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Fusion gene ID: 9709 |
FusionGeneSummary for DENND1A_LRRC69 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DENND1A_LRRC69 | Fusion gene ID: 9709 | Hgene | Tgene | Gene symbol | DENND1A | LRRC69 | Gene ID | 57706 | 100130742 |
| Gene name | DENN domain containing 1A | leucine rich repeat containing 69 | |
| Synonyms | FAM31A|KIAA1608 | - | |
| Cytomap | 9q33.3 | 8q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1 | leucine-rich repeat-containing protein 69 | |
| Modification date | 20180523 | 20180402 | |
| UniProtAcc | Q8TEH3 | Q6ZNQ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000473039, ENST00000373624, ENST00000542603, ENST00000394219, ENST00000373620, ENST00000394215, ENST00000373618, | ENST00000343709, ENST00000448384, ENST00000521519, | |
| Fusion gene scores | * DoF score | 13 X 8 X 10=1040 | 2 X 2 X 2=8 |
| # samples | 14 | 2 | |
| ** MAII score | log2(14/1040*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DENND1A [Title/Abstract] AND LRRC69 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DENND1A | GO:0032483 | regulation of Rab protein signal transduction | 20937701 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0T1-01A | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000473039 | ENST00000343709 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| 5UTR-3CDS | ENST00000473039 | ENST00000448384 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| 5UTR-intron | ENST00000473039 | ENST00000521519 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| In-frame | ENST00000373624 | ENST00000343709 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| Frame-shift | ENST00000373624 | ENST00000448384 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| 5CDS-intron | ENST00000373624 | ENST00000521519 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| intron-3CDS | ENST00000542603 | ENST00000343709 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| intron-3CDS | ENST00000542603 | ENST00000448384 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| intron-intron | ENST00000542603 | ENST00000521519 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| In-frame | ENST00000394219 | ENST00000343709 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| Frame-shift | ENST00000394219 | ENST00000448384 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| 5CDS-intron | ENST00000394219 | ENST00000521519 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| In-frame | ENST00000373620 | ENST00000343709 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| Frame-shift | ENST00000373620 | ENST00000448384 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| 5CDS-intron | ENST00000373620 | ENST00000521519 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| Frame-shift | ENST00000394215 | ENST00000343709 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| In-frame | ENST00000394215 | ENST00000448384 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| 5CDS-intron | ENST00000394215 | ENST00000521519 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| Frame-shift | ENST00000373618 | ENST00000343709 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| In-frame | ENST00000373618 | ENST00000448384 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
| 5CDS-intron | ENST00000373618 | ENST00000521519 | DENND1A | chr9 | 126519982 | - | LRRC69 | chr8 | 92231118 | + |
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FusionProtFeatures for DENND1A_LRRC69 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DENND1A | LRRC69 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DENND1A_LRRC69 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DENND1A_ENST00000373624_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_137aa MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLS >In-frame_DENND1A_ENST00000394219_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_105aa MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILRTGRXARIXSWCLSKYXFVLTN >In-frame_DENND1A_ENST00000373620_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_137aa MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLS >In-frame_DENND1A_ENST00000394215_chr9_126519982_-_LRRC69_ENST00000448384_chr8_92231118_+_107aa MLKWPIPGQVALFQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILRTGRXARIXSWCLSKYXFVL >In-frame_DENND1A_ENST00000373618_chr9_126519982_-_LRRC69_ENST00000448384_chr8_92231118_+_105aa MLKWPIPGQVALFQILRCRGNSRRTTVTSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILRTGRXARIXSWCLSKYXFVLTN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DENND1A_ENST00000373624_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_413nt ATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGAT CCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGAC AGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCT TCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTT >In-frame_DENND1A_ENST00000394219_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_317nt ATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTC ACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGA GCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTTACAAAT >In-frame_DENND1A_ENST00000373620_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_413nt ATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGAT CCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGAC AGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCT TCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTT >In-frame_DENND1A_ENST00000394215_chr9_126519982_-_LRRC69_ENST00000448384_chr8_92231118_+_323nt ATGTTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGAC AGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCT TCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTT >In-frame_DENND1A_ENST00000373618_chr9_126519982_-_LRRC69_ENST00000448384_chr8_92231118_+_317nt ATGTTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGCCTC ACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGA GCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTTACAAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DENND1A_ENST00000373624_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_742nt GCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGA GGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGG CCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAG GACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTCTACAGACTTTGACCAAGTT TTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAG ATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCT CTCCAAGTATTAATTTGTTCTTACAAATGTTTTACTCAACGTGACCCTAACCTCTTTGGAATTGCTCAGGTGTAGAACAGGTGAGGTGCT CATTCATAGCCTCACTCCACTTGCCCTGTCAGCTCTGCATACACAGATTATGCCCTACTTAAGATACCATGCCTGTTCTCTTTGTCAACA >In-frame_DENND1A_ENST00000394219_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_634nt GACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCC AGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGC CCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGT GGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTT ATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGT TCTTACAAATGTTTTACTCAACGTGACCCTAACCTCTTTGGAATTGCTCAGGTGTAGAACAGGTGAGGTGCTCATTCATAGCCTCACTCC ACTTGCCCTGTCAGCTCTGCATACACAGATTATGCCCTACTTAAGATACCATGCCTGTTCTCTTTGTCAACACATTAAATAAAGGAAGAA >In-frame_DENND1A_ENST00000373620_chr9_126519982_-_LRRC69_ENST00000343709_chr8_92231118_+_761nt ACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGAGCGAGCCTCGAG CGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGCGGGCAGCGCAGC GCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACATTTGAAGTATATG TTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCCGGAGGACTACAGTGACCAGGAAGTTC TACAGACTTTGACCAAGTTTTGTTTCCCCTTCTATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTG ACATTGACAGCAAACAGAGATTCGGGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAA GAATCTGAAGCTGGTGCCTCTCCAAGTATTAATTTGTTCTTACAAATGTTTTACTCAACGTGACCCTAACCTCTTTGGAATTGCTCAGGT GTAGAACAGGTGAGGTGCTCATTCATAGCCTCACTCCACTTGCCCTGTCAGCTCTGCATACACAGATTATGCCCTACTTAAGATACCATG >In-frame_DENND1A_ENST00000394215_chr9_126519982_-_LRRC69_ENST00000448384_chr8_92231118_+_602nt CGCGCGCCGGGCACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCGGCGGCGGCGAGGGA GCGAGCCTCGAGCGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTCGGCCGCGGGCGGGC GGGCAGCGCAGCGCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAATCCAGAGACCACAT TTGAAGTATATGTTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGGAAGTTCTACAGACTTTGACCAAGTTTTGTTTCCCCTTC TATGTGGACAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCGGGTTCTGC CGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCAAGTATTAA >In-frame_DENND1A_ENST00000373618_chr9_126519982_-_LRRC69_ENST00000448384_chr8_92231118_+_610nt GGCGGAGGGGGCGGCGCGCGCCGGGCACGCGCGCCGGCGACCATGGCGTTCGCCGGGCTGGAGCGAGTACATTAACCCCTGGAGGCGGCG GCGGCGGCGAGGGAGCGAGCCTCGAGCGGGCGGGCCCCAGCCTGAGGGAAGGGAGGAAGGGGCGGGGAGAGCGCCAGAGGGAGGCCGGTC GGCCGCGGGCGGGCGGGCAGCGCAGCGCCGAGCGGGGCCCGCGGGCCCATGAGGAGGCCTGGGGACCATGGGCTCCAGGATCAAGCAGAA TCCAGAGACCACATTTGAAGTATATGTTGAAGTGGCCTATCCCAGGACAGGTGGCACTCTTTCAGATCCTGAGGTGCAGAGGCAATTCCC GGAGGACTACAGTGACCAGCCTCACAGTTAGCCAAGTTGGCCAGAACTTCACATTCGTGCTCACTGACATTGACAGCAAACAGAGATTCG GGTTCTGCCGCTTATCTTCAGGAGCGAAGAGCTGCTTCTGTATCTTAAGGACTGGAAGATAAGCAAGAATCTGAAGCTGGTGCCTCTCCA |
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FusionGenePPI for DENND1A_LRRC69 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DENND1A | YWHAB, XPO1, CLTB, CLTC, GAK, PICALM, ANAPC15, LIMA1, GTSE1, ATL2, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, RTKN, CGN, MAST3, DENND4C, MAGI1, TESK2, DCLK1, PPM1H, ZNF638, SRSF12, MAPKAP1, SYDE1, AGAP1, CDC25B, CDK16, HDAC4, FAM110B, USP21, NF1, ANKRD34A, LPIN3, FAM53C, CBY1, NADK, FAM110A, CDC25C, TIAM1, KIAA1804, CAMSAP2, RASAL2, PHLDB2, GIGYF2, SH3RF3, PLEKHA7, MELK, KIF1C, GAB2, TBC1D25, NAV1, TANC2, DENND4A, PTPN13, RPTOR, RALGPS2, PTPN14, DEPDC1B, STARD13, OSBPL6, HDAC7, MLLT4, LARP1, PLEKHA5, EDC3, RAB11FIP2, SH3BP4, CHEK1, KIF1B, INPP5E | LRRC69 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DENND1A_LRRC69 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND1A_LRRC69 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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