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Fusion gene ID: 9717 |
FusionGeneSummary for DENND1B_ATP6V1G3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DENND1B_ATP6V1G3 | Fusion gene ID: 9717 | Hgene | Tgene | Gene symbol | DENND1B | ATP6V1G3 | Gene ID | 163486 | 127124 |
| Gene name | DENN domain containing 1B | ATPase H+ transporting V1 subunit G3 | |
| Synonyms | C1ORF18|C1orf218|FAM31B | ATP6G3|Vma10 | |
| Cytomap | 1q31.3 | 1q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member B | V-type proton ATPase subunit G 3ATPase, H+ transporting, lysosomal (vacuolar proton pump) subunit G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3V-ATPase 13 kDa subunit 3V-ATPase G subunit 3V-ATPase G3 subunitV-ATPase subunit G 3vacuolar | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q6P3S1 | Q96LB4 | |
| Ensembl transtripts involved in fusion gene | ENST00000400967, ENST00000235453, ENST00000367396, ENST00000477581, | ENST00000367382, ENST00000309309, ENST00000281087, ENST00000367381, ENST00000489986, | |
| Fusion gene scores | * DoF score | 7 X 3 X 5=105 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DENND1B [Title/Abstract] AND ATP6V1G3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-A92D-01A | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000400967 | ENST00000367382 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| In-frame | ENST00000400967 | ENST00000309309 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000400967 | ENST00000281087 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000400967 | ENST00000367381 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000400967 | ENST00000489986 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000235453 | ENST00000367382 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000235453 | ENST00000309309 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000235453 | ENST00000281087 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000235453 | ENST00000367381 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000235453 | ENST00000489986 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000367396 | ENST00000367382 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| In-frame | ENST00000367396 | ENST00000309309 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000367396 | ENST00000281087 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000367396 | ENST00000367381 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| Frame-shift | ENST00000367396 | ENST00000489986 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| intron-3CDS | ENST00000477581 | ENST00000367382 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| intron-3CDS | ENST00000477581 | ENST00000309309 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| intron-3CDS | ENST00000477581 | ENST00000281087 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| intron-3CDS | ENST00000477581 | ENST00000367381 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
| intron-3CDS | ENST00000477581 | ENST00000489986 | DENND1B | chr1 | 197684161 | - | ATP6V1G3 | chr1 | 198498311 | - |
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FusionProtFeatures for DENND1B_ATP6V1G3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DENND1B | ATP6V1G3 |
| Catalytic subunit of the peripheral V1 complex ofvacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifyinga variety of intracellular compartments in eukaryotic cells. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DENND1B_ATP6V1G3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DENND1B_ENST00000400967_chr1_197684161_-_ATP6V1G3_ENST00000309309_chr1_198498311_-_49aa >In-frame_DENND1B_ENST00000367396_chr1_197684161_-_ATP6V1G3_ENST00000309309_chr1_198498311_-_59aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DENND1B_ENST00000400967_chr1_197684161_-_ATP6V1G3_ENST00000309309_chr1_198498311_-_148nt ATGGCGGCAGCTCCACGGGAGGAGAAAAGATGGCCCCAACCTGTATTTTCGAATCCTGTGGTATTGTGGAAATTCCCAGAGGACTTTGGA >In-frame_DENND1B_ENST00000367396_chr1_197684161_-_ATP6V1G3_ENST00000309309_chr1_198498311_-_178nt ATGGACTGCAGGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGATCCTGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DENND1B_ENST00000400967_chr1_197684161_-_ATP6V1G3_ENST00000309309_chr1_198498311_-_540nt ATGGCGGCAGCTCCACGGGAGGAGAAAAGATGGCCCCAACCTGTATTTTCGAATCCTGTGGTATTGTGGAAATTCCCAGAGGACTTTGGA GACCAGGAAAAGGAAAGCGATTGAAGCAAGCCAAGGAGGAAGCAATGGTAGAAATTGACCAGTACAGAATGCAGAGAGATAAAGAGTTTC GACTAAAACAATCTAAGATAATGGGCTCTCAGAATAATCTCTCAGATGAAATAGAAGAACAAACACTAGGGAAGATACAAGAACTTAATG GACACTACAATAAGTATATGGAAAGTGTGATGAACCAGCTCTTGAGCATGGTCTGTGACATGAAACCAGAAATCCATGTGAACTACAGAG CCACCAACTAAATGTACATCACAGTTTTCAAGAAAAAAAAAGGTGTGTGAGTGCCACCTGGTTGCTTATGGCTTCGTATTTTTATGTTGA GAAATTTGAAATGAGAACCTTAAATTTACATTTACAGGAAATGTGACATAACTCATACATCGGCACTGAATTAAACAAAACAAAATACAA >In-frame_DENND1B_ENST00000367396_chr1_197684161_-_ATP6V1G3_ENST00000309309_chr1_198498311_-_740nt GCCGGGGGCGCAGCCGACATGGGCCCGCCGCCACGGCTGCTGTGAGCAGCCTCTTTCCCTGTGTGGCCGCCGGCGTGGGCGGGGACGGCG CGACCCTCGCGCGGCCGGGCTGCGGGCTTCCAGGCCAGCGCGCGGGGGCCGGACGGACAGCCCCACACCGACATGTAACCATGGACTGCA GGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGATCCTGTGGTATTGTGGA AATTCCCAGAGGACTTTGGAGACCAGGAAAAGGAAAGCGATTGAAGCAAGCCAAGGAGGAAGCAATGGTAGAAATTGACCAGTACAGAAT GCAGAGAGATAAAGAGTTTCGACTAAAACAATCTAAGATAATGGGCTCTCAGAATAATCTCTCAGATGAAATAGAAGAACAAACACTAGG GAAGATACAAGAACTTAATGGACACTACAATAAGTATATGGAAAGTGTGATGAACCAGCTCTTGAGCATGGTCTGTGACATGAAACCAGA AATCCATGTGAACTACAGAGCCACCAACTAAATGTACATCACAGTTTTCAAGAAAAAAAAAGGTGTGTGAGTGCCACCTGGTTGCTTATG GCTTCGTATTTTTATGTTGAGAAATTTGAAATGAGAACCTTAAATTTACATTTACAGGAAATGTGACATAACTCATACATCGGCACTGAA |
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FusionGenePPI for DENND1B_ATP6V1G3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DENND1B | SERPINA12, XPO1 | ATP6V1G3 | MTMR4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DENND1B_ATP6V1G3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND1B_ATP6V1G3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DENND1B | C0010346 | Crohn Disease | 1 | CTD_human |
| Hgene | DENND1B | C0023892 | Biliary cirrhosis | 1 | CTD_human |
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