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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 964

FusionGeneSummary for AEBP1_WDR26

check button Fusion gene summary
Fusion gene informationFusion gene name: AEBP1_WDR26
Fusion gene ID: 964
HgeneTgene
Gene symbol

AEBP1

WDR26

Gene ID

165

80232

Gene nameAE binding protein 1WD repeat domain 26
SynonymsACLPCDW2|GID7|MIP2|SKDEAS
Cytomap

7p13

1q42.11-q42.12

Type of geneprotein-codingprotein-coding
Descriptionadipocyte enhancer-binding protein 1aortic carboxypeptidase-like proteinWD repeat-containing protein 26CUL4- and DDB1-associated WDR protein 2GID complex subunit 7 homologmyocardial ischemic preconditioning upregulated protein 2
Modification date2018052320180522
UniProtAcc

Q8IUX7

Q9H7D7

Ensembl transtripts involved in fusion geneENST00000223357, ENST00000454218, 
ENST00000450684, 
ENST00000414423, 
ENST00000295024, ENST00000366852, 
ENST00000479727, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 6 X 4=120
# samples 56
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AEBP1 [Title/Abstract] AND WDR26 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA441028AEBP1chr7

44153734

-WDR26chr1

224576726

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000223357ENST00000414423AEBP1chr7

44153734

-WDR26chr1

224576726

+
5CDS-3UTRENST00000223357ENST00000295024AEBP1chr7

44153734

-WDR26chr1

224576726

+
5CDS-intronENST00000223357ENST00000366852AEBP1chr7

44153734

-WDR26chr1

224576726

+
5CDS-intronENST00000223357ENST00000479727AEBP1chr7

44153734

-WDR26chr1

224576726

+
intron-3UTRENST00000454218ENST00000414423AEBP1chr7

44153734

-WDR26chr1

224576726

+
intron-3UTRENST00000454218ENST00000295024AEBP1chr7

44153734

-WDR26chr1

224576726

+
intron-intronENST00000454218ENST00000366852AEBP1chr7

44153734

-WDR26chr1

224576726

+
intron-intronENST00000454218ENST00000479727AEBP1chr7

44153734

-WDR26chr1

224576726

+
5CDS-3UTRENST00000450684ENST00000414423AEBP1chr7

44153734

-WDR26chr1

224576726

+
5CDS-3UTRENST00000450684ENST00000295024AEBP1chr7

44153734

-WDR26chr1

224576726

+
5CDS-intronENST00000450684ENST00000366852AEBP1chr7

44153734

-WDR26chr1

224576726

+
5CDS-intronENST00000450684ENST00000479727AEBP1chr7

44153734

-WDR26chr1

224576726

+

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FusionProtFeatures for AEBP1_WDR26


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AEBP1

Q8IUX7

WDR26

Q9H7D7

May positively regulate MAP-kinase activity inadipocytes, leading to enhanced adipocyte proliferation andreduced adipocyte differentiation. May also positively regulateNF-kappa-B activity in macrophages by promoting thephosphorylation and subsequent degradation of I-kappa-B-alpha(NFKBIA), leading to enhanced macrophage inflammatoryresponsiveness. Can act as a transcriptional repressor.{ECO:0000250}. G-beta-like protein involved in cell signal transduction(PubMed:15378603, PubMed:19446606, PubMed:22065575,PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as anegative regulator in MAPK signaling pathway (PubMed:15378603).Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequentactivation in leukocytes (PubMed:22065575, PubMed:23625927). Actsas a negative regulator of the canonical Wnt signaling pathwaythrough preventing ubiquitination of beta-catenin CTNNB1 by thebeta-catenin destruction complex, thus negatively regulatingCTNNB1 degradation (PubMed:27098453). Serves as a scaffold tocoordinate PI3K/AKT pathway-driven cell growth and migration(PubMed:26895380). Protects cells from oxidative stress-inducedapoptosis via the down-regulation of AP-1 transcriptional activityas well as by inhibiting cytochrome c release from mitochondria(PubMed:19446606). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).{ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603,ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927,ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AEBP1_WDR26


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AEBP1_WDR26


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AEBP1_WDR26


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AEBP1_WDR26


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource