FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9553

FusionGeneSummary for DDX10_RAB6A

check button Fusion gene summary
Fusion gene informationFusion gene name: DDX10_RAB6A
Fusion gene ID: 9553
HgeneTgene
Gene symbol

DDX10

RAB6A

Gene ID

1662

5870

Gene nameDEAD-box helicase 10RAB6A, member RAS oncogene family
SynonymsDbp4|HRH-J8RAB6
Cytomap

11q22.3

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX10DDX10-NUP98 fusion protein type 2DEAD (Asp-Glu-Ala-Asp) box polypeptide 10DEAD box protein 10DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)ras-related protein Rab-6ARAB6, member RAS oncogene familyRab GTPase
Modification date2018051920180523
UniProtAcc

Q13206

P20340

Ensembl transtripts involved in fusion geneENST00000322536, ENST00000526794, 
ENST00000534221, 
ENST00000310653, 
ENST00000336083, ENST00000536566, 
ENST00000541588, 
Fusion gene scores* DoF score7 X 6 X 4=16812 X 8 X 8=768
# samples 819
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/768*10)=-2.01510689239021
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDX10 [Title/Abstract] AND RAB6A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAB6A

GO:0018125

peptidyl-cysteine methylation

11121396

TgeneRAB6A

GO:0034067

protein localization to Golgi apparatus

12447383|18243103


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A23Z-01ADDX10chr11

108722936

+RAB6Achr11

73389007

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000322536ENST00000310653DDX10chr11

108722936

+RAB6Achr11

73389007

-
Frame-shiftENST00000322536ENST00000336083DDX10chr11

108722936

+RAB6Achr11

73389007

-
Frame-shiftENST00000322536ENST00000536566DDX10chr11

108722936

+RAB6Achr11

73389007

-
Frame-shiftENST00000322536ENST00000541588DDX10chr11

108722936

+RAB6Achr11

73389007

-
Frame-shiftENST00000526794ENST00000310653DDX10chr11

108722936

+RAB6Achr11

73389007

-
Frame-shiftENST00000526794ENST00000336083DDX10chr11

108722936

+RAB6Achr11

73389007

-
Frame-shiftENST00000526794ENST00000536566DDX10chr11

108722936

+RAB6Achr11

73389007

-
Frame-shiftENST00000526794ENST00000541588DDX10chr11

108722936

+RAB6Achr11

73389007

-
intron-3CDSENST00000534221ENST00000310653DDX10chr11

108722936

+RAB6Achr11

73389007

-
intron-3CDSENST00000534221ENST00000336083DDX10chr11

108722936

+RAB6Achr11

73389007

-
intron-3CDSENST00000534221ENST00000536566DDX10chr11

108722936

+RAB6Achr11

73389007

-
intron-3CDSENST00000534221ENST00000541588DDX10chr11

108722936

+RAB6Achr11

73389007

-

Top

FusionProtFeatures for DDX10_RAB6A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX10

Q13206

RAB6A

P20340

Putative ATP-dependent RNA helicase. Protein transport. Regulator of membrane traffic fromthe Golgi apparatus towards the endoplasmic reticulum (ER). Has alow GTPase activity. Involved in COPI-independent retrogradetransport from the Golgi to the ER (PubMed:25962623).{ECO:0000269|PubMed:25962623}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DDX10_RAB6A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DDX10_RAB6A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DDX10G3BP2, SIRT7, CAND1, APP, OBSL1, NOL12, BYSL, SRFBP1, NTRK1, CKB, DDX56, KIAA0020, DDX54, PWP1, IFI16, EED, NOP56, ZNF2, RBM34, RPL18, DGCR8, RPL18A, CDX1, WDR46, FGF8, HIST1H1E, HIST1H1T, RPL30, ZC3HAV1, GLTSCR2, RPL37A, TRIM25RAB6APMM1, GOLGA1, BICD1, DCTN1, ERC1, RAB7A, CHM, CHML, GOLGA2, SYTL5, KIF20A, BICD2, RABGAP1, ELAVL1, RPA3, RPA2, RPA1, FKBP2, OCRL, SRPRB, HAX1, DNAAF2, TGFBR2, TREML2, RNF26, TMEM52B, RAB11B, ARF1, ETFA, RAB1A, RAB1B, RAB2A, OFD1, NPHP1, RPGRIP1L, GDI1, TSSC1, ZNF131, RAB6B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DDX10_RAB6A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DDX10_RAB6A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource