	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 9968

FusionGeneSummary for DIAPH3_DIAPH3

Fusion gene summary

Fusion gene information	Fusion gene name: DIAPH3_DIAPH3
	Fusion gene ID: 9968
		Hgene	Tgene
	Gene symbol	DIAPH3	DIAPH3
	Gene ID	81624	81624
	Gene name	diaphanous related formin 3	diaphanous related formin 3
	Synonyms	AN\|AUNA1\|DIA2\|DRF3\|NSDAN\|diap3\|mDia2	AN\|AUNA1\|DIA2\|DRF3\|NSDAN\|diap3\|mDia2
	Cytomap	13q21.2	13q21.2
	Type of gene	protein-coding	protein-coding
	Description	protein diaphanous homolog 3diaphanous homolog 3	protein diaphanous homolog 3diaphanous homolog 3
	Modification date	20180527	20180527
	UniProtAcc	Q9NSV4	Q9NSV4
	Ensembl transtripts involved in fusion gene	ENST00000400324, ENST00000400330, ENST00000400319, ENST00000400320, ENST00000377908, ENST00000267215, ENST00000465066,	ENST00000400324, ENST00000400330, ENST00000400319, ENST00000400320, ENST00000377908, ENST00000267215, ENST00000465066,
Fusion gene scores	* DoF score	3 X 4 X 3=36	10 X 10 X 7=700
	# samples	4	13
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/700*10)=-2.42884329880387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DIAPH3 [Title/Abstract] AND DIAPH3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA947531	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
ChiTaRS3.1			BU960336	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000400324	ENST00000400324	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000400324	ENST00000400330	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400324	ENST00000400319	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400324	ENST00000400320	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400324	ENST00000377908	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400324	ENST00000267215	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400324	ENST00000465066	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000400330	ENST00000400324	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000400330	ENST00000400330	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400330	ENST00000400319	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400330	ENST00000400320	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400330	ENST00000377908	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400330	ENST00000267215	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400330	ENST00000465066	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000400319	ENST00000400324	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000400319	ENST00000400330	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400319	ENST00000400319	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400319	ENST00000400320	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400319	ENST00000377908	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400319	ENST00000267215	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400319	ENST00000465066	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000400320	ENST00000400324	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000400320	ENST00000400330	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400320	ENST00000400319	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400320	ENST00000400320	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400320	ENST00000377908	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400320	ENST00000267215	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000400320	ENST00000465066	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000377908	ENST00000400324	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000377908	ENST00000400330	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000377908	ENST00000400319	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000377908	ENST00000400320	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000377908	ENST00000377908	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000377908	ENST00000267215	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000377908	ENST00000465066	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000267215	ENST00000400324	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000267215	ENST00000400330	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000267215	ENST00000400319	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000267215	ENST00000400320	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000267215	ENST00000377908	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000267215	ENST00000267215	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000267215	ENST00000465066	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000465066	ENST00000400324	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3UTR	ENST00000465066	ENST00000400330	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000465066	ENST00000400319	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000465066	ENST00000400320	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000465066	ENST00000377908	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000465066	ENST00000267215	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-intron	ENST00000465066	ENST00000465066	DIAPH3	chr13	60240013	-	DIAPH3	chr13	60240106	+
intron-3CDS	ENST00000400324	ENST00000400324	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400324	ENST00000400330	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400324	ENST00000400319	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400324	ENST00000400320	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400324	ENST00000377908	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400324	ENST00000267215	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-5UTR	ENST00000400324	ENST00000465066	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400330	ENST00000400324	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400330	ENST00000400330	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400330	ENST00000400319	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400330	ENST00000400320	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400330	ENST00000377908	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400330	ENST00000267215	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-5UTR	ENST00000400330	ENST00000465066	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400319	ENST00000400324	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400319	ENST00000400330	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400319	ENST00000400319	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400319	ENST00000400320	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400319	ENST00000377908	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400319	ENST00000267215	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-5UTR	ENST00000400319	ENST00000465066	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400320	ENST00000400324	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400320	ENST00000400330	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400320	ENST00000400319	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400320	ENST00000400320	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400320	ENST00000377908	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000400320	ENST00000267215	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-5UTR	ENST00000400320	ENST00000465066	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000377908	ENST00000400324	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000377908	ENST00000400330	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000377908	ENST00000400319	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000377908	ENST00000400320	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000377908	ENST00000377908	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000377908	ENST00000267215	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-5UTR	ENST00000377908	ENST00000465066	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000267215	ENST00000400324	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000267215	ENST00000400330	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000267215	ENST00000400319	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000267215	ENST00000400320	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000267215	ENST00000377908	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000267215	ENST00000267215	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-5UTR	ENST00000267215	ENST00000465066	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000465066	ENST00000400324	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000465066	ENST00000400330	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000465066	ENST00000400319	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000465066	ENST00000400320	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000465066	ENST00000377908	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-3CDS	ENST00000465066	ENST00000267215	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-
intron-5UTR	ENST00000465066	ENST00000465066	DIAPH3	chr13	60348315	-	DIAPH3	chr13	60385058	-

Top

FusionProtFeatures for DIAPH3_DIAPH3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DIAPH3 Q9NSV4	DIAPH3 Q9NSV4

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for DIAPH3_DIAPH3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DIAPH3_DIAPH3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for DIAPH3_DIAPH3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for DIAPH3_DIAPH3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 9968

FusionGeneSummary for DIAPH3_DIAPH3

FusionProtFeatures for DIAPH3_DIAPH3

FusionGeneSequence for DIAPH3_DIAPH3

FusionGenePPI for DIAPH3_DIAPH3

RelatedDrugs for DIAPH3_DIAPH3

RelatedDiseases for DIAPH3_DIAPH3