FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9927

FusionGeneSummary for DHX40_ACSM2B

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX40_ACSM2B
Fusion gene ID: 9927
HgeneTgene
Gene symbol

DHX40

ACSM2B

Gene ID

79665

348158

Gene nameDEAH-box helicase 40acyl-CoA synthetase medium chain family member 2B
SynonymsARG147|DDX40|PADACSM2|HXMA|HYST1046
Cytomap

17q23.1

16p12.3

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DHX40DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 40 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 40DEAH box protein 40acyl-coenzyme A synthetase ACSM2B, mitochondrialacyl-CoA synthetase medium-chain family member 2butyrate--CoA ligase 2Bbutyryl-coenzyme A synthetase 2Bmiddle-chain acyl-CoA synthetase 2Bxenobiotic/medium-chain fatty acid-CoA ligase HXM-Axenobiotic/m
Modification date2018052320180523
UniProtAcc

Q8IX18

Q68CK6

Ensembl transtripts involved in fusion geneENST00000251241, ENST00000451169, 
ENST00000425628, 
ENST00000329697, 
ENST00000565322, ENST00000565232, 
ENST00000567001, ENST00000414188, 
ENST00000567288, 
Fusion gene scores* DoF score6 X 5 X 4=1201 X 1 X 1=1
# samples 61
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DHX40 [Title/Abstract] AND ACSM2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A278-01ADHX40chr17

57665414

+ACSM2Bchr16

20552095

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000251241ENST00000329697DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000251241ENST00000565322DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000251241ENST00000565232DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000251241ENST00000567001DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
5CDS-intronENST00000251241ENST00000414188DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
5CDS-intronENST00000251241ENST00000567288DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000451169ENST00000329697DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000451169ENST00000565322DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000451169ENST00000565232DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000451169ENST00000567001DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
5CDS-intronENST00000451169ENST00000414188DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
5CDS-intronENST00000451169ENST00000567288DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000425628ENST00000329697DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000425628ENST00000565322DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000425628ENST00000565232DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
Frame-shiftENST00000425628ENST00000567001DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
5CDS-intronENST00000425628ENST00000414188DHX40chr17

57665414

+ACSM2Bchr16

20552095

-
5CDS-intronENST00000425628ENST00000567288DHX40chr17

57665414

+ACSM2Bchr16

20552095

-

Top

FusionProtFeatures for DHX40_ACSM2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX40

Q8IX18

ACSM2B

Q68CK6

Probable ATP-dependent RNA helicase. {ECO:0000250}. Has medium-chain fatty acid:CoA ligase activity withbroad substrate specificity (in vitro). Acts on acids from C(4) toC(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro). {ECO:0000269|PubMed:12616642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DHX40_ACSM2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DHX40_ACSM2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DHX40G3BP1, TERF2, IFIT2, CHUK, NAPA, HAUS7, SPG21, MAD2L1BP, PKN3, SPDL1, POGLUT1, MTHFD2, NUDCD1, FUS, ECE2, NTRK1, MED4, USP7, JMJD6, EPM2AIP1, IARS2ACSM2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DHX40_ACSM2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DHX40_ACSM2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource