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Fusion gene ID: 9971 |
FusionGeneSummary for DICER1_CCDC14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DICER1_CCDC14 | Fusion gene ID: 9971 | Hgene | Tgene | Gene symbol | DICER1 | CCDC14 | Gene ID | 23405 | 64770 |
| Gene name | dicer 1, ribonuclease III | coiled-coil domain containing 14 | |
| Synonyms | DCR1|Dicer|Dicer1e|HERNA|K12H4.8-LIKE|MNG1|RMSE2 | - | |
| Cytomap | 14q32.13 | 3q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endoribonuclease DicerDicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleasedicer 1, ribonuclease type IIIhelicase MOIhelicase with RNAse motif | coiled-coil domain-containing protein 14 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UPY3 | Q49A88 | |
| Ensembl transtripts involved in fusion gene | ENST00000343455, ENST00000526495, ENST00000393063, ENST00000527416, ENST00000527414, ENST00000556045, ENST00000541352, | ENST00000310351, ENST00000488653, ENST00000485727, ENST00000489746, ENST00000433542, ENST00000483247, | |
| Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 4 X 3 X 3=36 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DICER1 [Title/Abstract] AND CCDC14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DICER1 | GO:0030422 | production of siRNA involved in RNA interference | 15973356|17452327|23661684 |
| Hgene | DICER1 | GO:0031054 | pre-miRNA processing | 15973356|16357216|18178619|23661684|25549615 |
| Hgene | DICER1 | GO:0035087 | siRNA loading onto RISC involved in RNA interference | 15973356 |
| Hgene | DICER1 | GO:0035196 | production of miRNAs involved in gene silencing by miRNA | 15973356|23661684 |
| Hgene | DICER1 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | 18178619 |
| Hgene | DICER1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 21753850|25549615 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE836683 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000343455 | ENST00000310351 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000343455 | ENST00000488653 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000343455 | ENST00000485727 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000343455 | ENST00000489746 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000343455 | ENST00000433542 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-intron | ENST00000343455 | ENST00000483247 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000526495 | ENST00000310351 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000526495 | ENST00000488653 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000526495 | ENST00000485727 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000526495 | ENST00000489746 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000526495 | ENST00000433542 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-intron | ENST00000526495 | ENST00000483247 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000393063 | ENST00000310351 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000393063 | ENST00000488653 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000393063 | ENST00000485727 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000393063 | ENST00000489746 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000393063 | ENST00000433542 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-intron | ENST00000393063 | ENST00000483247 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527416 | ENST00000310351 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527416 | ENST00000488653 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527416 | ENST00000485727 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527416 | ENST00000489746 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527416 | ENST00000433542 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-intron | ENST00000527416 | ENST00000483247 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527414 | ENST00000310351 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527414 | ENST00000488653 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527414 | ENST00000485727 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527414 | ENST00000489746 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000527414 | ENST00000433542 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-intron | ENST00000527414 | ENST00000483247 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000556045 | ENST00000310351 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000556045 | ENST00000488653 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000556045 | ENST00000485727 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000556045 | ENST00000489746 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000556045 | ENST00000433542 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-intron | ENST00000556045 | ENST00000483247 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000541352 | ENST00000310351 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000541352 | ENST00000488653 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000541352 | ENST00000485727 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000541352 | ENST00000489746 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-3CDS | ENST00000541352 | ENST00000433542 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
| intron-intron | ENST00000541352 | ENST00000483247 | DICER1 | chr14 | 95569908 | + | CCDC14 | chr3 | 123634212 | + |
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FusionProtFeatures for DICER1_CCDC14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DICER1 | CCDC14 |
| Double-stranded RNA (dsRNA) endoribonuclease playing acentral role in short dsRNA-mediated post-transcriptional genesilencing. Cleaves naturally occurring long dsRNAs and shorthairpin pre-microRNAs (miRNA) into fragments of twenty-one totwenty-three nucleotides with 3' overhang of two nucleotides,producing respectively short interfering RNAs (siRNA) and maturemicroRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degradethem or prevent their translation. Gene silencing mediated bysiRNAs, also called RNA interference, controls the elimination oftranscripts from mobile and repetitive DNA elements of the genomebut also the degradation of exogenous RNA of viral origin forinstance. The miRNA pathway on the other side is a mean tospecifically regulate the expression of target genes.{ECO:0000269|PubMed:15242644, ECO:0000269|PubMed:15973356,ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387,ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16357216,ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327,ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:19219043}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DICER1_CCDC14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DICER1_CCDC14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DICER1_CCDC14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DICER1_CCDC14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DICER1 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | DICER1 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | DICER1 | C0028960 | Oligospermia | 1 | CTD_human |
| Hgene | DICER1 | C0302859 | Euthyroid Goiter | 1 | ORPHANET;UNIPROT |
| Hgene | DICER1 | C1266144 | Pleuropulmonary blastoma | 1 | CTD_human;HPO;ORPHANET;UNIPROT |
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