FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9840

FusionGeneSummary for DGKI_RAPGEF4

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKI_RAPGEF4
Fusion gene ID: 9840
HgeneTgene
Gene symbol

DGKI

RAPGEF4

Gene ID

9162

11069

Gene namediacylglycerol kinase iotaRap guanine nucleotide exchange factor 4
SynonymsDGK-IOTACAMP-GEFII|CGEF2|EPAC|EPAC 2|EPAC2|Nbla00496
Cytomap

7q33

2q31.1

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase iotaDAG kinase iotadiglyceride kinase iotarap guanine nucleotide exchange factor 4RAP guanine-nucleotide-exchange factor (GEF) 4Rap guanine nucleotide exchange factor (GEF) 4cAMP-regulated guanine nucleotide exchange factor IIexchange factor directly activated by cAMP 2exchange protein direc
Modification date2018051920180519
UniProtAcc

O75912

Q8WZA2

Ensembl transtripts involved in fusion geneENST00000453654, ENST00000288490, 
ENST00000424189, ENST00000446122, 
ENST00000494390, 
ENST00000264111, 
ENST00000397081, ENST00000409036, 
ENST00000397087, ENST00000538974, 
ENST00000540783, ENST00000539331, 
ENST00000473043, ENST00000535187, 
Fusion gene scores* DoF score3 X 3 X 2=188 X 8 X 5=320
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGKI [Title/Abstract] AND RAPGEF4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKI

GO:0046834

lipid phosphorylation

9830018


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF962288DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000453654ENST00000264111DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000453654ENST00000397081DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000453654ENST00000409036DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000453654ENST00000397087DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000453654ENST00000538974DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000453654ENST00000540783DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000453654ENST00000539331DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000453654ENST00000473043DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000453654ENST00000535187DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000288490ENST00000264111DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000288490ENST00000397081DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000288490ENST00000409036DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000288490ENST00000397087DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000288490ENST00000538974DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000288490ENST00000540783DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000288490ENST00000539331DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000288490ENST00000473043DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000288490ENST00000535187DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000424189ENST00000264111DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000424189ENST00000397081DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000424189ENST00000409036DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000424189ENST00000397087DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000424189ENST00000538974DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000424189ENST00000540783DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000424189ENST00000539331DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000424189ENST00000473043DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000424189ENST00000535187DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000446122ENST00000264111DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000446122ENST00000397081DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000446122ENST00000409036DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000446122ENST00000397087DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000446122ENST00000538974DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000446122ENST00000540783DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000446122ENST00000539331DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000446122ENST00000473043DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000446122ENST00000535187DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000494390ENST00000264111DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-3CDSENST00000494390ENST00000397081DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000494390ENST00000409036DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000494390ENST00000397087DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000494390ENST00000538974DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000494390ENST00000540783DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000494390ENST00000539331DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000494390ENST00000473043DGKIchr7

137466791

-RAPGEF4chr2

173901377

+
intron-intronENST00000494390ENST00000535187DGKIchr7

137466791

-RAPGEF4chr2

173901377

+

Top

FusionProtFeatures for DGKI_RAPGEF4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKI

O75912

RAPGEF4

Q8WZA2

Guanine nucleotide exchange factor (GEF) for RAP1A,RAP1B and RAP2A small GTPases that is activated by binding cAMP.Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:10777494,ECO:0000269|PubMed:9856955}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DGKI_RAPGEF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DGKI_RAPGEF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DGKI_RAPGEF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DGKI_RAPGEF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource