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Fusion gene ID: 9890 |
FusionGeneSummary for DHRS2_IL25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DHRS2_IL25 | Fusion gene ID: 9890 | Hgene | Tgene | Gene symbol | DHRS2 | IL25 | Gene ID | 10202 | 64806 |
| Gene name | dehydrogenase/reductase 2 | interleukin 25 | |
| Synonyms | HEP27|SDR25C1 | IL17E | |
| Cytomap | 14q11.2 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dehydrogenase/reductase SDR family member 2, mitochondrialdehydrogenase/reductase (SDR family) member 2dehydrogenase/reductase member 2dicarbonyl reductase HEP27protein Dshort chain dehydrogenase/reductase family 25C member 1short-chain alcohol dehy | interleukin-25interleukin-17E | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q13268 | Q9H293 | |
| Ensembl transtripts involved in fusion gene | ENST00000553896, ENST00000250383, ENST00000344777, | ENST00000397242, ENST00000329715, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DHRS2 [Title/Abstract] AND IL25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DHRS2 | GO:0009636 | response to toxic substance | 16685466 |
| Hgene | DHRS2 | GO:0034599 | cellular response to oxidative stress | 19443906 |
| Hgene | DHRS2 | GO:0055114 | oxidation-reduction process | 16685466 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-E7-A85H-01A | DHRS2 | chr14 | 24109104 | + | IL25 | chr14 | 23844834 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000553896 | ENST00000397242 | DHRS2 | chr14 | 24109104 | + | IL25 | chr14 | 23844834 | + |
| 3UTR-3CDS | ENST00000553896 | ENST00000329715 | DHRS2 | chr14 | 24109104 | + | IL25 | chr14 | 23844834 | + |
| Frame-shift | ENST00000250383 | ENST00000397242 | DHRS2 | chr14 | 24109104 | + | IL25 | chr14 | 23844834 | + |
| Frame-shift | ENST00000250383 | ENST00000329715 | DHRS2 | chr14 | 24109104 | + | IL25 | chr14 | 23844834 | + |
| Frame-shift | ENST00000344777 | ENST00000397242 | DHRS2 | chr14 | 24109104 | + | IL25 | chr14 | 23844834 | + |
| Frame-shift | ENST00000344777 | ENST00000329715 | DHRS2 | chr14 | 24109104 | + | IL25 | chr14 | 23844834 | + |
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FusionProtFeatures for DHRS2_IL25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DHRS2 | IL25 |
| Displays NADPH-dependent dicarbonyl reductase activityin vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed invitro with steroids, retinoids and sugars as substrates.Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53stabilization and increased transcription activity, resulting inthe accumulation of MDM2 and CDKN1A/p21.{ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751}. | Induces activation of NF-kappa-B and stimulatesproduction of the proinflammatory chemokine IL-8. Proinflammatorycytokine favoring Th2-type immune responses. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DHRS2_IL25 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DHRS2_IL25 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DHRS2 | CD4, ARRB1, MDM2, TCEA2, ZHX2, EXOSC5, ASB15, ASB18, APPBP2, HBB, HBA2, TMEFF1, PPME1, TACC3, ANAPC15, NAF1, MCM2, CDC73, SDC2, CD44, SDC1, AP3S1, GMEB1 | IL25 | IL17RB, MGMT |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DHRS2_IL25 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHRS2_IL25 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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