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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9732

FusionGeneSummary for DENND4A_DPP8

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND4A_DPP8
Fusion gene ID: 9732
HgeneTgene
Gene symbol

DENND4A

DPP8

Gene ID

10260

54878

Gene nameDENN domain containing 4Adipeptidyl peptidase 8
SynonymsIRLB|MYCPBPDP8|DPRP-1|DPRP1|MST097|MSTP097|MSTP135|MSTP141
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
DescriptionC-myc promoter-binding proteinDENN domain-containing protein 4ADENN/MADD domain containing 4Ac-myc promoter binding proteindipeptidyl peptidase 8DPP VIIIdipeptidyl peptidase IV-related protein 1dipeptidyl peptidase VIIIprolyl dipeptidase DPP8
Modification date2018052220180519
UniProtAcc

Q7Z401

Q6V1X1

Ensembl transtripts involved in fusion geneENST00000443035, ENST00000431932, 
ENST00000567323, 
ENST00000341861, 
ENST00000358939, ENST00000300141, 
ENST00000321147, ENST00000321118, 
ENST00000339244, ENST00000559233, 
ENST00000560048, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 2=8
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: DENND4A [Title/Abstract] AND DPP8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-RC-A6M3-01ADENND4Achr15

66021410

-DPP8chr15

65804902

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000443035ENST00000341861DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000443035ENST00000358939DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000443035ENST00000300141DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000443035ENST00000321147DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000443035ENST00000321118DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000443035ENST00000339244DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000443035ENST00000559233DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-intronENST00000443035ENST00000560048DENND4Achr15

66021410

-DPP8chr15

65804902

-
Frame-shiftENST00000431932ENST00000341861DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000431932ENST00000358939DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000431932ENST00000300141DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000431932ENST00000321147DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000431932ENST00000321118DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000431932ENST00000339244DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-5UTRENST00000431932ENST00000559233DENND4Achr15

66021410

-DPP8chr15

65804902

-
5CDS-intronENST00000431932ENST00000560048DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-3CDSENST00000567323ENST00000341861DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-5UTRENST00000567323ENST00000358939DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-5UTRENST00000567323ENST00000300141DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-5UTRENST00000567323ENST00000321147DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-5UTRENST00000567323ENST00000321118DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-5UTRENST00000567323ENST00000339244DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-5UTRENST00000567323ENST00000559233DENND4Achr15

66021410

-DPP8chr15

65804902

-
intron-intronENST00000567323ENST00000560048DENND4Achr15

66021410

-DPP8chr15

65804902

-

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FusionProtFeatures for DENND4A_DPP8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND4A

Q7Z401

DPP8

Q6V1X1

Probable guanine nucleotide exchange factor (GEF) whichmay activate RAB10. Promotes the exchange of GDP to GTP,converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-likeelement (interferon-stimulated response element) of MYC P2promoter. {ECO:0000269|PubMed:20937701,ECO:0000269|PubMed:8056341}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-1132192_3644951864DomainuDENN
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-113242_2004951864DomainMABP
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-1133192_3644951907DomainuDENN
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-113342_2004951907DomainMABP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-11321183_11894951864Compositional biasNote=Poly-Glu
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-11331183_11894951907Compositional biasNote=Poly-Glu
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-1132385_5214951864DomaincDENN
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-1132523_6414951864DomaindDENN
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-1133385_5214951907DomaincDENN
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-1133523_6414951907DomaindDENN
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-1132917_9334951864MotifBipartite nuclear localization signal
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-1133917_9334951907MotifBipartite nuclear localization signal
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-1132772_8084951864RepeatNote=PPR 1
HgeneDENND4Achr15:66021410chr15:65804902ENST00000431932-1132809_8434951864RepeatNote=PPR 2
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-1133772_8084951907RepeatNote=PPR 1
HgeneDENND4Achr15:66021410chr15:65804902ENST00000443035-1133809_8434951907RepeatNote=PPR 2


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FusionGeneSequence for DENND4A_DPP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DENND4A_ENST00000443035_chr15_66021410_-_DPP8_ENST00000341861_chr15_65804902_-_1382aa
MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVPQDYICIDVTPTGLSADLNNGSLVGPQIYLC
YRRGRDKPPLTDLGVLYDWKERLKQGCEIIQSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYG
AAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVP
LCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQKMQHGSSNGNRTAGCXDIXNCGLXGEYXITGSAXIGAFLCXAVF
LESAXKAACRYQKISWLHDGXGTTXFHVCEEEXSRWTSFRQNLLPCHVWXEQRKYTVLFXNSQNYQXSSSLNALLEASFGSFSGNTGLWN
VFSRRRTIKRKKTHWNSRNCFLRLSPRKWNISVSSRXWNLSRKRWRATRIYATTFKAQSSGNXLSQHTDGSKIMPCXSRLDCFYTXQRYL
DIXHRNQRRKETHLCAQXASQHGRRCQISWSRYLCSPRRIXXIFWLLVVSKSXNNSQWWXNSXNSIXRKXXIXGGNYSCYIPYVGNKEGR
FIPLSXNRYSKSXSHFXDVRNNDXCXRKDHRCHRXGTNSTFXDSIXRSXIYCQSWMDSXGKICLVHPTRSLPDSPTDSVDLTXIIYPSRR
XCYGKAETHXVSAXFCDATNYLXRNNRHLDKYPXHLSCFSPKSRRGNXVYFCLXMQNRFPSFIQNYIYFKGKQIXTIQWWAACSKXFQVS
YQRGDSNYQWXMGSSWPAWIXYPSXXSQKAGIFXRHQRLPFRASPVRSQLRKSWRGDKADXPWLLTFLLHQSALXLLYKXVXXPEESTLC
VPLQAIKSXRXPNLQNKGILGHHFGFSRSSSXLYSSRNFLFXKYYWIYIVWDALQASXSTAWKEISYCAVHIWWSSGAVGEXSVXRSQVF
PLEYPSLSRLCGCSDRQQGILSPRAXIXRRLXIXNGSNRNXRSGGRTPISSFSIXFHXLRSCGHPRLVLWRIPLPDGINAEVRYLQGCYC
WGPSHSVDLLXYRIHGTLYGSPXPEXTGLLLRICGHASRKVPLXTKSFTALTWFPGXECPFCTYQYITEFFSEGWKAIXFTDLSSGETQH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DENND4A_ENST00000443035_chr15_66021410_-_DPP8_ENST00000341861_chr15_65804902_-_4147nt
ATGATTGAAGACAAGGGGCCTCGTGTTGCTGACTACTTTGTTGTAGCAGGATTAACTGATGTTTCAAAGCCTCTAGAAGAAGAAATTCAC
TTCAATGATGCTTGTCATAAAGTAGCTAAACCAAAAGAACCTATTACAGATGTTTCAGTTATTATCAAATCTCTTGGGGAGGAAGTCCCA
CAGGATTATATCTGTATTGATGTTACCCCAACTGGATTGTCAGCTGATCTTAATAATGGAAGTCTTGTGGGGCCACAGATTTACCTTTGC
TATAGAAGAGGAAGAGATAAGCCTCCACTTACAGATCTGGGGGTTTTATATGACTGGAAAGAAAGATTGAAACAGGGTTGTGAAATTATT
CAGAGTACTCCCTATGGGCGCCCCGCAAATATTAGTGGGAGTACCTCATCACAAAGAATTTATATCACTTACCGAAGAGCCTCTGAAAAC
ATGACTCAGAATACGTTGGCTGTCACTGACATATGTATTATTATACCCAGTAAAGGAGAAAGCCCACCACACACGTTCTGCAAAGTCGAC
AAGAATCTCAATAACAGTATGTGGGGATCAGCAGTATACTTGTGTTATAAAAAATCGGTGGCAAAGACGAACACTGTATCTTACAAAGCT
GGCCTAATTTGTAGATATCCTCAAGAAGATTATGAGTCATTCTCACTACCGGAATCTGTTCCTCTATTTTGTTTACCAATGGGTGCAACC
ATTGAATGTTGGCCATCAAATAGCAAATACCCTCTGCCTGTATTTTCTACTTTTGTTTTAACTGGAGCCTCAGCTGAAAAGGTTTATGGT
GCTGCTATTCAGTTTTATGAACCATACTCTGAGGAGAATCTCACAGAAAAGCAGAGACTTCTTTTGGGTTTAACATCAGCAGATGGGAAG
TCTGATAGTTCCAAAACAATTCATACTAACAAATGCATCTGTCTTCTTTCTCACTGGCCTTTTTTTGATGCATTCAGGAAGTTTCTGACT
TTTCTGTATCGTTATTCCATCTCTGGGCCTCATGTCCTTCCAATTGAGAAGCATATTTCTCATTTTATGCATAAAGTTCCTTTTCCATCT
CCTCAGAGACCACGGATTTTAGTTCAGTTATCACCACATGATAATCTGATTCTCAGTCAGCCTGTGTCTTCACCTCTTCCACTAAGTGGT
GGCAAGTTTTCAACACTACTGCAGAATTTAGGCCCTGAAAATGCTGTGACACTACTGGTGTTTGCAGTAACAGAACATAAAATTCTTATC
CATTCCCTACGGCCATCCGTGCTTACTAGTGTGACAGAAGCATTAGTGTCTATGATTTTCCCTTTCCACTGGCCATGCCCGTATGTTCCT
CTCTGCCCACTGGCTTTAGCAGATGTCTTGAGTGCACCATGTCCATTCATAGTAGGGATTGATTCAAGATACTTTGATCTCTATGATCCT
CCACCAGATGTCAGTTGTGTTGATGTAGATACCAACACTATTTCTCAGAAAATGCAACATGGCAGCAGCAATGGAAACAGAACAGCTGGG
TGTTGAGATATTTGAAACTGCGGACTGTGAGGAGAATATTGAATCACAGGATCGGCCTAAATTGGAGCCTTTTTATGTTGAGCGGTATTC
CTGGAGTCAGCTTAAAAAGCTGCTTGCCGATACCAGAAAATATCATGGCTACATGATGGCTAAGGCACCACATGATTTCATGTTTGTGAA
GAGGAATGATCCAGATGGACCTCATTCAGACAGAATCTATTACCTTGCCATGTCTGGTGAGAACAGAGAAAATACACTGTTTTATTCTGA
AATTCCCAAAACTATCAATAGAGCAGCAGTCTTAATGCTCTCTTGGAAGCCTCTTTTGGATCTTTTTCAGGCAACACTGGACTATGGAAT
GTATTCTCGAGAAGAAGAACTATTAAGAGAAAGAAAACGCATTGGAACAGTCGGAATTGCTTCTTACGATTATCACCAAGGAAGTGGAAC
ATTTCTGTTTCAAGCCGGTAGTGGAATTTATCACGTAAAAGATGGAGGGCCACAAGGATTTACGCAACAACCTTTAAGGCCCAATCTAGT
GGAAACTAGTTGTCCCAACATACGGATGGATCCAAAATTATGCCCTGCTGATCCAGACTGGATTGCTTTTATACATAGCAACGATATTTG
GATATCTAACATCGTAACCAGAGAAGAAAGGAGACTCACTTATGTGCACAATGAGCTAGCCAACATGGAAGAAGATGCCAGATCAGCTGG
AGTCGCTACCTTTGTTCTCCAAGAAGAATTTGATAGATATTCTGGCTATTGGTGGTGTCCAAAAGCTGAAACAACTCCCAGTGGTGGTAA
AATTCTTAGAATTCTATATGAAGAAAATGATGAATCTGAGGTGGAAATTATTCATGTTACATCCCCTATGTTGGAAACAAGGAGGGCAGA
TTCATTCCGTTATCCTAAAACAGGTACAGCAAATCCTAAAGTCACTTTTAAGATGTCAGAAATAATGATTGATGCTGAAGGAAGGATCAT
AGATGTCATAGATAAGGAACTAATTCAACCTTTTGAGATTCTATTTGAAGGAGTTGAATATATTGCCAGAGCTGGATGGACTCCTGAGGG
AAAATATGCTTGGTCCATCCTACTAGATCGCTCCCAGACTCGCCTACAGATAGTGTTGATCTCACCTGAATTATTTATCCCAGTAGAAGA
TGATGTTATGGAAAGGCAGAGACTCATTGAGTCAGTGCCTGATTCTGTGACGCCACTAATTATCTATGAAGAAACAACAGACATCTGGAT
AAATATCCATGACATCTTTCATGTTTTTCCCCAAAGTCACGAAGAGGAAATTGAGTTTATTTTTGCCTCTGAATGCAAAACAGGTTTCCG
TCATTTATACAAAATTACATCTATTTTAAAGGAAAGCAAATATAAACGATCCAGTGGTGGGCTGCCTGCTCCAAGTGATTTCAAGTGTCC
TATCAAAGAGGAGATAGCAATTACCAGTGGTGAATGGGAAGTTCTTGGCCGGCATGGATCTAATATCCAAGTTGATGAAGTCAGAAGGCT
GGTATATTTTGAAGGCACCAAAGACTCCCCTTTAGAGCATCACCTGTACGTAGTCAGTTACGTAAATCCTGGAGAGGTGACAAGGCTGAC
TGACCGTGGCTACTCACATTCTTGCTGCATCAGTCAGCACTGTGACTTCTTTATAAGTAAGTATAGTAACCAGAAGAATCCACACTGTGT
GTCCCTTTACAAGCTATCAAGTCCTGAAGATGACCCAACTTGCAAAACAAAGGAATTTTGGGCCACCATTTTGGATTCAGCAGGTCCTCT
TCCTGACTATACTCCTCCAGAAATTTTCTCTTTTGAAAGTACTACTGGATTTACATTGTATGGGATGCTCTACAAGCCTCATGATCTACA
GCCTGGAAAGAAATATCCTACTGTGCTGTTCATATATGGTGGTCCTCAGGTGCAGTTGGTGAATAATCGGTTTAAAGGAGTCAAGTATTT
CCGCTTGAATACCCTAGCCTCTCTAGGTTATGTGGTTGTAGTGATAGACAACAGGGGATCCTGTCACCGAGGGCTTAAATTTGAAGGCGC
CTTTAAATATAAAATGGGTCAAATAGAAATTGACGATCAGGTGGAAGGACTCCAATATCTAGCTTCTCGATATGATTTCATTGACTTAGA
TCGTGTGGGCATCCACGGCTGGTCCTATGGAGGATACCTCTCCCTGATGGCATTAATGCAGAGGTCAGATATCTTCAGGGTTGCTATTGC
TGGGGCCCCAGTCACTCTGTGGATCTTCTATGATACAGGATACACGGAACGTTATATGGGTCACCCTGACCAGAATGAACAGGGCTATTA
CTTAGGATCTGTGGCCATGCAAGCAGAAAAGTTCCCCTCTGAACCAAATCGTTTACTGCTCTTACATGGTTTCCTGGATGAGAATGTCCA
TTTTGCACATACCAGTATATTACTGAGTTTTTTAGTGAGGGCTGGAAAGCCATATGATTTACAGATCTATCCTCAGGAGAGACACAGCAT
AAGAGTTCCTGAATCGGGAGAACATTATGAACTGCATCTTTTGCACTACCTTCAAGAAAACCTTGGATCACGTATTGCTGCTCTAAAAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_DENND4A_ENST00000443035_chr15_66021410_-_DPP8_ENST00000341861_chr15_65804902_-_8784nt
AAGCGGGCTCAGAGCGCCGCGGCATTCAGCCCCTCGTGTTCCGCTACCGCGCGTGCGGGATTCCGGCGCCGCTCTCCGAGCTCGATCCGC
TGCTCGCACGGGAGCCAGCTGGGTGTTATTTCTCAAACTCTGAGGCTGCGGAGTTCACACATTGAAATCTGTCATCTTTTTCAGAGAGAA
ACTTTCGGTAATGTATGTAACCTTCTGTAATGGAAGATGATTGAAGACAAGGGGCCTCGTGTTGCTGACTACTTTGTTGTAGCAGGATTA
ACTGATGTTTCAAAGCCTCTAGAAGAAGAAATTCACTTCAATGATGCTTGTCATAAAGTAGCTAAACCAAAAGAACCTATTACAGATGTT
TCAGTTATTATCAAATCTCTTGGGGAGGAAGTCCCACAGGATTATATCTGTATTGATGTTACCCCAACTGGATTGTCAGCTGATCTTAAT
AATGGAAGTCTTGTGGGGCCACAGATTTACCTTTGCTATAGAAGAGGAAGAGATAAGCCTCCACTTACAGATCTGGGGGTTTTATATGAC
TGGAAAGAAAGATTGAAACAGGGTTGTGAAATTATTCAGAGTACTCCCTATGGGCGCCCCGCAAATATTAGTGGGAGTACCTCATCACAA
AGAATTTATATCACTTACCGAAGAGCCTCTGAAAACATGACTCAGAATACGTTGGCTGTCACTGACATATGTATTATTATACCCAGTAAA
GGAGAAAGCCCACCACACACGTTCTGCAAAGTCGACAAGAATCTCAATAACAGTATGTGGGGATCAGCAGTATACTTGTGTTATAAAAAA
TCGGTGGCAAAGACGAACACTGTATCTTACAAAGCTGGCCTAATTTGTAGATATCCTCAAGAAGATTATGAGTCATTCTCACTACCGGAA
TCTGTTCCTCTATTTTGTTTACCAATGGGTGCAACCATTGAATGTTGGCCATCAAATAGCAAATACCCTCTGCCTGTATTTTCTACTTTT
GTTTTAACTGGAGCCTCAGCTGAAAAGGTTTATGGTGCTGCTATTCAGTTTTATGAACCATACTCTGAGGAGAATCTCACAGAAAAGCAG
AGACTTCTTTTGGGTTTAACATCAGCAGATGGGAAGTCTGATAGTTCCAAAACAATTCATACTAACAAATGCATCTGTCTTCTTTCTCAC
TGGCCTTTTTTTGATGCATTCAGGAAGTTTCTGACTTTTCTGTATCGTTATTCCATCTCTGGGCCTCATGTCCTTCCAATTGAGAAGCAT
ATTTCTCATTTTATGCATAAAGTTCCTTTTCCATCTCCTCAGAGACCACGGATTTTAGTTCAGTTATCACCACATGATAATCTGATTCTC
AGTCAGCCTGTGTCTTCACCTCTTCCACTAAGTGGTGGCAAGTTTTCAACACTACTGCAGAATTTAGGCCCTGAAAATGCTGTGACACTA
CTGGTGTTTGCAGTAACAGAACATAAAATTCTTATCCATTCCCTACGGCCATCCGTGCTTACTAGTGTGACAGAAGCATTAGTGTCTATG
ATTTTCCCTTTCCACTGGCCATGCCCGTATGTTCCTCTCTGCCCACTGGCTTTAGCAGATGTCTTGAGTGCACCATGTCCATTCATAGTA
GGGATTGATTCAAGATACTTTGATCTCTATGATCCTCCACCAGATGTCAGTTGTGTTGATGTAGATACCAACACTATTTCTCAGAAAATG
CAACATGGCAGCAGCAATGGAAACAGAACAGCTGGGTGTTGAGATATTTGAAACTGCGGACTGTGAGGAGAATATTGAATCACAGGATCG
GCCTAAATTGGAGCCTTTTTATGTTGAGCGGTATTCCTGGAGTCAGCTTAAAAAGCTGCTTGCCGATACCAGAAAATATCATGGCTACAT
GATGGCTAAGGCACCACATGATTTCATGTTTGTGAAGAGGAATGATCCAGATGGACCTCATTCAGACAGAATCTATTACCTTGCCATGTC
TGGTGAGAACAGAGAAAATACACTGTTTTATTCTGAAATTCCCAAAACTATCAATAGAGCAGCAGTCTTAATGCTCTCTTGGAAGCCTCT
TTTGGATCTTTTTCAGGCAACACTGGACTATGGAATGTATTCTCGAGAAGAAGAACTATTAAGAGAAAGAAAACGCATTGGAACAGTCGG
AATTGCTTCTTACGATTATCACCAAGGAAGTGGAACATTTCTGTTTCAAGCCGGTAGTGGAATTTATCACGTAAAAGATGGAGGGCCACA
AGGATTTACGCAACAACCTTTAAGGCCCAATCTAGTGGAAACTAGTTGTCCCAACATACGGATGGATCCAAAATTATGCCCTGCTGATCC
AGACTGGATTGCTTTTATACATAGCAACGATATTTGGATATCTAACATCGTAACCAGAGAAGAAAGGAGACTCACTTATGTGCACAATGA
GCTAGCCAACATGGAAGAAGATGCCAGATCAGCTGGAGTCGCTACCTTTGTTCTCCAAGAAGAATTTGATAGATATTCTGGCTATTGGTG
GTGTCCAAAAGCTGAAACAACTCCCAGTGGTGGTAAAATTCTTAGAATTCTATATGAAGAAAATGATGAATCTGAGGTGGAAATTATTCA
TGTTACATCCCCTATGTTGGAAACAAGGAGGGCAGATTCATTCCGTTATCCTAAAACAGGTACAGCAAATCCTAAAGTCACTTTTAAGAT
GTCAGAAATAATGATTGATGCTGAAGGAAGGATCATAGATGTCATAGATAAGGAACTAATTCAACCTTTTGAGATTCTATTTGAAGGAGT
TGAATATATTGCCAGAGCTGGATGGACTCCTGAGGGAAAATATGCTTGGTCCATCCTACTAGATCGCTCCCAGACTCGCCTACAGATAGT
GTTGATCTCACCTGAATTATTTATCCCAGTAGAAGATGATGTTATGGAAAGGCAGAGACTCATTGAGTCAGTGCCTGATTCTGTGACGCC
ACTAATTATCTATGAAGAAACAACAGACATCTGGATAAATATCCATGACATCTTTCATGTTTTTCCCCAAAGTCACGAAGAGGAAATTGA
GTTTATTTTTGCCTCTGAATGCAAAACAGGTTTCCGTCATTTATACAAAATTACATCTATTTTAAAGGAAAGCAAATATAAACGATCCAG
TGGTGGGCTGCCTGCTCCAAGTGATTTCAAGTGTCCTATCAAAGAGGAGATAGCAATTACCAGTGGTGAATGGGAAGTTCTTGGCCGGCA
TGGATCTAATATCCAAGTTGATGAAGTCAGAAGGCTGGTATATTTTGAAGGCACCAAAGACTCCCCTTTAGAGCATCACCTGTACGTAGT
CAGTTACGTAAATCCTGGAGAGGTGACAAGGCTGACTGACCGTGGCTACTCACATTCTTGCTGCATCAGTCAGCACTGTGACTTCTTTAT
AAGTAAGTATAGTAACCAGAAGAATCCACACTGTGTGTCCCTTTACAAGCTATCAAGTCCTGAAGATGACCCAACTTGCAAAACAAAGGA
ATTTTGGGCCACCATTTTGGATTCAGCAGGTCCTCTTCCTGACTATACTCCTCCAGAAATTTTCTCTTTTGAAAGTACTACTGGATTTAC
ATTGTATGGGATGCTCTACAAGCCTCATGATCTACAGCCTGGAAAGAAATATCCTACTGTGCTGTTCATATATGGTGGTCCTCAGGTGCA
GTTGGTGAATAATCGGTTTAAAGGAGTCAAGTATTTCCGCTTGAATACCCTAGCCTCTCTAGGTTATGTGGTTGTAGTGATAGACAACAG
GGGATCCTGTCACCGAGGGCTTAAATTTGAAGGCGCCTTTAAATATAAAATGGGTCAAATAGAAATTGACGATCAGGTGGAAGGACTCCA
ATATCTAGCTTCTCGATATGATTTCATTGACTTAGATCGTGTGGGCATCCACGGCTGGTCCTATGGAGGATACCTCTCCCTGATGGCATT
AATGCAGAGGTCAGATATCTTCAGGGTTGCTATTGCTGGGGCCCCAGTCACTCTGTGGATCTTCTATGATACAGGATACACGGAACGTTA
TATGGGTCACCCTGACCAGAATGAACAGGGCTATTACTTAGGATCTGTGGCCATGCAAGCAGAAAAGTTCCCCTCTGAACCAAATCGTTT
ACTGCTCTTACATGGTTTCCTGGATGAGAATGTCCATTTTGCACATACCAGTATATTACTGAGTTTTTTAGTGAGGGCTGGAAAGCCATA
TGATTTACAGATCTATCCTCAGGAGAGACACAGCATAAGAGTTCCTGAATCGGGAGAACATTATGAACTGCATCTTTTGCACTACCTTCA
AGAAAACCTTGGATCACGTATTGCTGCTCTAAAAGTGATATAATTTTGACCTGTGTAGAACTCTCTGGTATACACTGGCTATTTAACCAA
ATGAGGAGGTTTAATCAACAGAAAACACAGAATTGATCATCACATTTTGATACCTGCCATGTAACATCTACTCCTGAAAATAAATGTGGT
GCCATGCAGGGGTCTACGGTTTGTGGTAGTAATCTAATACCTTAACCCCACATGCTCAAAATCAAATGATACATATTCCTGAGAGACCCA
GCAATACCATAAGAATTACTAAAAAAAAAAAAAAAAAAAAGACATTAGCACCATGTATTCATACTACCCTATTTTCACTTTTAATAGTAT
TATAAACTTCATGAACTTAATTAGTGTATTTTTACAGTATACTTTTGAGTTTGTTAAAATATGATGATATTAGTGATTGGTTTGGTTCAG
TTCCAGAATCTTTGACTAGTTACAGATTTGATAGCACTTAAATGTAATTGAATAGCTTATGCTTCATTGCTTGGGCATATCCAGCATGTT
ATGAACTAATAACTATTAAACTTGACTTAACCAGTCATTCATTAATAATTTTTCAAGGATAACTTAGTGGCCTCCTAAAGACACTTGTTT
TGGCACTGACCAGTTTTTAGCCAATTTAATCTGTATCTAGTATAAATAATTCTCATTTTTCTTTGATGATATTAACAGAGTGGGCTTTTC
CTTTTGCATAAAGGCTAGTAACTGTATATGTAGCATGGATTTAATTAGTCATGATATTGATAATTACAGGCAGAAAATTTTTAATCAAAT
GATTAGAGCTTAAATATTTGCAGGCAAGTTTTTTTTTTTCCTTTAAGAAAAGGAAAAAGTACACATTCACTAGAATTCTTCAGAAAATTT
AGTGGTGCCAGTTTCCATTTGGTATTTCCTTATTAAAATATTCTAGAATTTTAAGGAGATTGAAGGGAATCACAGTGGGGTGGGGAGACC
TGGGTTTGGGGAATGACAGAGAGAAGAGGTGGTGAGGGCCTGATTAAAAACTAAGCAGAAGTAGTTTTAACAAAAATACTCATGAAAATG
TTTGGAAACTGAAATTTAAACAACTGTAATATTAAGGAAACCAGAATCAATAAATCACTGTCTTGCCAGCACAGCTACAGAGTAACATGA
TTCAGGGGAGGAAAAGTTCCTTAGAGTTACTTTTATAATTCTTTTTTTTTTTCCTCTTAGGTTTAGAAATCTTACAAATTTAAACTTTAT
CCTTTTAAAATTATTTGAACATAATTTAGATATTGTAAGCTTAAAATACAAATGTTTATAGATAACCTCTTTACCATAAACTAATCCCTG
GCAAGCCATGGCTCTCTTTTTTTTTTTGGTGTTTAAAGCCTGTAAACAGTTTTTCTGAATGATCATGAACTTTTCTTGGTTTAGCACTAG
GATTTAGCTATGAAGAGAGCTCATAGGCTTTCAGGTGCTAATTGAGATCTGCCCTGTTAGAGTCTTGGGGTGCTAGATTGGTCACATTGA
CACCAGTGGCAGGGAAGGCATCTATGAGTTTGATGCTTTTTATCACACACTTCAGTGTTTAGAAAGTTATTACCAATACTTTTAAACAAC
ACTCCAAGAAAATTTGCTATATTTCTTTCTCATCACTACAGAGAGAGTAGATTTCCCCATAGAGAGCACAGCCTCCATTAGTAAGGTTGG
TGACTATTGGTAAGAGGTGGACTTCATTGACACCAAGTGGGAGGTAGGGAAAGCCCAGAAATGGCAGGATGATATGGTGGTTCTGTCGTT
GGGAAAGGTATTGGGTTTTGCTGTTTGTATTTATACTGTATAATAGATACCACGCTTTTTCTTATTATCTGTATATGTATTGCTTTTCAT
GTTTGATATTTTCCCATGCCAAGATTTGTTTATATATATTTTCAATGTTAAATTAAATTGATTTGGGTAACTTTCTTCCCCAAGAAAGTA
TTTTCCCCCTTAAGTATATATCTGACTGTGGAGGGTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTGGACTAACTGGCCTCGAAGGATCTA
TCCTTATAATATATGCAAAGTAGAAATGGTATACAGTAGCTTTTAAGCAGCTACTCCATTGAAACCTCTCACCCATTAAGGCTGTTTCTT
CAAAGTGGCATCTCTTATTTTACCGAAACAAACTTAGAAAACTTCATGTACTCTGGAGTTCACAGGTGTTTTCCTTTTGCATGTTGCCTT
CTCCTTTCCTCCTATCACAAAGAATGCTTCTATTATCACTCCCAGTCACTTAAATGCCATTCTGCTTCTTTAGCAGGAAAAAATACCTGA
ATGAATTCTCTTACAGAAAGACAGTTTGACTGAATTTGCTTTTTACAATCAGTGTGGAAAATATCATAGTCAATTGAGGCAATCAGTAGA
AATCTCACTAAAAGTTTGTACCCCCTGAGTATGGGTAACAGCTTAAACGGCAAGAATATATAAAAGTAGCAACAGTTTAGTGGGAGCCAA
AAAGCACTAGGTTAAATATCATACTACGTTTTTAAAGACTTGATAAATGTGTACACTTGAACAACCATCCAGAGGGATAGTTACTTGAGC
ATTACAGAGTAGTGGAACTCAAAATCTAAGATTCATCTGGGATACTTCTAAAAGAAATGTAGAGTTTTGAATCTCACTCTTAAAAATGTG
TATTCCCAGGCTAGGCATGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGCGGGTGAATCACTTGAAGTCAGGAGATCAA
GACCAGCTTGGTCGACATGGTGAAACCCCGTCTCTACTAAAAGTACAAAAAAATTAGCTGGGCATGATGGCGTGTGCCTATAATCCCACC
TACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAAGTTGCAGTGAGCCGAGATGGCGCCACTGTAGTCCAGTCTGGG
CGACAGAGTGAGATTCTGCCTCAAAATAAATAAATAAATAAAAATTTGTATTCCATTGATTTGGGTAGACACCAGGAATGTGCATTTCTA
ACAAGCTTTCCAGGCGATCCTATAGTAAGTCATCTGTGGACTACTTTAAGAAACTCTTCTATAGAGAATGGAGTTGGATTAATAATAGGT
GATTTTTTACACTGGACTGATTCACAAGAACCTAAACAGTAGTCCATGAAGCTGCTCATCTGTGGTAACTATTTGGCCCCGTCTCACTCT
GAAAGCAGCAGGAGATGTTGTTTACTTTGTTTCTATCCCCTTTGTCTGGAGATTAATTTTGGAATGAAAGTTTTTCTCTCTATGCCATTC
CTGGTTCTTTTCCAAAGCCTCATACAAGAGGATTAGGTCACAATGCATGCATTACCTTTTAAAAGAATGCGATATTGATACCGATGCTTA
CTTTTTTTTTTTTACTACTTGTTTTATTCCTTCCAGAAAGTATAGCCCGCCTTTCTATAGCATAGTTCTCTTTAGGTGGAATGATTCCTA
TAAGATTTCTCATTATTAAATCATGCATTTTTCAAGATGGAATCAATATTTGATTTAATCTAAGCTGATATTCTCATTTGTTAGAAGAAC
AACCTACATGCTAGAGAGAGAGGAGGAAATATACCCACGACCACACAGCCAGTTAGTATCCAGTTGGTGCTGGACTCCAGCCAGGTGTCC
TGCCTCATGGTAGTTAAATGATATATAGAAAAGGTAAATTTTTAAAGAAATATTTATTAATATATTCCTATAAAACATTTTAAAGGTAAC
CACATAAAAATGGTTAATTTTTCCATTCCAAAGTAAATGCTAAGCATGTTTATTAATGAAGCAGTACTTCTGATTAGTATATGACATTCT
GAAGTTAATTAAACTCATTGCACTAAATGTGTCTTCCTTGGTATAGTGGAGGATTTGAGGATTGGAATATAGAGTAGAGTGCTTGCTTAA
GCCTGGGAGCCCATCTTTATAGCTATTTGATGTAAGAAAAGAGACATGGCCATTTCTAAACTATATAAGGTGAGTGTGTCTATTCCCAGC
AGATATAAAGGAAAAAGGAAACTTTTTTGATTCCCACCTTCCCAGCCTCACCTAGCCATCTTCCAGCCTCAAATATAGAGATGTTAGTGC
AAGGTCCTGGGCTCTAGGTGATCATTTCATAAGTCCTTTACAGATAAAGAAAAAGTAGTGTTTGTATGTTTGTTTTTAAGTAACCCCAAA
ACAAATTTATATTGTATTCAGCAAAATTGGAATTCAGGTGTTTAATTTTAGAACATGAAGTGCCTGCTGTTTTAAGCATTGACTTGTATA
AAAAGAATTGCATGTCTCCAGTAAGCTTATGGGTTTTCTCATTTTTAGGTATATGGCTTTTAATCATGTAAAGTGAAACATTAGTTTTCT


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FusionGenePPI for DENND4A_DPP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DENND4AYWHAB, YWHAQ, YWHAG, CEBPE, PCBD1, SERTAD1, TLX3, YWHAE, METTL6, CLK1, PTPRA, LYPD4, SCRN1, ASB3, NTRK3, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, CGN, DENND1A, SH3PXD2A, SRGAP2, RTKN, MAST3, EIF4E2, SIPA1L1, PPM1H, DENND4C, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, HDAC4, NF1, SRSF12, CBY1, INPP5EDPP8ELAVL1, ARMC9, CD44, AARS, CALU, DHPS, FUBP3, P3H1, PFDN1, SRP14, SRP9, UBXN7, WDR4, CIAO1, WDR90, DOK3, IL17A, UBXN4, SNRPN, IDO2, CCL22, ARHGEF16, ATF2, TSNAXIP1, EPS8L1, RIN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DENND4A_DPP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DENND4A_DPP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource