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Fusion gene ID: 9725 |
FusionGeneSummary for DENND2C_BCL2L15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DENND2C_BCL2L15 | Fusion gene ID: 9725 | Hgene | Tgene | Gene symbol | DENND2C | BCL2L15 | Gene ID | 163259 | 440603 |
| Gene name | DENN domain containing 2C | BCL2 like 15 | |
| Synonyms | dJ1156J9.1 | Bfk|C1orf178 | |
| Cytomap | 1p13.2 | 1p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DENN domain-containing protein 2CDENN/MADD domain containing 2CRP5-1156J9.1 | bcl-2-like protein 15bcl2-L-15pro-apoptotic Bcl-2 protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q68D51 | Q5TBC7 | |
| Ensembl transtripts involved in fusion gene | ENST00000393276, ENST00000393274, ENST00000393277, ENST00000481894, | ENST00000393316, ENST00000488450, ENST00000393320, ENST00000471267, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DENND2C [Title/Abstract] AND BCL2L15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-BR-A4J6-01A | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393276 | ENST00000393316 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393276 | ENST00000488450 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393276 | ENST00000393320 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393276 | ENST00000471267 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| In-frame | ENST00000393274 | ENST00000393316 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393274 | ENST00000488450 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393274 | ENST00000393320 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393274 | ENST00000471267 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| In-frame | ENST00000393277 | ENST00000393316 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393277 | ENST00000488450 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393277 | ENST00000393320 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5CDS-intron | ENST00000393277 | ENST00000471267 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5UTR-3CDS | ENST00000481894 | ENST00000393316 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5UTR-intron | ENST00000481894 | ENST00000488450 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5UTR-intron | ENST00000481894 | ENST00000393320 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
