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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9701

FusionGeneSummary for DEK_DEK

check button Fusion gene summary
Fusion gene informationFusion gene name: DEK_DEK
Fusion gene ID: 9701
HgeneTgene
Gene symbol

DEK

DEK

Gene ID

7913

7913

Gene nameDEK proto-oncogeneDEK proto-oncogene
SynonymsD6S231ED6S231E
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein DEKDEK oncogene (DNA binding)protein DEKDEK oncogene (DNA binding)
Modification date2018052720180527
UniProtAcc

P35659

P35659

Ensembl transtripts involved in fusion geneENST00000397239, ENST00000244776, 
ENST00000397239, ENST00000244776, 
Fusion gene scores* DoF score4 X 7 X 3=843 X 6 X 1=18
# samples 76
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/18*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DEK [Title/Abstract] AND DEK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ214682DEKchr6

18224464

+DEKchr6

18225752

-
ChiTaRS3.1BF034427DEKchr6

18224734

+DEKchr6

18224836

-
ChiTaRS3.1L44569DEKchr6

18258638

+DEKchr6

18236683

+
ChiTaRS3.1BM466063DEKchr6

18225161

-DEKchr6

18225235

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000397239ENST00000397239DEKchr6

18224464

+DEKchr6

18225752

-
intron-3UTRENST00000397239ENST00000244776DEKchr6

18224464

+DEKchr6

18225752

-
intron-3UTRENST00000244776ENST00000397239DEKchr6

18224464

+DEKchr6

18225752

-
intron-3UTRENST00000244776ENST00000244776DEKchr6

18224464

+DEKchr6

18225752

-
intron-3UTRENST00000397239ENST00000397239DEKchr6

18224734

+DEKchr6

18224836

-
intron-intronENST00000397239ENST00000244776DEKchr6

18224734

+DEKchr6

18224836

-
intron-3UTRENST00000244776ENST00000397239DEKchr6

18224734

+DEKchr6

18224836

-
intron-intronENST00000244776ENST00000244776DEKchr6

18224734

+DEKchr6

18224836

-
intron-intronENST00000397239ENST00000397239DEKchr6

18258638

+DEKchr6

18236683

+
intron-intronENST00000397239ENST00000244776DEKchr6

18258638

+DEKchr6

18236683

+
intron-intronENST00000244776ENST00000397239DEKchr6

18258638

+DEKchr6

18236683

+
intron-intronENST00000244776ENST00000244776DEKchr6

18258638

+DEKchr6

18236683

+
intron-3UTRENST00000397239ENST00000397239DEKchr6

18225161

-DEKchr6

18225235

+
intron-intronENST00000397239ENST00000244776DEKchr6

18225161

-DEKchr6

18225235

+
intron-3UTRENST00000244776ENST00000397239DEKchr6

18225161

-DEKchr6

18225235

+
intron-intronENST00000244776ENST00000244776DEKchr6

18225161

-DEKchr6

18225235

+

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FusionProtFeatures for DEK_DEK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DEK

P35659

DEK

P35659

Involved in chromatin organization.{ECO:0000269|PubMed:17524367}. Involved in chromatin organization.{ECO:0000269|PubMed:17524367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DEK_DEK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DEK_DEK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DEKTFAP2A, SRSF2, SRRM1, H2AFY, KHDRBS2, HIST1H1A, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, BAZ1B, DAXX, HDAC2, CREBBP, EP300, KAT2B, RAD21, HDGF, ELAVL1, CDK2, COPS5, CAND1, WIBG, DHX15, UTP14A, FTSJ3, S100A9, RPL37A, THRAP3, EXOSC2, VTN, TMED9, ESR1, TP53BP1, CSNK2A1, GANAB, IRF2BP2, PTPN12, CSNK2A2, SPOP, HIST3H3, CUL7, OBSL1, EED, BPTF, SFN, XPO1, RPL10, NOP56, MMGT1, RBPJ, POU5F1, NFATC2, BMI1, CDC14B, FOXA1DEKTFAP2A, SRSF2, SRRM1, H2AFY, KHDRBS2, HIST1H1A, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, BAZ1B, DAXX, HDAC2, CREBBP, EP300, KAT2B, RAD21, HDGF, ELAVL1, CDK2, COPS5, CAND1, WIBG, DHX15, UTP14A, FTSJ3, S100A9, RPL37A, THRAP3, EXOSC2, VTN, TMED9, ESR1, TP53BP1, CSNK2A1, GANAB, IRF2BP2, PTPN12, CSNK2A2, SPOP, HIST3H3, CUL7, OBSL1, EED, BPTF, SFN, XPO1, RPL10, NOP56, MMGT1, RBPJ, POU5F1, NFATC2, BMI1, CDC14B, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DEK_DEK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DEK_DEK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDEKC0027626Neoplasm Invasiveness1CTD_human
TgeneDEKC0027626Neoplasm Invasiveness1CTD_human