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Fusion gene ID: 9803 |
FusionGeneSummary for DGCR2_DESI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DGCR2_DESI1 | Fusion gene ID: 9803 | Hgene | Tgene | Gene symbol | DGCR2 | DESI1 | Gene ID | 9993 | 51029 |
| Gene name | DiGeorge syndrome critical region gene 2 | desumoylating isopeptidase 2 | |
| Synonyms | DGS-C|IDD|LAN|SEZ-12 | C1orf121|CGI-146|DESI|DESI1|DeSI-2|FAM152A|PNAS-4|PPPDE1 | |
| Cytomap | 22q11.21 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | integral membrane protein DGCR2/IDDDiGeorge syndrome critical region protein 2integral membrane protein deleted in DiGeorge syndrome | deubiquitinase DESI2desumoylating isopeptidase 2PPPDE peptidase domain-containing protein 1desumoylating isopeptidase 1family with sequence similarity 152, member A | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P98153 | Q6ICB0 | |
| Ensembl transtripts involved in fusion gene | ENST00000537045, ENST00000263196, ENST00000545799, ENST00000473832, | ENST00000263256, ENST00000463886, | |
| Fusion gene scores | * DoF score | 13 X 10 X 8=1040 | 3 X 1 X 2=6 |
| # samples | 15 | 3 | |
| ** MAII score | log2(15/1040*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
| Context | PubMed: DGCR2 [Title/Abstract] AND DESI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A0EE-01A | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000537045 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| 5CDS-intron | ENST00000537045 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| In-frame | ENST00000263196 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| 5CDS-intron | ENST00000263196 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| 3UTR-3CDS | ENST00000545799 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| 3UTR-intron | ENST00000545799 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| intron-3CDS | ENST00000473832 | ENST00000263256 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
| intron-intron | ENST00000473832 | ENST00000463886 | DGCR2 | chr22 | 19028571 | - | DESI1 | chr22 | 42003865 | - |
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FusionProtFeatures for DGCR2_DESI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DGCR2 | DESI1 |
| Putative adhesion receptor, that could be involved incell-cell or cell-matrix interactions required for normal celldifferentiation and migration. | Protease which deconjugates SUMO1, SUMO2 and SUMO3 fromsome substrate proteins. Has isopeptidase but not SUMO-processingactivity. Desumoylates ZBTB46 (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 115_241 | 465 | 551 | Domain | C-type lectin |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 270_333 | 465 | 551 | Domain | Note=VWFC |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 28_68 | 465 | 551 | Domain | LDL-receptor class A |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 115_241 | 424 | 510 | Domain | C-type lectin |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 270_333 | 424 | 510 | Domain | Note=VWFC |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 28_68 | 424 | 510 | Domain | LDL-receptor class A |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 21_349 | 465 | 551 | Topological domain | Extracellular |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 21_349 | 424 | 510 | Topological domain | Extracellular |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 350_368 | 465 | 551 | Transmembrane | Helical |
| Hgene | DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 350_368 | 424 | 510 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000263196 | - | 9 | 10 | 369_550 | 465 | 551 | Topological domain | Cytoplasmic |
| Hgene | >DGCR2 | chr22:19028571 | chr22:42003865 | ENST00000537045 | - | 8 | 9 | 369_550 | 424 | 510 | Topological domain | Cytoplasmic |
| Tgene | DESI1 | chr22:19028571 | chr22:42003865 | ENST00000263256 | - | 0 | 6 | 7_149 | 29 | 169 | Domain | PPPDE |
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FusionGeneSequence for DGCR2_DESI1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DGCR2_ENST00000537045_chr22_19028571_-_DESI1_ENST00000263256_chr22_42003865_-_564aa MVPKADSGAFLLLFLLVLTVTEPLRPEVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRV YLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKGSSEVFLPPDPIF ASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFLCKRSQTCVDIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALC ERPQGCQQYRKDPKECCKFMCLDPDGNSLFDSMASGMRLVVSCISSFLILSLLLFMVHRLRQRRRERIESLIGANLHHFNLGRRIPGFDY GPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDIGQPDDPPPPYEASIHPDSVFYDPAGKQLEGIWHTSIVVHKDEFFFGSGGI SSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALR >In-frame_DGCR2_ENST00000263196_chr22_19028571_-_DESI1_ENST00000263256_chr22_42003865_-_605aa MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRAR GGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLNGSLATFSTDQELRFVLAQEWDQPERSFGWKD QRKLWVGYQYVITGRNRSLEGRWEVAFKGSSEVFLPPDPIFASAMSENDNVFCAQLQCFHFPTLRHHDLHSWHAESCYEKSSFLCKRSQT CVDIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALCERPQGCQQYRKDPKECCKFMCLDPDGNSLFDSMASGMRLVVSCISSFLI LSLLLFMVHRLRQRRRERIESLIGANLHHFNLGRRIPGFDYGPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDIGQPDDPPPP YEASIHPDSVFYDPAGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DGCR2_ENST00000537045_chr22_19028571_-_DESI1_ENST00000263256_chr22_42003865_-_1692nt ATGGTGCCCAAGGCAGACAGCGGCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAAGTGACCGGG GAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAAC GTGGCGCAGCCCGTTCGCTTCAGCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTC TACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTG CGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGTTGTGGGTTGGCTATCAGTATGTT ATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTGGGAGGTGGCATTCAAAGGCTCTTCAGAGGTGTTCCTGCCCCCAGACCCCATCTTT GCCTCGGCCATGTCTGAGAACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACGACCTCCACAGC TGGCACGCCGAGAGCTGCTACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACGTGGTGGATGAA GGGTTCTACTTCACCCCTAAGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGT GAGAGGCCCCAGGGCTGCCAACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCAACAGTCTGTTT GACTCCATGGCCAGCGGGATGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGGTCCACCGGCTG CGCCAGCGGCGCCGGGAGCGCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTGGCTTTGATTAC GGCCCAGACGGGTTTGGCACGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACGACCCTCCACCT CCCTACACGGCATACAAGTACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGGACAGTGTGTTC TATGACCCTGCAGGGAAACAACTGGAAGGCATCTGGCACACATCCATAGTTGTGCACAAGGATGAGTTCTTCTTCGGCAGTGGTGGTATC TCCAGCTGCCCCCCGGGAGGGACATTGCTTGGGCCTCCAGACTCTGTGGTTGATGTGGGGAGTACAGAAGTCACAGAAGAAATCTTTCTG GAGTACCTCTCCTCCCTGGGGGAGTCCCTGTTCCGAGGTGAGGCCTACAACCTCTTTGAACACAATTGTAACACCTTCAGCAACGAAGTG GCACAGTTCCTGACTGGGCGGAAGATTCCTTCTTACATCACAGACCTGCCCTCTGAAGTTCTCTCCACGCCCTTTGGACAGGCACTTCGG >In-frame_DGCR2_ENST00000263196_chr22_19028571_-_DESI1_ENST00000263256_chr22_42003865_-_1815nt ATGGTGCCCAAGGCAGACAGCGGCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAGCTGCGGTGC AACCCTGGGCAGTTTGCGTGTCGCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGCTGGGCGACTTGCGAGGATGAG AGCGACGAAGCCAACTGTCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGA GGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCAC CACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGC TCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGAC CAGCGCAAGTTGTGGGTTGGCTATCAGTATGTTATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTGGGAGGTGGCATTCAAAGGCTCT TCAGAGGTGTTCCTGCCCCCAGACCCCATCTTTGCCTCGGCCATGTCTGAGAACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCAT TTCCCCACCCTGCGGCACCACGACCTCCACAGCTGGCACGCCGAGAGCTGCTACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACA TGTGTTGACATCAAGGACAACGTGGTGGATGAAGGGTTCTACTTCACCCCTAAGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGA GGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGTGAGAGGCCCCAGGGCTGCCAACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTC ATGTGTCTGGACCCAGATGGCAACAGTCTGTTTGACTCCATGGCCAGCGGGATGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATC CTGTCACTGCTGCTCTTCATGGTCCACCGGCTGCGCCAGCGGCGCCGGGAGCGCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTC AACCTCGGCCGCAGGATCCCTGGCTTTGATTACGGCCCAGACGGGTTTGGCACGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAG GGTGGGACTTTCCATTTCCACGACCCTCCACCTCCCTACACGGCATACAAGTACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCC TACGAGGCCTCCATCCACCCGGACAGTGTGTTCTATGACCCTGCAGGGAAACAACTGGAAGGCATCTGGCACACATCCATAGTTGTGCAC AAGGATGAGTTCTTCTTCGGCAGTGGTGGTATCTCCAGCTGCCCCCCGGGAGGGACATTGCTTGGGCCTCCAGACTCTGTGGTTGATGTG GGGAGTACAGAAGTCACAGAAGAAATCTTTCTGGAGTACCTCTCCTCCCTGGGGGAGTCCCTGTTCCGAGGTGAGGCCTACAACCTCTTT GAACACAATTGTAACACCTTCAGCAACGAAGTGGCACAGTTCCTGACTGGGCGGAAGATTCCTTCTTACATCACAGACCTGCCCTCTGAA GTTCTCTCCACGCCCTTTGGACAGGCACTTCGGCCCCTCCTGGACTCCATTCAGATCCAGCCTCCAGGAGGGAGCTCCGTGGGCAGACCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DGCR2_ENST00000537045_chr22_19028571_-_DESI1_ENST00000263256_chr22_42003865_-_5009nt GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAAGTGACCGGGGAGGTGCGTCCTCATCATGGGA AGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCCACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCA GCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCTGCTACCGGGTCTACCTGAGCGGGGAGAACTACT GGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTGACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAAT GGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGTTGTGGGTTGGCTATCAGTATGTTATCACTGGCCGGAACCGCTCCT TGGAAGGTCGCTGGGAGGTGGCATTCAAAGGCTCTTCAGAGGTGTTCCTGCCCCCAGACCCCATCTTTGCCTCGGCCATGTCTGAGAACG ACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACGACCTCCACAGCTGGCACGCCGAGAGCTGCTACG AGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACGTGGTGGATGAAGGGTTCTACTTCACCCCTAAGG GGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGGCTGCTCTCTGTGAGAGGCCCCAGGGCTGCCAAC AGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCAACAGTCTGTTTGACTCCATGGCCAGCGGGATGC GCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGGTCCACCGGCTGCGCCAGCGGCGCCGGGAGCGCA TCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTGGCTTTGATTACGGCCCAGACGGGTTTGGCACGG GCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACGACCCTCCACCTCCCTACACGGCATACAAGTACC CGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGGACAGTGTGTTCTATGACCCTGCAGGGAAACAAC TGGAAGGCATCTGGCACACATCCATAGTTGTGCACAAGGATGAGTTCTTCTTCGGCAGTGGTGGTATCTCCAGCTGCCCCCCGGGAGGGA CATTGCTTGGGCCTCCAGACTCTGTGGTTGATGTGGGGAGTACAGAAGTCACAGAAGAAATCTTTCTGGAGTACCTCTCCTCCCTGGGGG AGTCCCTGTTCCGAGGTGAGGCCTACAACCTCTTTGAACACAATTGTAACACCTTCAGCAACGAAGTGGCACAGTTCCTGACTGGGCGGA AGATTCCTTCTTACATCACAGACCTGCCCTCTGAAGTTCTCTCCACGCCCTTTGGACAGGCACTTCGGCCCCTCCTGGACTCCATTCAGA TCCAGCCTCCAGGAGGGAGCTCCGTGGGCAGACCCAACGGCCAGAGCTAACAGGACTGCCTGGGACCGCCCTGCCTCACCAGGGCTTTTC CTTTTTAAACAAAACAAACCCTACCAGATTTCTATTTTATAATTTTACATCAGAGCTAACAACCAGGGGACGGCTTTTTAAATTTCCCAG GGAAGGAGACCGTCAGGCCGCATGTAGACAATGCTGCTAAGAAACAGAACAAAATGCCACCCCTTCTAATAGTATTATACTAATTTATTA AGGCTGTCTTGTCTGTGCGTTCACTTCGGATGCTGTTTCCTAAGCGTCCTCCACACTGGAGAAAGGGAGGGGCTTTGTTTAAACAGAAAG CGAGTCACAGTTTGCGGGAGCCCCAACCTAGAACTCTTTCCAGAGAACACTCACGCTCTACCCAAGTTGCCAACACCTGTGGGACCCAGG TGAGTTTTAGAACATCCGTGACCCAGAAAGTTACTCTAGTGTTAAATGAACCAAAGGATTTGGTGTACATGGGACCGGTTTCAGGATGAC TAACCTAACCTAAGTGAACTCTTTAGCCACAACCCTCACCTTCCCTCCCTTACCCCAAGCAAGGCCAGTGCTGGAGCAGCCATTGCCTCC GGATCAAGGGAGTAACAGCAAGTATCAGGCCGGAGAAAACAGGATAAAGCCATTCCTCCTTCCACCTAGATGGATTGCCAATCTTCTGCC ATCAATTTTGGGAAACCTGCCTTTGTGCCCCCGAGGCTGCCTTTCCTCAGCATAGCTGACTTGTCATAGTGGATGAGGTCTGGGCTGGAG CAGTAGAAGCCAAGGCCTTTTTTCTGCAAGTAATGATGTAGGTTATTTGCAGTCTCTGTAACCACCATCCAGGCCAGTACGCAGTATTTA GCTGGGGACCAAGGGATGGGATTCCCTACTCTAAGAAAATACCTTTATTTTAATTATTATTATTTTTTGAGACGGAGTCTCGCTCTACCA CCCAGGCTGGTGTGCAGTGGCATGATCTCGGCTCACAGAAACCTCTGCCTCCCGGGTTCAAGTGGTTCTCCTGCCTCAGCCTCCTGAGTA GCTGGGATTACAGGTGCGTGCCACCACGCCAGGCTAATTTTTGTATTTTCAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTG GAACTCCTGACCTCGGGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCTGCCTGGCCAGAAAATAC CTTTGATATGGAAAGAATAATGATGTGAGGCCTGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATC ACTTGAGGTCAGGACTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGCATGGTGGCGC ATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGATTGCGATGAGCCGAGATCGTACCA GTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAAAAAAATAAAATAATGAAGTGGAATCAAGGTGGCAAGAAAATTTAGAATC GTTTCTGATAGGGACTTTCCCTTATCCTAAATGTGTTTTGAAGGCACACGTTATTTCCATTGTCATTCTGACTTTAGAAAGGCAGGTTGG GGCATGAGTGGGCATTTTCCTAATGACTTGCTGCTAGGAGGTTATAGGCAGGGAACAGTCTGGGAGTCTCTAATCCAGAGAGACTTTCAG ATTCCCTCTCTTCACATGAACCTCCATTAGTTAGATTTTGGGAAAGTGAGCATGAAGAAGGGACTCAGAGCTGCCAGGTACCCGAGTCTC AGGTCTGACATCCTTGGGCCCCTTCTGCCACAACTTCTTGCCACTTCACGGACTTGAATTATGTTGCTTCTTCCTGGAAGTCTGGCCTGC AGCACAGGCCTTTCCTCTCCAAAAAGCTGCTGCTCATTTCTGGCCCCATCTGCTGCTATCTTTGCCATCAGCCATCACAGTTTGGCATCA TCAGAGTCTCAGCTAGAGGAGCTGTCATTCTGCCTTAGTGTTTGCCTGCGACCTGACCAGGGGCATGACCAGCTGGGATGTCAAGTGACA TTTGGGAACTTGTAGAGGCCAAATGATTGAAAGTTTAATTCTTCTCAAGACCCACTGATTTGCCAGTGTGCATGGAAATAATAGATTAGA GCAGAAACTAGCAGGGACTGTTGTATAATCGTGATCTACTAGCAGAATTGGGCCCAAAGAGAAAGAATTTCTGAGGCTGGGTTTCTTCTG GGAGGGTAGCAGGTTGGTCTTGGCCAGTGCTCTGTTTCCCACCAGTGTTGTTCCCTTTTCCAGCTTGCCTGGCCCGGCTCTGTCTTCCAG GGTCCTGCTCCAGACCCCTCTGCCTGGGGTCTCCCCTCCATCCAGGGGGTTCTGGGCATCACAGCTCCTTTTTTTCCTTTCTCCTCTTCC AGATCCAGTTTCAGCTGGTTTGCTTCTTCCAGCAGGCACCCTTAGGCCCAGGAGCAGCTCCCCTGAGAGAATTTGAGTCACTCATTTCCT TGAACAGCACCCCCCTTTATACTAGCAGCCATTTGTGCCATTGCCTGTGCCCTAGGGTTTGTGGGGAGAGAGCGAGGGATCACTGAGCAG TTTTCCCAGAGCTCCATGGGAAGGCAAGCTCTCCCTCCCAATGGGAGCCCCACTGTCACTAACTGTAAACTCAGGCTCAGGCTTCAACTG CCTACCCCCATCCTCATATTTCTGTCTGTCCCAGCACCTCAGGAGCATTCTCATTGTGGCCGGCTAACTCCGCCTGGATGTGAACAGGCA AGCACAGTGGGAAATGAGTCACGTACTTGTATTGCACAGTGGACACCTCTAGAGGTCCATTGGTTTAAAGGGATAGGGAAGGAGGAGGGA TGAGACCATCACCCCCTCCCAGAAGTAAATCTAGTATCTGAGTTTTCTTTATGCCCTTGAGTCAAACTAATAACTGTCTAGTACGGAGGT >In-frame_DGCR2_ENST00000263196_chr22_19028571_-_DESI1_ENST00000263256_chr22_42003865_-_5132nt GGGGCGGGGCGGCGCGGCGCGGAGCCGAGCAGGACGGCCGCCATCTTGCGCGCAGCTGGAGTCGGTGCCTGAGGTTGCAGCCGAGAGTGT GCGCCAGCCCGCGGCCCAGCCGAAGCTCTTTCCCGCCGCCTCTCCGCGCCTCGCCCAGGTTCAGCTCCGCCTGACCCTCCGCTTGGCACG GTCCCCTGACCCTCAGTCCGGCCTGGTCCGGCCTTCCAGCCGCCCCGGGGACGATGAACGGAGGATAAATGGTGCCCAAGGCAGACAGCG GCGCCTTCCTGCTGCTCTTCCTGCTCGTGCTCACTGTCACCGAGCCGCTGCGGCCAGAGCTGCGGTGCAACCCTGGGCAGTTTGCGTGTC GCAGCGGCACCATCCAGTGCATCCCCCTCCCCTGGCAGTGTGACGGCTGGGCGACTTGCGAGGATGAGAGCGACGAAGCCAACTGTCCAG AAGTGACCGGGGAGGTGCGTCCTCATCATGGGAAGGAGGCTGTGGATCCGCGGCAGGGGCGGGCCAGAGGAGGCGACCCTTCGCACTTCC ACGCGGTGAACGTGGCGCAGCCCGTTCGCTTCAGCAGTTTCCTAGGGAAGTGCCCGACAGGGTGGCACCACTACGAAGGCACGGCCAGCT GCTACCGGGTCTACCTGAGCGGGGAGAACTACTGGGATGCCGCGCAGACCTGCCAGCGCCTGAATGGCTCTCTCGCCACCTTCTCCACTG ACCAGGAGCTGCGCTTTGTCCTGGCCCAGGAATGGGACCAGCCCGAGCGGAGCTTTGGTTGGAAGGACCAGCGCAAGTTGTGGGTTGGCT ATCAGTATGTTATCACTGGCCGGAACCGCTCCTTGGAAGGTCGCTGGGAGGTGGCATTCAAAGGCTCTTCAGAGGTGTTCCTGCCCCCAG ACCCCATCTTTGCCTCGGCCATGTCTGAGAACGACAACGTGTTCTGTGCCCAGCTTCAGTGCTTCCATTTCCCCACCCTGCGGCACCACG ACCTCCACAGCTGGCACGCCGAGAGCTGCTACGAGAAGTCTTCATTTCTGTGTAAAAGAAGTCAAACATGTGTTGACATCAAGGACAACG TGGTGGATGAAGGGTTCTACTTCACCCCTAAGGGGGACGACCCATGCCTGAGCTGCACCTGCCATGGAGGGGAGCCTGAGATGTGTGTGG CTGCTCTCTGTGAGAGGCCCCAGGGCTGCCAACAGTACCGCAAGGACCCCAAAGAGTGCTGCAAGTTCATGTGTCTGGACCCAGATGGCA ACAGTCTGTTTGACTCCATGGCCAGCGGGATGCGCCTGGTCGTCAGCTGCATCTCCTCCTTCCTCATCCTGTCACTGCTGCTCTTCATGG TCCACCGGCTGCGCCAGCGGCGCCGGGAGCGCATCGAGTCCCTGATTGGAGCAAACTTGCACCACTTCAACCTCGGCCGCAGGATCCCTG GCTTTGATTACGGCCCAGACGGGTTTGGCACGGGCCTCACGCCGCTGCATCTTTCTGACGACGGAGAGGGTGGGACTTTCCATTTCCACG ACCCTCCACCTCCCTACACGGCATACAAGTACCCGGACATCGGCCAGCCCGACGACCCTCCGCCGCCCTACGAGGCCTCCATCCACCCGG ACAGTGTGTTCTATGACCCTGCAGGGAAACAACTGGAAGGCATCTGGCACACATCCATAGTTGTGCACAAGGATGAGTTCTTCTTCGGCA GTGGTGGTATCTCCAGCTGCCCCCCGGGAGGGACATTGCTTGGGCCTCCAGACTCTGTGGTTGATGTGGGGAGTACAGAAGTCACAGAAG AAATCTTTCTGGAGTACCTCTCCTCCCTGGGGGAGTCCCTGTTCCGAGGTGAGGCCTACAACCTCTTTGAACACAATTGTAACACCTTCA GCAACGAAGTGGCACAGTTCCTGACTGGGCGGAAGATTCCTTCTTACATCACAGACCTGCCCTCTGAAGTTCTCTCCACGCCCTTTGGAC AGGCACTTCGGCCCCTCCTGGACTCCATTCAGATCCAGCCTCCAGGAGGGAGCTCCGTGGGCAGACCCAACGGCCAGAGCTAACAGGACT GCCTGGGACCGCCCTGCCTCACCAGGGCTTTTCCTTTTTAAACAAAACAAACCCTACCAGATTTCTATTTTATAATTTTACATCAGAGCT AACAACCAGGGGACGGCTTTTTAAATTTCCCAGGGAAGGAGACCGTCAGGCCGCATGTAGACAATGCTGCTAAGAAACAGAACAAAATGC CACCCCTTCTAATAGTATTATACTAATTTATTAAGGCTGTCTTGTCTGTGCGTTCACTTCGGATGCTGTTTCCTAAGCGTCCTCCACACT GGAGAAAGGGAGGGGCTTTGTTTAAACAGAAAGCGAGTCACAGTTTGCGGGAGCCCCAACCTAGAACTCTTTCCAGAGAACACTCACGCT CTACCCAAGTTGCCAACACCTGTGGGACCCAGGTGAGTTTTAGAACATCCGTGACCCAGAAAGTTACTCTAGTGTTAAATGAACCAAAGG ATTTGGTGTACATGGGACCGGTTTCAGGATGACTAACCTAACCTAAGTGAACTCTTTAGCCACAACCCTCACCTTCCCTCCCTTACCCCA AGCAAGGCCAGTGCTGGAGCAGCCATTGCCTCCGGATCAAGGGAGTAACAGCAAGTATCAGGCCGGAGAAAACAGGATAAAGCCATTCCT CCTTCCACCTAGATGGATTGCCAATCTTCTGCCATCAATTTTGGGAAACCTGCCTTTGTGCCCCCGAGGCTGCCTTTCCTCAGCATAGCT GACTTGTCATAGTGGATGAGGTCTGGGCTGGAGCAGTAGAAGCCAAGGCCTTTTTTCTGCAAGTAATGATGTAGGTTATTTGCAGTCTCT GTAACCACCATCCAGGCCAGTACGCAGTATTTAGCTGGGGACCAAGGGATGGGATTCCCTACTCTAAGAAAATACCTTTATTTTAATTAT TATTATTTTTTGAGACGGAGTCTCGCTCTACCACCCAGGCTGGTGTGCAGTGGCATGATCTCGGCTCACAGAAACCTCTGCCTCCCGGGT TCAAGTGGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCGTGCCACCACGCCAGGCTAATTTTTGTATTTTCAGTAGAG ACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTGGAACTCCTGACCTCGGGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACA GGCGTGAGCCACCGCTGCCTGGCCAGAAAATACCTTTGATATGGAAAGAATAATGATGTGAGGCCTGGCGCGGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAGGACTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTAC TAAAAATACAAAATTAGCCGGGCATGGTGGCGCATGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGG AGGCAGAGATTGCGATGAGCCGAGATCGTACCAGTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAAAAAAATAAAATAATGA AGTGGAATCAAGGTGGCAAGAAAATTTAGAATCGTTTCTGATAGGGACTTTCCCTTATCCTAAATGTGTTTTGAAGGCACACGTTATTTC CATTGTCATTCTGACTTTAGAAAGGCAGGTTGGGGCATGAGTGGGCATTTTCCTAATGACTTGCTGCTAGGAGGTTATAGGCAGGGAACA GTCTGGGAGTCTCTAATCCAGAGAGACTTTCAGATTCCCTCTCTTCACATGAACCTCCATTAGTTAGATTTTGGGAAAGTGAGCATGAAG AAGGGACTCAGAGCTGCCAGGTACCCGAGTCTCAGGTCTGACATCCTTGGGCCCCTTCTGCCACAACTTCTTGCCACTTCACGGACTTGA ATTATGTTGCTTCTTCCTGGAAGTCTGGCCTGCAGCACAGGCCTTTCCTCTCCAAAAAGCTGCTGCTCATTTCTGGCCCCATCTGCTGCT ATCTTTGCCATCAGCCATCACAGTTTGGCATCATCAGAGTCTCAGCTAGAGGAGCTGTCATTCTGCCTTAGTGTTTGCCTGCGACCTGAC CAGGGGCATGACCAGCTGGGATGTCAAGTGACATTTGGGAACTTGTAGAGGCCAAATGATTGAAAGTTTAATTCTTCTCAAGACCCACTG ATTTGCCAGTGTGCATGGAAATAATAGATTAGAGCAGAAACTAGCAGGGACTGTTGTATAATCGTGATCTACTAGCAGAATTGGGCCCAA AGAGAAAGAATTTCTGAGGCTGGGTTTCTTCTGGGAGGGTAGCAGGTTGGTCTTGGCCAGTGCTCTGTTTCCCACCAGTGTTGTTCCCTT TTCCAGCTTGCCTGGCCCGGCTCTGTCTTCCAGGGTCCTGCTCCAGACCCCTCTGCCTGGGGTCTCCCCTCCATCCAGGGGGTTCTGGGC ATCACAGCTCCTTTTTTTCCTTTCTCCTCTTCCAGATCCAGTTTCAGCTGGTTTGCTTCTTCCAGCAGGCACCCTTAGGCCCAGGAGCAG CTCCCCTGAGAGAATTTGAGTCACTCATTTCCTTGAACAGCACCCCCCTTTATACTAGCAGCCATTTGTGCCATTGCCTGTGCCCTAGGG TTTGTGGGGAGAGAGCGAGGGATCACTGAGCAGTTTTCCCAGAGCTCCATGGGAAGGCAAGCTCTCCCTCCCAATGGGAGCCCCACTGTC ACTAACTGTAAACTCAGGCTCAGGCTTCAACTGCCTACCCCCATCCTCATATTTCTGTCTGTCCCAGCACCTCAGGAGCATTCTCATTGT GGCCGGCTAACTCCGCCTGGATGTGAACAGGCAAGCACAGTGGGAAATGAGTCACGTACTTGTATTGCACAGTGGACACCTCTAGAGGTC CATTGGTTTAAAGGGATAGGGAAGGAGGAGGGATGAGACCATCACCCCCTCCCAGAAGTAAATCTAGTATCTGAGTTTTCTTTATGCCCT TGAGTCAAACTAATAACTGTCTAGTACGGAGGTGTTTGCTGGTTTTCTTCGGTGTTTTTTCTAATGCAATAAACTCATTTCTGCCTGCTG |
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FusionGenePPI for DGCR2_DESI1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DGCR2 | SMURF2, DDIT3, HNRNPD, IL9R, WWP2, PTPRK, ZACN, HTR3C, ADAM33 | DESI1 | ZBTB46, FGF7, MOV10, NXF1, HDAC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DGCR2_DESI1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DGCR2_DESI1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DGCR2 | C0036341 | Schizophrenia | 1 | CTD_human |
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