineA8 1.1e-11
PTGES3GOBP_Long_Chain_Fatty_Acid_Metabolic_ProcessHumanIntestineA8 8.2e-09
PTGES3GOBP_Monocarboxylic_Acid_Metabolic_ProcessHumanIntestineA8 7.3e-16
PTGES3GOBP_Organic_Acid_Biosynthetic_ProcessHumanIntestineA8 2.1e-08
PTGES3GOBP_Organic_Acid_Metabolic_ProcessHumanIntestineA8 2.5e-18
PTGES3GOBP_Prostanoid_Metabolic_ProcessHumanIntestineA8 2.1e-10
PTGES3GOBP_Regulation_Of_Cellular_Response_To_HeatHumanIntestineA8 3.0e-08
PTGES3GOBP_Regulation_Of_Dna_Biosynthetic_ProcessHumanIntestineA8 1.2e-08
PTGES3GOBP_Regulation_Of_Telomerase_ActivityHumanIntestineA8 2.4e-08
PTGES3GOBP_Small_Molecule_Biosynthetic_ProcessHumanIntestineA8 1.0e-14
PTGES3GOBP_Small_Molecule_Metabolic_ProcessHumanIntestineA8 2.1e-15
PTGES3GOBP_Telomerase_Holoenzyme_Complex_AssemblyHumanIntestineA8 2.9e-08
PTGES3GOBP_Unsaturated_Fatty_Acid_Metabolic_ProcessHumanIntestineA8 1.4e-12
PTGES3GOBP_Icosanoid_Biosynthetic_ProcessHumanPancreasPDAC-B-st1 2.4e-05
PTGES3GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_ProcessHumanPancreasPDAC-B-st1 8.9e-05
PTGES3GOBP_Prostanoid_Biosynthetic_ProcessHumanPancreasPDAC-B-st1 8.8e-05
PTGES3GOBP_Protein_FoldingHumanPancreasPDAC-B-st1 1.2e-05
PTGES3GOBP_Unsaturated_Fatty_Acid_Biosynthetic_ProcessHumanPancreasPDAC-B-st1 9.5e-06
PTGES3GOBP_Anatomical_Structure_HomeostasisHumanUterusrep_1 8.8e-07
PTGES3GOBP_Olefinic_Compound_Metabolic_ProcessHumanUterusrep_1 3.8e-07
PTGES3GOBP_Cellular_Response_To_HeatHumanUterusrep_25 6.3e-09
PTGES3GOBP_Regulation_Of_Cellular_Response_To_HeatHumanUterusrep_25 1.4e-10
PTGES3GOBP_Response_To_Temperature_StimulusHumanUterusrep_25 8.0e-06
PTGES3GOBP_Chaperone_Cofactor_Dependent_Protein_RefoldingHumanUterusrep_26 8.2e-11
PTGES3GOBP_Chaperone_Mediated_Protein_Complex_AssemblyHumanUterusrep_26 2.9e-11
PTGES3GOBP_Chromosome_OrganizationHumanUterusrep_26 1.2e-09
PTGES3GOBP_De_Novo_Protein_FoldingHumanUterusrep_26 1.8e-15
PTGES3GOBP_Fatty_Acid_Biosynthetic_ProcessHumanUterusrep_26 9.2e-10
PTGES3GOBP_Fatty_Acid_Metabolic_ProcessHumanUterusrep_26 1.3e-06
PTGES3GOBP_Homeostatic_ProcessHumanUterusrep_26 1.9e-07
PTGES3GOBP_Icosanoid_Biosynthetic_ProcessHumanUterusrep_26 1.8e-10
PTGES3GOBP_Long_Chain_Fatty_Acid_Metabolic_ProcessHumanUterusrep_26 1.9e-09
PTGES3GOBP_Monocarboxylic_Acid_Biosynthetic_ProcessHumanUterusrep_26 1.0e-07
PTGES3GOBP_Organic_Acid_Biosynthetic_ProcessHumanUterusrep_26 2.3e-06
PTGES3GOBP_Organic_Acid_Metabolic_ProcessHumanUterusrep_26 4.9e-06
PTGES3GOBP_Positive_Regulation_Of_Dna_Metabolic_ProcessHumanUterusrep_26 2.8e-06
PTGES3GOBP_Prostanoid_Biosynthetic_ProcessHumanUterusrep_26 3.4e-06
PTGES3GOBP_Prostanoid_Metabolic_ProcessHumanUterusrep_26 1.8e-10
PTGES3GOBP_Regulation_Of_Dna_Metabolic_ProcessHumanUterusrep_26 2.1e-06
PTGES3GOBP_Response_To_HeatHumanUterusrep_26 3.4e-07
PTGES3GOBP_Ribonucleoprotein_Complex_Subunit_OrganizationHumanUterusrep_26 4.6e-06
PTGES3GOBP_Small_Molecule_Biosynthetic_ProcessHumanUterusrep_26 5.8e-09
PTGES3GOBP_Telomerase_Holoenzyme_Complex_AssemblyHumanUterusrep_26 1.6e-13
PTGES3GOBP_Unsaturated_Fatty_Acid_Biosynthetic_ProcessHumanUterusrep_26 2.1e-10
PTGES3GOBP_Unsaturated_Fatty_Acid_Metabolic_ProcessHumanUterusrep_26 3.3e-07
PTGES3GOBP_Cyclooxygenase_PathwayHumanUterusrep_29 2.8e-08
PTGES3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessHumanUterusrep_29 2.8e-06
PTGES3GOBP_Arachidonic_Acid_Metabolic_ProcessHumanBreastrep_1 1.2e-10
PTGES3GOBP_Homeostatic_ProcessHumanBreastrep_1 9.0e-53
PTGES3GOBP_Regulation_Of_Cellular_Response_To_HeatHumanBreastrep_1 1.9e-16
PTGES3GOBP_Regulation_Of_Response_To_StressHumanBreastrep_1 3.4e-19
PTGES3GOBP_Response_To_Abiotic_StimulusHumanBreastrep_1 2.6e-19
PTGES3GOBP_Response_To_Temperature_StimulusHumanBreastrep_1 1.2e-34
PTGES3GOBP_Cellular_Lipid_Metabolic_ProcessHumanBreastrep_5 2.6e-07
PTGES3GOBP_Chaperone_Cofactor_Dependent_Protein_RefoldingHumanBreastrep_5 1.3e-10
PTGES3GOBP_Chaperone_Mediated_Protein_FoldingHumanBreastrep_5 2.9e-08
PTGES3GOBP_De_Novo_Protein_FoldingHumanBreastrep_5 2.0e-10
PTGES3GOBP_Fatty_Acid_Biosynthetic_ProcessHumanBreastrep_5 2.8e-12
PTGES3GOBP_Fatty_Acid_Metabolic_ProcessHumanBreastrep_5 1.2e-06
PTGES3GOBP_Icosanoid_Metabolic_ProcessHumanBreastrep_5 2.9e-07
PTGES3GOBP_Lipid_Biosynthetic_ProcessHumanBreastrep_5 7.0e-04
PTGES3GOBP_Lipid_Metabolic_ProcessHumanBreastrep_5 2.9e-06
PTGES3GOBP_Monocarboxylic_Acid_Biosynthetic_ProcessHumanBreastrep_5 2.9e-17
PTGES3GOBP_Organic_Acid_Biosynthetic_ProcessHumanBreastrep_5 3.5e-09
PTGES3GOBP_Positive_Regulation_Of_Catalytic_ActivityHumanBreastrep_5 1.9e-12
PTGES3GOBP_Positive_Regulation_Of_Molecular_FunctionHumanBreastrep_5 7.4e-10
PTGES3GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessHumanBreastrep_5 8.0e-09
PTGES3GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_ProcessHumanBreastrep_5 5.9e-12
PTGES3GOBP_Protein_FoldingHumanBreastrep_5 6.0e-09
PTGES3GOBP_Regulation_Of_Cellular_Response_To_StressHumanBreastrep_5 8.1e-10
PTGES3GOBP_Regulation_Of_Phosphorus_Metabolic_ProcessHumanBreastrep_5 2.5e-06
PTGES3GOBP_Response_To_Xenobiotic_StimulusHumanBreastrep_5 2.9e-05
PTGES3GOBP_Unsaturated_Fatty_Acid_Metabolic_ProcessHumanBreastrep_5 3.8e-09
PTGES3GOBP_Cellular_Response_To_HeatHumanBreastrep_6 1.3e-04
PTGES3GOBP_Chaperone_Mediated_Protein_Complex_AssemblyHumanBreastrep_6 9.1e-08
PTGES3GOBP_Chromosome_OrganizationHumanBreastrep_6 1.1e-06
PTGES3GOBP_Cyclooxygenase_PathwayHumanBreastrep_6 6.7e-06
PTGES3GOBP_Dna_Biosynthetic_ProcessHumanBreastrep_6 5.0e-13
PTGES3GOBP_Dna_Metabolic_ProcessHumanBreastrep_6 1.4e-10
PTGES3GOBP_Long_Chain_Fatty_Acid_Metabolic_ProcessHumanBreastrep_6 6.3e-10
PTGES3GOBP_Monocarboxylic_Acid_Metabolic_ProcessHumanBreastrep_6 6.1e-07
PTGES3GOBP_Olefinic_Compound_Metabolic_ProcessHumanBreastrep_6 1.5e-08
PTGES3GOBP_Organic_Acid_Metabolic_ProcessHumanBreastrep_6 6.7e-05
PTGES3GOBP_Positive_Regulation_Of_Dna_Biosynthetic_ProcessHumanBreastrep_6 1.1e-07
PTGES3GOBP_Positive_Regulation_Of_Dna_Metabolic_ProcessHumanBreastrep_6 2.4e-08
PTGES3GOBP_Positive_Regulation_Of_Telomerase_ActivityHumanBreastrep_6 9.3e-09
PTGES3GOBP_Positive_Regulation_Of_Transferase_ActivityHumanBreastrep_6 3.2e-05
PTGES3GOBP_Protein_StabilizationHumanBreastrep_6 1.8e-07
PTGES3GOBP_Regulation_Of_Dna_Biosynthetic_ProcessHumanBreastrep_6 4.0e-08
PTGES3GOBP_Regulation_Of_Dna_Metabolic_ProcessHumanBreastrep_6 9.5e-08
PTGES3GOBP_Regulation_Of_Protein_StabilityHumanBreastrep_6 1.6e-08
PTGES3GOBP_Regulation_Of_Telomerase_ActivityHumanBreastrep_6 4.2e-07
PTGES3GOBP_Regulation_Of_Transferase_ActivityHumanBreastrep_6 4.6e-05
PTGES3GOBP_Ribonucleoprotein_Complex_BiogenesisHumanBreastrep_6 1.3e-07
PTGES3GOBP_Ribonucleoprotein_Complex_Subunit_OrganizationHumanBreastrep_6 1.4e-08
PTGES3GOBP_Rna_Dependent_Dna_Biosynthetic_ProcessHumanBreastrep_6 9.8e-09
PTGES3GOBP_Small_Molecule_Biosynthetic_ProcessHumanBreastrep_6 1.0e-06
PTGES3GOBP_Small_Molecule_Metabolic_ProcessHumanBreastrep_6 5.5e-09
PTGES3GOBP_Telomerase_Holoenzyme_Complex_AssemblyHumanBreastrep_6 3.0e-09
PTGES3GOBP_Telomere_Maintenance_Via_Telomere_LengtheningHumanBreastrep_6 8.1e-08
PTGES3GOBP_Telomere_OrganizationHumanBreastrep_6 6.0e-08
PTGES3GOBP_Icosanoid_Biosynthetic_ProcessHumanSkinP2_rep2 2.3e-08
PTGES3GOBP_Prostanoid_Biosynthetic_ProcessHumanSkinP2_rep2 4.3e-08
PTGES3GOBP_Unsaturated_Fatty_Acid_Metabolic_ProcessHumanSkinP2_rep3 8.1e-08
PTGES3GOBP_Protein_StabilizationHumanSkinP5_rep1 2.1e-11
PTGES3GOBP_Cyclooxygenase_PathwayHumanSkinP5_rep2 1.1e-10
PTGES3GOBP_Regulation_Of_Protein_StabilityHumanSkinP5_rep2 5.8e-08
PTGES3GOBP_Chaperone_Mediated_Protein_Complex_AssemblyHumanSkinP5_rep3 8.4e-14
PTGES3GOBP_Positive_Regulation_Of_Telomerase_ActivityHumanSkinP5_rep3 2.4e-08
PTGES3GOBP_Regulation_Of_Telomerase_ActivityHumanSkinP5_rep3 1.4e-08
PTGES3GOBP_Telomerase_Holoenzyme_Complex_AssemblyHumanSkinP5_rep3 6.2e-14
PTGES3GOBP_Regulation_Of_Cellular_Response_To_HeatHumanSkinP10_rep2 7.2e-13
PTGES3GOBP_Fatty_Acid_Biosynthetic_ProcessHumanLungrep_2 7.8e-07
PTGES3GOBP_Icosanoid_Metabolic_ProcessHumanLungrep_2 4.6e-07

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PTGES3 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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PTGES3 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for PTGES3 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for PTGES3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
PTGES3Q15185DB00316AcetaminophenProstaglandin E synthase 3 SmallMoleculeDrugapproved
PTGES3Q15185DB09130CopperProstaglandin E synthase 3 SmallMoleculeDrugapproved|investigational

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Related Diseases for PTGES3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
PTGES3C0149504Encephalopathy, Toxic1CTD_human
PTGES3C0154659Toxic Encephalitis1CTD_human
PTGES3C0235032Neurotoxicity Syndromes1CTD_human