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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9733

FusionGeneSummary for DENND4A_HBD

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND4A_HBD
Fusion gene ID: 9733
HgeneTgene
Gene symbol

DENND4A

HBD

Gene ID

10260

3045

Gene nameDENN domain containing 4Ahemoglobin subunit delta
SynonymsIRLB|MYCPBP-
Cytomap

15q22.31

11p15.4

Type of geneprotein-codingprotein-coding
DescriptionC-myc promoter-binding proteinDENN domain-containing protein 4ADENN/MADD domain containing 4Ac-myc promoter binding proteinhemoglobin subunit deltadelta globindelta-globin chainhemoglobin delta chainhemoglobin, delta
Modification date2018052220180523
UniProtAcc

Q7Z401

P02042

Ensembl transtripts involved in fusion geneENST00000443035, ENST00000431932, 
ENST00000567323, 
ENST00000292901, 
ENST00000380299, 
Fusion gene scores* DoF score4 X 4 X 4=641 X 1 X 1=1
# samples 41
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DENND4A [Title/Abstract] AND HBD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8077-01ADENND4Achr15

66084348

-HBDchr11

5255443

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000443035ENST00000292901DENND4Achr15

66084348

-HBDchr11

5255443

-
5UTR-3CDSENST00000443035ENST00000380299DENND4Achr15

66084348

-HBDchr11

5255443

-
5UTR-3CDSENST00000431932ENST00000292901DENND4Achr15

66084348

-HBDchr11

5255443

-
5UTR-3CDSENST00000431932ENST00000380299DENND4Achr15

66084348

-HBDchr11

5255443

-
intron-3CDSENST00000567323ENST00000292901DENND4Achr15

66084348

-HBDchr11

5255443

-
intron-3CDSENST00000567323ENST00000380299DENND4Achr15

66084348

-HBDchr11

5255443

-

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FusionProtFeatures for DENND4A_HBD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND4A

Q7Z401

HBD

P02042

Probable guanine nucleotide exchange factor (GEF) whichmay activate RAB10. Promotes the exchange of GDP to GTP,converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-likeelement (interferon-stimulated response element) of MYC P2promoter. {ECO:0000269|PubMed:20937701,ECO:0000269|PubMed:8056341}. Involved in oxygen transport from the lung to thevarious peripheral tissues.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DENND4A_HBD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DENND4A_HBD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DENND4AYWHAB, YWHAQ, YWHAG, CEBPE, PCBD1, SERTAD1, TLX3, YWHAE, METTL6, CLK1, PTPRA, LYPD4, SCRN1, ASB3, NTRK3, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, MAST3, EIF4E2, SIPA1L1, PPM1H, DENND4C, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, HDAC4, NF1, SRSF12, CBY1, INPP5EHBDAPP, EMD, HBQ1, HBZ, HLA-DPA1, CD1B, MUC1, ICAM2, NUFIP1, NT5DC1, GDPD1, FGF10, IGSF8, POMK, SLC30A4, MMP3, PLCZ1, MCM2, ERBB3, UPF3A, TNFSF8, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DENND4A_HBD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DENND4A_HBD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHBDC0022548Keloid1CTD_human
TgeneHBDC0263454Chloracne1CTD_human