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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9912

FusionGeneSummary for DHX30_ZDHHC3

check button Fusion gene summary
Fusion gene informationFusion gene name: DHX30_ZDHHC3
Fusion gene ID: 9912
HgeneTgene
Gene symbol

DHX30

ZDHHC3

Gene ID

22907

51304

Gene nameDExH-box helicase 30zinc finger DHHC-type containing 3
SynonymsDDX30|NEDMIAL|RETCORDHHC-3|DHHC3|GODZ|ZNF373
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionputative ATP-dependent RNA helicase DHX30DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 30DEAH (Asp-Glu-Ala-His) box helicase 30DEAH (Asp-Glu-Ala-His) box polypeptide 30DEAH box protein 30DEAH-box helicase 30retina co-repressorpalmitoyltransferase ZDHHC3DHHC1 proteinGolgi apparatus-specific protein with DHHC zinc finger domaingolgi-specific DHHC Zinc Finger Proteinzinc finger DHHC domain-containing protein 3zinc finger protein 373zinc finger, DHHC domain containing 3
Modification date2018052320180523
UniProtAcc

Q7L2E3

Q9NYG2

Ensembl transtripts involved in fusion geneENST00000446256, ENST00000445061, 
ENST00000476446, ENST00000348968, 
ENST00000457607, 
ENST00000466084, 
ENST00000296127, ENST00000424952, 
ENST00000342790, 
Fusion gene scores* DoF score7 X 6 X 6=2524 X 3 X 4=48
# samples 85
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DHX30 [Title/Abstract] AND ZDHHC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZDHHC3

GO:0018345

protein palmitoylation

21926431|23034182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-J4-A67K-01ADHX30chr3

47883227

+ZDHHC3chr3

45000952

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000446256ENST00000466084DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000446256ENST00000296127DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000446256ENST00000424952DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000446256ENST00000342790DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-intronENST00000445061ENST00000466084DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000445061ENST00000296127DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000445061ENST00000424952DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000445061ENST00000342790DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
intron-intronENST00000476446ENST00000466084DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
intron-5UTRENST00000476446ENST00000296127DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
intron-5UTRENST00000476446ENST00000424952DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
intron-5UTRENST00000476446ENST00000342790DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-intronENST00000348968ENST00000466084DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000348968ENST00000296127DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000348968ENST00000424952DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000348968ENST00000342790DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-intronENST00000457607ENST00000466084DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000457607ENST00000296127DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000457607ENST00000424952DHX30chr3

47883227

+ZDHHC3chr3

45000952

-
5CDS-5UTRENST00000457607ENST00000342790DHX30chr3

47883227

+ZDHHC3chr3

45000952

-

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FusionProtFeatures for DHX30_ZDHHC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHX30

Q7L2E3

ZDHHC3

Q9NYG2

Plays an important role in the assembly of themitochondrial large ribosomal subunit (PubMed:25683715). Requiredfor optimal function of the zinc-finger antiviral protein ZC3HAV1(By similarity). Associates with mitochondrial DNA(PubMed:18063578). {ECO:0000250|UniProtKB:Q5BJS0,ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:25683715}. Palmitoyltransferase with broad specificity(PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptorson their gamma subunit (GABRG1, GABRG2 and GABRG3), whichregulates synaptic clustering and/or cell surface stability (Bysimilarity). Palmitoylates glutamate receptors GRIA1 and GRIA2,which leads to their retention in Golgi. May also palmitoylateDLG4, DNAJC5 and SNAP25 (By similarity).{ECO:0000250|UniProtKB:Q8R173, ECO:0000269|PubMed:21926431,ECO:0000269|PubMed:23034182}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DHX30_ZDHHC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DHX30_ZDHHC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DHX30H2AFX, ICT1, DHX58, OAS3, EIF2AK2, HDGF, SIRT7, HNRNPA1, CUL3, CUL4B, CUL5, CUL1, COPS5, CAND1, GRK5, ILF3, GNAI2, RAB31, NDUFA2, ESR1, FN1, SKIL, HNRNPD, TARDBP, NEDD4, WWOX, GRSF1, IVNS1ABP, STAU1, ENO1, MOV10, NXF1, OBSL1, CCDC8, EZH2, SUZ12, RNF2, HIST1H1A, PRR11, ILF2, NTRK1, IFI16, TCTN2, HNRNPU, RPL10, NOP56, IBTK, LDHD, KMT2E, NF2, FAM136A, CISD3, ZNF746, MCMBP, WDR46, RRS1, GLTSCR2, RPL18A, ZNF2, FGF8, RRP8, ZC3HAV1, ZNF324B, CDX1, RPL30, CPNE4, GPATCH4, RPL37A, PDGFB, ZNF71, PPAN, HIST1H1E, DGCR8, RPL18, RBM34, CNBP, FGF3, SART3, LTF, ZFC3H1, GSPT2, RPS14, STUB1, NKRF, NCL, CYLD, INO80B, COX15, PDHA1, G3BP1, MTF1ZDHHC3EWSR1, NEDD4L, ELAVL1, UBQLN4, SMAD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DHX30_ZDHHC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DHX30_ZDHHC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource