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Fusion gene ID: 9543 |
FusionGeneSummary for DDT_GHRL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDT_GHRL | Fusion gene ID: 9543 | Hgene | Tgene | Gene symbol | DDT | GHRL | Gene ID | 1652 | 51738 |
| Gene name | D-dopachrome tautomerase | ghrelin and obestatin prepropeptide | |
| Synonyms | D-DT|DDCT|MIF-2|MIF2 | MTLRP | |
| Cytomap | 22q11.23 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-dopachrome decarboxylasephenylpyruvate tautomerase II | appetite-regulating hormoneIn2c-preproghrelinghrelin, growth hormone secretagogue receptor ligandghrelin/obestatin preprohormoneghrelin/obestatin prepropeptidegrowth hormone-releasing peptidemotilin-related peptideprepro-appetite regulatory hormone | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P30046 | Q9UBU3 | |
| Ensembl transtripts involved in fusion gene | ENST00000398344, ENST00000350608, ENST00000404092, ENST00000403754, ENST00000430101, | ENST00000335542, ENST00000430179, ENST00000422159, ENST00000450603, ENST00000449554, ENST00000446937, ENST00000457360, ENST00000437422, ENST00000439975, ENST00000287656, ENST00000449238, ENST00000429122, ENST00000476283, | |
| Fusion gene scores | * DoF score | 6 X 2 X 4=48 | 3 X 2 X 2=12 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DDT [Title/Abstract] AND GHRL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDT | GO:0010760 | negative regulation of macrophage chemotaxis | 21817065 |
| Hgene | DDT | GO:0032760 | positive regulation of tumor necrosis factor production | 21817065 |
| Tgene | GHRL | GO:0001937 | negative regulation of endothelial cell proliferation | 15572208 |
| Tgene | GHRL | GO:0008154 | actin polymerization or depolymerization | 15232612 |
| Tgene | GHRL | GO:0009725 | response to hormone | 15232612 |
| Tgene | GHRL | GO:0016358 | dendrite development | 16491079 |
| Tgene | GHRL | GO:0032691 | negative regulation of interleukin-1 beta production | 15232612 |
| Tgene | GHRL | GO:0042127 | regulation of cell proliferation | 15564328|16394173 |
| Tgene | GHRL | GO:0042322 | negative regulation of circadian sleep/wake cycle, REM sleep | 18329818 |
| Tgene | GHRL | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | 15232612 |
| Tgene | GHRL | GO:0043066 | negative regulation of apoptotic process | 15158140 |
| Tgene | GHRL | GO:0043627 | response to estrogen | 15292338 |
| Tgene | GHRL | GO:0045409 | negative regulation of interleukin-6 biosynthetic process | 15232612 |
| Tgene | GHRL | GO:0046010 | positive regulation of circadian sleep/wake cycle, non-REM sleep | 18329818 |
| Tgene | GHRL | GO:0046697 | decidualization | 17494105 |
| Tgene | GHRL | GO:0050728 | negative regulation of inflammatory response | 15232612 |
| Tgene | GHRL | GO:0051461 | positive regulation of corticotropin secretion | 12566947 |
| Tgene | GHRL | GO:0051464 | positive regulation of cortisol secretion | 12566947|18329818 |
| Tgene | GHRL | GO:0051965 | positive regulation of synapse assembly | 16491079 |
| Tgene | GHRL | GO:0060124 | positive regulation of growth hormone secretion | 12566947|18329818 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-PG-A915-01A | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000398344 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000398344 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000398344 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000398344 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000350608 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000350608 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000350608 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000350608 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000404092 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| In-frame | ENST00000404092 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000404092 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000404092 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000403754 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000403754 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000403754 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000403754 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000430101 | ENST00000335542 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| Frame-shift | ENST00000430101 | ENST00000430179 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000422159 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000450603 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000449554 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000446937 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000457360 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000437422 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000439975 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000287656 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000449238 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-intron | ENST00000430101 | ENST00000429122 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
| 5CDS-5UTR | ENST00000430101 | ENST00000476283 | DDT | chr22 | 24315957 | - | GHRL | chr3 | 10328496 | - |
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FusionProtFeatures for DDT_GHRL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDT | GHRL |
| Tautomerization of D-dopachrome with decarboxylation togive 5,6-dihydroxyindole (DHI). |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DDT_GHRL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DDT_ENST00000350608_chr22_24315957_-_GHRL_ENST00000335542_chr3_10328496_-_43aa >In-frame_DDT_ENST00000350608_chr22_24315957_-_GHRL_ENST00000430179_chr3_10328496_-_43aa >In-frame_DDT_ENST00000404092_chr22_24315957_-_GHRL_ENST00000335542_chr3_10328496_-_43aa >In-frame_DDT_ENST00000404092_chr22_24315957_-_GHRL_ENST00000430179_chr3_10328496_-_43aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DDT_ENST00000350608_chr22_24315957_-_GHRL_ENST00000335542_chr3_10328496_-_129nt TTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGGGGTTCAGTACCAGCAGCACAGCCAGGCCCTGGGGAAGTTTCTTCAGGACATC >In-frame_DDT_ENST00000350608_chr22_24315957_-_GHRL_ENST00000430179_chr3_10328496_-_129nt TTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGGGGTTCAGTACCAGCAGCACAGCCAGGCCCTGGGGAAGTTTCTTCAGGACATC >In-frame_DDT_ENST00000404092_chr22_24315957_-_GHRL_ENST00000335542_chr3_10328496_-_129nt TTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGGGGTTCAGTACCAGCAGCACAGCCAGGCCCTGGGGAAGTTTCTTCAGGACATC >In-frame_DDT_ENST00000404092_chr22_24315957_-_GHRL_ENST00000430179_chr3_10328496_-_129nt TTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGGGGTTCAGTACCAGCAGCACAGCCAGGCCCTGGGGAAGTTTCTTCAGGACATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DDT_ENST00000350608_chr22_24315957_-_GHRL_ENST00000335542_chr3_10328496_-_741nt GATCCCGGTGCCAGGGACCCTGCCCAGTTCCAGGCGTCGCCCTGACCCAGAAACGACTGGGCGCCGCCGTCCTGGAAAGGCCCCAGCGCA CGGACATCTGAGGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGG GGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCA TGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACA GCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGTTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGG GGTTCAGTACCAGCAGCACAGCCAGGCCCTGGGGAAGTTTCTTCAGGACATCCTCTGGGAAGAGGCCAAAGAGGCCCCAGCCGACAAGTG ATCGCCCACAAGCCTTACTCACCTCTCTCTAAGTTTAGAAGCGCTCATCTGGCTTTTCGCTTGCTTCTGCAGCAACTCCCACGACTGTTG TACAAGCTCAGGAGGCGAATAAATGTTCAAACTGTATGCTGATGTTCCAAATGGGAATTTATTTCAAAGAGGAAAAGTTAATATTTTACT >In-frame_DDT_ENST00000350608_chr22_24315957_-_GHRL_ENST00000430179_chr3_10328496_-_666nt GATCCCGGTGCCAGGGACCCTGCCCAGTTCCAGGCGTCGCCCTGACCCAGAAACGACTGGGCGCCGCCGTCCTGGAAAGGCCCCAGCGCA CGGACATCTGAGGAGCTGTTTCCGTTCCTCTGCCCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGG GGCTGGAGAAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCA TGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACA GCGCCCACTTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGTTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGG GGTTCAGTACCAGCAGCACAGCCAGGCCCTGGGGAAGTTTCTTCAGGACATCCTCTGGGAAGAGGCCAAAGAGGCCCCAGCCGACAAGTG ATCGCCCACAAGCCTTACTCACCTCTCTCTAAGTTTAGAAGCGCTCATCTGGCTTTTCGCTTGCTTCTGCAGCAACTCCCACGACTGTTG >In-frame_DDT_ENST00000404092_chr22_24315957_-_GHRL_ENST00000335542_chr3_10328496_-_888nt ATCCCTTCAAGGCCACTCAGTCCACAGCATTCTCTGGTGGCAGACGCTGCAGGAGGAGCCCATCAGTGCTGGCTGCTGAGTCTTTGAAAG CGGACCCACGGTGGCAGCATGGTGCCCAACACGTGGAGGCTGCAGTGCGGGAGGACCTCTTCCAGGAGGCCCTCCCAGCTGTCCTGAAGG CCAAGGACCTGCCTCCAGTAGAACCTGCTGTTAAAGAGAATCTGAAGACCTTAATGCAGCTTTTCTTGCTAGCTGTTTCCGTTCCTCTGC CCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCT CCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGC AGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGC TAGCCCTGGGCCAGGACCGTTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGGGGTTCAGTACCAGCAGCACAGCCAGGCCCTGGG GAAGTTTCTTCAGGACATCCTCTGGGAAGAGGCCAAAGAGGCCCCAGCCGACAAGTGATCGCCCACAAGCCTTACTCACCTCTCTCTAAG TTTAGAAGCGCTCATCTGGCTTTTCGCTTGCTTCTGCAGCAACTCCCACGACTGTTGTACAAGCTCAGGAGGCGAATAAATGTTCAAACT >In-frame_DDT_ENST00000404092_chr22_24315957_-_GHRL_ENST00000430179_chr3_10328496_-_813nt ATCCCTTCAAGGCCACTCAGTCCACAGCATTCTCTGGTGGCAGACGCTGCAGGAGGAGCCCATCAGTGCTGGCTGCTGAGTCTTTGAAAG CGGACCCACGGTGGCAGCATGGTGCCCAACACGTGGAGGCTGCAGTGCGGGAGGACCTCTTCCAGGAGGCCCTCCCAGCTGTCCTGAAGG CCAAGGACCTGCCTCCAGTAGAACCTGCTGTTAAAGAGAATCTGAAGACCTTAATGCAGCTTTTCTTGCTAGCTGTTTCCGTTCCTCTGC CCGCCATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAGAAACGACTCTGCGCCGCCGCTGCCT CCATCCTGGGCAAACCTGCGGACCGCGTGAACGTGACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGC AGCTGTCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCACTTCTTTGAGTTTCTCACCAAGGAGC TAGCCCTGGGCCAGGACCGTTCAACGCCCCCTTTGATGTTGGAATCAAGCTGTCAGGGGTTCAGTACCAGCAGCACAGCCAGGCCCTGGG GAAGTTTCTTCAGGACATCCTCTGGGAAGAGGCCAAAGAGGCCCCAGCCGACAAGTGATCGCCCACAAGCCTTACTCACCTCTCTCTAAG TTTAGAAGCGCTCATCTGGCTTTTCGCTTGCTTCTGCAGCAACTCCCACGACTGTTGTACAAGCTCAGGAGGCGAATAAATGTTCAAACT |
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FusionGenePPI for DDT_GHRL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DDT | DSTYK, HECW2 | GHRL | MLNR, TBXA2R, PTGER3, PTGIR, UBQLN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDT_GHRL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDT_GHRL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GHRL | C0038358 | Gastric ulcer | 2 | CTD_human |
| Tgene | GHRL | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | GHRL | C0006625 | Cachexia | 1 | CTD_human |
| Tgene | GHRL | C0009319 | Colitis | 1 | CTD_human |
| Tgene | GHRL | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| Tgene | GHRL | C0011581 | Depressive disorder | 1 | CTD_human |
| Tgene | GHRL | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Tgene | GHRL | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | GHRL | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | GHRL | C0027794 | Neural Tube Defects | 1 | CTD_human |
| Tgene | GHRL | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | GHRL | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | GHRL | C0036572 | Seizures | 1 | CTD_human |
| Tgene | GHRL | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | GHRL | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Tgene | GHRL | C0687132 | heavy drinking | 1 | PSYGENET |
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