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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 952

FusionGeneSummary for ADSL_CDH18

check button Fusion gene summary
Fusion gene informationFusion gene name: ADSL_CDH18
Fusion gene ID: 952
HgeneTgene
Gene symbol

ADSL

CDH18

Gene ID

158

1016

Gene nameadenylosuccinate lyasecadherin 18
SynonymsAMPS|ASASE|ASLCDH14|CDH14L|CDH24
Cytomap

22q13.1

5p14.3

Type of geneprotein-codingprotein-coding
Descriptionadenylosuccinate lyaseadenylosuccinasecadherin-18cadherin 18, type 2cadherin-14cadherin-like 24ey-cadherin
Modification date2018052320180523
UniProtAcc

P30566

Q13634

Ensembl transtripts involved in fusion geneENST00000216194, ENST00000454266, 
ENST00000342312, ENST00000480775, 
ENST00000382275, ENST00000507958, 
ENST00000502796, ENST00000511273, 
ENST00000274170, ENST00000506372, 
ENST00000510297, 
Fusion gene scores* DoF score3 X 3 X 2=189 X 6 X 6=324
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADSL [Title/Abstract] AND CDH18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADSL

GO:0006167

AMP biosynthetic process

11428554

HgeneADSL

GO:0051262

protein tetramerization

16973378


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-P4-A5EB-01AADSLchr22

40757346

+CDH18chr5

19981287

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000216194ENST00000382275ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000216194ENST00000507958ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000216194ENST00000502796ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000216194ENST00000511273ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000216194ENST00000274170ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000216194ENST00000506372ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000216194ENST00000510297ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000454266ENST00000382275ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000454266ENST00000507958ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000454266ENST00000502796ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000454266ENST00000511273ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000454266ENST00000274170ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000454266ENST00000506372ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000454266ENST00000510297ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000342312ENST00000382275ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000342312ENST00000507958ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-5UTRENST00000342312ENST00000502796ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000342312ENST00000511273ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000342312ENST00000274170ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000342312ENST00000506372ADSLchr22

40757346

+CDH18chr5

19981287

-
5CDS-intronENST00000342312ENST00000510297ADSLchr22

40757346

+CDH18chr5

19981287

-
3UTR-5UTRENST00000480775ENST00000382275ADSLchr22

40757346

+CDH18chr5

19981287

-
3UTR-5UTRENST00000480775ENST00000507958ADSLchr22

40757346

+CDH18chr5

19981287

-
3UTR-5UTRENST00000480775ENST00000502796ADSLchr22

40757346

+CDH18chr5

19981287

-
3UTR-intronENST00000480775ENST00000511273ADSLchr22

40757346

+CDH18chr5

19981287

-
3UTR-intronENST00000480775ENST00000274170ADSLchr22

40757346

+CDH18chr5

19981287

-
3UTR-intronENST00000480775ENST00000506372ADSLchr22

40757346

+CDH18chr5

19981287

-
3UTR-intronENST00000480775ENST00000510297ADSLchr22

40757346

+CDH18chr5

19981287

-

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FusionProtFeatures for ADSL_CDH18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADSL

P30566

CDH18

Q13634

Catalyzes two non-sequential steps in de novo AMPsynthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarateplus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, andthereby also contributes to de novo IMP synthesis, and convertssuccinyladenosine monophosphate (SAMP) to AMP and fumarate.{ECO:0000269|PubMed:10888601}. Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADSL_CDH18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADSL_CDH18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADSLUSP15, USP4, DDA1, UBC, TYMS, NOV, CTSC, DNAJB1, DRG2, EHD4, EIF1AX, GTF2I, NPLOC4, PDE12, PLIN3, RAD23B, SAE1, UBQLN2, XPNPEP1, API5, BTF3L4, NT5C2, OXSR1, PAIP1, TWF1, WARS, WDR4, CALCOCO2, REL, NXF1, KLHL20, COMTD1, TEKT4, TEKT2, ABAT, CRIP1, G3BP1, G3BP2, GART, GPT2, LDHB, PFAS, RPE, SOD1, ALDH8A1, ATIC, PAICS, TPI1, NTRK1, MED4, SSX2IP, OFD1, CEP104, CEP152, CNTROB, FGFR1OP, CEP128, CEP135, CEP89, FBF1, RPGRIP1, CENPJ, MCM2, OTUB1, MTMR7, SNRNP27, FGB, ALOX5, USP47, GTF2E2, TRIM25CDH18CTNNB1, CDH6, CDH18, MYOG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADSL_CDH18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADSL_CDH18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADSLC0268126Adenylosuccinate lyase deficiency (disorder)8CTD_human;ORPHANET;UNIPROT
HgeneADSLC0004352Autistic Disorder1CTD_human;HPO
TgeneCDH18C0001973Alcoholic Intoxication, Chronic1PSYGENET