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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9790

FusionGeneSummary for DFFA_ATP11B

check button Fusion gene summary
Fusion gene informationFusion gene name: DFFA_ATP11B
Fusion gene ID: 9790
HgeneTgene
Gene symbol

DFFA

ATP11B

Gene ID

1676

23200

Gene nameDNA fragmentation factor subunit alphaATPase phospholipid transporting 11B (putative)
SynonymsDFF-45|DFF1|ICADATPIF|ATPIR
Cytomap

1p36.22

3q26.33

Type of geneprotein-codingprotein-coding
DescriptionDNA fragmentation factor subunit alphaDFF45DNA fragmentation factor 45 kDa subunitDNA fragmentation factor, 45kDa, alpha polypeptideinhibitor of CADprobable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B protein
Modification date2018052320180523
UniProtAcc

O00273

Q9Y2G3

Ensembl transtripts involved in fusion geneENST00000377038, ENST00000377036, 
ENST00000323116, ENST00000493826, 
ENST00000482794, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 5 X 4=140
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DFFA [Title/Abstract] AND ATP11B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDFFA

GO:1900118

negative regulation of execution phase of apoptosis

9564035

HgeneDFFA

GO:1902511

negative regulation of apoptotic DNA fragmentation

15572351


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN266606DFFAchr1

10521256

-ATP11Bchr3

182575205

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377038ENST00000323116DFFAchr1

10521256

-ATP11Bchr3

182575205

+
intron-intronENST00000377038ENST00000493826DFFAchr1

10521256

-ATP11Bchr3

182575205

+
intron-intronENST00000377038ENST00000482794DFFAchr1

10521256

-ATP11Bchr3

182575205

+
intron-intronENST00000377036ENST00000323116DFFAchr1

10521256

-ATP11Bchr3

182575205

+
intron-intronENST00000377036ENST00000493826DFFAchr1

10521256

-ATP11Bchr3

182575205

+
intron-intronENST00000377036ENST00000482794DFFAchr1

10521256

-ATP11Bchr3

182575205

+

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FusionProtFeatures for DFFA_ATP11B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DFFA

O00273

ATP11B

Q9Y2G3

Inhibitor of the caspase-activated DNase (DFF40). Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). Involved in regulation of sensitivity tocisplatin; may contribute to secretory vesicle transport ofcisplatin from Golgi to plasma membrane.{ECO:0000269|PubMed:23585472, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DFFA_ATP11B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DFFA_ATP11B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DFFA_ATP11B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DFFA_ATP11B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource