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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9640

FusionGeneSummary for DDX54_CUX1

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX54_CUX1
Fusion gene ID: 9640
HgeneTgene
Gene symbol

DDX54

CUX1

Gene ID

79039

1523

Gene nameDEAD-box helicase 54cut like homeobox 1
SynonymsDP97CASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GOLIM6|Nbla10317|p100|p110|p200|p75
Cytomap

12q24.13

7q22.1

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX54ATP-dependent RNA helicase DP97DEAD (Asp-Glu-Ala-Asp) box polypeptide 54DEAD box RNA helicase 97 kDaDEAD box helicase 97 KDaDEAD box protein 54protein CASPCCAAT displacement proteincut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317
Modification date2018052220180523
UniProtAcc

Q8TDD1

Q13948

Ensembl transtripts involved in fusion geneENST00000314045, ENST00000306014, 
ENST00000549271, 		ENST00000437600, 
ENST00000292538, ENST00000393824, 
ENST00000547394, ENST00000360264, 
ENST00000425244, ENST00000292535, 
ENST00000549414, ENST00000556210, 
ENST00000550008, ENST00000546411, 
ENST00000560541, 
Fusion gene scores* DoF score3 X 3 X 2=1812 X 13 X 5=780
# samples 314
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX54 [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX54

GO:0006396

RNA processing

12466272

HgeneDDX54

GO:0016070

RNA metabolic process

12466272


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF588530DDX54chr12

113600962

+CUX1chr7

101552939

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000314045ENST00000437600DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000292538DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000393824DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000547394DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000360264DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000425244DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000292535DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000549414DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000556210DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000550008DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000546411DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000314045ENST00000560541DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000437600DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000292538DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000393824DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000547394DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000360264DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000425244DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000292535DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000549414DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000556210DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000550008DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000546411DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000306014ENST00000560541DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000437600DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000292538DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000393824DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000547394DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000360264DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000425244DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000292535DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000549414DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000556210DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000550008DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000546411DDX54chr12

113600962

+CUX1chr7

101552939

-
intron-intronENST00000549271ENST00000560541DDX54chr12

113600962

+CUX1chr7

101552939

-

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FusionProtFeatures for DDX54_CUX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX54

Q8TDD1

CUX1

Q13948

Has RNA-dependent ATPase activity. Represses thetranscriptional activity of nuclear receptors.{ECO:0000269|PubMed:12466272}. May be involved in intra-Golgi retrograde transport.{ECO:0000269|PubMed:15718469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DDX54_CUX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DDX54_CUX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DDX54_CUX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DDX54_CUX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDDX54C0023903Liver neoplasms1CTD_human
HgeneDDX54C0032460Polycystic Ovary Syndrome1CTD_human
HgeneDDX54C0032927Precancerous Conditions1CTD_human
TgeneCUX1C0041696Unipolar Depression3PSYGENET
TgeneCUX1C1269683Major Depressive Disorder3PSYGENET
TgeneCUX1C0525045Mood Disorders1PSYGENET
TgeneCUX1C0596263Carcinogenesis1CTD_human