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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9972

FusionGeneSummary for DICER1_CLMN

check button Fusion gene summary
Fusion gene informationFusion gene name: DICER1_CLMN
Fusion gene ID: 9972
HgeneTgene
Gene symbol

DICER1

CLMN

Gene ID

23405

79789

Gene namedicer 1, ribonuclease IIIcalmin
SynonymsDCR1|Dicer|Dicer1e|HERNA|K12H4.8-LIKE|MNG1|RMSE2-
Cytomap

14q32.13

14q32.13

Type of geneprotein-codingprotein-coding
Descriptionendoribonuclease DicerDicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleasedicer 1, ribonuclease type IIIhelicase MOIhelicase with RNAse motifcalmincalmin (calponin-like, transmembrane)calponin-like transmembrane domain protein
Modification date2018052320180523
UniProtAcc

Q9UPY3

Q96JQ2

Ensembl transtripts involved in fusion geneENST00000343455, ENST00000526495, 
ENST00000393063, ENST00000527416, 
ENST00000527414, ENST00000556045, 
ENST00000541352, 
ENST00000298912, 
ENST00000557215, ENST00000556441, 
Fusion gene scores* DoF score8 X 5 X 6=2403 X 3 X 2=18
# samples 93
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DICER1 [Title/Abstract] AND CLMN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDICER1

GO:0030422

production of siRNA involved in RNA interference

15973356|17452327|23661684

HgeneDICER1

GO:0031054

pre-miRNA processing

15973356|16357216|18178619|23661684|25549615

HgeneDICER1

GO:0035087

siRNA loading onto RISC involved in RNA interference

15973356

HgeneDICER1

GO:0035196

production of miRNAs involved in gene silencing by miRNA

15973356|23661684

HgeneDICER1

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

18178619

HgeneDICER1

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

21753850|25549615


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-A4QI-01ADICER1chr14

95623567

-CLMNchr14

95663031

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000343455ENST00000298912DICER1chr14

95623567

-CLMNchr14

95663031

-
5UTR-intronENST00000343455ENST00000557215DICER1chr14

95623567

-CLMNchr14

95663031

-
5UTR-intronENST00000343455ENST00000556441DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-3CDSENST00000526495ENST00000298912DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000526495ENST00000557215DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000526495ENST00000556441DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-3CDSENST00000393063ENST00000298912DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000393063ENST00000557215DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000393063ENST00000556441DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-3CDSENST00000527416ENST00000298912DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000527416ENST00000557215DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000527416ENST00000556441DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-3CDSENST00000527414ENST00000298912DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000527414ENST00000557215DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000527414ENST00000556441DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-3CDSENST00000556045ENST00000298912DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000556045ENST00000557215DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000556045ENST00000556441DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-3CDSENST00000541352ENST00000298912DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000541352ENST00000557215DICER1chr14

95623567

-CLMNchr14

95663031

-
intron-intronENST00000541352ENST00000556441DICER1chr14

95623567

-CLMNchr14

95663031

-

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FusionProtFeatures for DICER1_CLMN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DICER1

Q9UPY3

CLMN

Q96JQ2

Double-stranded RNA (dsRNA) endoribonuclease playing acentral role in short dsRNA-mediated post-transcriptional genesilencing. Cleaves naturally occurring long dsRNAs and shorthairpin pre-microRNAs (miRNA) into fragments of twenty-one totwenty-three nucleotides with 3' overhang of two nucleotides,producing respectively short interfering RNAs (siRNA) and maturemicroRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degradethem or prevent their translation. Gene silencing mediated bysiRNAs, also called RNA interference, controls the elimination oftranscripts from mobile and repetitive DNA elements of the genomebut also the degradation of exogenous RNA of viral origin forinstance. The miRNA pathway on the other side is a mean tospecifically regulate the expression of target genes.{ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356,ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387,ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216,ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327,ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:19219043}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DICER1_CLMN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DICER1_CLMN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DICER1AGO1, AGO3, AGO4, PIWIL4, PIWIL3, PIWIL2, AGO2, USP49, DHX58, EIF2AK2, PIWIL1, SIRT7, DHX9, CUL3, ALB, NOS2, GEMIN4, CALCOCO2, TARBP2, MMS19, NPM1, HDAC11, DDX20, SMN1, DICER1, PRKAB2, ALOX5, CUL4A, FBXL14, TRIM71, MTFR2, GNL2, GTPBP4, MTFR1, MYSM1, NOC3L, POP1, PRKRA, STAU2, AURKA, CCDC8, ZMAT3, RPS2, MEMO1, PNKD, SFRP4, ILF2, AAMP, FOXD4L6, PRG2, USP7, KALRN, NTRK1, CEP19, HNRNPD, RAP1B, SORT1, MAD2L2, SYNCRIP, TIMM13, SGTB, ACTR5, USF1, CRY2, TRMT2A, ADAMTS4, CPA6, TRIM41, STRBP, KIAA1683, RPL15, CFAP20, INO80B, TRIM25CLMNPPP1CC, CDH1, TCTEX1D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DICER1_CLMN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DICER1_CLMN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDICER1C0036341Schizophrenia2PSYGENET
HgeneDICER1C0014175Endometriosis1CTD_human
HgeneDICER1C0028960Oligospermia1CTD_human
HgeneDICER1C0302859Euthyroid Goiter1ORPHANET;UNIPROT
HgeneDICER1C1266144Pleuropulmonary blastoma1CTD_human;HPO;ORPHANET;UNIPROT