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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9964

FusionGeneSummary for DIAPH2_MAGEA11

check button Fusion gene summary
Fusion gene informationFusion gene name: DIAPH2_MAGEA11
Fusion gene ID: 9964
HgeneTgene
Gene symbol

DIAPH2

MAGEA11

Gene ID

1730

4110

Gene namediaphanous related formin 2MAGE family member A11
SynonymsDIA|DIA2|DRF2|POF|POF2|POF2ACT1.11|MAGE-11|MAGE11|MAGEA-11
Cytomap

Xq21.33

Xq28

Type of geneprotein-codingprotein-coding
Descriptionprotein diaphanous homolog 2diaphanous homolog 2diaphorase-2melanoma-associated antigen 11MAGE-11 antigencancer/testis antigen 1.11cancer/testis antigen family 1, member 11melanoma antigen family A, 11melanoma antigen family A11
Modification date2018051920180519
UniProtAcc

O60879

P43364

Ensembl transtripts involved in fusion geneENST00000355827, ENST00000373054, 
ENST00000373061, ENST00000373049, 
ENST00000324765, 
ENST00000333104, 
ENST00000355220, 
Fusion gene scores* DoF score7 X 7 X 5=2451 X 1 X 1=1
# samples 81
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DIAPH2 [Title/Abstract] AND MAGEA11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-V1-A9Z7-01ADIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355827ENST00000333104DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-intronENST00000355827ENST00000355220DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-5UTRENST00000373054ENST00000333104DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-intronENST00000373054ENST00000355220DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-5UTRENST00000373061ENST00000333104DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-intronENST00000373061ENST00000355220DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-5UTRENST00000373049ENST00000333104DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-intronENST00000373049ENST00000355220DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-5UTRENST00000324765ENST00000333104DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+
5CDS-intronENST00000324765ENST00000355220DIAPH2chrX

95993761

+MAGEA11chrX

148770498

+

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FusionProtFeatures for DIAPH2_MAGEA11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIAPH2

O60879

MAGEA11

P43364

Could be involved in oogenesis. Involved in theregulation of endosome dynamics. Implicated in a novel signaltransduction pathway, in which isoform 3 and CSK are sequentiallyactivated by RHOD to regulate the motility of early endosomesthrough interactions with the actin cytoskeleton.{ECO:0000269|PubMed:12577064}. Acts as androgen receptor coregulator that increasesandrogen receptor activity by modulating the receptors interdomaininteraction. May play a role in embryonal development and tumortransformation or aspects of tumor progression.{ECO:0000269|PubMed:15684378}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DIAPH2_MAGEA11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DIAPH2_MAGEA11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DIAPH2RHOD, CDC42, TCERG1, APBB1, POLR1A, PAPD5MAGEA11MGME1, LNX1, BIRC2, DNAJC10, MXD3, PSMF1, NDUFAF1, COX7A2L, NIF3L1, ILF3, NOL4, CLUAP1, ENOX2, AKR1C3, PRKRIP1, KIAA0408, VTA1, MCRS1, UBE2D4, SNX20, PHYH, OTUB2, PNKD, NDEL1, NDUFB9, MYOZ1, ARHGAP29, MLF1, DIEXF, EWSR1, ZBTB16, PRDX3, TRIM51, TRMT1, TMEM123, BEX2, TCF25, TEX37, PNKP, FAM156A, ACMSD, C18orf54, ACTN1, CEP76, TCEANC, RADIL, NSUN4, TRIM27, SH2D4A, CDKN2B, CCDC14, ZSWIM2, TCEA2, SNX7, WTAP, IL11, ZNF655, CCDC185, MED28, POLR1D, AR, MAGEA11, EP300, NCOA2, EGLN1, EGLN2, EGLN3, PGR, FKBP5, NR3C1, SKP1, MAPK3, RBL1, RB1, E2F1, ALDH5A1, PDE4B, CSNK2A1, HOXB5, IL6ST, NOS3, PIN4, STAR, TPM3, MTA1, JADE3, GNPDA1, BCL2L11, USP20, TXN2, WDYHV1, RBM23, DOCK10, CCDC146, PCBD2, CDC20B, ZCCHC12, THEM5, SUV39H2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DIAPH2_MAGEA11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DIAPH2_MAGEA11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource