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Fusion gene ID: 9757 |
FusionGeneSummary for DENR_KNTC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DENR_KNTC1 | Fusion gene ID: 9757 | Hgene | Tgene | Gene symbol | DENR | KNTC1 | Gene ID | 8562 | 9735 |
| Gene name | density regulated re-initiation and release factor | kinetochore associated 1 | |
| Synonyms | DRP|DRP1|SMAP-3 | ROD | |
| Cytomap | 12q24.31 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | density-regulated proteinsmooth muscle cell associated protein-3 | kinetochore-associated protein 1Rough Deal homolog, centromere/kinetochore protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O43583 | P50748 | |
| Ensembl transtripts involved in fusion gene | ENST00000280557, ENST00000455982, | ENST00000450485, ENST00000333479, ENST00000545065, ENST00000537348, ENST00000436959, ENST00000534995, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 7 X 4=196 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DENR [Title/Abstract] AND KNTC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DENR | GO:0001731 | formation of translation preinitiation complex | 20713520 |
| Hgene | DENR | GO:0032790 | ribosome disassembly | 20713520 |
| Hgene | DENR | GO:0075522 | IRES-dependent viral translational initiation | 20713520 |
| Tgene | KNTC1 | GO:0007093 | mitotic cell cycle checkpoint | 11146660 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-50-5946-01A | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000280557 | ENST00000450485 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000280557 | ENST00000333479 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-3UTR | ENST00000280557 | ENST00000545065 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000280557 | ENST00000537348 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000280557 | ENST00000436959 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000280557 | ENST00000534995 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000455982 | ENST00000450485 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000455982 | ENST00000333479 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-3UTR | ENST00000455982 | ENST00000545065 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000455982 | ENST00000537348 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000455982 | ENST00000436959 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
| 5CDS-intron | ENST00000455982 | ENST00000534995 | DENR | chr12 | 123249934 | + | KNTC1 | chr12 | 123078823 | + |
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FusionProtFeatures for DENR_KNTC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DENR | KNTC1 |
| May be involved in the translation of target mRNAs byscanning and recognition of the initiation codon. Involved intranslation initiation; promotes recruitmnet of aminoacetyledinitiator tRNA to P site of 40S ribosomes. Can promote release ofdeacylated tRNA and mRNA from recycled 40S subunits followingABCE1-mediated dissociation of post-termination ribosomalcomplexes into subunits. Plays a role in the modulation of thetranslational profile of a subset of cancer-related mRNAs whenrecruited to the translational initiation complex by the oncogeneMCTS1. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:17878526,ECO:0000269|PubMed:20713520}. | Essential component of the mitotic checkpoint, whichprevents cells from prematurely exiting mitosis. Required for theassembly of the dynein-dynactin and MAD1-MAD2 complexes ontokinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131).Its function related to the spindle assembly machinery is proposedto depend on its association in the mitotic RZZ complex.{ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237,ECO:0000269|PubMed:15824131, ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DENR_KNTC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DENR_KNTC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DENR | MCTS1, ELAVL1, DMAP1, NLRX1, XRCC4, EEF2K, NELFB, HMGB3, HNRNPA2B1, HNRNPD, PPP1CB, RPL10, UBXN1, FSD1, NFKBIA, NUDT6, OXNAD1, RWDD2B, SLC25A32, TALDO1, CDK5R1, EIF2D, EWSR1, XPO1, DUSP5, DOCK11, NTMT1, RB1CC1, ATG13, COPS5, DHTKD1, NSUN4, SNRNP27, COPS2, AMZ2, FGB, PDLIM5, COPS7A, USP47, COPS4, VDAC2, COPS6, BTBD1, COPS7B, CHGA, PDK1, MAPT | KNTC1 | VHL, ZW10, PIAS4, PPP6R1, VARS, BSG, TMEM171, CA14, LPAR6, RP2, SCN2B, NTRK1, NIPSNAP1, ACTR5, TMEM206, C12orf49, HTR2C, LAMP3, EPHA1, EDNRB, TMEM108, CHRM4, SIGLECL1, SLC15A1, IL13RA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DENR_KNTC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENR_KNTC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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