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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9634

FusionGeneSummary for DDX50_WASF1

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX50_WASF1
Fusion gene ID: 9634
HgeneTgene
Gene symbol

DDX50

WASF1

Gene ID

79009

8936

Gene nameDExD-box helicase 50WAS protein family member 1
SynonymsGU2|GUB|RH-II/GuB|mcdrhSCAR1|WAVE|WAVE1
Cytomap

10q22.1

6q21

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX50DEAD (Asp-Glu-Ala-Asp) box polypeptide 50DEAD box protein 50DEAD-box helicase 50RNA helicase II/Gu betagu-betamalignant cell derived RNA helicasenucleolar protein GU2wiskott-Aldrich syndrome protein family member 1WASP family protein member 1homology of dictyostelium scar 1protein WAVE-1verprolin homology domain-containing protein 1
Modification date2018051920180522
UniProtAcc

Q9BQ39

Q92558

Ensembl transtripts involved in fusion geneENST00000373585, ENST00000466265, 
ENST00000392587, ENST00000392586, 
ENST00000392588, ENST00000392589, 
ENST00000359451, 
Fusion gene scores* DoF score4 X 4 X 1=168 X 7 X 3=168
# samples 68
** MAII scorelog2(6/16*10)=1.90689059560852
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX50 [Title/Abstract] AND WASF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK056044DDX50chr10

70672986

+WASF1chr6

110422924

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000373585ENST00000392587DDX50chr10

70672986

+WASF1chr6

110422924

-
Frame-shiftENST00000373585ENST00000392586DDX50chr10

70672986

+WASF1chr6

110422924

-
Frame-shiftENST00000373585ENST00000392588DDX50chr10

70672986

+WASF1chr6

110422924

-
Frame-shiftENST00000373585ENST00000392589DDX50chr10

70672986

+WASF1chr6

110422924

-
Frame-shiftENST00000373585ENST00000359451DDX50chr10

70672986

+WASF1chr6

110422924

-
intron-3CDSENST00000466265ENST00000392587DDX50chr10

70672986

+WASF1chr6

110422924

-
intron-3CDSENST00000466265ENST00000392586DDX50chr10

70672986

+WASF1chr6

110422924

-
intron-3CDSENST00000466265ENST00000392588DDX50chr10

70672986

+WASF1chr6

110422924

-
intron-3CDSENST00000466265ENST00000392589DDX50chr10

70672986

+WASF1chr6

110422924

-
intron-3CDSENST00000466265ENST00000359451DDX50chr10

70672986

+WASF1chr6

110422924

-

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FusionProtFeatures for DDX50_WASF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX50

Q9BQ39

WASF1

Q92558

Downstream effector molecule involved in thetransmission of signals from tyrosine kinase receptors and smallGTPases to the actin cytoskeleton. Promotes formation of actinfilaments. Part of the WAVE complex that regulates lamellipodiaformation. The WAVE complex regulates actin filamentreorganization via its interaction with the Arp2/3 complex (Bysimilarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (Bysimilarity). {ECO:0000250|UniProtKB:Q8R5H6,ECO:0000269|PubMed:9889097}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DDX50_WASF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DDX50_WASF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DDX50_WASF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DDX50_WASF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource