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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9828

FusionGeneSummary for DGKD_SLC25A17

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKD_SLC25A17
Fusion gene ID: 9828
HgeneTgene
Gene symbol

DGKD

SLC25A17

Gene ID

8527

10478

Gene namediacylglycerol kinase deltasolute carrier family 25 member 17
SynonymsDGKdelta|dgkd-2PMP34
Cytomap

2q37.1

22q13.2

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase deltaDAG kinase deltaDGK-deltadiacylglycerol kinase, delta 130kDadiglyceride kinase deltaperoxisomal membrane protein PMP34solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
Modification date2018051920180523
UniProtAcc

Q16760

O43808

Ensembl transtripts involved in fusion geneENST00000264057, ENST00000409813, 
ENST00000489613, 		ENST00000491545, 
ENST00000435456, ENST00000402844, 
ENST00000544408, ENST00000542412, 
Fusion gene scores* DoF score7 X 3 X 9=1895 X 2 X 7=70
# samples 108
** MAII scorelog2(10/189*10)=-0.918386234446348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/70*10)=0.192645077942396
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DGKD [Title/Abstract] AND SLC25A17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKD

GO:0010033

response to organic substance

12200442

HgeneDGKD

GO:0051260

protein homooligomerization

12200442


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N8-A4PQ-01ADGKDchr2

234299129

+SLC25A17chr22

41175129

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264057ENST00000491545DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000264057ENST00000435456DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000264057ENST00000402844DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000264057ENST00000544408DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000264057ENST00000542412DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000409813ENST00000491545DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000409813ENST00000435456DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000409813ENST00000402844DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000409813ENST00000544408DGKDchr2

234299129

+SLC25A17chr22

41175129

-
5CDS-5UTRENST00000409813ENST00000542412DGKDchr2

234299129

+SLC25A17chr22

41175129

-
intron-5UTRENST00000489613ENST00000491545DGKDchr2

234299129

+SLC25A17chr22

41175129

-
intron-5UTRENST00000489613ENST00000435456DGKDchr2

234299129

+SLC25A17chr22

41175129

-
intron-5UTRENST00000489613ENST00000402844DGKDchr2

234299129

+SLC25A17chr22

41175129

-
intron-5UTRENST00000489613ENST00000544408DGKDchr2

234299129

+SLC25A17chr22

41175129

-
intron-5UTRENST00000489613ENST00000542412DGKDchr2

234299129

+SLC25A17chr22

41175129

-

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FusionProtFeatures for DGKD_SLC25A17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKD

Q16760

SLC25A17

O43808

May function as signaling molecule.{ECO:0000269|PubMed:17880279}. Isoform 2 may be involved in cell growth andtumorigenesis. Involved in clathrin-dependent endocytosis.{ECO:0000269|PubMed:17880279}. Peroxisomal transporter for multiple cofactors likecoenzyme A (CoA), flavin adenine dinucleotide (FAD), flavinmononucleotide (FMN) and nucleotide adenosine monophosphate (AMP),and to a lesser extent for nicotinamide adenine dinucleotide(NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD andNAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate andbathophenanthroline in vitro. {ECO:0000269|PubMed:12445829,ECO:0000269|PubMed:22185573}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DGKD_SLC25A17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DGKD_SLC25A17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DGKDDGKH, HAX1, IGSF21, DGKD, TNFRSF14, SREK1, FEZ1, TRIM25SLC25A17PEX19, ILF3, ESYT2, FUT8, HNRNPU, EVPL, HNRNPUL2, UQCRB, SAMM50, HECW2, MOV10, NXF1, PTH1R, EIF3F, GNAI2, SLC39A4, SGCA, ERGIC3, TCTN3, VSIG1, TMCO3, C3AR1, SLC39A9, RANBP6, SLC39A12, LRRC8B, NPY2R, VIPR1, SCGB2A2, SLC1A1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DGKD_SLC25A17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DGKD_SLC25A17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource