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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9567

FusionGeneSummary for DDX19A_ABCC11

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX19A_ABCC11
Fusion gene ID: 9567
HgeneTgene
Gene symbol

DDX19A

ABCC11

Gene ID

55308

85320

Gene nameDEAD-box helicase 19AATP binding cassette subfamily C member 11
SynonymsDDX19-DDX19L|DDX19LEWWD|MRP8|WW
Cytomap

16q22.1

16q12.1

Type of geneprotein-codingprotein-coding
DescriptionATP-dependent RNA helicase DDX19ADDX19-like proteinDEAD (Asp-Glu-Ala-As) box polypeptide 19ADEAD (Asp-Glu-Ala-Asp) box polypeptide 19ADEAD box protein 19ARNA helicaseATP-binding cassette sub-family C member 11ATP-binding cassette protein C11ATP-binding cassette transporter MRP8ATP-binding cassette transporter sub-family C member 11ATP-binding cassette, sub-family C (CFTR/MRP), member 11multi-resistance protein 8
Modification date2018052220180523
UniProtAcc

Q9NUU7

Q96J66

Ensembl transtripts involved in fusion geneENST00000302243, ENST00000562509, 
ENST00000417604, ENST00000443119, 
ENST00000353782, ENST00000356608, 
ENST00000394747, ENST00000394748, 
ENST00000537808, ENST00000565329, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 2 X 2=16
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DDX19A [Title/Abstract] AND ABCC11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCC11

GO:0015711

organic anion transport

15537867|16359813

TgeneABCC11

GO:0015865

purine nucleotide transport

12764137


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-91-6847-01ADDX19Achr16

70384508

+ABCC11chr16

48269088

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000302243ENST00000353782DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000302243ENST00000356608DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000302243ENST00000394747DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000302243ENST00000394748DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000302243ENST00000537808DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000302243ENST00000565329DDX19Achr16

70384508

+ABCC11chr16

48269088

-
3UTR-3CDSENST00000562509ENST00000353782DDX19Achr16

70384508

+ABCC11chr16

48269088

-
3UTR-intronENST00000562509ENST00000356608DDX19Achr16

70384508

+ABCC11chr16

48269088

-
3UTR-intronENST00000562509ENST00000394747DDX19Achr16

70384508

+ABCC11chr16

48269088

-
3UTR-intronENST00000562509ENST00000394748DDX19Achr16

70384508

+ABCC11chr16

48269088

-
3UTR-intronENST00000562509ENST00000537808DDX19Achr16

70384508

+ABCC11chr16

48269088

-
3UTR-intronENST00000562509ENST00000565329DDX19Achr16

70384508

+ABCC11chr16

48269088

-
Frame-shitENST00000417604ENST00000353782DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000417604ENST00000356608DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000417604ENST00000394747DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000417604ENST00000394748DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000417604ENST00000537808DDX19Achr16

70384508

+ABCC11chr16

48269088

-
5CDS-intronENST00000417604ENST00000565329DDX19Achr16

70384508

+ABCC11chr16

48269088

-
intron-3CDSENST00000443119ENST00000353782DDX19Achr16

70384508

+ABCC11chr16

48269088

-
intron-intronENST00000443119ENST00000356608DDX19Achr16

70384508

+ABCC11chr16

48269088

-
intron-intronENST00000443119ENST00000394747DDX19Achr16

70384508

+ABCC11chr16

48269088

-
intron-intronENST00000443119ENST00000394748DDX19Achr16

70384508

+ABCC11chr16

48269088

-
intron-intronENST00000443119ENST00000537808DDX19Achr16

70384508

+ABCC11chr16

48269088

-
intron-intronENST00000443119ENST00000565329DDX19Achr16

70384508

+ABCC11chr16

48269088

-

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FusionProtFeatures for DDX19A_ABCC11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX19A

Q9NUU7

ABCC11

Q96J66

ATP-dependent RNA helicase involved in mRNA export fromthe nucleus. Rather than unwinding RNA duplexes, DDX19 functionsas a remodeler of ribonucleoprotein particles, whereby proteinsbound to nuclear mRNA are dissociated and replaced by cytoplasmicmRNA binding proteins (By similarity). {ECO:0000250}. Participates in physiological processes involving bileacids, conjugated steroids and cyclic nucleotides(PubMed:12764137, PubMed:15537867). Enhances the cellularextrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867).Stimulates the ATP-dependent uptake of a range of physiologicaland synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroidsulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) andestrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholateand taurocholate, and methotrexate (PubMed:15537867,PubMed:25896536). Probably functions to secrete earwax(PubMed:16444273, PubMed:19383836). Required for the secretion ofcomponents contributing to axillary odor formation(PubMed:19710689). {ECO:0000269|PubMed:12764137,ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273,ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689,ECO:0000269|PubMed:25896536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DDX19A_ABCC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DDX19A_ABCC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DDX19AMDFI, MIF4GD, SMARCAD1, SPTBN1, XPO1, NXF1, SPTAN1, LIG4, HDAC6, FUBP1, HMGB3, CCDC8, DDX25, DDX19B, NUP214, NUP88, NUP62, CTIF, EIF4E, PABPC1, SEPHS1, WDR12, NIF3L1, NTRK1, SNW1, CDC5L, NR3C1, AR, HSD17B10, G3BP1ABCC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DDX19A_ABCC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DDX19A_ABCC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource