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Fusion gene ID: 9916 |
FusionGeneSummary for DHX34_C5AR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHX34_C5AR1 | Fusion gene ID: 9916 | Hgene | Tgene | Gene symbol | DHX34 | C5AR1 | Gene ID | 9704 | 728 |
| Gene name | DExH-box helicase 34 | complement C5a receptor 1 | |
| Synonyms | DDX34|HRH1 | C5A|C5AR|C5R1|CD88 | |
| Cytomap | 19q13.32 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DHX34DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34DEAH (Asp-Glu-Ala-His) box polypeptide 34DEAH box protein 34DEAH-box helicase 34probable ATP-dependent helicase DHX34 | C5a anaphylatoxin chemotactic receptor 1C5a anaphylatoxin receptorC5a ligandC5a-Rcomplement component 5 receptor 1complement component 5a receptor 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14147 | P21730 | |
| Ensembl transtripts involved in fusion gene | ENST00000328771, ENST00000471451, | ENST00000595501, ENST00000355085, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DHX34 [Title/Abstract] AND C5AR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | C5AR1 | GO:0038178 | complement component C5a signaling pathway | 10571060 |
| Tgene | C5AR1 | GO:0042789 | mRNA transcription by RNA polymerase II | 22496247 |
| Tgene | C5AR1 | GO:0050679 | positive regulation of epithelial cell proliferation | 22496247 |
| Tgene | C5AR1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22496247 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-18-3415-01A | DHX34 | chr19 | 47852609 | + | C5AR1 | chr19 | 47795235 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3UTR | ENST00000328771 | ENST00000595501 | DHX34 | chr19 | 47852609 | + | C5AR1 | chr19 | 47795235 | + |
| 5UTR-intron | ENST00000328771 | ENST00000355085 | DHX34 | chr19 | 47852609 | + | C5AR1 | chr19 | 47795235 | + |
| intron-3UTR | ENST00000471451 | ENST00000595501 | DHX34 | chr19 | 47852609 | + | C5AR1 | chr19 | 47795235 | + |
| intron-intron | ENST00000471451 | ENST00000355085 | DHX34 | chr19 | 47852609 | + | C5AR1 | chr19 | 47795235 | + |
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FusionProtFeatures for DHX34_C5AR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHX34 | C5AR1 |
| Probable ATP-binding RNA helicase. | Receptor for the chemotactic and inflammatory peptideanaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471,PubMed:9553099, PubMed:10636859, PubMed:15153520,PubMed:29300009). The ligand interacts with at least two sites onthe receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region whichactivates downstream signaling events (PubMed:8182049,PubMed:7622471, PubMed:9553099). Receptor activation stimulateschemotaxis, granule enzyme release, intracellular calcium releaseand superoxide anion production (PubMed:10636859,PubMed:15153520). {ECO:0000269|PubMed:10636859,ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994,ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471,ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DHX34_C5AR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DHX34_C5AR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DHX34 | POLA2, GSK3B, RPS6KA6, TRMT2A, EXOC8, KIF3A, TRIM25 | C5AR1 | C5, GNAI2, GNAI3, ARRB2, ARRB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHX34_C5AR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHX34_C5AR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C5AR1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | C5AR1 | C0036983 | Septic Shock | 1 | CTD_human |
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