|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 9946 |
FusionGeneSummary for DHX8_PCTP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX8_PCTP | Fusion gene ID: 9946 | Hgene | Tgene | Gene symbol | DHX8 | PCTP | Gene ID | 1659 | 58488 |
| Gene name | DEAH-box helicase 8 | phosphatidylcholine transfer protein | |
| Synonyms | DDX8|Dhr2|HRH1|PRP22|PRPF22 | PC-TP|STARD2 | |
| Cytomap | 17q21.31 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1 | phosphatidylcholine transfer proteinSTART domain-containing protein 2StAR-related lipid transfer (START) domain containing 2stAR-related lipid transfer protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14562 | Q9UKL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000540306, ENST00000262415, | ENST00000573500, ENST00000576221, ENST00000268896, ENST00000576183, ENST00000325214, | |
| Fusion gene scores | * DoF score | 13 X 8 X 11=1144 | 7 X 3 X 3=63 |
| # samples | 13 | 8 | |
| ** MAII score | log2(13/1144*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/63*10)=0.344648171387446 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DHX8 [Title/Abstract] AND PCTP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DHX8 | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
| Tgene | PCTP | GO:0015914 | phospholipid transport | 12055623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-05-5425-01A | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000540306 | ENST00000573500 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-3UTR | ENST00000540306 | ENST00000576221 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-intron | ENST00000540306 | ENST00000268896 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-intron | ENST00000540306 | ENST00000576183 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-intron | ENST00000540306 | ENST00000325214 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| In-frame | ENST00000262415 | ENST00000573500 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-3UTR | ENST00000262415 | ENST00000576221 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-intron | ENST00000262415 | ENST00000268896 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-intron | ENST00000262415 | ENST00000576183 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
| 5CDS-intron | ENST00000262415 | ENST00000325214 | DHX8 | chr17 | 41585888 | + | PCTP | chr17 | 53900122 | + |
Top |
FusionProtFeatures for DHX8_PCTP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHX8 | PCTP |
| Involved in pre-mRNA splicing as component of thespliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).Facilitates nuclear export of spliced mRNA by releasing the RNAfrom the spliceosome (PubMed:8608946).{ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346,ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. | Catalyzes the transfer of phosphatidylcholine betweenmembranes. Binds a single lipid molecule.{ECO:0000269|PubMed:12055623}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DHX8 | chr17:41585888 | chr17:53900122 | ENST00000262415 | + | 16 | 23 | 172_175 | 834 | 1221 | Compositional bias | Note=Poly-Lys |
| Hgene | DHX8 | chr17:41585888 | chr17:53900122 | ENST00000262415 | + | 16 | 23 | 176_228 | 834 | 1221 | Compositional bias | Note=Arg/Ser-rich (RS domain) |
| Hgene | DHX8 | chr17:41585888 | chr17:53900122 | ENST00000262415 | + | 16 | 23 | 265_336 | 834 | 1221 | Domain | S1 motif |
| Hgene | DHX8 | chr17:41585888 | chr17:53900122 | ENST00000262415 | + | 16 | 23 | 575_738 | 834 | 1221 | Domain | Helicase ATP-binding |
| Hgene | DHX8 | chr17:41585888 | chr17:53900122 | ENST00000262415 | + | 16 | 23 | 685_688 | 834 | 1221 | Motif | Note=DEAH box |
| Hgene | DHX8 | chr17:41585888 | chr17:53900122 | ENST00000262415 | + | 16 | 23 | 588_595 | 834 | 1221 | Nucleotide binding | ATP |
| Tgene | >PCTP | chr17:41585888 | chr17:53900122 | ENST00000268896 | + | 0 | 6 | 1_212 | -42 | 215 | Domain | START |
| Tgene | >PCTP | chr17:41585888 | chr17:53900122 | ENST00000325214 | + | 0 | 6 | 1_212 | -51 | 143 | Domain | START |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DHX8 | chr17:41585888 | chr17:53900122 | ENST00000262415 | + | 16 | 23 | 756_936 | 834 | 1221 | Domain | Helicase C-terminal |
Top |
FusionGeneSequence for DHX8_PCTP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DHX8_ENST00000540306_chr17_41585888_+_PCTP_ENST00000573500_chr17_53900122_+_861aa MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQ TMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDIYNG KVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLR GHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRV SEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIIL >In-frame_DHX8_ENST00000262415_chr17_41585888_+_PCTP_ENST00000573500_chr17_53900122_+_861aa MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGAEFTDSLISNLLRLIQ TMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDIYNG KVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLR GHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRV SEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIIL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DHX8_ENST00000540306_chr17_41585888_+_PCTP_ENST00000573500_chr17_53900122_+_2583nt ATGGCTGTGGCTGTAGCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTG GTGTCAAAGGTTTGCACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAAT ACCACCTTTGATACTTTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAA ACCATGCGGCCTCCAGCGAAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCA GTCCTTTGCCAACCGGACAACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAA GCTTTAATGCCCAGCGCAGCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGA GATCGAAACCGAGATCGAGACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCC AGGACCCGGGAGAGGAATAAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAA TATGGAGAGCGGAATCTGGATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGC AAAGTTACCAGCATCATGCAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTC CGGCGGGAGGGTCGTGTGGCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAG ACCAGCCTGAGCATGAAGGATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAG GAGACCTCAATGCGGAATCCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGC CTCACCCGAATCTCTGACCCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGAT GAAGAGACTGGCATTCTCCCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGA GGGCACACTAAGCAAAGCATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGT GCCTTGGCCAAAGAAAGGCGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTT GACCCTCTGCCTGATGCGGAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAG CATGCCTTTGGGGGCAACAAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTG AAGGAGCAATTGGTCCAGGCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAG TACCTGGCGGAGGCAGGCTACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTG TCAGAGGAGTTTGGTTGTTGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTAC ATGACAGATGGGATGTTGCTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGG ACAATTCACACTGATGTGCTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTG GATGCAGTGAAGTTTTCTCAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAG GAACCTGAGACAGATTATCTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTG ACTGGTCAGGAAGAAATTGATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTC CCAGTGTACTCTGCTCTTCCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGAATCAGAGCAGAACCAAG >In-frame_DHX8_ENST00000262415_chr17_41585888_+_PCTP_ENST00000573500_chr17_53900122_+_2583nt ATGGCTGTGGCTGTAGCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTG GTGTCAAAGGTTTGCACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAAT ACCACCTTTGATACTTTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAA ACCATGCGGCCTCCAGCGAAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCA GTCCTTTGCCAACCGGACAACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAA GCTTTAATGCCCAGCGCAGCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGA GATCGAAACCGAGATCGAGACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCC AGGACCCGGGAGAGGAATAAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAA TATGGAGAGCGGAATCTGGATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGC AAAGTTACCAGCATCATGCAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTC CGGCGGGAGGGTCGTGTGGCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAG ACCAGCCTGAGCATGAAGGATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAG GAGACCTCAATGCGGAATCCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGC CTCACCCGAATCTCTGACCCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGAT GAAGAGACTGGCATTCTCCCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGA GGGCACACTAAGCAAAGCATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGT GCCTTGGCCAAAGAAAGGCGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTT GACCCTCTGCCTGATGCGGAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAG CATGCCTTTGGGGGCAACAAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTG AAGGAGCAATTGGTCCAGGCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAG TACCTGGCGGAGGCAGGCTACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTG TCAGAGGAGTTTGGTTGTTGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTAC ATGACAGATGGGATGTTGCTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGG ACAATTCACACTGATGTGCTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTG GATGCAGTGAAGTTTTCTCAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAG GAACCTGAGACAGATTATCTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTG ACTGGTCAGGAAGAAATTGATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTC CCAGTGTACTCTGCTCTTCCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGAATCAGAGCAGAACCAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DHX8_ENST00000540306_chr17_41585888_+_PCTP_ENST00000573500_chr17_53900122_+_2907nt AGTGAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTA GCCATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGC ACTGAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACT TTTAAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCA GCGAAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCG GACAACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGC GCAGCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGAT CGAGACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGG AATAAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAAT CTGGATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATC ATGCAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGT GTGGCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATG AAGGATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGG AATCCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCT GACCCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATT CTCCCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAA AGCATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAA AGGCGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGAT GCGGAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGC AACAAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTC CAGGCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCA GGCTACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGT TGTTGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATG TTGCTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGAT GTGCTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTT TCTCAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGAT TATCTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAA ATTGATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCT CTTCCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAAT CAGAGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAGATTGAGTGGAAGGAAGAGGAAGGACATAAAGATAAAGACATG AGAAAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGGGTGCAGGTATCATTTCTTATCTCATTGTTTTTTCTCATAAGCCCTGAATTAA TTCATTTATTCACAGTATTTTCGCAGATGTGAAATTCACATATTATTCACAGATGTGTTCACTATCATCTATGTACTGGAAAGATAGCAG >In-frame_DHX8_ENST00000262415_chr17_41585888_+_PCTP_ENST00000573500_chr17_53900122_+_2904nt GAAAGCTGGAACCCGGCCGGAGTAGCTCTGAGCGCCGGCTGTGAGGAAGGAGGTTCTGGGCAAGCTATAGCCATGGCTGTGGCTGTAGCC ATGGCGGGAGCCTTAATCGGGTCGGAGCCAGGCCCCGCGGAAGAACTTGCCAAACTCGAGTACCTGTCTTTGGTGTCAAAGGTTTGCACT GAGCTGGACAATCACTTGGGGATCAACGACAAGGACCTTGCTGAATTTGTGATCAGTCTTGCTGAGAAAAATACCACCTTTGATACTTTT AAGGCTTCTCTCGTCAAAAATGGTGCAGAATTTACGGATTCTCTTATTAGTAACTTGCTGCGTCTCATACAAACCATGCGGCCTCCAGCG AAGCCTTCCACTAGCAAAGATCCAGTTGTTAAACCTAAAACAGAAAAAGAAAAGCTGAAGGAACTCTTCCCAGTCCTTTGCCAACCGGAC AACCCTTCTGTTCGGACCATGTTGGATGAAGATGATGTGAAAGTTGCTGTGGATGTCCTGAAAGAACTGGAAGCTTTAATGCCCAGCGCA GCAGGCCAGGAGAAGCAAAGAGATGCTGAACACCGGGACAGGACAAAGAAGAAGAAGCGGAGTCGAAGCCGAGATCGAAACCGAGATCGA GACAGAGATAGGGAACGAAACCGAGATAGAGACCACAAGCGGAGACACCGATCCCGCTCTCGATCACGTTCCAGGACCCGGGAGAGGAAT AAAGTGAAGTCTAGATATCGGTCCAGGAGCAGGAGTCAGAGTCCCCCCAAAGACCGGAAGGACCGGGACAAATATGGAGAGCGGAATCTG GATAGATGGCGGGATAAGCATGTGGACCGCCCTCCTCCAGAAGAGCCCACCATTGGTGACATTTATAATGGCAAAGTTACCAGCATCATG CAGTTTGGTTGCTTTGTGCAGCTGGAAGGACTAAGGAAGCGGTGGGAAGGCCTGGTGCACATCTCTGAGCTCCGGCGGGAGGGTCGTGTG GCCAATGTAGCTGATGTCGTGAGCAAAGGCCAGAGGGTCAAAGTCAAAGTGCTGTCCTTCACTGGGACCAAGACCAGCCTGAGCATGAAG GATGTGGATCAAGAGACTGGAGAAGATCTAAACCCAAATAGACGGCGAAATCTTGTCGGGGAGACCAATGAGGAGACCTCAATGCGGAAT CCTGATAGACCCACTCACTTGTCCCTTGTCAGTGCTCCTGAAGTAGAGGACGACTCACTGGAACGCAAGCGCCTCACCCGAATCTCTGAC CCAGAGAAGTGGGAGATCAAACAGATGATTGCTGCCAATGTCCTTTCCAAAGAAGAATTTCCAGACTTTGATGAAGAGACTGGCATTCTC CCTAAGGTGGATGATGAAGAAGATGAGGACCTTGAGATTGAATTGGTTGAGGAAGAGCCTCCATTCCTGAGAGGGCACACTAAGCAAAGC ATGGACATGAGCCCCATTAAAATTGTCAAGAACCCAGACGGCTCCCTCTCCCAAGCAGCAATGATGCAGAGTGCCTTGGCCAAAGAAAGG CGGGAACTCAAACAGGCCCAGCGGGAAGCTGAGATGGATTCTATTCCCATGGGACTCAACAAACACTGGGTTGACCCTCTGCCTGATGCG GAAGGCAGACAGATTGCTGCCAACATGAGGGGTATTGGGATGATGCCCAATGATATTCCTGAGTGGAAGAAGCATGCCTTTGGGGGCAAC AAAGCCTCTTACGGAAAAAAGACCCAGATGTCAATCCTTGAGCAGAGGGAGAGCCTGCCCATCTACAAACTGAAGGAGCAATTGGTCCAG GCCGTCCATGACAATCAGATCCTGATTGTCATTGGTGAGACAGGATCTGGAAAGACAACACAGATCACCCAGTACCTGGCGGAGGCAGGC TACACTTCCAGGGGCAAGATTGGGTGTACCCAGCCCAGAAGAGTGGCAGCTATGTCGGTGGCCAAAAGAGTGTCAGAGGAGTTTGGTTGT TGCTTAGGCCAAGAGGTGGGCTACACCATTCGATTTGAGGACTGCACTAGCCCTGAAACAGTCATCAAGTACATGACAGATGGGATGTTG CTTAGAGAGTGCTTGATTGACCCTGACCTCACTCAGTACGCGATCATCATGTTGGACGAGGCACATGAGAGGACAATTCACACTGATGTG CTCTTTGGATTGTTGAAAAAGACAGTTCAGAAACGGCAGGACATGAAGCTGATTGTCACCTCAGCCACCTTGGATGCAGTGAAGTTTTCT CAATACTTCTATGAAGCTCCCATTTTCACCATCCCAGGTCGAACATATCCAGTGGAAATACTGTACACAAAGGAACCTGAGACAGATTAT CTGGATGCCAGCCTGATTACTGTTATGCAGATTCATTTAACAGAACCACCAGGTGATATCCTGGTCTTCCTGACTGGTCAGGAAGAAATT GATACTGCTTGTGAGATCCTGTATGAAAGAATGAAATCCCTGGGACCTGATGTTCCAGAGTTAATTATCCTCCCAGTGTACTCTGCTCTT CCCAGTGAGATGCAGACCCGAATCTTTGACCCAGCTCCACCAGGCAGCAGAAAGAATCAGAGCAGAACCAAGCGGGAAGCTCAGAATCAG AGAGACCTCATCAAGTTTTTGGCAAACCCAAACATTCTGCAATAGATTGAGTGGAAGGAAGAGGAAGGACATAAAGATAAAGACATGAGA AAAGAAGCTGAGTCTTTGTTGAAACACTGAAATGGGTGCAGGTATCATTTCTTATCTCATTGTTTTTTCTCATAAGCCCTGAATTAATTC ATTTATTCACAGTATTTTCGCAGATGTGAAATTCACATATTATTCACAGATGTGTTCACTATCATCTATGTACTGGAAAGATAGCAGTGA |
Top |
FusionGenePPI for DHX8_PCTP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DHX8 | USP12, SIRT7, CUL3, CAND1, SMAD2, SMAD3, CRNKL1, PHF5A, KANSL1, MYPN, TAF9, POLR1B, NOTCH1, PRPF40A, CHERP, PRPF38A, ISY1, RBMX2, MFAP1, DHX8, THOC1, RBM7, SAP30BP, NKAP, ZCCHC10, BAG3, SRPK2, SRPK1, LIN28A, XRN2, NUDCD1, ENO1, SHMT2, MOV10, NXF1, OBSL1, RPL26L1, RPL26, RBM28, FTSJ3, CACTIN, RPL10A, RPL5, C11orf57, XAB2, RSL1D1, CDC5L, AQR, SNW1, MORC2, AHCYL2, AHCYL1, NOP2, CCDC12, RPL15, JMJD6, RPL32, RPL36AL, CDC40, SNIP1, PRPF19, NTRK1, IFI16, CHCHD10, HIST1H1T, CDX1, SYF2, RPL18A, PNN, PPIE, CD2BP2, EAPP, TSSC4, DLST, TRIM25 | PCTP | ACOT13, PAX3, AGTRAP, VAPA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DHX8_PCTP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DHX8_PCTP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|