| 5UTR-intron | ENST00000481894 | ENST00000471267 | DENND2C | chr1 | 115161007 | - | BCL2L15 | chr1 | 114429280 | - |
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FusionProtFeatures for DENND2C_BCL2L15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DENND2C | BCL2L15 |
| Guanine nucleotide exchange factor (GEF) which mayactivate RAB9A and RAB9B. Promotes the exchange of GDP to GTP,converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DENND2C | chr1:115161007 | chr1:114429280 | ENST00000393274 | - | 8 | 21 | 492_641 | 441 | 929 | Domain | uDENN |
| Hgene | >DENND2C | chr1:115161007 | chr1:114429280 | ENST00000393274 | - | 8 | 21 | 663_796 | 441 | 929 | Domain | cDENN |
| Hgene | >DENND2C | chr1:115161007 | chr1:114429280 | ENST00000393274 | - | 8 | 21 | 798_888 | 441 | 929 | Domain | dDENN |
| Hgene | >DENND2C | chr1:115161007 | chr1:114429280 | ENST00000393276 | - | 5 | 18 | 492_641 | 384 | 872 | Domain | uDENN |
| Hgene | >DENND2C | chr1:115161007 | chr1:114429280 | ENST00000393276 | - | 5 | 18 | 663_796 | 384 | 872 | Domain | cDENN |
| Hgene | >DENND2C | chr1:115161007 | chr1:114429280 | ENST00000393276 | - | 5 | 18 | 798_888 | 384 | 872 | Domain | dDENN |
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FusionGeneSequence for DENND2C_BCL2L15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DENND2C_ENST00000393276_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_506aa MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKKNPIAERKSKNLDVTSRENVGLDINENTKSH DQSENENKKHEYDDTHFFKNESESNWVCSRVKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKYGGKIRGRSKRK SFEFEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLVLKIDDI FESKRGKKKVKLHSYTGKELPPTKGEPCSFDVAIIAGRLRMLGDQFNGELEASAKNVIAETIKGQTGAILQDTVESLSKTWCAQDSSLAY >In-frame_DENND2C_ENST00000393274_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_563aa MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKKNPIAERKSKNLDVTSRENVGLDINENTKSH DQSENENKKHEYDDTHFFKNESESNWVCSRVKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKYGGKIRGRSKRK SFEFEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLPPKPQFL HRKTMEVKNSQAYLRSKLTKDTTLPVTLTEWKLFRAGEVANTKRKNLPRLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGEPCSFDVA IIAGRLRMLGDQFNGELEASAKNVIAETIKGQTGAILQDTVESLSKTWCAQDSSLAYERAFLAVSVKLLEYMAHIAPEVVGQVAIPMTGM >In-frame_DENND2C_ENST00000393277_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_563aa MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKKNPIAERKSKNLDVTSRENVGLDINENTKSH DQSENENKKHEYDDTHFFKNESESNWVCSRVKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKYGGKIRGRSKRK SFEFEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLPPKPQFL HRKTMEVKNSQAYLRSKLTKDTTLPVTLTEWKLFRAGEVANTKRKNLPRLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGEPCSFDVA IIAGRLRMLGDQFNGELEASAKNVIAETIKGQTGAILQDTVESLSKTWCAQDSSLAYERAFLAVSVKLLEYMAHIAPEVVGQVAIPMTGM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DENND2C_ENST00000393276_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_1518nt ATGGATGTTGGTTTTTCTCGTACTACTGTTCAGACACTGTCAAGAAGCCACTGCAAAAACATCAAACAAAAAATTTCTCAATGGGAAGGA AGGGCTAATGGTATATCTAATCCAGAAAAGTGGTGTCCAAAGGACTTTGGAGTGAGATATAACTGTCACCAAGAGATCCGTCTTAAGAAA AATCCTATAGCTGAGAGAAAGAGCAAAAACTTGGATGTAACCAGCCGTGAAAATGTGGGTCTAGATATAAATGAAAATACCAAAAGCCAT GATCAAAGTGAGAATGAAAATAAGAAACATGAATATGACGATACACACTTCTTTAAAAATGAATCAGAATCCAACTGGGTATGTTCTCGG GTCAAAGAAATTGAAAGCTGTAAAGAAGATGTCTTAGATCCAGAGACTTCATTACCTCCAGGAAACTTCTATACCTCACAAATACTGTGG AAGAAAATAGAAGCACTTCCCCCAGATAAACTCTTAAATTTGGCTTTAGAACATTGTGACTCTTCAGAAAAAGAACTGAACTTCAGAGTT CTGGATAGTTCATACGGAATAACCAAGAGCTTAGAAAATATTTACTCTGAACCTGAGGGGCAAGAATGTGGACCTTCCATAAATCCTTTG CCAAAACCTCGTAGGACATTCAGATATTTATCCGAATCTGGTGTTACGCCGTATAAAGAAAGAAACTGTGACAAAAAATACTGTGAAAAT AACTCTTGTGCACAATCTTCTTTGGCCTCTTCTCAGGAACCTGAACCAAAGAAATATGGTGGAAAAATCAGAGGAAGATCTAAAAGGAAA TCCTTTGAATTTGAGGATATTCAGCACTTTCGAAATCGGAACTCACAGACGATTCGTGAAGAACTTGGAAGAAATTCTGGGTCAGCACTT TATTACACACAGTCTGAGGACAATATCTATGAAGATATCATATATCCCACCAAAGAAAATCCATATGAAGATATTCCAGTGCAGCCTTTA CCTATGTGGAGATCCCCTTCAGCATGGAAGCTACCACCCGCTAAAAGTGCTTTTAAAGCACCCAAGCTTGTATTGAAAATAGATGACATA TTTGAATCTAAAAGAGGGAAGAAGAAGGTAAAGTTACATTCTTACACTGGAAAGGAATTACCTCCGACAAAAGGAGAGCCTTGTTCTTTT GATGTGGCTATCATTGCTGGTCGCCTTCGGATGTTGGGTGACCAGTTCAACGGAGAATTGGAAGCTTCTGCCAAAAACGTCATTGCAGAA ACCATTAAGGGACAGACAGGAGCTATACTCCAGGACACTGTGGAATCTCTCAGCAAGACCTGGTGTGCTCAGGATTCCAGCTTAGCTTAT GAGAGAGCTTTTCTGGCAGTGTCAGTGAAACTTCTTGAGTACATGGCTCACATTGCTCCTGAAGTAGTGGGACAGGTGGCTATCCCCATG >In-frame_DENND2C_ENST00000393274_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_1689nt ATGGATGTTGGTTTTTCTCGTACTACTGTTCAGACACTGTCAAGAAGCCACTGCAAAAACATCAAACAAAAAATTTCTCAATGGGAAGGA AGGGCTAATGGTATATCTAATCCAGAAAAGTGGTGTCCAAAGGACTTTGGAGTGAGATATAACTGTCACCAAGAGATCCGTCTTAAGAAA AATCCTATAGCTGAGAGAAAGAGCAAAAACTTGGATGTAACCAGCCGTGAAAATGTGGGTCTAGATATAAATGAAAATACCAAAAGCCAT GATCAAAGTGAGAATGAAAATAAGAAACATGAATATGACGATACACACTTCTTTAAAAATGAATCAGAATCCAACTGGGTATGTTCTCGG GTCAAAGAAATTGAAAGCTGTAAAGAAGATGTCTTAGATCCAGAGACTTCATTACCTCCAGGAAACTTCTATACCTCACAAATACTGTGG AAGAAAATAGAAGCACTTCCCCCAGATAAACTCTTAAATTTGGCTTTAGAACATTGTGACTCTTCAGAAAAAGAACTGAACTTCAGAGTT CTGGATAGTTCATACGGAATAACCAAGAGCTTAGAAAATATTTACTCTGAACCTGAGGGGCAAGAATGTGGACCTTCCATAAATCCTTTG CCAAAACCTCGTAGGACATTCAGATATTTATCCGAATCTGGTGTTACGCCGTATAAAGAAAGAAACTGTGACAAAAAATACTGTGAAAAT AACTCTTGTGCACAATCTTCTTTGGCCTCTTCTCAGGAACCTGAACCAAAGAAATATGGTGGAAAAATCAGAGGAAGATCTAAAAGGAAA TCCTTTGAATTTGAGGATATTCAGCACTTTCGAAATCGGAACTCACAGACGATTCGTGAAGAACTTGGAAGAAATTCTGGGTCAGCACTT TATTACACACAGTCTGAGGACAATATCTATGAAGATATCATATATCCCACCAAAGAAAATCCATATGAAGATATTCCAGTGCAGCCTTTA CCTATGTGGAGATCCCCTTCAGCATGGAAGCTACCACCCGCTAAAAGTGCTTTTAAAGCACCCAAGCTCCCTCCAAAACCTCAGTTCCTT CACCGGAAGACTATGGAAGTAAAGAACTCACAGGCTTATTTGCGGTCAAAGCTTACAAAAGATACAACTTTGCCGGTCACTTTAACGGAA TGGAAGCTTTTCCGAGCTGGTGAAGTTGCAAACACGAAAAGGAAAAATCTTCCAAGGCTTGTATTGAAAATAGATGACATATTTGAATCT AAAAGAGGGAAGAAGAAGGTAAAGTTACATTCTTACACTGGAAAGGAATTACCTCCGACAAAAGGAGAGCCTTGTTCTTTTGATGTGGCT ATCATTGCTGGTCGCCTTCGGATGTTGGGTGACCAGTTCAACGGAGAATTGGAAGCTTCTGCCAAAAACGTCATTGCAGAAACCATTAAG GGACAGACAGGAGCTATACTCCAGGACACTGTGGAATCTCTCAGCAAGACCTGGTGTGCTCAGGATTCCAGCTTAGCTTATGAGAGAGCT TTTCTGGCAGTGTCAGTGAAACTTCTTGAGTACATGGCTCACATTGCTCCTGAAGTAGTGGGACAGGTGGCTATCCCCATGACGGGTATG >In-frame_DENND2C_ENST00000393277_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_1689nt ATGGATGTTGGTTTTTCTCGTACTACTGTTCAGACACTGTCAAGAAGCCACTGCAAAAACATCAAACAAAAAATTTCTCAATGGGAAGGA AGGGCTAATGGTATATCTAATCCAGAAAAGTGGTGTCCAAAGGACTTTGGAGTGAGATATAACTGTCACCAAGAGATCCGTCTTAAGAAA AATCCTATAGCTGAGAGAAAGAGCAAAAACTTGGATGTAACCAGCCGTGAAAATGTGGGTCTAGATATAAATGAAAATACCAAAAGCCAT GATCAAAGTGAGAATGAAAATAAGAAACATGAATATGACGATACACACTTCTTTAAAAATGAATCAGAATCCAACTGGGTATGTTCTCGG GTCAAAGAAATTGAAAGCTGTAAAGAAGATGTCTTAGATCCAGAGACTTCATTACCTCCAGGAAACTTCTATACCTCACAAATACTGTGG AAGAAAATAGAAGCACTTCCCCCAGATAAACTCTTAAATTTGGCTTTAGAACATTGTGACTCTTCAGAAAAAGAACTGAACTTCAGAGTT CTGGATAGTTCATACGGAATAACCAAGAGCTTAGAAAATATTTACTCTGAACCTGAGGGGCAAGAATGTGGACCTTCCATAAATCCTTTG CCAAAACCTCGTAGGACATTCAGATATTTATCCGAATCTGGTGTTACGCCGTATAAAGAAAGAAACTGTGACAAAAAATACTGTGAAAAT AACTCTTGTGCACAATCTTCTTTGGCCTCTTCTCAGGAACCTGAACCAAAGAAATATGGTGGAAAAATCAGAGGAAGATCTAAAAGGAAA TCCTTTGAATTTGAGGATATTCAGCACTTTCGAAATCGGAACTCACAGACGATTCGTGAAGAACTTGGAAGAAATTCTGGGTCAGCACTT TATTACACACAGTCTGAGGACAATATCTATGAAGATATCATATATCCCACCAAAGAAAATCCATATGAAGATATTCCAGTGCAGCCTTTA CCTATGTGGAGATCCCCTTCAGCATGGAAGCTACCACCCGCTAAAAGTGCTTTTAAAGCACCCAAGCTCCCTCCAAAACCTCAGTTCCTT CACCGGAAGACTATGGAAGTAAAGAACTCACAGGCTTATTTGCGGTCAAAGCTTACAAAAGATACAACTTTGCCGGTCACTTTAACGGAA TGGAAGCTTTTCCGAGCTGGTGAAGTTGCAAACACGAAAAGGAAAAATCTTCCAAGGCTTGTATTGAAAATAGATGACATATTTGAATCT AAAAGAGGGAAGAAGAAGGTAAAGTTACATTCTTACACTGGAAAGGAATTACCTCCGACAAAAGGAGAGCCTTGTTCTTTTGATGTGGCT ATCATTGCTGGTCGCCTTCGGATGTTGGGTGACCAGTTCAACGGAGAATTGGAAGCTTCTGCCAAAAACGTCATTGCAGAAACCATTAAG GGACAGACAGGAGCTATACTCCAGGACACTGTGGAATCTCTCAGCAAGACCTGGTGTGCTCAGGATTCCAGCTTAGCTTATGAGAGAGCT TTTCTGGCAGTGTCAGTGAAACTTCTTGAGTACATGGCTCACATTGCTCCTGAAGTAGTGGGACAGGTGGCTATCCCCATGACGGGTATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DENND2C_ENST00000393276_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_2271nt GGGGCTAGGGGGTGGGGCTGCAGCCGGGACGGGGCCTTCGGCAGGGCCTGCGGGGGCGGGACGGAGCGGACCCGAGTGATACCCGGGAGA CTAGCTTGGCCACAGGAGACAACGTTGAGGTACAGACAGGATTATTCAAGATCAGGTTGTAGCCATTTTCAACAAGGATCACTGATCAAA ATTTTCTTTTTACAAAGAGATTTACAAGTTAAACATGAAGGGAAAATACTGGAATCATTTGGATTCTGACAGGATAAAGAATACAATATT TCACATTTACTTGTAATGGAACCTTTGTAAGATTCATCACTTGTCATTCACCCAGTTGGGAACATGGATGTTGGTTTTTCTCGTACTACT GTTCAGACACTGTCAAGAAGCCACTGCAAAAACATCAAACAAAAAATTTCTCAATGGGAAGGAAGGGCTAATGGTATATCTAATCCAGAA AAGTGGTGTCCAAAGGACTTTGGAGTGAGATATAACTGTCACCAAGAGATCCGTCTTAAGAAAAATCCTATAGCTGAGAGAAAGAGCAAA AACTTGGATGTAACCAGCCGTGAAAATGTGGGTCTAGATATAAATGAAAATACCAAAAGCCATGATCAAAGTGAGAATGAAAATAAGAAA CATGAATATGACGATACACACTTCTTTAAAAATGAATCAGAATCCAACTGGGTATGTTCTCGGGTCAAAGAAATTGAAAGCTGTAAAGAA GATGTCTTAGATCCAGAGACTTCATTACCTCCAGGAAACTTCTATACCTCACAAATACTGTGGAAGAAAATAGAAGCACTTCCCCCAGAT AAACTCTTAAATTTGGCTTTAGAACATTGTGACTCTTCAGAAAAAGAACTGAACTTCAGAGTTCTGGATAGTTCATACGGAATAACCAAG AGCTTAGAAAATATTTACTCTGAACCTGAGGGGCAAGAATGTGGACCTTCCATAAATCCTTTGCCAAAACCTCGTAGGACATTCAGATAT TTATCCGAATCTGGTGTTACGCCGTATAAAGAAAGAAACTGTGACAAAAAATACTGTGAAAATAACTCTTGTGCACAATCTTCTTTGGCC TCTTCTCAGGAACCTGAACCAAAGAAATATGGTGGAAAAATCAGAGGAAGATCTAAAAGGAAATCCTTTGAATTTGAGGATATTCAGCAC TTTCGAAATCGGAACTCACAGACGATTCGTGAAGAACTTGGAAGAAATTCTGGGTCAGCACTTTATTACACACAGTCTGAGGACAATATC TATGAAGATATCATATATCCCACCAAAGAAAATCCATATGAAGATATTCCAGTGCAGCCTTTACCTATGTGGAGATCCCCTTCAGCATGG AAGCTACCACCCGCTAAAAGTGCTTTTAAAGCACCCAAGCTTGTATTGAAAATAGATGACATATTTGAATCTAAAAGAGGGAAGAAGAAG GTAAAGTTACATTCTTACACTGGAAAGGAATTACCTCCGACAAAAGGAGAGCCTTGTTCTTTTGATGTGGCTATCATTGCTGGTCGCCTT CGGATGTTGGGTGACCAGTTCAACGGAGAATTGGAAGCTTCTGCCAAAAACGTCATTGCAGAAACCATTAAGGGACAGACAGGAGCTATA CTCCAGGACACTGTGGAATCTCTCAGCAAGACCTGGTGTGCTCAGGATTCCAGCTTAGCTTATGAGAGAGCTTTTCTGGCAGTGTCAGTG AAACTTCTTGAGTACATGGCTCACATTGCTCCTGAAGTAGTGGGACAGGTGGCTATCCCCATGACGGGTATGATCAATGGGAACCAAGCC ATCCGGGAGTTCATCCAGGGCCAGGGAGGTTGGGAAAATCTGGAGAGCTGAAGAGTTGGAGCTATTCACGAGACTGAACATCACTTCCTT GTTGACTGATTGGGTGATTGATTCCTGGGAATTCAAACAAACAAATAAAAAAGCACTTTTTTCATTTTATCAGAACTGAACTTAGCTGAA TAAGTTATTTTTTACTGATTGTTAAAGTTGGGAGCAGCTGCCAGAGGCCTGCAGAGTTGGTTTTTGTTTTGTTTTGTTTTGTCAACTTAA TGCAAACCACAGAGATTTTCTACTTTCTGTTTTCACATGAGTTTTAATGAGGTTCTGTTGAAGCAAAGACCCCTAGACACAAAGTAATGA CTTGTTAGTAGTGGAATTATAAGCAACAGGGCAGGCCTTTGCTGGAGGTATTTTGAGAGAAAGGGAGAACAATGGAAACTATTTCTTCAG >In-frame_DENND2C_ENST00000393274_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_2735nt TGATACCCGGGAGACTAGCTTGGCCACAGGAGACAACGTTGAGGTACAGACAGGTGGCAGAGAAACAAACATCGGTATTGCTTAAACCAC TTGCTATTTCCAGTTCCGGCTGTATGTACCAAAACTTAATCTTATATAGTACCCCAAAGAGGTGCTATGAAAATTAATTGTGATAGTGTG ATTGAAGTGATTGGCACATAGTATTTAACAAAATATTTAATGAAGTGTAATCACTGTTCTTGCTGTTTTAATTCTCACAATACTCTGTAT GAAGTGGGTGTTCAATAAGTATTTGATGAATCTTTAAAAATTTGCTAGGTCTACCATAACCAAATACCGCAGATTGAGTGGTTCAAACGC CAGAGATTGATATTCTCACAAGTCTGGAGGCTGTAGAAATCTAACATCAAGGTGCCAACAGGGATTATTCAAGATCAGGTTGTAGCCATT TTCAACAAGGATCACTGATCAAAATTTTCTTTTTACAAAGAGATTTACAAGTTAAACATGAAGGGAAAATACTGGAATCATTTGGATTCT GACAGGATAAAGAATACAATATTTCACATTTACTTGTAATGGAACCTTTGTAAGATTCATCACTTGTCATTCACCCAGTTGGGAACATGG ATGTTGGTTTTTCTCGTACTACTGTTCAGACACTGTCAAGAAGCCACTGCAAAAACATCAAACAAAAAATTTCTCAATGGGAAGGAAGGG CTAATGGTATATCTAATCCAGAAAAGTGGTGTCCAAAGGACTTTGGAGTGAGATATAACTGTCACCAAGAGATCCGTCTTAAGAAAAATC CTATAGCTGAGAGAAAGAGCAAAAACTTGGATGTAACCAGCCGTGAAAATGTGGGTCTAGATATAAATGAAAATACCAAAAGCCATGATC AAAGTGAGAATGAAAATAAGAAACATGAATATGACGATACACACTTCTTTAAAAATGAATCAGAATCCAACTGGGTATGTTCTCGGGTCA AAGAAATTGAAAGCTGTAAAGAAGATGTCTTAGATCCAGAGACTTCATTACCTCCAGGAAACTTCTATACCTCACAAATACTGTGGAAGA AAATAGAAGCACTTCCCCCAGATAAACTCTTAAATTTGGCTTTAGAACATTGTGACTCTTCAGAAAAAGAACTGAACTTCAGAGTTCTGG ATAGTTCATACGGAATAACCAAGAGCTTAGAAAATATTTACTCTGAACCTGAGGGGCAAGAATGTGGACCTTCCATAAATCCTTTGCCAA AACCTCGTAGGACATTCAGATATTTATCCGAATCTGGTGTTACGCCGTATAAAGAAAGAAACTGTGACAAAAAATACTGTGAAAATAACT CTTGTGCACAATCTTCTTTGGCCTCTTCTCAGGAACCTGAACCAAAGAAATATGGTGGAAAAATCAGAGGAAGATCTAAAAGGAAATCCT TTGAATTTGAGGATATTCAGCACTTTCGAAATCGGAACTCACAGACGATTCGTGAAGAACTTGGAAGAAATTCTGGGTCAGCACTTTATT ACACACAGTCTGAGGACAATATCTATGAAGATATCATATATCCCACCAAAGAAAATCCATATGAAGATATTCCAGTGCAGCCTTTACCTA TGTGGAGATCCCCTTCAGCATGGAAGCTACCACCCGCTAAAAGTGCTTTTAAAGCACCCAAGCTCCCTCCAAAACCTCAGTTCCTTCACC GGAAGACTATGGAAGTAAAGAACTCACAGGCTTATTTGCGGTCAAAGCTTACAAAAGATACAACTTTGCCGGTCACTTTAACGGAATGGA AGCTTTTCCGAGCTGGTGAAGTTGCAAACACGAAAAGGAAAAATCTTCCAAGGCTTGTATTGAAAATAGATGACATATTTGAATCTAAAA GAGGGAAGAAGAAGGTAAAGTTACATTCTTACACTGGAAAGGAATTACCTCCGACAAAAGGAGAGCCTTGTTCTTTTGATGTGGCTATCA TTGCTGGTCGCCTTCGGATGTTGGGTGACCAGTTCAACGGAGAATTGGAAGCTTCTGCCAAAAACGTCATTGCAGAAACCATTAAGGGAC AGACAGGAGCTATACTCCAGGACACTGTGGAATCTCTCAGCAAGACCTGGTGTGCTCAGGATTCCAGCTTAGCTTATGAGAGAGCTTTTC TGGCAGTGTCAGTGAAACTTCTTGAGTACATGGCTCACATTGCTCCTGAAGTAGTGGGACAGGTGGCTATCCCCATGACGGGTATGATCA ATGGGAACCAAGCCATCCGGGAGTTCATCCAGGGCCAGGGAGGTTGGGAAAATCTGGAGAGCTGAAGAGTTGGAGCTATTCACGAGACTG AACATCACTTCCTTGTTGACTGATTGGGTGATTGATTCCTGGGAATTCAAACAAACAAATAAAAAAGCACTTTTTTCATTTTATCAGAAC TGAACTTAGCTGAATAAGTTATTTTTTACTGATTGTTAAAGTTGGGAGCAGCTGCCAGAGGCCTGCAGAGTTGGTTTTTGTTTTGTTTTG TTTTGTCAACTTAATGCAAACCACAGAGATTTTCTACTTTCTGTTTTCACATGAGTTTTAATGAGGTTCTGTTGAAGCAAAGACCCCTAG ACACAAAGTAATGACTTGTTAGTAGTGGAATTATAAGCAACAGGGCAGGCCTTTGCTGGAGGTATTTTGAGAGAAAGGGAGAACAATGGA >In-frame_DENND2C_ENST00000393277_chr1_115161007_-_BCL2L15_ENST00000393316_chr1_114429280_-_2442nt GGGGCTAGGGGGTGGGGCTGCAGCCGGGACGGGGCCTTCGGCAGGGCCTGCGGGGGCGGGACGGAGCGGACCCGAGTGATACCCGGGAGA CTAGCTTGGCCACAGGAGACAACGTTGAGGTACAGACAGGATTATTCAAGATCAGGTTGTAGCCATTTTCAACAAGGATCACTGATCAAA ATTTTCTTTTTACAAAGAGATTTACAAGTTAAACATGAAGGGAAAATACTGGAATCATTTGGATTCTGACAGGATAAAGAATACAATATT TCACATTTACTTGTAATGGAACCTTTGTAAGATTCATCACTTGTCATTCACCCAGTTGGGAACATGGATGTTGGTTTTTCTCGTACTACT GTTCAGACACTGTCAAGAAGCCACTGCAAAAACATCAAACAAAAAATTTCTCAATGGGAAGGAAGGGCTAATGGTATATCTAATCCAGAA AAGTGGTGTCCAAAGGACTTTGGAGTGAGATATAACTGTCACCAAGAGATCCGTCTTAAGAAAAATCCTATAGCTGAGAGAAAGAGCAAA AACTTGGATGTAACCAGCCGTGAAAATGTGGGTCTAGATATAAATGAAAATACCAAAAGCCATGATCAAAGTGAGAATGAAAATAAGAAA CATGAATATGACGATACACACTTCTTTAAAAATGAATCAGAATCCAACTGGGTATGTTCTCGGGTCAAAGAAATTGAAAGCTGTAAAGAA GATGTCTTAGATCCAGAGACTTCATTACCTCCAGGAAACTTCTATACCTCACAAATACTGTGGAAGAAAATAGAAGCACTTCCCCCAGAT AAACTCTTAAATTTGGCTTTAGAACATTGTGACTCTTCAGAAAAAGAACTGAACTTCAGAGTTCTGGATAGTTCATACGGAATAACCAAG AGCTTAGAAAATATTTACTCTGAACCTGAGGGGCAAGAATGTGGACCTTCCATAAATCCTTTGCCAAAACCTCGTAGGACATTCAGATAT TTATCCGAATCTGGTGTTACGCCGTATAAAGAAAGAAACTGTGACAAAAAATACTGTGAAAATAACTCTTGTGCACAATCTTCTTTGGCC TCTTCTCAGGAACCTGAACCAAAGAAATATGGTGGAAAAATCAGAGGAAGATCTAAAAGGAAATCCTTTGAATTTGAGGATATTCAGCAC TTTCGAAATCGGAACTCACAGACGATTCGTGAAGAACTTGGAAGAAATTCTGGGTCAGCACTTTATTACACACAGTCTGAGGACAATATC TATGAAGATATCATATATCCCACCAAAGAAAATCCATATGAAGATATTCCAGTGCAGCCTTTACCTATGTGGAGATCCCCTTCAGCATGG AAGCTACCACCCGCTAAAAGTGCTTTTAAAGCACCCAAGCTCCCTCCAAAACCTCAGTTCCTTCACCGGAAGACTATGGAAGTAAAGAAC TCACAGGCTTATTTGCGGTCAAAGCTTACAAAAGATACAACTTTGCCGGTCACTTTAACGGAATGGAAGCTTTTCCGAGCTGGTGAAGTT GCAAACACGAAAAGGAAAAATCTTCCAAGGCTTGTATTGAAAATAGATGACATATTTGAATCTAAAAGAGGGAAGAAGAAGGTAAAGTTA CATTCTTACACTGGAAAGGAATTACCTCCGACAAAAGGAGAGCCTTGTTCTTTTGATGTGGCTATCATTGCTGGTCGCCTTCGGATGTTG GGTGACCAGTTCAACGGAGAATTGGAAGCTTCTGCCAAAAACGTCATTGCAGAAACCATTAAGGGACAGACAGGAGCTATACTCCAGGAC ACTGTGGAATCTCTCAGCAAGACCTGGTGTGCTCAGGATTCCAGCTTAGCTTATGAGAGAGCTTTTCTGGCAGTGTCAGTGAAACTTCTT GAGTACATGGCTCACATTGCTCCTGAAGTAGTGGGACAGGTGGCTATCCCCATGACGGGTATGATCAATGGGAACCAAGCCATCCGGGAG TTCATCCAGGGCCAGGGAGGTTGGGAAAATCTGGAGAGCTGAAGAGTTGGAGCTATTCACGAGACTGAACATCACTTCCTTGTTGACTGA TTGGGTGATTGATTCCTGGGAATTCAAACAAACAAATAAAAAAGCACTTTTTTCATTTTATCAGAACTGAACTTAGCTGAATAAGTTATT TTTTACTGATTGTTAAAGTTGGGAGCAGCTGCCAGAGGCCTGCAGAGTTGGTTTTTGTTTTGTTTTGTTTTGTCAACTTAATGCAAACCA CAGAGATTTTCTACTTTCTGTTTTCACATGAGTTTTAATGAGGTTCTGTTGAAGCAAAGACCCCTAGACACAAAGTAATGACTTGTTAGT AGTGGAATTATAAGCAACAGGGCAGGCCTTTGCTGGAGGTATTTTGAGAGAAAGGGAGAACAATGGAAACTATTTCTTCAGATGTAGCCC 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FusionGenePPI for DENND2C_BCL2L15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DENND2C | LYN, HID1, ARHGAP42 | BCL2L15 | MEOX2, SDCBP, TEAD2, BAX, MANF |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DENND2C_BCL2L15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND2C_BCL2L15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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