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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9502

FusionGeneSummary for DDB1_FOXP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DDB1_FOXP1
Fusion gene ID: 9502
HgeneTgene
Gene symbol

DDB1

FOXP1

Gene ID

1642

27086

Gene namedamage specific DNA binding protein 1forkhead box P1
SynonymsDDBA|UV-DDB1|XAP1|XPCE|XPE|XPE-BF12CC4|HSPC215|MFH|QRF1|hFKH1B
Cytomap

11q12.2

3p13

Type of geneprotein-codingprotein-coding
DescriptionDNA damage-binding protein 1DDB p127 subunitDNA damage-binding protein aHBV X-associated protein 1UV-DDB 1UV-damaged DNA-binding factorUV-damaged DNA-binding protein 1XAP-1XPE-binding factordamage-specific DNA binding protein 1, 127kDaxeroderma forkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead
Modification date2018052320180522
UniProtAcc

Q16531

Q9H334

Ensembl transtripts involved in fusion geneENST00000301764, ENST00000450997, 
ENST00000451943, ENST00000538470, 
ENST00000545930, 
ENST00000318789, 
ENST00000475937, ENST00000493089, 
ENST00000484350, ENST00000318779, 
ENST00000491238, ENST00000498215, 
ENST00000468577, ENST00000472382, 
Fusion gene scores* DoF score12 X 12 X 6=86437 X 16 X 17=10064
# samples 1440
** MAII scorelog2(14/864*10)=-2.6256044852185
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(40/10064*10)=-4.65306001710456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DDB1 [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDB1

GO:0006511

ubiquitin-dependent protein catabolic process

11673459

HgeneDDB1

GO:0035518

histone H2A monoubiquitination

22334663

HgeneDDB1

GO:0051702

interaction with symbiont

23137809

HgeneDDB1

GO:0070914

UV-damage excision repair

22334663

TgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

TgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

TgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

TgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

TgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

TgeneFOXP1

GO:0036035

osteoclast development

18799727

TgeneFOXP1

GO:0042116

macrophage activation

18799727

TgeneFOXP1

GO:0042117

monocyte activation

18799727

TgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

TgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

TgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

TgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

TgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

TgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

TgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

TgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1H45478DDB1chr11

61091528

-FOXP1chr3

71005534

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000301764ENST00000318789DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000475937DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000493089DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000484350DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000318779DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000491238DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000498215DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000468577DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000301764ENST00000472382DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-3UTRENST00000450997ENST00000318789DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000475937DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000493089DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000484350DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000318779DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000491238DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000498215DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000468577DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000450997ENST00000472382DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-3UTRENST00000451943ENST00000318789DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000475937DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000493089DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000484350DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000318779DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000491238DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000498215DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000468577DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000451943ENST00000472382DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-3UTRENST00000538470ENST00000318789DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000475937DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000493089DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000484350DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000318779DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000491238DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000498215DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000468577DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000538470ENST00000472382DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-3UTRENST00000545930ENST00000318789DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000475937DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000493089DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000484350DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000318779DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000491238DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000498215DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000468577DDB1chr11

61091528

-FOXP1chr3

71005534

-
intron-intronENST00000545930ENST00000472382DDB1chr11

61091528

-FOXP1chr3

71005534

-

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FusionProtFeatures for DDB1_FOXP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDB1

Q16531

FOXP1

Q9H334

Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruitproteins of the nucleotide excision repair pathway (the NERpathway) to initiate DNA repair. The UV-DDB complex preferentiallybinds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts(6-4 PP), apurinic sites and short mismatches. Also appears tofunction as a component of numerous distinct DCX (DDB1-CUL4-X-box)E3 ubiquitin-protein ligase complexes which mediate theubiquitination and subsequent proteasomal degradation of targetproteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substraterecognition component recruited by DDB1. DCX(DDB2) (also known asDDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinatehistone H2A, histone H3 and histone H4 at sites of UV-induced DNAdamage. The ubiquitination of histones may facilitate theirremoval from the nucleosome and promote subsequent DNA repair.DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding byXPC and promote NER. DCX(DTL) plays a role in PCNA-dependentpolyubiquitination of CDT1 and MDM2-dependent ubiquitination ofTP53 in response to radiation-induced DNA damage and during DNAreplication. DCX(ERCC8) (the CSA complex) plays a role intranscription-coupled repair (TCR). May also play a role inubiquitination of CDKN1B/p27kip when associated with CUL4 andSKP2. {ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464,ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621,ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242,ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935,ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110,ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588,ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868,ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899,ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460,ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DDB1_FOXP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DDB1_FOXP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DDB1_FOXP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DDB1_FOXP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDDB1C0038356Stomach Neoplasms1CTD_human
TgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
TgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
TgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
TgeneFOXP1C0042900Vitiligo1CTD_human
TgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
TgeneFOXP1C3495559Juvenile arthritis1CTD_human
TgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT