FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9939

FusionGeneSummary for DHX8_ARL4D

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX8_ARL4D
Fusion gene ID: 9939
HgeneTgene
Gene symbol

DHX8

ARL4D

Gene ID

1659

379

Gene nameDEAH-box helicase 8ADP ribosylation factor like GTPase 4D
SynonymsDDX8|Dhr2|HRH1|PRP22|PRPF22ARF4L|ARL6
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1ADP-ribosylation factor-like protein 4DADP-ribosylation factor-like 4DADP-ribosylation factor-like 6ADP-ribosylation factor-like protein 4L
Modification date2018052320180523
UniProtAcc

Q14562

P49703

Ensembl transtripts involved in fusion geneENST00000540306, ENST00000262415, 
ENST00000320033, 
Fusion gene scores* DoF score13 X 8 X 11=11446 X 4 X 5=120
# samples 137
** MAII scorelog2(13/1144*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHX8 [Title/Abstract] AND ARL4D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHX8

GO:0000398

mRNA splicing, via spliceosome

28076346


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-04-1517-01ADHX8chr17

41577471

+ARL4Dchr17

41477029

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000540306ENST00000320033DHX8chr17

41577471

+ARL4Dchr17

41477029

+
5CDS-5UTRENST00000262415ENST00000320033DHX8chr17

41577471

+ARL4Dchr17

41477029

+

Top

FusionProtFeatures for DHX8_ARL4D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX8

Q14562

ARL4D

P49703

Involved in pre-mRNA splicing as component of thespliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).Facilitates nuclear export of spliced mRNA by releasing the RNAfrom the spliceosome (PubMed:8608946).{ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346,ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. Small GTP-binding protein which cycles between aninactive GDP-bound and an active GTP-bound form, and the rate ofcycling is regulated by guanine nucleotide exchange factors (GEF)and GTPase-activating proteins (GAP). GTP-binding protein thatdoes not act as an allosteric activator of the cholera toxincatalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to theplasma membrane in GDP-bound form. {ECO:0000269|PubMed:17398095}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DHX8_ARL4D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DHX8_ARL4D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DHX8USP12, SIRT7, CUL3, CAND1, SMAD2, SMAD3, CRNKL1, PHF5A, KANSL1, MYPN, TAF9, POLR1B, NOTCH1, PRPF40A, CHERP, PRPF38A, ISY1, RBMX2, MFAP1, DHX8, THOC1, RBM7, SAP30BP, NKAP, ZCCHC10, BAG3, SRPK2, SRPK1, LIN28A, XRN2, NUDCD1, ENO1, SHMT2, MOV10, NXF1, OBSL1, RPL26L1, RPL26, RBM28, FTSJ3, CACTIN, RPL10A, RPL5, C11orf57, XAB2, RSL1D1, CDC5L, AQR, SNW1, MORC2, AHCYL2, AHCYL1, NOP2, CCDC12, RPL15, JMJD6, RPL32, RPL36AL, CDC40, SNIP1, PRPF19, NTRK1, IFI16, CHCHD10, HIST1H1T, CDX1, SYF2, RPL18A, PNN, PPIE, CD2BP2, EAPP, TSSC4, DLST, TRIM25ARL4DDNAJA1, EML4, MAPK8IP3, NDRG1, PGAM1, PRKCSH, EPRS, SNRPN, EIF2B1, TLE1, UBR1, UNC119, APP, CCDC102B, TERF2, TUBA3C, TERF2IP, IFI30, CYTH2, ARF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DHX8_ARL4D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DHX8_ARL4D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource