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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9875

FusionGeneSummary for DHFR_LSP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DHFR_LSP1
Fusion gene ID: 9875
HgeneTgene
Gene symbol

DHFR

LSP1

Gene ID

1719

4046

Gene namedihydrofolate reductaselymphocyte specific protein 1
SynonymsDHFRP1|DYRWP34|pp52
Cytomap

5q14.1

11p15.5

Type of geneprotein-codingprotein-coding
Descriptiondihydrofolate reductaselymphocyte-specific protein 147 kDa actin binding protein52 kDa phosphoproteinF-actin binding and cytoskeleton associated proteinleufactin (leukocyte F-actin binding protein)leukocyte-specific protein 1lymphocyte-specific antigen WP34
Modification date2018052320180527
UniProtAcc

P00374

P33241

Ensembl transtripts involved in fusion geneENST00000439211, ENST00000505337, 
ENST00000511032, ENST00000504396, 
ENST00000513048, 		ENST00000311604, 
ENST00000381775, ENST00000405957, 
ENST00000406638, ENST00000485341, 
ENST00000599825, 
Fusion gene scores* DoF score4 X 4 X 1=166 X 5 X 3=90
# samples 46
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHFR [Title/Abstract] AND LSP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHFR

GO:0017148

negative regulation of translation

8490020

HgeneDHFR

GO:0046452

dihydrofolate metabolic process

2303423|23707606

HgeneDHFR

GO:0046653

tetrahydrofolate metabolic process

12096917|21876184

HgeneDHFR

GO:0046654

tetrahydrofolate biosynthetic process

2303423

HgeneDHFR

GO:0055114

oxidation-reduction process

23707606


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1M33552DHFRchr5

79946335

-LSP1chr11

1874307

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000439211ENST00000311604DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000439211ENST00000381775DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000439211ENST00000405957DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000439211ENST00000406638DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000439211ENST00000485341DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000439211ENST00000599825DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-5UTRENST00000505337ENST00000311604DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000505337ENST00000381775DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000505337ENST00000405957DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000505337ENST00000406638DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000505337ENST00000485341DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000505337ENST00000599825DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-5UTRENST00000511032ENST00000311604DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000511032ENST00000381775DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000511032ENST00000405957DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000511032ENST00000406638DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000511032ENST00000485341DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000511032ENST00000599825DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-5UTRENST00000504396ENST00000311604DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000504396ENST00000381775DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000504396ENST00000405957DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000504396ENST00000406638DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000504396ENST00000485341DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000504396ENST00000599825DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-5UTRENST00000513048ENST00000311604DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000513048ENST00000381775DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000513048ENST00000405957DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000513048ENST00000406638DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000513048ENST00000485341DHFRchr5

79946335

-LSP1chr11

1874307

+
intron-intronENST00000513048ENST00000599825DHFRchr5

79946335

-LSP1chr11

1874307

+

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FusionProtFeatures for DHFR_LSP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHFR

P00374

LSP1

P33241

Key enzyme in folate metabolism. Contributes to the denovo mitochondrial thymidylate biosynthesis pathway. Catalyzes anessential reaction for de novo glycine and purine synthesis, andfor DNA precursor synthesis. Binds its own mRNA and that of DHFR2.{ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DHFR_LSP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DHFR_LSP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DHFR_LSP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDHFRP00374DB00563MethotrexateDihydrofolate reductasesmall moleculeapproved
HgeneDHFRP00374DB01131ProguanilDihydrofolate reductasesmall moleculeapproved
HgeneDHFRP00374DB00642PemetrexedDihydrofolate reductasesmall moleculeapproved|investigational
HgeneDHFRP00374DB01157TrimetrexateDihydrofolate reductasesmall moleculeapproved|investigational
HgeneDHFRP00374DB06813PralatrexateDihydrofolate reductasesmall moleculeapproved|investigational
HgeneDHFRP00374DB00205PyrimethamineDihydrofolate reductasesmall moleculeapproved|investigational|vet_approved
HgeneDHFRP00374DB00440TrimethoprimDihydrofolate reductasesmall moleculeapproved|vet_approved
HgeneDHFRP00374DB00798GentamicinDihydrofolate reductasesmall moleculeapproved|vet_approved

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RelatedDiseases for DHFR_LSP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDHFRC0002888Anemia, Megaloblastic2CTD_human;HPO
HgeneDHFRC0025521Inborn Errors of Metabolism2CTD_human
HgeneDHFRC0027765nervous system disorder2CTD_human
HgeneDHFRC3151205Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency2ORPHANET;UNIPROT
HgeneDHFRC0000786Spontaneous abortion1CTD_human
HgeneDHFRC0003873Rheumatoid Arthritis1CTD_human
HgeneDHFRC0004352Autistic Disorder1CTD_human
HgeneDHFRC0009404Colorectal Neoplasms1CTD_human
HgeneDHFRC0016412Folic Acid Deficiency1CTD_human
HgeneDHFRC0021361Female infertility1CTD_human
HgeneDHFRC0027627Neoplasm Metastasis1CTD_human
HgeneDHFRC0029463Osteosarcoma1CTD_human
HgeneDHFRC0030312Pancytopenia1CTD_human;HPO
HgeneDHFRC0041755Adverse reaction to drug1CTD_human
HgeneDHFRC1458155Mammary Neoplasms1CTD_human
HgeneDHFRC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneLSP1C1458155Mammary Neoplasms2CTD_human
TgeneLSP1C0006663Calcinosis1CTD_human
TgeneLSP1C0009324Ulcerative Colitis1CTD_human
TgeneLSP1C0018824Heart valve disease1CTD_human