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Fusion gene ID: 9732 |
FusionGeneSummary for DENND4A_DPP8 |
Fusion gene summary |
Fusion gene information | Fusion gene name: DENND4A_DPP8 | Fusion gene ID: 9732 | Hgene | Tgene | Gene symbol | DENND4A | DPP8 | Gene ID | 10260 | 54878 |
Gene name | DENN domain containing 4A | dipeptidyl peptidase 8 | |
Synonyms | IRLB|MYCPBP | DP8|DPRP-1|DPRP1|MST097|MSTP097|MSTP135|MSTP141 | |
Cytomap | 15q22.31 | 15q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | C-myc promoter-binding proteinDENN domain-containing protein 4ADENN/MADD domain containing 4Ac-myc promoter binding protein | dipeptidyl peptidase 8DPP VIIIdipeptidyl peptidase IV-related protein 1dipeptidyl peptidase VIIIprolyl dipeptidase DPP8 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q7Z401 | Q6V1X1 | |
Ensembl transtripts involved in fusion gene | ENST00000443035, ENST00000431932, ENST00000567323, | ENST00000341861, ENST00000358939, ENST00000300141, ENST00000321147, ENST00000321118, ENST00000339244, ENST00000559233, ENST00000560048, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: DENND4A [Title/Abstract] AND DPP8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-RC-A6M3-01A | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000443035 | ENST00000341861 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000443035 | ENST00000358939 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000443035 | ENST00000300141 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000443035 | ENST00000321147 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000443035 | ENST00000321118 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000443035 | ENST00000339244 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000443035 | ENST00000559233 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-intron | ENST00000443035 | ENST00000560048 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
Frame-shift | ENST00000431932 | ENST00000341861 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000431932 | ENST00000358939 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000431932 | ENST00000300141 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000431932 | ENST00000321147 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000431932 | ENST00000321118 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000431932 | ENST00000339244 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-5UTR | ENST00000431932 | ENST00000559233 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
5CDS-intron | ENST00000431932 | ENST00000560048 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-3CDS | ENST00000567323 | ENST00000341861 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-5UTR | ENST00000567323 | ENST00000358939 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-5UTR | ENST00000567323 | ENST00000300141 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-5UTR | ENST00000567323 | ENST00000321147 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-5UTR | ENST00000567323 | ENST00000321118 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-5UTR | ENST00000567323 | ENST00000339244 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-5UTR | ENST00000567323 | ENST00000559233 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
intron-intron | ENST00000567323 | ENST00000560048 | DENND4A | chr15 | 66021410 | - | DPP8 | chr15 | 65804902 | - |
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FusionProtFeatures for DENND4A_DPP8 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DENND4A | DPP8 |
Probable guanine nucleotide exchange factor (GEF) whichmay activate RAB10. Promotes the exchange of GDP to GTP,converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-likeelement (interferon-stimulated response element) of MYC P2promoter. {ECO:0000269|PubMed:20937701,ECO:0000269|PubMed:8056341}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 192_364 | 495 | 1864 | Domain | uDENN |
Hgene | DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 42_200 | 495 | 1864 | Domain | MABP |
Hgene | DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 192_364 | 495 | 1907 | Domain | uDENN |
Hgene | DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 42_200 | 495 | 1907 | Domain | MABP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 1183_1189 | 495 | 1864 | Compositional bias | Note=Poly-Glu |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 1183_1189 | 495 | 1907 | Compositional bias | Note=Poly-Glu |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 385_521 | 495 | 1864 | Domain | cDENN |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 523_641 | 495 | 1864 | Domain | dDENN |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 385_521 | 495 | 1907 | Domain | cDENN |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 523_641 | 495 | 1907 | Domain | dDENN |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 917_933 | 495 | 1864 | Motif | Bipartite nuclear localization signal |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 917_933 | 495 | 1907 | Motif | Bipartite nuclear localization signal |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 772_808 | 495 | 1864 | Repeat | Note=PPR 1 |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000431932 | - | 11 | 32 | 809_843 | 495 | 1864 | Repeat | Note=PPR 2 |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 772_808 | 495 | 1907 | Repeat | Note=PPR 1 |
Hgene | >DENND4A | chr15:66021410 | chr15:65804902 | ENST00000443035 | - | 11 | 33 | 809_843 | 495 | 1907 | Repeat | Note=PPR 2 |
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FusionGeneSequence for DENND4A_DPP8 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_DENND4A_ENST00000443035_chr15_66021410_-_DPP8_ENST00000341861_chr15_65804902_-_1382aa MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVPQDYICIDVTPTGLSADLNNGSLVGPQIYLC YRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYG AAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVP LCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQKMQHGSSNGNRTAGCXDIXNCGLXGEYXITGSAXIGAFLCXAVF LESAXKAACRYQKISWLHDGXGTTXFHVCEEEXSRWTSFRQNLLPCHVWXEQRKYTVLFXNSQNYQXSSSLNALLEASFGSFSGNTGLWN VFSRRRTIKRKKTHWNSRNCFLRLSPRKWNISVSSRXWNLSRKRWRATRIYATTFKAQSSGNXLSQHTDGSKIMPCXSRLDCFYTXQRYL DIXHRNQRRKETHLCAQXASQHGRRCQISWSRYLCSPRRIXXIFWLLVVSKSXNNSQWWXNSXNSIXRKXXIXGGNYSCYIPYVGNKEGR FIPLSXNRYSKSXSHFXDVRNNDXCXRKDHRCHRXGTNSTFXDSIXRSXIYCQSWMDSXGKICLVHPTRSLPDSPTDSVDLTXIIYPSRR XCYGKAETHXVSAXFCDATNYLXRNNRHLDKYPXHLSCFSPKSRRGNXVYFCLXMQNRFPSFIQNYIYFKGKQIXTIQWWAACSKXFQVS YQRGDSNYQWXMGSSWPAWIXYPSXXSQKAGIFXRHQRLPFRASPVRSQLRKSWRGDKADXPWLLTFLLHQSALXLLYKXVXXPEESTLC VPLQAIKSXRXPNLQNKGILGHHFGFSRSSSXLYSSRNFLFXKYYWIYIVWDALQASXSTAWKEISYCAVHIWWSSGAVGEXSVXRSQVF PLEYPSLSRLCGCSDRQQGILSPRAXIXRRLXIXNGSNRNXRSGGRTPISSFSIXFHXLRSCGHPRLVLWRIPLPDGINAEVRYLQGCYC WGPSHSVDLLXYRIHGTLYGSPXPEXTGLLLRICGHASRKVPLXTKSFTALTWFPGXECPFCTYQYITEFFSEGWKAIXFTDLSSGETQH |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_DENND4A_ENST00000443035_chr15_66021410_-_DPP8_ENST00000341861_chr15_65804902_-_4147nt ATGATTGAAGACAAGGGGCCTCGTGTTGCTGACTACTTTGTTGTAGCAGGATTAACTGATGTTTCAAAGCCTCTAGAAGAAGAAATTCAC TTCAATGATGCTTGTCATAAAGTAGCTAAACCAAAAGAACCTATTACAGATGTTTCAGTTATTATCAAATCTCTTGGGGAGGAAGTCCCA CAGGATTATATCTGTATTGATGTTACCCCAACTGGATTGTCAGCTGATCTTAATAATGGAAGTCTTGTGGGGCCACAGATTTACCTTTGC TATAGAAGAGGAAGAGATAAGCCTCCACTTACAGATCTGGGGGTTTTATATGACTGGAAAGAAAGATTGAAACAGGGTTGTGAAATTATT CAGAGTACTCCCTATGGGCGCCCCGCAAATATTAGTGGGAGTACCTCATCACAAAGAATTTATATCACTTACCGAAGAGCCTCTGAAAAC ATGACTCAGAATACGTTGGCTGTCACTGACATATGTATTATTATACCCAGTAAAGGAGAAAGCCCACCACACACGTTCTGCAAAGTCGAC AAGAATCTCAATAACAGTATGTGGGGATCAGCAGTATACTTGTGTTATAAAAAATCGGTGGCAAAGACGAACACTGTATCTTACAAAGCT GGCCTAATTTGTAGATATCCTCAAGAAGATTATGAGTCATTCTCACTACCGGAATCTGTTCCTCTATTTTGTTTACCAATGGGTGCAACC ATTGAATGTTGGCCATCAAATAGCAAATACCCTCTGCCTGTATTTTCTACTTTTGTTTTAACTGGAGCCTCAGCTGAAAAGGTTTATGGT GCTGCTATTCAGTTTTATGAACCATACTCTGAGGAGAATCTCACAGAAAAGCAGAGACTTCTTTTGGGTTTAACATCAGCAGATGGGAAG TCTGATAGTTCCAAAACAATTCATACTAACAAATGCATCTGTCTTCTTTCTCACTGGCCTTTTTTTGATGCATTCAGGAAGTTTCTGACT TTTCTGTATCGTTATTCCATCTCTGGGCCTCATGTCCTTCCAATTGAGAAGCATATTTCTCATTTTATGCATAAAGTTCCTTTTCCATCT CCTCAGAGACCACGGATTTTAGTTCAGTTATCACCACATGATAATCTGATTCTCAGTCAGCCTGTGTCTTCACCTCTTCCACTAAGTGGT GGCAAGTTTTCAACACTACTGCAGAATTTAGGCCCTGAAAATGCTGTGACACTACTGGTGTTTGCAGTAACAGAACATAAAATTCTTATC CATTCCCTACGGCCATCCGTGCTTACTAGTGTGACAGAAGCATTAGTGTCTATGATTTTCCCTTTCCACTGGCCATGCCCGTATGTTCCT CTCTGCCCACTGGCTTTAGCAGATGTCTTGAGTGCACCATGTCCATTCATAGTAGGGATTGATTCAAGATACTTTGATCTCTATGATCCT CCACCAGATGTCAGTTGTGTTGATGTAGATACCAACACTATTTCTCAGAAAATGCAACATGGCAGCAGCAATGGAAACAGAACAGCTGGG TGTTGAGATATTTGAAACTGCGGACTGTGAGGAGAATATTGAATCACAGGATCGGCCTAAATTGGAGCCTTTTTATGTTGAGCGGTATTC CTGGAGTCAGCTTAAAAAGCTGCTTGCCGATACCAGAAAATATCATGGCTACATGATGGCTAAGGCACCACATGATTTCATGTTTGTGAA GAGGAATGATCCAGATGGACCTCATTCAGACAGAATCTATTACCTTGCCATGTCTGGTGAGAACAGAGAAAATACACTGTTTTATTCTGA AATTCCCAAAACTATCAATAGAGCAGCAGTCTTAATGCTCTCTTGGAAGCCTCTTTTGGATCTTTTTCAGGCAACACTGGACTATGGAAT GTATTCTCGAGAAGAAGAACTATTAAGAGAAAGAAAACGCATTGGAACAGTCGGAATTGCTTCTTACGATTATCACCAAGGAAGTGGAAC ATTTCTGTTTCAAGCCGGTAGTGGAATTTATCACGTAAAAGATGGAGGGCCACAAGGATTTACGCAACAACCTTTAAGGCCCAATCTAGT GGAAACTAGTTGTCCCAACATACGGATGGATCCAAAATTATGCCCTGCTGATCCAGACTGGATTGCTTTTATACATAGCAACGATATTTG GATATCTAACATCGTAACCAGAGAAGAAAGGAGACTCACTTATGTGCACAATGAGCTAGCCAACATGGAAGAAGATGCCAGATCAGCTGG AGTCGCTACCTTTGTTCTCCAAGAAGAATTTGATAGATATTCTGGCTATTGGTGGTGTCCAAAAGCTGAAACAACTCCCAGTGGTGGTAA AATTCTTAGAATTCTATATGAAGAAAATGATGAATCTGAGGTGGAAATTATTCATGTTACATCCCCTATGTTGGAAACAAGGAGGGCAGA TTCATTCCGTTATCCTAAAACAGGTACAGCAAATCCTAAAGTCACTTTTAAGATGTCAGAAATAATGATTGATGCTGAAGGAAGGATCAT AGATGTCATAGATAAGGAACTAATTCAACCTTTTGAGATTCTATTTGAAGGAGTTGAATATATTGCCAGAGCTGGATGGACTCCTGAGGG AAAATATGCTTGGTCCATCCTACTAGATCGCTCCCAGACTCGCCTACAGATAGTGTTGATCTCACCTGAATTATTTATCCCAGTAGAAGA TGATGTTATGGAAAGGCAGAGACTCATTGAGTCAGTGCCTGATTCTGTGACGCCACTAATTATCTATGAAGAAACAACAGACATCTGGAT AAATATCCATGACATCTTTCATGTTTTTCCCCAAAGTCACGAAGAGGAAATTGAGTTTATTTTTGCCTCTGAATGCAAAACAGGTTTCCG TCATTTATACAAAATTACATCTATTTTAAAGGAAAGCAAATATAAACGATCCAGTGGTGGGCTGCCTGCTCCAAGTGATTTCAAGTGTCC TATCAAAGAGGAGATAGCAATTACCAGTGGTGAATGGGAAGTTCTTGGCCGGCATGGATCTAATATCCAAGTTGATGAAGTCAGAAGGCT GGTATATTTTGAAGGCACCAAAGACTCCCCTTTAGAGCATCACCTGTACGTAGTCAGTTACGTAAATCCTGGAGAGGTGACAAGGCTGAC TGACCGTGGCTACTCACATTCTTGCTGCATCAGTCAGCACTGTGACTTCTTTATAAGTAAGTATAGTAACCAGAAGAATCCACACTGTGT GTCCCTTTACAAGCTATCAAGTCCTGAAGATGACCCAACTTGCAAAACAAAGGAATTTTGGGCCACCATTTTGGATTCAGCAGGTCCTCT TCCTGACTATACTCCTCCAGAAATTTTCTCTTTTGAAAGTACTACTGGATTTACATTGTATGGGATGCTCTACAAGCCTCATGATCTACA GCCTGGAAAGAAATATCCTACTGTGCTGTTCATATATGGTGGTCCTCAGGTGCAGTTGGTGAATAATCGGTTTAAAGGAGTCAAGTATTT CCGCTTGAATACCCTAGCCTCTCTAGGTTATGTGGTTGTAGTGATAGACAACAGGGGATCCTGTCACCGAGGGCTTAAATTTGAAGGCGC CTTTAAATATAAAATGGGTCAAATAGAAATTGACGATCAGGTGGAAGGACTCCAATATCTAGCTTCTCGATATGATTTCATTGACTTAGA TCGTGTGGGCATCCACGGCTGGTCCTATGGAGGATACCTCTCCCTGATGGCATTAATGCAGAGGTCAGATATCTTCAGGGTTGCTATTGC TGGGGCCCCAGTCACTCTGTGGATCTTCTATGATACAGGATACACGGAACGTTATATGGGTCACCCTGACCAGAATGAACAGGGCTATTA CTTAGGATCTGTGGCCATGCAAGCAGAAAAGTTCCCCTCTGAACCAAATCGTTTACTGCTCTTACATGGTTTCCTGGATGAGAATGTCCA TTTTGCACATACCAGTATATTACTGAGTTTTTTAGTGAGGGCTGGAAAGCCATATGATTTACAGATCTATCCTCAGGAGAGACACAGCAT AAGAGTTCCTGAATCGGGAGAACATTATGAACTGCATCTTTTGCACTACCTTCAAGAAAACCTTGGATCACGTATTGCTGCTCTAAAAGT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_DENND4A_ENST00000443035_chr15_66021410_-_DPP8_ENST00000341861_chr15_65804902_-_8784nt AAGCGGGCTCAGAGCGCCGCGGCATTCAGCCCCTCGTGTTCCGCTACCGCGCGTGCGGGATTCCGGCGCCGCTCTCCGAGCTCGATCCGC TGCTCGCACGGGAGCCAGCTGGGTGTTATTTCTCAAACTCTGAGGCTGCGGAGTTCACACATTGAAATCTGTCATCTTTTTCAGAGAGAA ACTTTCGGTAATGTATGTAACCTTCTGTAATGGAAGATGATTGAAGACAAGGGGCCTCGTGTTGCTGACTACTTTGTTGTAGCAGGATTA ACTGATGTTTCAAAGCCTCTAGAAGAAGAAATTCACTTCAATGATGCTTGTCATAAAGTAGCTAAACCAAAAGAACCTATTACAGATGTT TCAGTTATTATCAAATCTCTTGGGGAGGAAGTCCCACAGGATTATATCTGTATTGATGTTACCCCAACTGGATTGTCAGCTGATCTTAAT AATGGAAGTCTTGTGGGGCCACAGATTTACCTTTGCTATAGAAGAGGAAGAGATAAGCCTCCACTTACAGATCTGGGGGTTTTATATGAC TGGAAAGAAAGATTGAAACAGGGTTGTGAAATTATTCAGAGTACTCCCTATGGGCGCCCCGCAAATATTAGTGGGAGTACCTCATCACAA AGAATTTATATCACTTACCGAAGAGCCTCTGAAAACATGACTCAGAATACGTTGGCTGTCACTGACATATGTATTATTATACCCAGTAAA GGAGAAAGCCCACCACACACGTTCTGCAAAGTCGACAAGAATCTCAATAACAGTATGTGGGGATCAGCAGTATACTTGTGTTATAAAAAA TCGGTGGCAAAGACGAACACTGTATCTTACAAAGCTGGCCTAATTTGTAGATATCCTCAAGAAGATTATGAGTCATTCTCACTACCGGAA TCTGTTCCTCTATTTTGTTTACCAATGGGTGCAACCATTGAATGTTGGCCATCAAATAGCAAATACCCTCTGCCTGTATTTTCTACTTTT GTTTTAACTGGAGCCTCAGCTGAAAAGGTTTATGGTGCTGCTATTCAGTTTTATGAACCATACTCTGAGGAGAATCTCACAGAAAAGCAG AGACTTCTTTTGGGTTTAACATCAGCAGATGGGAAGTCTGATAGTTCCAAAACAATTCATACTAACAAATGCATCTGTCTTCTTTCTCAC TGGCCTTTTTTTGATGCATTCAGGAAGTTTCTGACTTTTCTGTATCGTTATTCCATCTCTGGGCCTCATGTCCTTCCAATTGAGAAGCAT ATTTCTCATTTTATGCATAAAGTTCCTTTTCCATCTCCTCAGAGACCACGGATTTTAGTTCAGTTATCACCACATGATAATCTGATTCTC AGTCAGCCTGTGTCTTCACCTCTTCCACTAAGTGGTGGCAAGTTTTCAACACTACTGCAGAATTTAGGCCCTGAAAATGCTGTGACACTA CTGGTGTTTGCAGTAACAGAACATAAAATTCTTATCCATTCCCTACGGCCATCCGTGCTTACTAGTGTGACAGAAGCATTAGTGTCTATG ATTTTCCCTTTCCACTGGCCATGCCCGTATGTTCCTCTCTGCCCACTGGCTTTAGCAGATGTCTTGAGTGCACCATGTCCATTCATAGTA GGGATTGATTCAAGATACTTTGATCTCTATGATCCTCCACCAGATGTCAGTTGTGTTGATGTAGATACCAACACTATTTCTCAGAAAATG CAACATGGCAGCAGCAATGGAAACAGAACAGCTGGGTGTTGAGATATTTGAAACTGCGGACTGTGAGGAGAATATTGAATCACAGGATCG