	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 9769

FusionGeneSummary for DEPDC5_SFI1

Fusion gene summary

Fusion gene information	Fusion gene name: DEPDC5_SFI1
	Fusion gene ID: 9769
		Hgene	Tgene
	Gene symbol	DEPDC5	SFI1
	Gene ID	9681	9814
	Gene name	DEP domain containing 5	SFI1 centrin binding protein
	Synonyms	DEP.5\|FFEVF\|FFEVF1	PISD\|PPP1R139\|hSfi1p
	Cytomap	22q12.2-q12.3	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	GATOR complex protein DEPDC5DEP domain-containing protein 5	protein SFI1 homologSfi1 homolog, spindle assembly associatedhomolog of yeast Sfi1protein phosphatase 1, regulatory subunit 139
	Modification date	20180523	20180519
	UniProtAcc	O75140	A8K8P3
	Ensembl transtripts involved in fusion gene	ENST00000535622, ENST00000400246, ENST00000266091, ENST00000382105, ENST00000400249, ENST00000382112, ENST00000382111, ENST00000400248, ENST00000494060, ENST00000536766, ENST00000400242, ENST00000539165,	ENST00000443326, ENST00000414585, ENST00000540643, ENST00000432498, ENST00000443011, ENST00000400289, ENST00000400288, ENST00000474741,
Fusion gene scores	* DoF score	8 X 7 X 4=224	5 X 4 X 4=80
	# samples	7	5
	** MAII score	log2(7/224*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DEPDC5 [Title/Abstract] AND SFI1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SFI1	GO:0010923	negative regulation of phosphatase activity	19389623

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-D8-A140-01A	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000535622	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000535622	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000535622	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000535622	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000535622	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000535622	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000535622	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000535622	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400246	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000266091	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382105	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400249	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382112	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000382111	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000400248	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000494060	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
5CDS-intron	ENST00000536766	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000400242	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000443326	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000414585	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000540643	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000432498	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000443011	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000400289	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000400288	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+
intron-intron	ENST00000539165	ENST00000474741	DEPDC5	chr22	32215211	+	SFI1	chr22	31924676	+

Top

FusionProtFeatures for DEPDC5_SFI1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DEPDC5 O75140	SFI1 A8K8P3

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for DEPDC5_SFI1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DEPDC5_SFI1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
DEPDC5	ZNF414, NPRL2, WDR24, RRAGC, RRAGA, NPRL3, RRAGB, C7orf60, SZT2, C12orf66, ITFG2, KPTN	SFI1	KRT19, RADIL, MDFI, CETN2, CDC5L, CRX, GCSH, LPXN, SFI1, MAD2L2, SERTAD1, CCDC120, CCDC57, FAM131C, GOLGA2, CETN1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for DEPDC5_SFI1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for DEPDC5_SFI1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DEPDC5	C1858477	Epilepsy, Partial, with Variable Foci	3	CTD_human;UNIPROT
Hgene	DEPDC5	C2239176	Liver carcinoma	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 9769

FusionGeneSummary for DEPDC5_SFI1

FusionProtFeatures for DEPDC5_SFI1

FusionGeneSequence for DEPDC5_SFI1

FusionGenePPI for DEPDC5_SFI1

RelatedDrugs for DEPDC5_SFI1

RelatedDiseases for DEPDC5_SFI1