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Fusion gene ID: 9915 |
FusionGeneSummary for DHX34_ARHGAP35 |
Fusion gene summary |
Fusion gene information | Fusion gene name: DHX34_ARHGAP35 | Fusion gene ID: 9915 | Hgene | Tgene | Gene symbol | DHX34 | ARHGAP35 | Gene ID | 9704 | 2909 |
Gene name | DExH-box helicase 34 | Rho GTPase activating protein 35 | |
Synonyms | DDX34|HRH1 | GRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP | |
Cytomap | 19q13.32 | 19q13.32 | |
Type of gene | protein-coding | protein-coding | |
Description | probable ATP-dependent RNA helicase DHX34DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 34DEAH (Asp-Glu-Ala-His) box polypeptide 34DEAH box protein 34DEAH-box helicase 34probable ATP-dependent helicase DHX34 | rho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q14147 | Q9NRY4 | |
Ensembl transtripts involved in fusion gene | ENST00000328771, ENST00000471451, | ENST00000404338, ENST00000598548, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 9 X 7 X 5=315 |
# samples | 6 | 9 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DHX34 [Title/Abstract] AND ARHGAP35 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ARHGAP35 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 1894621 |
Tgene | ARHGAP35 | GO:0045892 | negative regulation of transcription, DNA-templated | 1894621 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-39-5034-01A | DHX34 | chr19 | 47863327 | + | ARHGAP35 | chr19 | 47491246 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000328771 | ENST00000404338 | DHX34 | chr19 | 47863327 | + | ARHGAP35 | chr19 | 47491246 | + |
5CDS-intron | ENST00000328771 | ENST00000598548 | DHX34 | chr19 | 47863327 | + | ARHGAP35 | chr19 | 47491246 | + |
3UTR-3CDS | ENST00000471451 | ENST00000404338 | DHX34 | chr19 | 47863327 | + | ARHGAP35 | chr19 | 47491246 | + |
3UTR-intron | ENST00000471451 | ENST00000598548 | DHX34 | chr19 | 47863327 | + | ARHGAP35 | chr19 | 47491246 | + |
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FusionProtFeatures for DHX34_ARHGAP35 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DHX34 | ARHGAP35 |
Probable ATP-binding RNA helicase. | Rho GTPase-activating protein (GAP) (PubMed:19673492,PubMed:28894085). Binds several acidic phospholipids whichinhibits the Rho GAP activity to promote the Rac GAP activity(PubMed:19673492). This binding is inhibited by phosphorylation byPRKCA (PubMed:19673492). Involved in cell differentiation as wellas cell adhesion and migration, plays an important role in retinaltissue morphogenesis, neural tube fusion, midline fusion of thecerebral hemispheres and mammary gland branching