GCCTAAATTGGAGCCTTTTTATGTTGAGCGGTATTCCTGGAGTCAGCTTAAAAAGCTGCTTGCCGATACCAGAAAATATCATGGCTACAT GATGGCTAAGGCACCACATGATTTCATGTTTGTGAAGAGGAATGATCCAGATGGACCTCATTCAGACAGAATCTATTACCTTGCCATGTC TGGTGAGAACAGAGAAAATACACTGTTTTATTCTGAAATTCCCAAAACTATCAATAGAGCAGCAGTCTTAATGCTCTCTTGGAAGCCTCT TTTGGATCTTTTTCAGGCAACACTGGACTATGGAATGTATTCTCGAGAAGAAGAACTATTAAGAGAAAGAAAACGCATTGGAACAGTCGG AATTGCTTCTTACGATTATCACCAAGGAAGTGGAACATTTCTGTTTCAAGCCGGTAGTGGAATTTATCACGTAAAAGATGGAGGGCCACA AGGATTTACGCAACAACCTTTAAGGCCCAATCTAGTGGAAACTAGTTGTCCCAACATACGGATGGATCCAAAATTATGCCCTGCTGATCC AGACTGGATTGCTTTTATACATAGCAACGATATTTGGATATCTAACATCGTAACCAGAGAAGAAAGGAGACTCACTTATGTGCACAATGA GCTAGCCAACATGGAAGAAGATGCCAGATCAGCTGGAGTCGCTACCTTTGTTCTCCAAGAAGAATTTGATAGATATTCTGGCTATTGGTG GTGTCCAAAAGCTGAAACAACTCCCAGTGGTGGTAAAATTCTTAGAATTCTATATGAAGAAAATGATGAATCTGAGGTGGAAATTATTCA TGTTACATCCCCTATGTTGGAAACAAGGAGGGCAGATTCATTCCGTTATCCTAAAACAGGTACAGCAAATCCTAAAGTCACTTTTAAGAT GTCAGAAATAATGATTGATGCTGAAGGAAGGATCATAGATGTCATAGATAAGGAACTAATTCAACCTTTTGAGATTCTATTTGAAGGAGT TGAATATATTGCCAGAGCTGGATGGACTCCTGAGGGAAAATATGCTTGGTCCATCCTACTAGATCGCTCCCAGACTCGCCTACAGATAGT GTTGATCTCACCTGAATTATTTATCCCAGTAGAAGATGATGTTATGGAAAGGCAGAGACTCATTGAGTCAGTGCCTGATTCTGTGACGCC ACTAATTATCTATGAAGAAACAACAGACATCTGGATAAATATCCATGACATCTTTCATGTTTTTCCCCAAAGTCACGAAGAGGAAATTGA GTTTATTTTTGCCTCTGAATGCAAAACAGGTTTCCGTCATTTATACAAAATTACATCTATTTTAAAGGAAAGCAAATATAAACGATCCAG TGGTGGGCTGCCTGCTCCAAGTGATTTCAAGTGTCCTATCAAAGAGGAGATAGCAATTACCAGTGGTGAATGGGAAGTTCTTGGCCGGCA TGGATCTAATATCCAAGTTGATGAAGTCAGAAGGCTGGTATATTTTGAAGGCACCAAAGACTCCCCTTTAGAGCATCACCTGTACGTAGT CAGTTACGTAAATCCTGGAGAGGTGACAAGGCTGACTGACCGTGGCTACTCACATTCTTGCTGCATCAGTCAGCACTGTGACTTCTTTAT AAGTAAGTATAGTAACCAGAAGAATCCACACTGTGTGTCCCTTTACAAGCTATCAAGTCCTGAAGATGACCCAACTTGCAAAACAAAGGA ATTTTGGGCCACCATTTTGGATTCAGCAGGTCCTCTTCCTGACTATACTCCTCCAGAAATTTTCTCTTTTGAAAGTACTACTGGATTTAC ATTGTATGGGATGCTCTACAAGCCTCATGATCTACAGCCTGGAAAGAAATATCCTACTGTGCTGTTCATATATGGTGGTCCTCAGGTGCA GTTGGTGAATAATCGGTTTAAAGGAGTCAAGTATTTCCGCTTGAATACCCTAGCCTCTCTAGGTTATGTGGTTGTAGTGATAGACAACAG GGGATCCTGTCACCGAGGGCTTAAATTTGAAGGCGCCTTTAAATATAAAATGGGTCAAATAGAAATTGACGATCAGGTGGAAGGACTCCA ATATCTAGCTTCTCGATATGATTTCATTGACTTAGATCGTGTGGGCATCCACGGCTGGTCCTATGGAGGATACCTCTCCCTGATGGCATT AATGCAGAGGTCAGATATCTTCAGGGTTGCTATTGCTGGGGCCCCAGTCACTCTGTGGATCTTCTATGATACAGGATACACGGAACGTTA TATGGGTCACCCTGACCAGAATGAACAGGGCTATTACTTAGGATCTGTGGCCATGCAAGCAGAAAAGTTCCCCTCTGAACCAAATCGTTT ACTGCTCTTACATGGTTTCCTGGATGAGAATGTCCATTTTGCACATACCAGTATATTACTGAGTTTTTTAGTGAGGGCTGGAAAGCCATA TGATTTACAGATCTATCCTCAGGAGAGACACAGCATAAGAGTTCCTGAATCGGGAGAACATTATGAACTGCATCTTTTGCACTACCTTCA AGAAAACCTTGGATCACGTATTGCTGCTCTAAAAGTGATATAATTTTGACCTGTGTAGAACTCTCTGGTATACACTGGCTATTTAACCAA ATGAGGAGGTTTAATCAACAGAAAACACAGAATTGATCATCACATTTTGATACCTGCCATGTAACATCTACTCCTGAAAATAAATGTGGT GCCATGCAGGGGTCTACGGTTTGTGGTAGTAATCTAATACCTTAACCCCACATGCTCAAAATCAAATGATACATATTCCTGAGAGACCCA GCAATACCATAAGAATTACTAAAAAAAAAAAAAAAAAAAAGACATTAGCACCATGTATTCATACTACCCTATTTTCACTTTTAATAGTAT TATAAACTTCATGAACTTAATTAGTGTATTTTTACAGTATACTTTTGAGTTTGTTAAAATATGATGATATTAGTGATTGGTTTGGTTCAG TTCCAGAATCTTTGACTAGTTACAGATTTGATAGCACTTAAATGTAATTGAATAGCTTATGCTTCATTGCTTGGGCATATCCAGCATGTT ATGAACTAATAACTATTAAACTTGACTTAACCAGTCATTCATTAATAATTTTTCAAGGATAACTTAGTGGCCTCCTAAAGACACTTGTTT TGGCACTGACCAGTTTTTAGCCAATTTAATCTGTATCTAGTATAAATAATTCTCATTTTTCTTTGATGATATTAACAGAGTGGGCTTTTC CTTTTGCATAAAGGCTAGTAACTGTATATGTAGCATGGATTTAATTAGTCATGATATTGATAATTACAGGCAGAAAATTTTTAATCAAAT GATTAGAGCTTAAATATTTGCAGGCAAGTTTTTTTTTTTCCTTTAAGAAAAGGAAAAAGTACACATTCACTAGAATTCTTCAGAAAATTT AGTGGTGCCAGTTTCCATTTGGTATTTCCTTATTAAAATATTCTAGAATTTTAAGGAGATTGAAGGGAATCACAGTGGGGTGGGGAGACC TGGGTTTGGGGAATGACAGAGAGAAGAGGTGGTGAGGGCCTGATTAAAAACTAAGCAGAAGTAGTTTTAACAAAAATACTCATGAAAATG TTTGGAAACTGAAATTTAAACAACTGTAATATTAAGGAAACCAGAATCAATAAATCACTGTCTTGCCAGCACAGCTACAGAGTAACATGA TTCAGGGGAGGAAAAGTTCCTTAGAGTTACTTTTATAATTCTTTTTTTTTTTCCTCTTAGGTTTAGAAATCTTACAAATTTAAACTTTAT CCTTTTAAAATTATTTGAACATAATTTAGATATTGTAAGCTTAAAATACAAATGTTTATAGATAACCTCTTTACCATAAACTAATCCCTG GCAAGCCATGGCTCTCTTTTTTTTTTTGGTGTTTAAAGCCTGTAAACAGTTTTTCTGAATGATCATGAACTTTTCTTGGTTTAGCACTAG GATTTAGCTATGAAGAGAGCTCATAGGCTTTCAGGTGCTAATTGAGATCTGCCCTGTTAGAGTCTTGGGGTGCTAGATTGGTCACATTGA CACCAGTGGCAGGGAAGGCATCTATGAGTTTGATGCTTTTTATCACACACTTCAGTGTTTAGAAAGTTATTACCAATACTTTTAAACAAC ACTCCAAGAAAATTTGCTATATTTCTTTCTCATCACTACAGAGAGAGTAGATTTCCCCATAGAGAGCACAGCCTCCATTAGTAAGGTTGG TGACTATTGGTAAGAGGTGGACTTCATTGACACCAAGTGGGAGGTAGGGAAAGCCCAGAAATGGCAGGATGATATGGTGGTTCTGTCGTT GGGAAAGGTATTGGGTTTTGCTGTTTGTATTTATACTGTATAATAGATACCACGCTTTTTCTTATTATCTGTATATGTATTGCTTTTCAT GTTTGATATTTTCCCATGCCAAGATTTGTTTATATATATTTTCAATGTTAAATTAAATTGATTTGGGTAACTTTCTTCCCCAAGAAAGTA TTTTCCCCCTTAAGTATATATCTGACTGTGGAGGGTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTGGACTAACTGGCCTCGAAGGATCTA TCCTTATAATATATGCAAAGTAGAAATGGTATACAGTAGCTTTTAAGCAGCTACTCCATTGAAACCTCTCACCCATTAAGGCTGTTTCTT CAAAGTGGCATCTCTTATTTTACCGAAACAAACTTAGAAAACTTCATGTACTCTGGAGTTCACAGGTGTTTTCCTTTTGCATGTTGCCTT CTCCTTTCCTCCTATCACAAAGAATGCTTCTATTATCACTCCCAGTCACTTAAATGCCATTCTGCTTCTTTAGCAGGAAAAAATACCTGA ATGAATTCTCTTACAGAAAGACAGTTTGACTGAATTTGCTTTTTACAATCAGTGTGGAAAATATCATAGTCAATTGAGGCAATCAGTAGA AATCTCACTAAAAGTTTGTACCCCCTGAGTATGGGTAACAGCTTAAACGGCAAGAATATATAAAAGTAGCAACAGTTTAGTGGGAGCCAA AAAGCACTAGGTTAAATATCATACTACGTTTTTAAAGACTTGATAAATGTGTACACTTGAACAACCATCCAGAGGGATAGTTACTTGAGC ATTACAGAGTAGTGGAACTCAAAATCTAAGATTCATCTGGGATACTTCTAAAAGAAATGTAGAGTTTTGAATCTCACTCTTAAAAATGTG TATTCCCAGGCTAGGCATGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGCGGGTGAATCACTTGAAGTCAGGAGATCAA GACCAGCTTGGTCGACATGGTGAAACCCCGTCTCTACTAAAAGTACAAAAAAATTAGCTGGGCATGATGGCGTGTGCCTATAATCCCACC TACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAAGTTGCAGTGAGCCGAGATGGCGCCACTGTAGTCCAGTCTGGG CGACAGAGTGAGATTCTGCCTCAAAATAAATAAATAAATAAAAATTTGTATTCCATTGATTTGGGTAGACACCAGGAATGTGCATTTCTA ACAAGCTTTCCAGGCGATCCTATAGTAAGTCATCTGTGGACTACTTTAAGAAACTCTTCTATAGAGAATGGAGTTGGATTAATAATAGGT GATTTTTTACACTGGACTGATTCACAAGAACCTAAACAGTAGTCCATGAAGCTGCTCATCTGTGGTAACTATTTGGCCCCGTCTCACTCT GAAAGCAGCAGGAGATGTTGTTTACTTTGTTTCTATCCCCTTTGTCTGGAGATTAATTTTGGAATGAAAGTTTTTCTCTCTATGCCATTC CTGGTTCTTTTCCAAAGCCTCATACAAGAGGATTAGGTCACAATGCATGCATTACCTTTTAAAAGAATGCGATATTGATACCGATGCTTA CTTTTTTTTTTTTACTACTTGTTTTATTCCTTCCAGAAAGTATAGCCCGCCTTTCTATAGCATAGTTCTCTTTAGGTGGAATGATTCCTA TAAGATTTCTCATTATTAAATCATGCATTTTTCAAGATGGAATCAATATTTGATTTAATCTAAGCTGATATTCTCATTTGTTAGAAGAAC AACCTACATGCTAGAGAGAGAGGAGGAAATATACCCACGACCACACAGCCAGTTAGTATCCAGTTGGTGCTGGACTCCAGCCAGGTGTCC TGCCTCATGGTAGTTAAATGATATATAGAAAAGGTAAATTTTTAAAGAAATATTTATTAATATATTCCTATAAAACATTTTAAAGGTAAC CACATAAAAATGGTTAATTTTTCCATTCCAAAGTAAATGCTAAGCATGTTTATTAATGAAGCAGTACTTCTGATTAGTATATGACATTCT GAAGTTAATTAAACTCATTGCACTAAATGTGTCTTCCTTGGTATAGTGGAGGATTTGAGGATTGGAATATAGAGTAGAGTGCTTGCTTAA GCCTGGGAGCCCATCTTTATAGCTATTTGATGTAAGAAAAGAGACATGGCCATTTCTAAACTATATAAGGTGAGTGTGTCTATTCCCAGC AGATATAAAGGAAAAAGGAAACTTTTTTGATTCCCACCTTCCCAGCCTCACCTAGCCATCTTCCAGCCTCAAATATAGAGATGTTAGTGC AAGGTCCTGGGCTCTAGGTGATCATTTCATAAGTCCTTTACAGATAAAGAAAAAGTAGTGTTTGTATGTTTGTTTTTAAGTAACCCCAAA ACAAATTTATATTGTATTCAGCAAAATTGGAATTCAGGTGTTTAATTTTAGAACATGAAGTGCCTGCTGTTTTAAGCATTGACTTGTATA AAAAGAATTGCATGTCTCCAGTAAGCTTATGGGTTTTCTCATTTTTAGGTATATGGCTTTTAATCATGTAAAGTGAAACATTAGTTTTCT 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FusionGenePPI for DENND4A_DPP8 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DENND4A | YWHAB, YWHAQ, YWHAG, CEBPE, PCBD1, SERTAD1, TLX3, YWHAE, METTL6, CLK1, PTPRA, LYPD4, SCRN1, ASB3, NTRK3, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, MAST3, EIF4E2, SIPA1L1, PPM1H, DENND4C, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, HDAC4, NF1, SRSF12, CBY1, INPP5E | DPP8 | ELAVL1, ARMC9, CD44, AARS, CALU, DHPS, FUBP3, P3H1, PFDN1, SRP14, SRP9, UBXN7, WDR4, CIAO1, WDR90, DOK3, IL17A, UBXN4, SNRPN, IDO2, CCL22, ARHGEF16, ATF2, TSNAXIP1, EPS8L1, RIN1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DENND4A_DPP8 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND4A_DPP8 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |