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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: NFAT5 (spascer ID:10725)

Gene summary for NFAT5

Gene summary

Gene information
	Species	Human
	Gene symbol	NFAT5
	Gene ID	10725
	Gene name	nuclear factor of activated T cells 5
	Synonyms	NF-AT5\|NFATL1\|NFATZ\|OREBP\|TONEBP
	Cytomap	16q22.1
	Type of gene	protein-coding
	Description	nuclear factor of activated T-cells 5NFAT-like protein 1T-cell transcription factor NFAT5TonE-binding proteinglutamine rich protein H65nuclear factor of activated T-cells 5, tonicity-responsiveosmotic response element-binding proteintonicity-respon
	Modification date	20220513
	UniProtAcc	O94916

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
NFAT5	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	21873635	Function
NFAT5	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
NFAT5	GO:0001816	cytokine production	21873635	Process
NFAT5	GO:0005667	transcription regulator complex	21873635	Component
NFAT5	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
NFAT5	GO:0008134	transcription factor binding	21873635	Function
NFAT5	GO:0033173	calcineurin-NFAT signaling cascade	21873635	Process

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Spatial pattern events for NFAT5

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
NFAT5	Human	Liver	rep_liver2	34417225	6.98e-16
NFAT5	Human	Uterus	rep_3	34857954	5.92e-11
NFAT5	Human	Breast	CID44971	34493872	2.25e-12

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E
Uterus_rep_3_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has NFAT5 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
NFAT5	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	3.1e-68
NFAT5	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
NFAT5	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
NFAT5	GOBP_Cytokine_Production	Human	Brain	rep_4	4.1e-17
NFAT5	GOBP_Cytokine_Production	Human	Liver	rep_1	1.0e-70
NFAT5	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
NFAT5	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
NFAT5	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
NFAT5	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	3.4e-10
NFAT5	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
NFAT5	GOBP_Cytokine_Production	Human	Intestine	rep_colon4	9.0e-12
NFAT5	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
NFAT5	GOBP_Biological_Adhesion	Human	Intestine	A3	6.7e-11
NFAT5	GOBP_Cell_Cell_Adhesion	Human	Intestine	A3	2.5e-07
NFAT5	GOBP_Cytokine_Production	Human	Intestine	A3	8.9e-12
NFAT5	GOBP_Excretion	Human	Intestine	A3	4.5e-11
NFAT5	GOBP_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Intestine	A3	5.6e-07
NFAT5	GOBP_Leukocyte_Cell_Cell_Adhesion	Human	Intestine	A3	6.3e-09
NFAT5	GOBP_Nik_Nf_Kappab_Signaling	Human	Intestine	A3	2.0e-08
NFAT5	GOBP_Positive_Regulation_Of_Cell_Adhesion	Human	Intestine	A3	4.4e-10
NFAT5	GOBP_Positive_Regulation_Of_Cell_Cell_Adhesion	Human	Intestine	A3	5.1e-10
NFAT5	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-10
NFAT5	GOBP_Positive_Regulation_Of_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Intestine	A3	2.2e-08
NFAT5	GOBP_Positive_Regulation_Of_Leukocyte_Cell_Cell_Adhesion	Human	Intestine	A3	4.0e-07
NFAT5	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	5.1e-13
NFAT5	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
NFAT5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Intestine	A3	9.4e-13
NFAT5	GOBP_Regulation_Of_Cell_Adhesion	Human	Intestine	A3	1.5e-10
NFAT5	GOBP_Regulation_Of_Cell_Cell_Adhesion	Human	Intestine	A3	1.2e-07
NFAT5	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
NFAT5	GOBP_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Intestine	A3	2.5e-08
NFAT5	GOBP_Response_To_Abiotic_Stimulus	Human	Intestine	A3	5.3e-18
NFAT5	GOBP_Second_Messenger_Mediated_Signaling	Human	Intestine	A3	1.7e-07
NFAT5	GOBP_Calcineurin_Mediated_Signaling	Human	Intestine	A8	2.7e-17
NFAT5	GOBP_Calcium_Mediated_Signaling	Human	Intestine	A8	2.9e-10
NFAT5	GOBP_Inositol_Phosphate_Mediated_Signaling	Human	Intestine	A8	9.0e-20
NFAT5	GOBP_Regulation_Of_Calcineurin_Mediated_Signaling	Human	Intestine	A8	6.2e-19
NFAT5	GOBP_Regulation_Of_Calcium_Mediated_Signaling	Human	Intestine	A8	1.4e-11
NFAT5	GOBP_Regulation_Of_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Intestine	A8	1.2e-07
NFAT5	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
NFAT5	GOBP_Response_To_Osmotic_Stress	Human	Pancreas	PDAC-B-st1	5.0e-05
NFAT5	GOBP_Calcium_Mediated_Signaling	Human	Uterus	rep_1	4.1e-06
NFAT5	GOBP_Positive_Regulation_Of_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Uterus	rep_25	6.0e-13
NFAT5	GOBP_Regulation_Of_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Uterus	rep_25	2.3e-17
NFAT5	GOBP_Excretion	Human	Uterus	rep_26	4.1e-12
NFAT5	GOBP_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Uterus	rep_26	8.0e-11
NFAT5	GOBP_Nik_Nf_Kappab_Signaling	Human	Uterus	rep_26	1.7e-11
NFAT5	GOBP_Positive_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Uterus	rep_26	8.9e-10
NFAT5	GOBP_Regulation_Of_Calcium_Mediated_Signaling	Human	Uterus	rep_26	2.0e-07
NFAT5	GOBP_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Uterus	rep_26	8.5e-12
NFAT5	GOBP_Second_Messenger_Mediated_Signaling	Human	Uterus	rep_26	3.8e-08
NFAT5	GOBP_Positive_Regulation_Of_Cell_Cell_Adhesion	Human	Uterus	rep_28	5.4e-06
NFAT5	GOBP_Positive_Regulation_Of_Leukocyte_Cell_Cell_Adhesion	Human	Uterus	rep_28	9.7e-06
NFAT5	GOBP_Biological_Adhesion	Human	Uterus	rep_29	3.3e-06
NFAT5	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_29	5.5e-06
NFAT5	GOBP_Biological_Adhesion	Human	Breast	rep_1	4.0e-110
NFAT5	GOBP_Cell_Cell_Adhesion	Human	Breast	rep_1	3.6e-45
NFAT5	GOBP_Cytokine_Production	Human	Breast	rep_1	6.5e-12
NFAT5	GOBP_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Breast	rep_1	1.1e-21
NFAT5	GOBP_Positive_Regulation_Of_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Breast	rep_1	5.0e-04
NFAT5	GOBP_Regulation_Of_Cell_Adhesion	Human	Breast	rep_1	1.7e-16
NFAT5	GOBP_Regulation_Of_Leukocyte_Adhesion_To_Vascular_Endothelial_Cell	Human	Breast	rep_1	3.0e-28
NFAT5	GOBP_Response_To_Abiotic_Stimulus	Human	Breast	rep_1	2.6e-19
NFAT5	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
NFAT5	GOBP_Positive_Regulation_Of_Cell_Cell_Adhesion	Human	Breast	rep_2	2.3e-04
NFAT5	GOBP_Positive_Regulation_Of_Leukocyte_Cell_Cell_Adhesion	Human	Breast	rep_2	5.9e-07
NFAT5	GOBP_Calcineurin_Mediated_Signaling	Human	Breast	rep_5	4.9e-04
NFAT5	GOBP_Calcium_Mediated_Signaling	Human	Breast	rep_5	6.1e-14
NFAT5	GOBP_Nik_Nf_Kappab_Signaling	Human	Breast	rep_5	1.3e-07
NFAT5	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	5.3e-08
NFAT5	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_5	8.0e-09
NFAT5	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
NFAT5	GOBP_Regulation_Of_Calcineurin_Mediated_Signaling	Human	Breast	rep_5	2.4e-04
NFAT5	GOBP_Regulation_Of_Calcium_Mediated_Signaling	Human	Breast	rep_5	3.1e-06
NFAT5	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
NFAT5	GOBP_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Breast	rep_5	2.7e-07
NFAT5	GOBP_Response_To_Osmotic_Stress	Human	Breast	rep_5	6.5e-08
NFAT5	GOBP_Second_Messenger_Mediated_Signaling	Human	Breast	rep_5	3.6e-06
NFAT5	GOBP_Excretion	Human	Breast	rep_6	5.0e-16
NFAT5	GOBP_Positive_Regulation_Of_Nik_Nf_Kappab_Signaling	Human	Breast	rep_6	4.3e-06
NFAT5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Breast	rep_6	4.2e-06
NFAT5	GOBP_Excretion	Human	Skin	P10_rep1	1.7e-09
NFAT5	GOBP_Biological_Adhesion	Human	Lung	rep_2	6.6e-07
NFAT5	GOBP_Cell_Cell_Adhesion	Human	Lung	rep_2	5.3e-07
NFAT5	GOBP_Positive_Regulation_Of_Cell_Cell_Adhesion	Human	Lung	rep_2	8.2e-08
NFAT5	GOBP_Positive_Regulation_Of_Leukocyte_Cell_Cell_Adhesion	Human	Lung	rep_2	4.4e-07

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NFAT5 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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NFAT5 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for NFAT5 envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
Nfat5	Lymph	control	Ifit3 high B	Malat1,Spag9,Ddx17, etc.	0.271
Nfat5	Lymph	control	Mature B	Malat1,Spag9,Ddx17, etc.	0.373
Nfat5	Lymph	control	CD8 T	Malat1,Spag9,Ddx17, etc.	0.252
Nfat5	Lymph	disease	Ifit3 high B	Malat1,Mir155hg,Tbc1d4, etc.	0.308
Nfat5	Lymph	disease	Mature B	Malat1,Mir155hg,Tbc1d4, etc.	0.35

Motif information.

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Related Drugs for NFAT5

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NFAT5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source