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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9686

FusionGeneSummary for DEDD2_LIPE

check button Fusion gene summary
Fusion gene informationFusion gene name: DEDD2_LIPE
Fusion gene ID: 9686
HgeneTgene
Gene symbol

DEDD2

LIPE

Gene ID

162989

3991

Gene namedeath effector domain containing 2lipase E, hormone sensitive type
SynonymsFLAME-3|FLAME3AOMS4|FPLD6|HSL|LHS
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionDNA-binding death effector domain-containing protein 2DED-containing protein FLAME-3FADD-like anti-apoptotic molecule 3hormone-sensitive lipasehormone-sensitive lipase testicular isoformlipase, hormone-sensitive
Modification date2018052320180519
UniProtAcc

Q8WXF8

Q05469

Ensembl transtripts involved in fusion geneENST00000336034, ENST00000595337, 
ENST00000593804, ENST00000596251, 
ENST00000598727, 
ENST00000244289, 
ENST00000602000, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DEDD2 [Title/Abstract] AND LIPE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDEDD2

GO:0030262

apoptotic nuclear changes

11741985


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0797-01ADEDD2chr19

42713851

-LIPEchr19

42912268

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000336034ENST00000244289DEDD2chr19

42713851

-LIPEchr19

42912268

-
5CDS-5UTRENST00000336034ENST00000602000DEDD2chr19

42713851

-LIPEchr19

42912268

-
Frame-shitENST00000595337ENST00000244289DEDD2chr19

42713851

-LIPEchr19

42912268

-
5CDS-5UTRENST00000595337ENST00000602000DEDD2chr19

42713851

-LIPEchr19

42912268

-
5UTR-3CDSENST00000593804ENST00000244289DEDD2chr19

42713851

-LIPEchr19

42912268

-
5UTR-5UTRENST00000593804ENST00000602000DEDD2chr19

42713851

-LIPEchr19

42912268

-
Frame-shitENST00000596251ENST00000244289DEDD2chr19

42713851

-LIPEchr19

42912268

-
5CDS-5UTRENST00000596251ENST00000602000DEDD2chr19

42713851

-LIPEchr19

42912268

-
Frame-shitENST00000598727ENST00000244289DEDD2chr19

42713851

-LIPEchr19

42912268

-
5CDS-5UTRENST00000598727ENST00000602000DEDD2chr19

42713851

-LIPEchr19

42912268

-

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FusionProtFeatures for DEDD2_LIPE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DEDD2

Q8WXF8

LIPE

Q05469

May play a critical role in death receptor-inducedapoptosis and may target CASP8 and CASP10 to the nucleus. Mayregulate degradation of intermediate filaments during apoptosis.May play a role in the general transcription machinery in thenucleus and might be an important regulator of the activity ofGTF3C3. In adipose tissue and heart, it primarily hydrolyzesstored triglycerides to free fatty acids, while in steroidogenictissues, it principally converts cholesteryl esters to freecholesterol for steroid hormone production.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DEDD2_LIPE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DEDD2_LIPE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DEDD2CFLAR, DEDD, CASP8, CASP10, DEDD2, GTF3C3, HNRNPAB, NR2E3, RBFOX2, RHOXF2, CDK6, ATG16L1, CDCA7LLIPENSFL1C, PTRF, PLIN1, FABP4, PLIN5, PLIN2, PLIN3, MTNR1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DEDD2_LIPE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DEDD2_LIPE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource