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Fusion gene ID: 9728 |
FusionGeneSummary for DENND3_DENND3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DENND3_DENND3 | Fusion gene ID: 9728 | Hgene | Tgene | Gene symbol | DENND3 | DENND3 | Gene ID | 22898 | 22898 |
| Gene name | DENN domain containing 3 | DENN domain containing 3 | |
| Synonyms | - | - | |
| Cytomap | 8q24.3 | 8q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DENN domain-containing protein 3DENN/MADD domain containing 3 | DENN domain-containing protein 3DENN/MADD domain containing 3 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | A2RUS2 | A2RUS2 | |
| Ensembl transtripts involved in fusion gene | ENST00000518347, ENST00000424248, ENST00000262585, ENST00000519811, ENST00000518806, ENST00000523308, | ENST00000518347, ENST00000424248, ENST00000262585, ENST00000519811, ENST00000518806, ENST00000523308, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 5 X 5=125 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DENND3 [Title/Abstract] AND DENND3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA449866 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000518347 | ENST00000518347 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518347 | ENST00000424248 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518347 | ENST00000262585 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518347 | ENST00000519811 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518347 | ENST00000518806 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518347 | ENST00000523308 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000424248 | ENST00000518347 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000424248 | ENST00000424248 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000424248 | ENST00000262585 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000424248 | ENST00000519811 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000424248 | ENST00000518806 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000424248 | ENST00000523308 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000262585 | ENST00000518347 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000262585 | ENST00000424248 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000262585 | ENST00000262585 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000262585 | ENST00000519811 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000262585 | ENST00000518806 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000262585 | ENST00000523308 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000519811 | ENST00000518347 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000519811 | ENST00000424248 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000519811 | ENST00000262585 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000519811 | ENST00000519811 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000519811 | ENST00000518806 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000519811 | ENST00000523308 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518806 | ENST00000518347 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518806 | ENST00000424248 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518806 | ENST00000262585 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518806 | ENST00000519811 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518806 | ENST00000518806 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000518806 | ENST00000523308 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000523308 | ENST00000518347 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000523308 | ENST00000424248 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000523308 | ENST00000262585 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000523308 | ENST00000519811 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000523308 | ENST00000518806 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
| intron-intron | ENST00000523308 | ENST00000523308 | DENND3 | chr8 | 142203974 | + | DENND3 | chr8 | 142202644 | + |
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FusionProtFeatures for DENND3_DENND3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DENND3 | DENND3 |
| Guanine nucleotide exchange factor (GEF) activatingRAB12. Promotes the exchange of GDP to GTP, converting inactiveGDP-bound RAB12 into its active GTP-bound form (PubMed:20937701).Regulates autophagy in response to starvation through RAB12activation. Starvation leads to ULK1/2-dependent phosphorylationof Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3adapter proteins and leads to up-regulation of GEF activitytowards RAB12 (By similarity). Also plays a role in proteintransport from recycling endosomes to lysosomes, regulating, forinstance, the degradation of the transferrin receptor and of theamino acid transporter PAT4 (PubMed:20937701). Starvation alsoinduces phosphorylation at Tyr-858, which leads to up-regulatedGEF activity and initiates autophagy (By similarity).{ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}. | Guanine nucleotide exchange factor (GEF) activatingRAB12. Promotes the exchange of GDP to GTP, converting inactiveGDP-bound RAB12 into its active GTP-bound form (PubMed:20937701).Regulates autophagy in response to starvation through RAB12activation. Starvation leads to ULK1/2-dependent phosphorylationof Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3adapter proteins and leads to up-regulation of GEF activitytowards RAB12 (By similarity). Also plays a role in proteintransport from recycling endosomes to lysosomes, regulating, forinstance, the degradation of the transferrin receptor and of theamino acid transporter PAT4 (PubMed:20937701). Starvation alsoinduces phosphorylation at Tyr-858, which leads to up-regulatedGEF activity and initiates autophagy (By similarity).{ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DENND3_DENND3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DENND3_DENND3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DENND3_DENND3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND3_DENND3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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