morphogenesis (Bysimilarity). Transduces signals from p21-ras to the nucleus,acting via the ras GTPase-activating protein (GAP) (Bysimilarity). Transduces SRC-dependent signals from cell-surfaceadhesion molecules, such as laminin, to promote neurite outgrowth.Regulates axon outgrowth, guidance and fasciculation (Bysimilarity). Modulates Rho GTPase-dependent F-actinpolymerization, organization and assembly, is involved inpolarized cell migration and in the positive regulation ofciliogenesis and cilia elongation (By similarity). During mammarygland development, is required in both the epithelial and stromalcompartments for ductal outgrowth (By similarity). Repressestranscription of the glucocorticoid receptor by binding to thecis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; thisfunction is however unclear and would need additional experimentalevidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128,ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621,ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DHX34 | chr19:47863327 | chr19:47491246 | ENST00000328771 | + | 5 | 17 | 172_332 | 458 | 1144 | Domain | Helicase ATP-binding |
Hgene | DHX34 | chr19:47863327 | chr19:47491246 | ENST00000328771 | + | 5 | 17 | 279_282 | 458 | 1144 | Motif | Note=DEAH box |
Hgene | DHX34 | chr19:47863327 | chr19:47491246 | ENST00000328771 | + | 5 | 17 | 185_192 | 458 | 1144 | Nucleotide binding | ATP |
Tgene | >ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 1440_1490 | 1275 | 1500 | Compositional bias | Note=Pro-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DHX34 | chr19:47863327 | chr19:47491246 | ENST00000328771 | + | 5 | 17 | 368_536 | 458 | 1144 | Domain | Helicase C-terminal |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 1249_1436 | 1275 | 1500 | Domain | Rho-GAP |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 270_327 | 1275 | 1500 | Domain | Note=FF 1 |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 368_422 | 1275 | 1500 | Domain | Note=FF 2 |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 429_483 | 1275 | 1500 | Domain | Note=FF 3 |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 485_550 | 1275 | 1500 | Domain | Note=FF 4 |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 592_767 | 1275 | 1500 | Domain | pG1 pseudoGTPase |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 783_947 | 1275 | 1500 | Domain | pG2 pseudoGTPase |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 201_203 | 1275 | 1500 | Nucleotide binding | GTP |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 229_231 | 1275 | 1500 | Nucleotide binding | GTP |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 33_37 | 1275 | 1500 | Nucleotide binding | GTP |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 95_97 | 1275 | 1500 | Nucleotide binding | GTP |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 1213_1236 | 1275 | 1500 | Region | Required for phospholipid binding and regulation of the substrate preference |
Tgene | ARHGAP35 | chr19:47863327 | chr19:47491246 | ENST00000404338 | + | 1 | 6 | 1_266 | 1275 | 1500 | Region | Has GTPase activity%2C required for proper localization |
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FusionGeneSequence for DHX34_ARHGAP35 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_DHX34_ENST00000328771_chr19_47863327_+_ARHGAP35_ENST00000404338_chr19_47491246_+_683aa MPPPRTREGRDRRDHHRAPSEEEALEKWDWNCPETRRLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSI PALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQV VVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSL PQYEVLIVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPR PFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTID GIRFVVDSGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHAL KEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_DHX34_ENST00000328771_chr19_47863327_+_ARHGAP35_ENST00000404338_chr19_47491246_+_2049nt ATGCCTCCTCCTAGAACAAGGGAGGGCAGGGATCGCCGAGACCACCACCGGGCTCCCAGCGAGGAAGAGGCCTTGGAGAAATGGGACTGG AATTGTCCAGAGACGCGTCGCCTCTTGGAAGATGCCTTCTTCCGTGAAGAGGATTACATCCGTCAGGGTTCTGAGGAATGTCAGAAGTTT TGGACCTTCTTTGAACGCCTGCAGAGATTCCAGAATCTCAAGACCTCCAGGAAGGAGGAGAAAGACCCTGGACAGCCCAAGCACAGCATC CCAGCGCTGGCCGACCTACCTCGCACTTACGACCCACGTTACCGCATCAACCTCTCTGTTCTTGGCCCTGCCACGCGGGGCTCTCAGGGA CTGGGCAGGCACTTGCCCGCGGAGAGAGTGGCTGAGTTCCGCCGAGCCCTGTTGCACTACCTGGACTTTGGCCAGAAGCAGGCATTTGGG CGTCTGGCCAAGCTGCAGCGTGAGCGGGCAGCCCTCCCCATCGCCCAGTATGGGAACCGCATCCTGCAGACGCTGAAGGAGCACCAGGTG GTGGTAGTGGCCGGTGACACCGGCTGTGGCAAGTCCACTCAGGTGCCCCAGTACCTGCTGGCTGCTGGCTTCAGTCATGTGGCGTGCACC CAGCCCCGGCGGATCGCCTGCATCTCACTGGCCAAGCGTGTGGGCTTTGAGAGCCTCAGTCAGTATGGCTCACAGGTCGGCTACCAGATC CGCTTTGAGAGCACACGTTCGGCGGCCACCAAGATTGTATTCCTGACAGTGGGGCTGCTCCTGCGACAAATCCAGCGGGAACCCAGCCTG CCCCAGTATGAGGTCCTGATTGTGGATGAAGTCCATGAGCGGCATCTCCACAACGATTTCCTCCTGGGCGTCCTCCAGCGCCTGTTGCCC ACGCGGCCTGACCTCAAGGTCATCCTCATGTCGGCCACCATCAACATCTCGCTCTTCTCCAGCTATTTCAGCAATGCCCCTGTGGTACAG GTGCCTGGGAGGCTGTTCCCCATCACGGTTGTGTACCAGCCGCAGGAGGCGGAGCCGACCACGTCCAAGTCAGAGAAGCTGGACCCGCGG CCTTTCCTGAGGGTGCTGGAGTCCATTGACCACAAGTACCCGCCTGAGGAGCGGGGTGACCTCCTCGTCTTCCTCAGCGGCATGGCGGAG ATCAGCGCCGTGCTGGAGGCTGCCCAGACCTATGCCAGCCACACCCAGCGCTGGGTGGTACTGCCACTGCACAGCGCCCTGTCTGTGGCC GACCAGGACAAGGTATTTGATGTGGCACCCCCTGGAGTCCGGAAATGCATCCTCTCCACCAACATTGCTGAGACCTCAGTCACCATTGAC GGGATCCGCTTCGTAGTAGATTCCGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGA CAGTTTGATCAAGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAA CTGCCTGACCCCCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTT AAGGAGGTATTAAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAG GTGAATCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCC ACGCGCACCTACCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCC AGGCCCAGCTCCCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_DHX34_ENST00000328771_chr19_47863327_+_ARHGAP35_ENST00000404338_chr19_47491246_+_6787nt ACGAGATGGCTGTGTGCGCAGGCGCAAGACTAGCGCTCTTGGGACCGGAAGTTAAGGCGTTCGCGGCGTGTGAATCCAGGGCCTGAAAAC CCAGAATGAACTTGTGTCCATCCCAGAGATCACTGCAGATGTCATGAGGTACCCTTTGTGTCACCAGCTCAAGCAGGCCTCTGGCCACTT TATCATCTGTGGTGGTCCTGTGCCGTGACCAGGAGGAAAAATTAGCTCTTTGAAGAGAAAGTAGTTCTCTATTGCAGGCACTGGCCTCTT AAATTGTTGCAGGTGGGGAATGGATGAGAATATTTGTTTTGGGTGATCAGAACTGAGACTCCTATTGTGGATTAGTAACATGCCTCCTCC TAGAACAAGGGAGGGCAGGGATCGCCGAGACCACCACCGGGCTCCCAGCGAGGAAGAGGCCTTGGAGAAATGGGACTGGAATTGTCCAGA GACGCGTCGCCTCTTGGAAGATGCCTTCTTCCGTGAAGAGGATTACATCCGTCAGGGTTCTGAGGAATGTCAGAAGTTTTGGACCTTCTT TGAACGCCTGCAGAGATTCCAGAATCTCAAGACCTCCAGGAAGGAGGAGAAAGACCCTGGACAGCCCAAGCACAGCATCCCAGCGCTGGC CGACCTACCTCGCACTTACGACCCACGTTACCGCATCAACCTCTCTGTTCTTGGCCCTGCCACGCGGGGCTCTCAGGGACTGGGCAGGCA CTTGCCCGCGGAGAGAGTGGCTGAGTTCCGCCGAGCCCTGTTGCACTACCTGGACTTTGGCCAGAAGCAGGCATTTGGGCGTCTGGCCAA GCTGCAGCGTGAGCGGGCAGCCCTCCCCATCGCCCAGTATGGGAACCGCATCCTGCAGACGCTGAAGGAGCACCAGGTGGTGGTAGTGGC CGGTGACACCGGCTGTGGCAAGTCCACTCAGGTGCCCCAGTACCTGCTGGCTGCTGGCTTCAGTCATGTGGCGTGCACCCAGCCCCGGCG GATCGCCTGCATCTCACTGGCCAAGCGTGTGGGCTTTGAGAGCCTCAGTCAGTATGGCTCACAGGTCGGCTACCAGATCCGCTTTGAGAG CACACGTTCGGCGGCCACCAAGATTGTATTCCTGACAGTGGGGCTGCTCCTGCGACAAATCCAGCGGGAACCCAGCCTGCCCCAGTATGA GGTCCTGATTGTGGATGAAGTCCATGAGCGGCATCTCCACAACGATTTCCTCCTGGGCGTCCTCCAGCGCCTGTTGCCCACGCGGCCTGA CCTCAAGGTCATCCTCATGTCGGCCACCATCAACATCTCGCTCTTCTCCAGCTATTTCAGCAATGCCCCTGTGGTACAGGTGCCTGGGAG GCTGTTCCCCATCACGGTTGTGTACCAGCCGCAGGAGGCGGAGCCGACCACGTCCAAGTCAGAGAAGCTGGACCCGCGGCCTTTCCTGAG GGTGCTGGAGTCCATTGACCACAAGTACCCGCCTGAGGAGCGGGGTGACCTCCTCGTCTTCCTCAGCGGCATGGCGGAGATCAGCGCCGT GCTGGAGGCTGCCCAGACCTATGCCAGCCACACCCAGCGCTGGGTGGTACTGCCACTGCACAGCGCCCTGTCTGTGGCCGACCAGGACAA GGTATTTGATGTGGCACCCCCTGGAGTCCGGAAATGCATCCTCTCCACCAACATTGCTGAGACCTCAGTCACCATTGACGGGATCCGCTT CGTAGTAGATTCCGGACTGAGCACGGAAGGCATCTACCGGGTCAGCGGGAACAAGTCTGAGATGGAGAGTCTGCAGAGACAGTTTGATCA AGACCACAACCTGGACCTGGCAGAGAAAGACTTTACGGTGAATACCGTGGCTGGTGCCATGAAGAGCTTTTTCTCAGAACTGCCTGACCC CCTGGTCCCGTATAACATGCAGATCGACTTGGTGGAAGCACACAAAATCAACGACCGGGAGCAGAAGTTGCATGCCCTTAAGGAGGTATT AAAGAAATTTCCAAAGGAAAACCACGAAGTCTTCAAGTATGTCATCTCTCACCTAAACAAGGTCAGCCACAACAACAAGGTGAATCTCAT GACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGACCTGATTTCAGCACTATGGACGCCCTCACAGCCACGCGCACCTA CCAGACAATCATTGAACTCTTTATCCAGCAGTGCCCCTTCTTCTTCTACAATCGGCCCATCACCGAGCCCCCCGGCGCCAGGCCCAGCTC CCCCTCTGCCGTGGCTTCCACCGTCCCCTTCCTCACTTCCACGCCTGTCACAAGTCAGCCGTCGCCCCCACAGTCGCCTCCACCCACCCC CCAGTCCCCAATGCAGCCACTGCTTCCCTCCCAGCTTCAAGCCGAACACACGCTGTGAGCCACCAAGACCTGGGGCGACAGGAGAACCGG TCCTCTCTCTGACGGGGTGGCATTTGGCCTTGAACAAAACCAAGTCCACTGGGGACAGAGGCAGGGGCAAGTGGCTCTCCCCATTACCTT CTCAAGACCTCAGTGGGAGCACCAGCCAATGGTACCATCGGCTGGGCTGCCAGGTACCCTGGGCCTGGCGCTGCAGACCTGAGCTGGCTT GGACCCATTTGAGGACTGAACTAGGCAGGCAATGGCTCCAGTGCCCTCCCTCTGTTCCCTGGACCACCACCCCACGTAGCTGCTCACACC AGCCTCCGGGTGCCTCCCTCTGCTTGTACAGAGCCCATGGTCGGGACAGTGCCCTGGCCTTTGCCGGGGAGGAGGATGCTCTGAGATTCA GGGTGGGGCTGGCAACCCCTGAAGAGAACACTTCCTGTTGGTCTGTCTCTTCCCACCTTCCATCTGCACACACCCCCAAGGTAAGGGTAC AGCCCGGCTGGCGGCCTCCTTGGGAACGTGTAGGCCACGGCTCTGCCACCACTAGGTACCTGCTGAGGGCGCTGGCTCTGCAGATCAGAA CAACGGAGGATAGCTTTGTGCCTGGACCCAGAGAGTGTGGGACTCCCCGCTTCATCCCCACCGTCCCACTCCACAGCCTTCCCGAAACAT TCCCTGGCAAACAAAGGAACACTAGGAGAAAAAATGGAAAAACCCTTCCAGTAATTAAAAAGGAAGAAACCACAGAAAGAAAACTACAGA CCTCAAGATTCCACTCTGTGCCCGCCTCTGCCGGGAGGGAGGGAGGCACACAGGTGGAGCTGACCCTCGTCTTTGTGGCAGCAAAACCAG GATGCCTGGAGCTGTGGCCTGAGGGCCTGCTGGGGTCCCACTCACCCACTTAGGTCTAGTCGCTAGATCCCCCGTTTTCCCAAGAAGAGG GTTCGAGCCCTTGGTGGGGACAGCTGGGGAGATGGCAGTGCAGGCTGGAACCTGGGCTGCCCCAGAACACAGTCCATTACGATAGAAACA CTAATTGAGCATGTGCGTGGGGTGGGGGTGTGTGTGCACATGTGAGTGTGAGTGTGTGTGGGCGCTTGGTGGGGGGTTGGGGACAGCTGG AAGGTGCCAGGTGCACTTGGGGTTGGGGTTGGTGTGTTGGGTGTTGAAGTGGAATCGTTTCATCCCAGCCATGGAGGCCACCAGCAGGAG TGTTCATGGGGATGTGGGCGAGGTGGGGCACTTTGAAGGAATGGCGGTCTGCTGGTGCCCTCGAAGGGGCATCCTTCCTGGTCTTCGCTG ACCCAGAGGCGCTGTGCCTGCATATCATCCACCACCACCCTAGCCCAGCCTTCCCACTGCCCCAGGAAAAGCTCTTCTCCTGGCCACCTC TGCCCCCCAGCACCTCAAACTTGCATGGCTGGGCTGTGGCCTCTGCGGCCAGGAAGCCTGACACTAGGCACCCCCCAGGCGAGAGCTAGT GGGGTGCAGAGGGCCCCATGCCAGACAGCCCTTGGGGCTCGTTGCACTTTAAGAAATAGGATCTGTGGTGTATTCCAGGGGGCCTGATGG ACACCTTTCCCGGGCGTCTGCAGCTGCCCTGCCCGTGCCCGCCTGCAGTGGTTGGAGACGGGAGTGGCCCTTCGGCTCCCGAGCTCCCTC TGGGGACGGCTGGCTCACTGTCTCCAGTTCTCAATGGCCAACGAAGGTGCTTGGAAACACCTAACCTTGCAAGTTTTACCGCCTTTTGAG GAACACAAATCGGAGAACAAACCCAGGGTTCAGGCGTGTTTTCTGTGAATGTTGGATGATGAATTTTTGTCTCTTCTGGTGGAGCTGTGC CTGGCCCTGTAGGCCCAGGGTTGGCTGGAAGGTGACATCTGTGTTTCGTTTTAGCTGAGGTTGGCAGAAACGTTCCCAAACTCCCCCAGC CCTGGACCCCAGCAGATGAGGAAACGGCCCCATTTACTGACCCCGCCCCCTTTTCGAGGTTATGCTCACCTGGTCAGCTCCTCACGTAAT TGGGGGTGGAGGGAAAGCATGGTGGTGCCCTGGGCCGTCCCTGTGTGAACGCAGGCAAAAGCAGCCCAGTCCCCCTCACTGCTTGAGCTA ACACTGCCACCTCTTTTGTGTGAGCACAAAAGCCACGTCCCAAGCCACCTGGCCCGATTCCACAGATGTATGTGCGGCCAGTGACTTCCC CAGGAGTGTGGAGGGGGTGGTGAGGAGGAGCACCTGGGCTCTCTACCCCTCTCCTCACAGAAGTACCTGAAACTAGGTCTGGGGCACTCC CAATGCAGCGCCTTGTCAGCCAAGGTGGGCAGGCAGGGACTGTGGCAGCTTATGTCCAAAGGGAGCCCCCATGCACAGGAAGCCACAGGG TTCCTCTTGTTTCCCCCGCTAACTTCAGCCTCTCATCTGCTGCTCCGGGCTGAGGGACTAGAGGACATCTCGGTCGTTTGAGGGGCATGG CCAGTCGTGGCAGGCCGGCCTTCAGCGTCCGGTCAGGGAAGCGTGCAGCCCAAATGGGCACTTGCATGGGAGCCACAGAGGAGCGTCCCT GGGGATTGTTGGGACCATGCTGCCCCCACTCCCGCTTTTGTTGGGGCTCTAAGTTCTGGAAGGTGTGTGCACAGAGGGTGCTCATGGGAC TCGCATGCAGCTCTCAGCACTGGGTGGGAGGGCGTTGGCTTGTCCAGAATGGGGACGTGGGGCAGCCACCCCTGCCCAGCGAGAGCGCAG ACACCGTGTGAGGGGACAGCAGCCCTTGGTGCAAAGCCAGAGACTGATCCTGGCTCTGACGGCTGAAGAGGGAAGACCCAAGGCTGGGTG GCGTGGCTCGTGAATCCACTTAGAATTCTTGGCTTGTGTCGCATACTGGGTGTCACGGCACACATTTACTCTGCATTGTCCCCGTCTTTC CCATCGCCTAGCGTTTGGGGAGGAACAGGGAGAGAGCTTCGGGGCGTCTGTCTCCGTGCTCTCCTGCCTCCACCGCCTTGGTTTTGCTTC CTGCTGGAGGCAGGGCACCTGCTGCGACCCAGATTCTTCTGCAGGATGTGTCTGTCTTTGTCACGGTGGACAGAGGGTGACATCATAGGA GCAGCTCGCTGGCCAGAAGGGGATGGGGGCATCCCTGTGCCTCACTCAGCTCCTGCTGCTCTTAGGGAAAGGAGGCCTGGGTCAAGCCAG CATCCCCTTGGTAAAGACCCCCGCAGGCCACCAGGCATTCTGGACACGCACACACACACACACACACACACACACACACAAAACTTCACA GCAGGCCAGCTGCAGTGACTTGTCATCAAGAGTCACCTCAGCTGCGCCCCCCTCCCATCCTTTCCTATGAGAAGCCACTGCTTTGGGGGC GCCGGCTAGAAAAAGTAGGGTGCGGTGGCCAGGAGGGCCCCTGCCGCGCGGGGGGCTGGGTCTGGTTGAGTCGCTGCTTTCCCGAGGGCA GCGCAGGGATCCGGGGAAGCTGCGGCAGGGAGCGGGCGCCGGCTTCGTGGCTCTGAGGTGTAACGGGGGTGGGCTCCCTCCCTCGGAGGA CATCGTCTGTGTCCAGGTCAGAAAGTGGCCCAGGAAGGGGGCAGTTTCTGTCGCGGGTCCGGTGGGGGCGCGGCCGCGGTGCGGTCGGTG CAGCGTGGCCAATGCGCGGCGCGCGCGGGGGACAGAGCAGGAGGCGGTCTGTCACCTCGGCCACTGCTGACCTGGGCTGGCCTCCCCCAG CCCTCCCGTGGCGGAGCCGGCAGCGATGCTACAGGCCTAAGTTATTGTTTGCATAAAAAGAATCATGTTCCCTGTGTACATTTAAGAAAA AAACAAAAAAACGGAAATGTCAGAATTGTATGGAAATAAAACTTGTTTGAAAATTTGGAATAGTGCTGCTGCCAGCTTATTTTTCTGGTA CTTGTATTTTCACATGTTAAATGATCTTTATATATGTTGAATTAACAAATATTTTGAGTTTCTGAGAAAAAACAAAACATATTAATGGTA TTGAAATGTGTTAGTAGTCTGGCTGTGTGCCCAAAATTCTGTTTCGCAGCAAAAGTGAAGACCTGTATGTAAAGAAAGTATAACAATTAT TTCTTTGTATTTTAGGGGCTTTAACCGGAACATCGTCTAGCTGGTGTTAGGAATGTTTGCTTAATTTCCAGACTTTTTTTTAAAAACACA TCGTGGGTTTTTTGAGGCTCCAACCTGATTAGTGCATGGTCAGCCCTCAATGAAGGCTGAGGCATCTCTGACTGAGGTGTTTTTGTTTGG TTTTGTTTTTTAAAATCATGTATTTGCTACAAAGTATTGTACTTGTCTCAATGGGAATGGTGTAAAAAACAAAAGGCCTTATGTGATCTG 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FusionGenePPI for DHX34_ARHGAP35 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DHX34 | POLA2, GSK3B, RPS6KA6, TRMT2A, EXOC8, KIF3A, TRIM25 | ARHGAP35 | RASA1, RHOA, GRB2, BCL6, RND1, RND2, RND3, KRT31, TCERG1, NTRK1, CDC42, RAC1, SERPINB2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHX34_ARHGAP35 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHX34_ARHGAP35 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ARHGAP35 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |