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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: POLD3 (spascer ID:10714)

Gene summary for POLD3

Gene summary

Gene information
	Species	Human
	Gene symbol	POLD3
	Gene ID	10714
	Gene name	DNA polymerase delta 3, accessory subunit
	Synonyms	P66\|P68\|PPP1R128
	Cytomap	11q13.4
	Type of gene	protein-coding
	Description	DNA polymerase delta subunit 3DNA polymerase delta subunit CDNA polymerase delta subunit p66DNA polymerase delta subunit p68Pol delta C subunit (p66)polymerase (DNA) delta 3, accessory subunitpolymerase (DNA-directed), delta 3, accessory subunitpro
	Modification date	20220513
	UniProtAcc	Q15054

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
POLD3	GO:0003887	DNA-directed DNA polymerase activity	21873635	Function
POLD3	GO:0006271	DNA strand elongation involved in DNA replication	21873635	Process
POLD3	GO:0006297	nucleotide-excision repair, DNA gap filling	21873635	Process
POLD3	GO:0043625	delta DNA polymerase complex	21873635	Component
POLD3	GO:1904161	DNA synthesis involved in UV-damage excision repair	21873635	Process

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Spatial pattern events for POLD3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
POLD3	Human	Liver	rep_liver1	34417225	1.89e-15
POLD3	Human	Uterus	rep_3	34857954	3.35e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Uterus_rep_3_H&E

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Spatial pattern pathway has POLD3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
POLD3	GOBP_Cellular_Response_To_Abiotic_Stimulus	Human	Bladder	rep_2	7.0e-07
POLD3	GOBP_Dna_Dependent_Dna_Replication	Human	Bladder	rep_4	5.7e-05
POLD3	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
POLD3	GOBP_Cell_Cycle_Process	Human	Intestine	A3	2.7e-14
POLD3	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Intestine	A3	6.6e-16
POLD3	GOBP_Cellular_Response_To_Radiation	Human	Intestine	A3	6.7e-10
POLD3	GOBP_Chromosome_Organization	Human	Intestine	A3	2.5e-13
POLD3	GOBP_Dna_Biosynthetic_Process	Human	Intestine	A3	9.4e-13
POLD3	GOBP_Dna_Dependent_Dna_Replication	Human	Intestine	A3	2.2e-07
POLD3	GOBP_Dna_Metabolic_Process	Human	Intestine	A3	1.2e-09
POLD3	GOBP_Dna_Repair	Human	Intestine	A3	4.4e-09
POLD3	GOBP_Dna_Replication	Human	Intestine	A3	2.5e-08
POLD3	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
POLD3	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Intestine	A3	1.9e-08
POLD3	GOBP_Nucleotide_Excision_Repair	Human	Intestine	A3	8.1e-09
POLD3	GOBP_Response_To_Abiotic_Stimulus	Human	Intestine	A3	5.3e-18
POLD3	GOBP_Response_To_Light_Stimulus	Human	Intestine	A3	9.1e-14
POLD3	GOBP_Response_To_Radiation	Human	Intestine	A3	6.3e-07
POLD3	GOBP_Response_To_Uv	Human	Intestine	A3	1.2e-08
POLD3	GOBP_Cellular_Homeostasis	Human	Intestine	A8	2.1e-11
POLD3	GOBP_Cellular_Response_To_Abiotic_Stimulus	Human	Intestine	A8	2.5e-11
POLD3	GOBP_Detection_Of_Stimulus	Human	Intestine	A8	2.4e-11
POLD3	GOBP_Dna_Strand_Elongation_Involved_In_Dna_Replication	Human	Intestine	A8	6.2e-13
POLD3	GOBP_Dna_Synthesis_Involved_In_Dna_Repair	Human	Intestine	A8	9.2e-15
POLD3	GOBP_Mismatch_Repair	Human	Intestine	A8	3.0e-08
POLD3	GOBP_Nucleotide_Excision_Repair_Dna_Gap_Filling	Human	Intestine	A8	3.8e-18
POLD3	GOBP_Nucleotide_Excision_Repair_Dna_Incision	Human	Intestine	A8	8.6e-16
POLD3	GOBP_Postreplication_Repair	Human	Intestine	A8	3.3e-07
POLD3	GOBP_Telomere_Maintenance_Via_Semi_Conservative_Replication	Human	Intestine	A8	1.5e-08
POLD3	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Intestine	A8	3.5e-07
POLD3	GOBP_Translesion_Synthesis	Human	Intestine	A8	3.1e-13
POLD3	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Pancreas	PDAC-B-st1	4.0e-06
POLD3	GOBP_Mismatch_Repair	Human	Pancreas	PDAC-A-st2	3.1e-05
POLD3	GOBP_Nucleotide_Excision_Repair	Human	Pancreas	PDAC-A-st2	4.7e-06
POLD3	GOBP_Telomere_Maintenance_Via_Semi_Conservative_Replication	Human	Pancreas	PDAC-A-st2	1.9e-06
POLD3	GOBP_Anatomical_Structure_Homeostasis	Human	Uterus	rep_1	8.8e-07
POLD3	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Uterus	rep_1	2.3e-08
POLD3	GOBP_Dna_Strand_Elongation	Human	Uterus	rep_25	4.6e-11
POLD3	GOBP_Dna_Synthesis_Involved_In_Dna_Repair	Human	Uterus	rep_25	1.3e-10
POLD3	GOBP_Nucleotide_Excision_Repair_Dna_Gap_Filling	Human	Uterus	rep_25	6.0e-10
POLD3	GOBP_Postreplication_Repair	Human	Uterus	rep_25	5.2e-06
POLD3	GOBP_Translesion_Synthesis	Human	Uterus	rep_25	4.9e-06
POLD3	GOBP_Uv_Damage_Excision_Repair	Human	Uterus	rep_25	9.0e-15
POLD3	GOBP_Cell_Cycle_Dna_Replication	Human	Uterus	rep_26	3.2e-07
POLD3	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Uterus	rep_26	2.4e-07
POLD3	GOBP_Cellular_Response_To_Uv	Human	Uterus	rep_26	6.2e-07
POLD3	GOBP_Chromosome_Organization	Human	Uterus	rep_26	1.2e-09
POLD3	GOBP_Dna_Dependent_Dna_Replication	Human	Uterus	rep_26	2.7e-14
POLD3	GOBP_Dna_Replication	Human	Uterus	rep_26	1.5e-09
POLD3	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
POLD3	GOBP_Nucleotide_Excision_Repair	Human	Uterus	rep_26	1.3e-07
POLD3	GOBP_Nucleotide_Excision_Repair_Dna_Incision	Human	Uterus	rep_26	8.0e-09
POLD3	GOBP_Response_To_Uv	Human	Uterus	rep_26	1.4e-06
POLD3	GOBP_Cellular_Homeostasis	Human	Breast	rep_1	2.8e-10
POLD3	GOBP_Detection_Of_Stimulus	Human	Breast	rep_1	1.8e-04
POLD3	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
POLD3	GOBP_Response_To_Abiotic_Stimulus	Human	Breast	rep_1	2.6e-19
POLD3	GOBP_Cellular_Response_To_Abiotic_Stimulus	Human	Breast	rep_5	1.3e-06
POLD3	GOBP_Nucleotide_Excision_Repair_Dna_Incision	Human	Breast	rep_5	5.5e-07
POLD3	GOBP_Response_To_Radiation	Human	Breast	rep_5	3.8e-06
POLD3	GOBP_Uv_Damage_Excision_Repair	Human	Breast	rep_5	9.1e-08
POLD3	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
POLD3	GOBP_Cell_Cycle_Process	Human	Breast	rep_6	6.7e-09
POLD3	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Breast	rep_6	6.0e-06
POLD3	GOBP_Cellular_Response_To_Radiation	Human	Breast	rep_6	5.1e-06
POLD3	GOBP_Cellular_Response_To_Uv	Human	Breast	rep_6	4.9e-05
POLD3	GOBP_Chromosome_Organization	Human	Breast	rep_6	1.1e-06
POLD3	GOBP_Dna_Biosynthetic_Process	Human	Breast	rep_6	5.0e-13
POLD3	GOBP_Dna_Dependent_Dna_Replication	Human	Breast	rep_6	5.7e-04
POLD3	GOBP_Dna_Metabolic_Process	Human	Breast	rep_6	1.4e-10
POLD3	GOBP_Dna_Repair	Human	Breast	rep_6	1.0e-09
POLD3	GOBP_Dna_Replication	Human	Breast	rep_6	3.5e-07
POLD3	GOBP_Dna_Synthesis_Involved_In_Dna_Repair	Human	Breast	rep_6	3.5e-07
POLD3	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Breast	rep_6	2.6e-05
POLD3	GOBP_Postreplication_Repair	Human	Breast	rep_6	6.3e-06
POLD3	GOBP_Response_To_Light_Stimulus	Human	Breast	rep_6	1.5e-09
POLD3	GOBP_Response_To_Uv	Human	Breast	rep_6	5.2e-08
POLD3	GOBP_Telomere_Organization	Human	Breast	rep_6	6.0e-08
POLD3	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Breast	rep_6	2.3e-11
POLD3	GOBP_Dna_Repair	Human	Skin	P5_rep1	1.7e-08
POLD3	GOBP_Response_To_Light_Stimulus	Human	Skin	P5_rep1	4.5e-08
POLD3	GOBP_Uv_Damage_Excision_Repair	Human	Skin	P5_rep1	2.9e-17
POLD3	GOBP_Nucleotide_Excision_Repair_Dna_Gap_Filling	Human	Skin	P5_rep3	1.5e-23
POLD3	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Skin	P10_rep1	1.1e-08
POLD3	GOBP_Translesion_Synthesis	Human	Skin	P10_rep1	2.6e-08
POLD3	GOBP_Dna_Synthesis_Involved_In_Dna_Repair	Human	Skin	P10_rep2	2.5e-11
POLD3	GOBP_Mismatch_Repair	Human	Skin	P10_rep2	2.2e-10
POLD3	GOBP_Nucleotide_Excision_Repair_Dna_Incision	Human	Skin	P10_rep2	4.7e-09
POLD3	GOBP_Telomere_Maintenance_Via_Semi_Conservative_Replication	Human	Skin	P10_rep2	1.7e-09
POLD3	GOBP_Cellular_Homeostasis	Human	Lung	rep_2	7.3e-07

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POLD3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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POLD3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for POLD3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for POLD3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for POLD3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
POLD3	C0009402	Colorectal Carcinoma	2	CTD_human
POLD3	C0009404	Colorectal Neoplasms	2	CTD_human