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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9795

FusionGeneSummary for DGAT1_TCEB1

check button Fusion gene summary
Fusion gene informationFusion gene name: DGAT1_TCEB1
Fusion gene ID: 9795
HgeneTgene
Gene symbol

DGAT1

TCEB1

Gene ID

8694

6921

Gene namediacylglycerol O-acyltransferase 1elongin C
SynonymsARAT|ARGP1|DGAT|DIAR7SIII|TCEB1
Cytomap

8q24.3

8q21.11

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol O-acyltransferase 1ACAT related gene product 1acyl coenzyme A:cholesterol acyltransferase related gene 1acyl-CoA retinol O-fatty-acyltransferaseacyl-CoA:diacylglycerol acyltransferasediacylglycerol O-acyltransferase homologdiglycerideelongin-CRNA polymerase II transcription factor SIII subunit CSIII p15elongin 15 kDa subunittranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)transcription elongation factor B polypeptide 1transcription elongation factor B su
Modification date2018052320180523
UniProtAcc

O75907

Ensembl transtripts involved in fusion geneENST00000527438, ENST00000332324, 
ENST00000531896, 
ENST00000602840, 
ENST00000518127, ENST00000520210, 
ENST00000520242, ENST00000519487, 
ENST00000284811, ENST00000522337, 
ENST00000523815, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: DGAT1 [Title/Abstract] AND TCEB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGAT1

GO:0019432

triglyceride biosynthetic process

18238778|18458083


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE734547DGAT1chr8

145540746

-TCEB1chr8

74884487

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000527438ENST00000602840DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-5UTRENST00000527438ENST00000518127DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000527438ENST00000520210DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000527438ENST00000520242DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000527438ENST00000519487DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000527438ENST00000284811DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000527438ENST00000522337DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000527438ENST00000523815DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000332324ENST00000602840DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-5UTRENST00000332324ENST00000518127DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000332324ENST00000520210DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000332324ENST00000520242DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000332324ENST00000519487DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000332324ENST00000284811DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000332324ENST00000522337DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000332324ENST00000523815DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000531896ENST00000602840DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-5UTRENST00000531896ENST00000518127DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000531896ENST00000520210DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000531896ENST00000520242DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000531896ENST00000519487DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000531896ENST00000284811DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000531896ENST00000522337DGAT1chr8

145540746

-TCEB1chr8

74884487

-
intron-intronENST00000531896ENST00000523815DGAT1chr8

145540746

-TCEB1chr8

74884487

-

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FusionProtFeatures for DGAT1_TCEB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGAT1

O75907

TCEB1

Catalyzes the terminal and only committed step intriacylglycerol synthesis by using diacylglycerol and fatty acylCoA as substrates. In contrast to DGAT2 it is not essential forsurvival. May be involved in VLDL (very low density lipoprotein)assembly. In liver, plays a role in esterifying exogenous fattyacids to glycerol. Functions as the major acyl-CoA retinolacyltransferase (ARAT) in the skin, where it acts to maintainretinoid homeostasis and prevent retinoid toxicity leading to skinand hair disorders. {ECO:0000269|PubMed:16214399,ECO:0000269|PubMed:9756920}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DGAT1_TCEB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DGAT1_TCEB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DGAT1_TCEB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DGAT1_TCEB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource