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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9837

FusionGeneSummary for DGKH_DGKH

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKH_DGKH
Fusion gene ID: 9837
HgeneTgene
Gene symbol

DGKH

DGKH

Gene ID

160851

160851

Gene namediacylglycerol kinase etadiacylglycerol kinase eta
SynonymsDGKetaDGKeta
Cytomap

13q14.11

13q14.11

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase etaDAG kinase etadiglyceride kinase etadiacylglycerol kinase etaDAG kinase etadiglyceride kinase eta
Modification date2018051920180519
UniProtAcc

Q86XP1

Q86XP1

Ensembl transtripts involved in fusion geneENST00000540693, ENST00000337343, 
ENST00000379274, ENST00000261491, 
ENST00000536612, ENST00000498255, 
ENST00000538674, 
ENST00000540693, 
ENST00000337343, ENST00000379274, 
ENST00000261491, ENST00000536612, 
ENST00000498255, ENST00000538674, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 7 X 3=147
# samples 38
** MAII scorelog2(3/8*10)=1.90689059560852log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DGKH [Title/Abstract] AND DGKH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKH

GO:0046473

phosphatidic acid metabolic process

23949095

TgeneDGKH

GO:0046473

phosphatidic acid metabolic process

23949095


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF373800DGKHchr13

42742071

-DGKHchr13

42741978

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000540693ENST00000540693DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000540693ENST00000337343DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000540693ENST00000379274DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000540693ENST00000261491DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000540693ENST00000536612DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000540693ENST00000498255DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000540693ENST00000538674DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000337343ENST00000540693DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000337343ENST00000337343DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000337343ENST00000379274DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000337343ENST00000261491DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000337343ENST00000536612DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000337343ENST00000498255DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000337343ENST00000538674DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000379274ENST00000540693DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000379274ENST00000337343DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000379274ENST00000379274DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000379274ENST00000261491DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000379274ENST00000536612DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000379274ENST00000498255DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000379274ENST00000538674DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000261491ENST00000540693DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000261491ENST00000337343DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000261491ENST00000379274DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000261491ENST00000261491DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000261491ENST00000536612DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000261491ENST00000498255DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000261491ENST00000538674DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000536612ENST00000540693DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000536612ENST00000337343DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000536612ENST00000379274DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000536612ENST00000261491DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000536612ENST00000536612DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000536612ENST00000498255DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000536612ENST00000538674DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000498255ENST00000540693DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000498255ENST00000337343DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000498255ENST00000379274DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000498255ENST00000261491DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000498255ENST00000536612DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000498255ENST00000498255DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000498255ENST00000538674DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000538674ENST00000540693DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000538674ENST00000337343DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000538674ENST00000379274DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000538674ENST00000261491DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000538674ENST00000536612DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000538674ENST00000498255DGKHchr13

42742071

-DGKHchr13

42741978

+
intron-intronENST00000538674ENST00000538674DGKHchr13

42742071

-DGKHchr13

42741978

+

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FusionProtFeatures for DGKH_DGKH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKH

Q86XP1

DGKH

Q86XP1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DGKH_DGKH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DGKH_DGKH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DGKH_DGKH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DGKH_DGKH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDGKHC0005586Bipolar Disorder5PSYGENET
HgeneDGKHC0011881Diabetic Nephropathy1CTD_human
HgeneDGKHC0036341Schizophrenia1PSYGENET
HgeneDGKHC0041696Unipolar Depression1PSYGENET
HgeneDGKHC2678248Mood instability1PSYGENET
TgeneDGKHC0005586Bipolar Disorder5PSYGENET
TgeneDGKHC0011881Diabetic Nephropathy1CTD_human
TgeneDGKHC0036341Schizophrenia1PSYGENET
TgeneDGKHC0041696Unipolar Depression1PSYGENET
TgeneDGKHC2678248Mood instability1PSYGENET