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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9915

FusionGeneSummary for DHX34_ARHGAP35

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX34_ARHGAP35
Fusion gene ID: 9915
HgeneTgene
Gene symbol

DHX34

ARHGAP35

Gene ID

9704

2909

Gene nameDExH-box helicase 34Rho GTPase activating protein 35
SynonymsDDX34|HRH1GRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP
Cytomap

19q13.32

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DHX34DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34DEAH (Asp-Glu-Ala-His) box polypeptide 34DEAH box protein 34DEAH-box helicase 34probable ATP-dependent helicase DHX34rho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A
Modification date2018052320180522
UniProtAcc

Q14147

Q9NRY4

Ensembl transtripts involved in fusion geneENST00000328771, ENST00000471451, 
ENST00000404338, ENST00000598548, 
Fusion gene scores* DoF score5 X 5 X 4=1009 X 7 X 5=315
# samples 69
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHX34 [Title/Abstract] AND ARHGAP35 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARHGAP35

GO:0000122

negative regulation of transcription by RNA polymerase II

1894621

TgeneARHGAP35

GO:0045892

negative regulation of transcription, DNA-templated

1894621


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-39-5034-01ADHX34chr19

47863327

+ARHGAP35chr19

47491246

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000328771ENST00000404338DHX34chr19

47863327

+ARHGAP35chr19

47491246

+
5CDS-intronENST00000328771ENST00000598548DHX34chr19

47863327

+ARHGAP35chr19

47491246

+
3UTR-3CDSENST00000471451ENST00000404338DHX34chr19

47863327

+ARHGAP35chr19

47491246

+
3UTR-intronENST00000471451ENST00000598548DHX34chr19

47863327

+ARHGAP35chr19

47491246

+

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FusionProtFeatures for DHX34_ARHGAP35


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX34

Q14147

ARHGAP35

Q9NRY4

Probable ATP-binding RNA helicase. Rho GTPase-activating protein (GAP) (PubMed:19673492,PubMed:28894085). Binds several acidic phospholipids whichinhibits the Rho GAP activity to promote the Rac GAP activity(PubMed:19673492). This binding is inhibited by phosphorylation byPRKCA (PubMed:19673492). Involved in cell differentiation as wellas cell adhesion and migration, plays an important role in retinaltissue morphogenesis, neural tube fusion, midline fusion of thecerebral hemispheres and mammary gland branching morphogenesis (Bysimilarity). Transduces signals from p21-ras to the nucleus,acting via the ras GTPase-activating protein (GAP) (Bysimilarity). Transduces SRC-dependent signals from cell-surfaceadhesion molecules, such as laminin, to promote neurite outgrowth.Regulates axon outgrowth, guidance and fasciculation (Bysimilarity). Modulates Rho GTPase-dependent F-actinpolymerization, organization and assembly, is involved inpolarized cell migration and in the positive regulation ofciliogenesis and cilia elongation (By similarity). During mammarygland development, is required in both the epithelial and stromalcompartments for ductal outgrowth (By similarity). Repressestranscription of the glucocorticoid receptor by binding to thecis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; thisfunction is however unclear and would need additional experimentalevidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128,ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621,ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX34chr19:47863327chr19:47491246ENST00000328771+517172_3324581144DomainHelicase ATP-binding
HgeneDHX34chr19:47863327chr19:47491246ENST00000328771+517279_2824581144MotifNote=DEAH box
HgeneDHX34chr19:47863327chr19:47491246ENST00000328771+517185_1924581144Nucleotide bindingATP
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+161440_149012751500Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHX34chr19:47863327chr19:47491246ENST00000328771+517368_5364581144DomainHelicase C-terminal
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+161249_143612751500DomainRho-GAP
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16270_32712751500DomainNote=FF 1
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16368_42212751500DomainNote=FF 2
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16429_48312751500DomainNote=FF 3
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16485_55012751500DomainNote=FF 4
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16592_76712751500DomainpG1 pseudoGTPase
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16783_94712751500DomainpG2 pseudoGTPase
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16201_20312751500Nucleotide bindingGTP
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+16229_23112751500Nucleotide bindingGTP
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+1633_3712751500Nucleotide bindingGTP
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+1695_9712751500Nucleotide bindingGTP
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+161213_123612751500RegionRequired for phospholipid binding and regulation of the substrate preference
TgeneARHGAP35chr19:47863327chr19:47491246ENST00000404338+161_26612751500RegionHas GTPase activity%2C required for proper localization


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FusionGeneSequence for DHX34_ARHGAP35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DHX34_ENST00000328771_chr19_47863327_+_ARHGAP35_ENST00000404338_chr19_47491246_+_683aa
MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSI
PALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV
VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSL
PQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR
PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTID
GIRFVVDSGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHAL
KEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DHX34_ENST00000328771_chr19_47863327_+_ARHGAP35_ENST00000404338_chr19_47491246_+_2049nt
ATGCCTCCTCCTAGAACAAGGGAGGGCAGGGATCGCCGAGACCACCACCGGGCTCCCAGCGAGGAAGAGGCCTTGGAGAAATGGGACTGG
AATTGTCCAGAGACGCGTCGCCTCTTGGAAGATGCCTTCTTCCGTGAAGAGGATTACATCCGTCAGGGTTCTGAGGAATGTCAGAAGTTT
TGGACCTTCTTTGAACGCCTGCAGAGATTCCAGAATCTCAAGACCTCCAGGAAGGAGGAGAAAGACCCTGGACAGCCCAAGCACAGCATC
CCAGCGCTGGCCGACCTACCTCGCACTTACGACCCACGTTACCGCATCAACCTCTCTGTTCTTGGCCCTGCCACGCGGGGCTCTCAGGGA
CTGGGCAGGCACTTGCCCGCGGAGAGAGTGGCTGAGTTCCGCCGAGCCCTGTTGCACTACCTGGACTTTGGCCAGAAGCAGGCATTTGGG
CGTCTGGCCAAGCTGCAGCGTGAGCGGGCAGCCCTCCCCATCGCCCAGTATGGGAACCGCATCCTGCAGACGCTGAAGGAGCACCAGGTG
GTGGTAGTGGCCGGTGACACCGGCTGTGGCAAGTCCACTCAGGTGCCCCAGTACCTGCTGGCTGCTGGCTTCAGTCATGTGGCGTGCACC
CAGCCCCGGCGGATCGCCTGCATCTCACTGGCCAAGCGTGTGGGCTTTGAGAGCCTCAGTCAGTATGGCTCACAGGTCGGCTACCAGATC
CGCTTTGAGAGCACACGTTCGGCGGCCACCAAGATTGTATTCCTGACAGTGGGGCTGCTCCTGCGACAAATCCAGCGGGAACCCAGCCTG
CCCCAGTATGAGGTCCTGATTGTGGATGAAGTCCATGAGCGGCATCTCCACAACGATTTCCTCCTGGGCGTCCTCCAGCGCCTGTTGCCC
ACGCGGCCTGACCTCAAGGTCATCCTCATGTCGGCCACCATCAACATCTCGCTCTTCTCCAGCTATTTCAGCAATGCCCCTGTGGTACAG
GTGCCTGGGAGGCTGTTCCCCATCACGGTTGTGTACCAGCCGCAGGAGGCGGAGCCGACCACGTCCAAGTCAGAGAAGCTGGACCCGCGG
CCTTTCCTGAGGGTGCTGGAGTCCATTGACCACAAGTACCCGCCTGAGGAGCGGGGTGACCTCCTCGTCTTCCTCAGCGGCATGGCGGAG
ATCAGCGCCGTGCTGGAGGCTGCCCAGACCTATGCCAGCCACACCCAGCGCTGGGTGGTACTGCCACTGCACAGCGCCCTGTCTGTGGCC
GACCAGGACAAGGTATTTGATGTGGCACCCCCTGGAGTCCGGAAATGCATCCTCTCCACCAACATTGCTGAGACCTCAGTCACCATTGAC
GGGATCCGCTTCGTAGTAGATTCCGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGA
CAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAA
CTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTT
AAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAG
GTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCC
ACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCC
AGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_DHX34_ENST00000328771_chr19_47863327_+_ARHGAP35_ENST00000404338_chr19_47491246_+_6787nt
ACGAGATGGCTGTGTGCGCAGGCGCAAGACTAGCGCTCTTGGGACCGGAAGTTAAGGCGTTCGCGGCGTGTGAATCCAGGGCCTGAAAAC
CCAGAATGAACTTGTGTCCATCCCAGAGATCACTGCAGATGTCATGAGGTACCCTTTGTGTCACCAGCTCAAGCAGGCCTCTGGCCACTT
TATCATCTGTGGTGGTCCTGTGCCGTGACCAGGAGGAAAAATTAGCTCTTTGAAGAGAAAGTAGTTCTCTATTGCAGGCACTGGCCTCTT
AAATTGTTGCAGGTGGGGAATGGATGAGAATATTTGTTTTGGGTGATCAGAACTGAGACTCCTATTGTGGATTAGTAACATGCCTCCTCC
TAGAACAAGGGAGGGCAGGGATCGCCGAGACCACCACCGGGCTCCCAGCGAGGAAGAGGCCTTGGAGAAATGGGACTGGAATTGTCCAGA
GACGCGTCGCCTCTTGGAAGATGCCTTCTTCCGTGAAGAGGATTACATCCGTCAGGGTTCTGAGGAATGTCAGAAGTTTTGGACCTTCTT
TGAACGCCTGCAGAGATTCCAGAATCTCAAGACCTCCAGGAAGGAGGAGAAAGACCCTGGACAGCCCAAGCACAGCATCCCAGCGCTGGC
CGACCTACCTCGCACTTACGACCCACGTTACCGCATCAACCTCTCTGTTCTTGGCCCTGCCACGCGGGGCTCTCAGGGACTGGGCAGGCA
CTTGCCCGCGGAGAGAGTGGCTGAGTTCCGCCGAGCCCTGTTGCACTACCTGGACTTTGGCCAGAAGCAGGCATTTGGGCGTCTGGCCAA
GCTGCAGCGTGAGCGGGCAGCCCTCCCCATCGCCCAGTATGGGAACCGCATCCTGCAGACGCTGAAGGAGCACCAGGTGGTGGTAGTGGC
CGGTGACACCGGCTGTGGCAAGTCCACTCAGGTGCCCCAGTACCTGCTGGCTGCTGGCTTCAGTCATGTGGCGTGCACCCAGCCCCGGCG
GATCGCCTGCATCTCACTGGCCAAGCGTGTGGGCTTTGAGAGCCTCAGTCAGTATGGCTCACAGGTCGGCTACCAGATCCGCTTTGAGAG
CACACGTTCGGCGGCCACCAAGATTGTATTCCTGACAGTGGGGCTGCTCCTGCGACAAATCCAGCGGGAACCCAGCCTGCCCCAGTATGA
GGTCCTGATTGTGGATGAAGTCCATGAGCGGCATCTCCACAACGATTTCCTCCTGGGCGTCCTCCAGCGCCTGTTGCCCACGCGGCCTGA
CCTCAAGGTCATCCTCATGTCGGCCACCATCAACATCTCGCTCTTCTCCAGCTATTTCAGCAATGCCCCTGTGGTACAGGTGCCTGGGAG
GCTGTTCCCCATCACGGTTGTGTACCAGCCGCAGGAGGCGGAGCCGACCACGTCCAAGTCAGAGAAGCTGGACCCGCGGCCTTTCCTGAG
GGTGCTGGAGTCCATTGACCACAAGTACCCGCCTGAGGAGCGGGGTGACCTCCTCGTCTTCCTCAGCGGCATGGCGGAGATCAGCGCCGT
GCTGGAGGCTGCCCAGACCTATGCCAGCCACACCCAGCGCTGGGTGGTACTGCCACTGCACAGCGCCCTGTCTGTGGCCGACCAGGACAA
GGTATTTGATGTGGCACCCCCTGGAGTCCGGAAATGCATCCTCTCCACCAACATTGCTGAGACCTCAGTCACCATTGACGGGATCCGCTT
CGTAGTAGATTCCGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGACAGTTTGATCA
AGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAACTGCCTGACCC
CCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTTAAGGAGGTATT
AAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAGGTGAATCTCAT
GACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCCACGCGCACCTA
CCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCCAGGCCCAGCTC
CCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCTCCACCCACCCC
CCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCCACCAAGACCTGGGGCGACAGGAGAACCGG
TCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGGCAGGGGCAAGTGGCTCTCCCCATTACCTT
CTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTGGGCCTGGCGCTGCAGACCTGAGCTGGCTT
GGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTGGACCACCACCCCACGTAGCTGCTCACACC
AGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTTTGCCGGGGAGGAGGATGCTCTGAGATTCA
GGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCCATCTGCACACACCCCCAAGGTAAGGGTAC
AGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCTGCTGAGGGCGCTGGCTCTGCAGATCAGAA
CAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCACCGTCCCACTCCACAGCCTTCCCGAAACAT
TCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAAGGAAGAAACCACAGAAAGAAAACTACAGA
CCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCTGACCCTCGTCTTTGTGGCAGCAAAACCAG
GATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTCGCTAGATCCCCCGTTTTCCCAAGAAGAGG
GTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCCCCAGAACACAGTCCATTACGATAGAAACA
CTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGGGCGCTTGGTGGGGGGTTGGGGACAGCTGG
AAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTCATCCCAGCCATGGAGGCCACCAGCAGGAG
TGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCTCGAAGGGGCATCCTTCCTGGTCTTCGCTG
ACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCCCCAGGAAAAGCTCTTCTCCTGGCCACCTC
TGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGACACTAGGCACCCCCCAGGCGAGAGCTAGT
GGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGATCTGTGGTGTATTCCAGGGGGCCTGATGG
ACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGGGAGTGGCCCTTCGGCTCCCGAGCTCCCTC
TGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACCTAACCTTGCAAGTTTTACCGCCTTTTGAG
GAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATGAATTTTTGTCTCTTCTGGTGGAGCTGTGC
CTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGTTGGCAGAAACGTTCCCAAACTCCCCCAGC
CCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTTATGCTCACCTGGTCAGCTCCTCACGTAAT
TGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAGCAGCCCAGTCCCCCTCACTGCTTGAGCTA
ACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCCACAGATGTATGTGCGGCCAGTGACTTCCC
CAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGAAGTACCTGAAACTAGGTCTGGGGCACTCC
CAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAGGGAGCCCCCATGCACAGGAAGCCACAGGG
TTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAGAGGACATCTCGGTCGTTTGAGGGGCATGG
CCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCACTTGCATGGGAGCCACAGAGGAGCGTCCCT
GGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAAGGTGTGTGCACAGAGGGTGCTCATGGGAC
TCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGGGCAGCCACCCCTGCCCAGCGAGAGCGCAG
ACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACGGCTGAAGAGGGAAGACCCAAGGCTGGGTG
GCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCACACATTTACTCTGCATTGTCCCCGTCTTTC
CCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTCTCCTGCCTCCACCGCCTTGGTTTTGCTTC
CTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGTCACGGTGGACAGAGGGTGACATCATAGGA
GCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTCTTAGGGAAAGGAGGCCTGGGTCAAGCCAG
CATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACACACACACACACACACACACAAAACTTCACA
GCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCTTTCCTATGAGAAGCCACTGCTTTGGGGGC
GCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGTCTGGTTGAGTCGCTGCTTTCCCGAGGGCA
GCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGTAACGGGGGTGGGCTCCCTCCCTCGGAGGA
CATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCGGTGGGGGCGCGGCCGCGGTGCGGTCGGTG
CAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGCCACTGCTGACCTGGGCTGGCCTCCCCCAG
CCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGAATCATGTTCCCTGTGTACATTTAAGAAAA
AAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAATAGTGCTGCTGCCAGCTTATTTTTCTGGTA
CTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTTTCTGAGAAAAAACAAAACATATTAATGGTA
TTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGACCTGTATGTAAAGAAAGTATAACAATTAT
TTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCTTAATTTCCAGACTTTTTTTTAAAAACACA
TCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAGGCATCTCTGACTGAGGTGTTTTTGTTTGG
TTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGTGTAAAAAACAAAAGGCCTTATGTGATCTG


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FusionGenePPI for DHX34_ARHGAP35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DHX34POLA2, GSK3B, RPS6KA6, TRMT2A, EXOC8, KIF3A, TRIM25ARHGAP35RASA1, RHOA, GRB2, BCL6, RND1, RND2, RND3, KRT31, TCERG1, NTRK1, CDC42, RAC1, SERPINB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DHX34_ARHGAP35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DHX34_ARHGAP35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARHGAP35C0152013Adenocarcinoma of lung (disorder)1CTD_human