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Fusion gene ID: 9646 |
FusionGeneSummary for DDX58_PRSS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX58_PRSS3 | Fusion gene ID: 9646 | Hgene | Tgene | Gene symbol | DDX58 | PRSS3 | Gene ID | 23586 | 5646 |
| Gene name | DExD/H-box helicase 58 | serine protease 3 | |
| Synonyms | RIG-I|RIGI|RLR-1|SGMRT2 | MTG|PRSS4|T9|TRY3|TRY4 | |
| Cytomap | 9p21.1 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58DEAD box protein 58DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptideRNA helicase RIG-Iretinoic acid-inducible gene 1 proteinretinoic acid-inducible gene I protein | trypsin-3brain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine 3protease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsinogen 4trypsinogen 5trypsinogen IV | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | O95786 | P35030 | |
| Ensembl transtripts involved in fusion gene | ENST00000379882, ENST00000379868, ENST00000379883, ENST00000545044, ENST00000542096, | ENST00000361005, ENST00000342836, ENST00000429677, ENST00000379405, ENST00000495682, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 7 X 2 X 6=84 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DDX58 [Title/Abstract] AND PRSS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDX58 | GO:0009597 | detection of virus | 17079289 |
| Hgene | DDX58 | GO:0010628 | positive regulation of gene expression | 24409285 |
| Hgene | DDX58 | GO:0030334 | regulation of cell migration | 19122199 |
| Hgene | DDX58 | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production | 24409285 |
| Hgene | DDX58 | GO:0032727 | positive regulation of interferon-alpha production | 19576794 |
| Hgene | DDX58 | GO:0032728 | positive regulation of interferon-beta production | 17079289 |
| Hgene | DDX58 | GO:0032755 | positive regulation of interleukin-6 production | 24409285 |
| Hgene | DDX58 | GO:0032757 | positive regulation of interleukin-8 production | 24409285 |
| Hgene | DDX58 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17079289 |
| Hgene | DDX58 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 17079289 |
| Hgene | DDX58 | GO:0051607 | defense response to virus | 21478870 |
| Tgene | PRSS3 | GO:0006508 | proteolysis | 6698368 |
| Tgene | PRSS3 | GO:0031638 | zymogen activation | 6698368 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4444-01A | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000379882 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-3CDS | ENST00000379882 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-3CDS | ENST00000379882 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-3CDS | ENST00000379882 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| intron-intron | ENST00000379882 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000379868 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-intron | ENST00000379868 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| In-frame | ENST00000379883 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5CDS-intron | ENST00000379883 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000545044 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-intron | ENST00000545044 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000361005 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000342836 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000429677 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-3CDS | ENST00000542096 | ENST00000379405 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
| 5UTR-intron | ENST00000542096 | ENST00000495682 | DDX58 | chr9 | 32500803 | - | PRSS3 | chr9 | 33796641 | + |
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FusionProtFeatures for DDX58_PRSS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX58 | PRSS3 |
| Innate immune receptor which acts as a cytoplasmicsensor of viral nucleic acids and plays a major role in sensingviral infection and in the activation of a cascade of antiviralresponses including the induction of type I interferons andproinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb inlength). In addition to the 5'-triphosphate moiety, blunt-end basepairing at the 5'-end of the RNA is very essential. Overhangs atthe non-triphosphorylated end of the dsRNA RNA have no majorimpact on its activity. A 3'overhang at the 5'triphosphate enddecreases and any 5'overhang at the 5' triphosphate end abolishesits activity. Upon ligand binding it associates with mitochondriaantiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferonregulatory factors: IRF3 and IRF7 which in turn activatetranscription of antiviral immunological genes, includinginterferons (IFNs); IFN-alpha and IFN-beta. Detects both positiveand negative strand RNA viruses including members of the familiesParamyxoviridae: Human respiratory syncytial virus and measlesvirus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV),Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japaneseencephalitis virus (JEV), hepatitis C virus (HCV), dengue virus(DENV) and west Nile virus (WNV). It also detects rotavirus andreovirus. Also involved in antiviral signaling in response toviruses containing a dsDNA genome such as Epstein-Barr virus(EBV). Detects dsRNA produced from non-self dsDNA by RNApolymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs).May play important roles in granulocyte production anddifferentiation, bacterial phagocytosis and in the regulation ofcell migration. {ECO:0000269|PubMed:15208624,ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763,ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868,ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086,ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564,ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254,ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DDX58_PRSS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000361005_chr9_33796641_+_315aa MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVPFDDDDK IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKL SSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGP >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000342836_chr9_33796641_+_315aa MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVPFDDDDK IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKL SSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGP >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000429677_chr9_33796641_+_315aa MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVPFDDDDK IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKL SSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGP >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000379405_chr9_33796641_+_315aa MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAVAVPFDDDDK IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKL SSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000361005_chr9_33796641_+_945nt ATGACCACCGAGCAGCGACGCAGCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCC CCCTGGTTTAGGGAGGAAGAGGTGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTC CTGTTGGAGCTCCAGGAGGAAGGCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAG ATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATC AGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGG AATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTC TCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGC TGGGGCAACACTCTGAGCTTTGGTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCC TCCTACCCTGGAAAGATTACCAACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCT GTGGTCTGCAACGGACAGCTCCAAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTAC >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000342836_chr9_33796641_+_945nt ATGACCACCGAGCAGCGACGCAGCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCC CCCTGGTTTAGGGAGGAAGAGGTGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTC CTGTTGGAGCTCCAGGAGGAAGGCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAG ATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATC AGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGG AATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTC TCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGC TGGGGCAACACTCTGAGCTTTGGTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCC TCCTACCCTGGAAAGATTACCAACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCT GTGGTCTGCAACGGACAGCTCCAAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTAC >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000429677_chr9_33796641_+_945nt ATGACCACCGAGCAGCGACGCAGCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCC CCCTGGTTTAGGGAGGAAGAGGTGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTC CTGTTGGAGCTCCAGGAGGAAGGCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAG ATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATC AGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGG AATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTC TCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGC TGGGGCAACACTCTGAGCTTTGGTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCC TCCTACCCTGGAAAGATTACCAACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCT GTGGTCTGCAACGGACAGCTCCAAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTAC >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000379405_chr9_33796641_+_945nt ATGACCACCGAGCAGCGACGCAGCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCC CCCTGGTTTAGGGAGGAAGAGGTGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTC CTGTTGGAGCTCCAGGAGGAAGGCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAG ATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATC AGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGG AATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTC TCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGC TGGGGCAACACTCTGAGCTTTGGTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCC TCCTACCCTGGAAAGATTACCAACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCT GTGGTCTGCAACGGACAGCTCCAAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000361005_chr9_33796641_+_1154nt TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000342836_chr9_33796641_+_1155nt TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000429677_chr9_33796641_+_1153nt TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG >In-frame_DDX58_ENST00000379883_chr9_32500803_-_PRSS3_ENST00000379405_chr9_33796641_+_1154nt TAGTTATTAAAGTTCCTATGCAGCTCCGCCTCGCGTCCGGCCTCATTTCCTCGGAAAATCCCTGCTTTCCCCGCTCGCCACGCCCTCCTC CTACCCGGCTTTAAAGCTAGTGAGGCACAGCCTGCGGGGAACGTAGCTAGCTGCAAGCAGAGGCCGGCATGACCACCGAGCAGCGACGCA GCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTGGACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGGAAGAGG TGCAGTATATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTCCTGTTGGAGCTCCAGGAGGAAG GCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTG AGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAG CAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGG CCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATG CCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTG GTGCTGACTACCCAGACGAGCTGAAGTGCCTGGATGCTCCGGTGCTGACCCAGGCTGAGTGTAAAGCCTCCTACCCTGGAAAGATTACCA ACAGCATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCCTGCCAGCGTGACTCTGGTGGCCCTGTGGTCTGCAACGGACAGCTCC AAGGAGTTGTCTCCTGGGGCCATGGCTGTGCCTGGAAGAACAGGCCTGGAGTCTACACCAAGGTCTACAACTATGTGGACTGGATTAAGG |
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FusionGenePPI for DDX58_PRSS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DDX58 | CYLD, IRF3, UBE2K, UBE2D1, UBE2D2, UBE2D3, TRIM25, MAVS, RAI14, WRNIP1, RBCK1, RNF31, PRKRIR, PRKCA, PRKCB, PRKCG, ISG15, TRIM32, TSPAN6, SRC, DDX58, MBP, USP4, NLRC5, RNF135, TBK1, IKBKE, IKBKG, USP21, USP3, MEX3C, UBC, IFIT3, USP15, TIA1, VAPA, IRGM, UBD, GLTSCR2, HDAC6, RNF122 | PRSS3 | TFPI, HDGF, ALB, RPS6KB2, HNRNPA1, MCM2, SHC1, RC3H1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDX58_PRSS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDX58_PRSS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DDX58 | C0019196 | Hepatitis C | 1 | CTD_human |
| Hgene | DDX58 | C0021400 | Influenza | 1 | CTD_human |
| Hgene | DDX58 | C0033860 | Psoriasis | 1 | CTD_human |
| Hgene | DDX58 | C4225380 | SINGLETON-MERTEN SYNDROME 2 | 1 | UNIPROT |
| Tgene | PRSS3 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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