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Fusion gene ID: 9490 |
FusionGeneSummary for DDA1_TMEM38A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDA1_TMEM38A | Fusion gene ID: 9490 | Hgene | Tgene | Gene symbol | DDA1 | TMEM38A | Gene ID | 79016 | 79041 |
| Gene name | DET1 and DDB1 associated 1 | transmembrane protein 38A | |
| Synonyms | C19orf58|PCIA1 | TRIC-A|TRICA | |
| Cytomap | 19p13.11 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DET1- and DDB1-associated protein 1PCIA-1cross-immune reaction antigen PCIA1placenta cross-immune reaction antigen 1 | trimeric intracellular cation channel type A | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9BW61 | Q9H6F2 | |
| Ensembl transtripts involved in fusion gene | ENST00000359866, | ENST00000187762, | |
| Fusion gene scores | * DoF score | 4 X 4 X 5=80 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DDA1 [Title/Abstract] AND TMEM38A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A6YQ-01A | DDA1 | chr19 | 17425198 | + | TMEM38A | chr19 | 16790795 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000359866 | ENST00000187762 | DDA1 | chr19 | 17425198 | + | TMEM38A | chr19 | 16790795 | + |
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FusionProtFeatures for DDA1_TMEM38A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDA1 | TMEM38A |
| May be involved in ubiquitination and subsequentproteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction withCUL4A and WD repeat proteins. {ECO:0000269|PubMed:17452440}. | Monovalent cation channel required for maintenance ofrapid intracellular calcium release. May act as a potassiumcounter-ion channel that functions in synchronization with calciumrelease from intracellular stores. {ECO:0000250|UniProtKB:Q3TMP8}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 135_143 | 41 | 300 | Compositional bias | Note=His-rich |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 107_144 | 41 | 300 | Topological domain | Cytoplasmic |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 166_178 | 41 | 300 | Topological domain | Lumenal |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 200_209 | 41 | 300 | Topological domain | Cytoplasmic |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 231_234 | 41 | 300 | Topological domain | Lumenal |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 256_299 | 41 | 300 | Topological domain | Cytoplasmic |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 40_51 | 41 | 300 | Topological domain | Cytoplasmic |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 73_85 | 41 | 300 | Topological domain | Lumenal |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 145_165 | 41 | 300 | Transmembrane | Helical%3BName%3D4 |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 179_199 | 41 | 300 | Transmembrane | Helical%3BName%3D5 |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 210_230 | 41 | 300 | Transmembrane | Helical%3BName%3D6 |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 235_255 | 41 | 300 | Transmembrane | Helical%3BName%3D7 |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 52_72 | 41 | 300 | Transmembrane | Helical%3BName%3D2 |
| Tgene | >TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 86_106 | 41 | 300 | Transmembrane | Helical%3BName%3D3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 1_18 | 41 | 300 | Topological domain | Lumenal |
| Tgene | TMEM38A | chr19:17425198 | chr19:16790795 | ENST00000187762 | + | 0 | 6 | 19_39 | 41 | 300 | Transmembrane | Helical%3BName%3D1 |
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FusionGeneSequence for DDA1_TMEM38A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DDA1_ENST00000359866_chr19_17425198_+_TMEM38A_ENST00000187762_chr19_16790795_+_304aa MADFLKGLPVYNKSNFSRFHADSVCKASNRRPSVYLPTREYPSEQRAVELSRRHPIASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSS ILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPE TNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDALEGYICPVLFGSACGGDHHHDNHGGSH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DDA1_ENST00000359866_chr19_17425198_+_TMEM38A_ENST00000187762_chr19_16790795_+_912nt ATGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATTTCACGCGGACTCCGTGTGCAAAGCCTCGAACCGA CGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGAGAGCAGTCGAACTGTCCCGGCGCCACCCCATCGCGTCCTGGCTG TGCGCCATGCTGCATTGCTTCGGGAGCTACATCCTGGCTGATCTGCTCCTTGGGGAGCCACTGATCGATTACTTCAGCAACAACTCCAGC ATCCTGCTGGCCTCAGCTGTCTGGTACTTGATTTTCTTCTGCCCCCTGGACCTCTTCTACAAGTGTGTCTGCTTCCTGCCTGTGAAACTC ATCTTCGTGGCCATGAAGGAGGTGGTGCGAGTCCGCAAGATCGCGGTGGGCATCCATCACGCCCATCACCACTACCACCACGGGTGGTTC GTCATGATTGCAACTGGGTGGGTCAAAGGTTCTGGTGTCGCCCTCATGTCCAACTTTGAGCAGCTGCTCCGAGGGGTCTGGAAGCCAGAG ACCAACGAGATCCTGCACATGTCTTTCCCCACCAAGGCCAGCCTGTATGGAGCCATCCTCTTCACCCTCCAGCAGACCCGCTGGCTCCCA GTGTCCAAAGCCAGCCTCATCTTCATCTTCACCTTGTTCATGGTGTCCTGTAAGGTGTTTCTGACAGCCACCCACTCACACAGCTCCCCC TTTGATGCCCTGGAGGGCTACATCTGCCCCGTGCTGTTTGGTTCGGCCTGCGGGGGTGACCATCACCACGACAACCATGGTGGGTCCCAC AGCGGTGGTGGGCCAGGAGCTCAGCATTCGGCCATGCCCGCCAAGTCCAAGGAGGAGTTGAGCGAGGGCTCCAGGAAGAAGAAGGCCAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DDA1_ENST00000359866_chr19_17425198_+_TMEM38A_ENST00000187762_chr19_16790795_+_2694nt GGCGCCATCAGTGTGGGCTGTGCCGTGGCTGGAAGTTACTGTGAGGCGGCGGCTAAGAAGGCGGCTCTGGTGGCGGCGGTGGAGGCTGAG GCGGCGGCCGAGGCGGCGACGGAGGAAACAGAAGATGGCAGATTTTTTGAAAGGACTGCCTGTCTACAACAAAAGCAATTTTAGTCGATT TCACGCGGACTCCGTGTGCAAAGCCTCGAACCGACGGCCCTCAGTCTACCTGCCTACCCGCGAGTACCCGTCTGAACAGAGAGCAGTCGA ACTGTCCCGGCGCCACCCCATCGCGTCCTGGCTGTGCGCCATGCTGCATTGCTTCGGGAGCTACATCCTGGCTGATCTGCTCCTTGGGGA GCCACTGATCGATTACTTCAGCAACAACTCCAGCATCCTGCTGGCCTCAGCTGTCTGGTACTTGATTTTCTTCTGCCCCCTGGACCTCTT CTACAAGTGTGTCTGCTTCCTGCCTGTGAAACTCATCTTCGTGGCCATGAAGGAGGTGGTGCGAGTCCGCAAGATCGCGGTGGGCATCCA TCACGCCCATCACCACTACCACCACGGGTGGTTCGTCATGATTGCAACTGGGTGGGTCAAAGGTTCTGGTGTCGCCCTCATGTCCAACTT TGAGCAGCTGCTCCGAGGGGTCTGGAAGCCAGAGACCAACGAGATCCTGCACATGTCTTTCCCCACCAAGGCCAGCCTGTATGGAGCCAT CCTCTTCACCCTCCAGCAGACCCGCTGGCTCCCAGTGTCCAAAGCCAGCCTCATCTTCATCTTCACCTTGTTCATGGTGTCCTGTAAGGT GTTTCTGACAGCCACCCACTCACACAGCTCCCCCTTTGATGCCCTGGAGGGCTACATCTGCCCCGTGCTGTTTGGTTCGGCCTGCGGGGG TGACCATCACCACGACAACCATGGTGGGTCCCACAGCGGTGGTGGGCCAGGAGCTCAGCATTCGGCCATGCCCGCCAAGTCCAAGGAGGA GTTGAGCGAGGGCTCCAGGAAGAAGAAGGCCAAGAAGGCGGATTAGGGGGTGGCCCAAGGGGCACCGGGGAGAGGACCCGGACCCAGGAC CCTCTGAGCTGGGAGGCTTCCTGCGCTCAGATCTATCCTTTCCTGGCCTTGACTTCCCCATCTGCAAATCAGGGTCATTGGCTCACCCTC CAGGGCTGATGTGGGGGTTGAGATATGGGGATGAGGATGAAGAACTTTTGTAGAAATCGGGGTTCCCTCTTTCTCTCTGCCAGGACCCCA TAGAGTCACAGCTTTTGGAGGGGTTCACAGAATCCTGGCAGCAGCTCCAGTCAAGAATGTCACTGGTTGGCATGATATTCTTAGTTGTAT TTTTCCTTCTTTAAAATTGCATCTTGACCAGGCACAGTGGCTCATGCCTATAATCCTAGCACTTTGGGAGGCCGAGGCGGGCAGATCACC TGAGGTCAGGAGTTCAAGACCAGCTTGGCCAACATGGTGAAACCCCATCTCTACCAAAAATACAAAAATTAGCCAGACGTGGTGGTGCAC GCCTTTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACATGAATCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATCTTCCCACT GCACTCCAGCCTGGCCAATAAGACCTGTCTCCAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAAATTGCATATTGACTCCTGAAGAACTT CAAGCCATGTTGAGATCCATTCATTTGATGGACATTTTCTAAGTACCTGTGAGCCAGGTGCTGCCATTTCAAAGTCTCTTCTTACCACGC TCCTCAGTGGCTAGACATTTTCACGTGGCCAGAAAGTCCCGACTCTTGCTGGGCGTCCCTGGACAAGTTGCCTTCCTCCTCTGAGCTTGG CGCTCCCCATCTGTATAGTGGAGACCCTTGGCCCCCCTCTGTACGGAAGGGCCGATGCGAAGCTGCAGTTAAAAAAGGCTCACATGCTCC TAGCCTCGTGCAGTCAGGAGGGGAGACCAGGACAGTTGGAAATTATGATTGCAAATGGCTTTGCATTTTAGATCATTCGTGTGTGTGGAT CAGAGAAACGCACAAGTTCCCTGGCACAAAGGAAGCCCTCAGTAGACACGTCTAGGGCAGGCTTGAGAGATCAGATGGCGTGAAAGGCTT GTGATCTGTTCGTCTCAGGCTCCCCCTAAACCAAAGAAATGGAAACAGCTGGTTGGGGTTCCACGATCCAGCTCTATCAAGGGGCTCTGA GTGTGCACAGTTGGGACCTGGATGTATCAGGTCTCCCTCAGGCTGGAGTCCACTGTCACTCATTCAGCCATTGAACAAACATACAGATGC TTACCTGCTCTGTGGTCAGCCTTGTGCTGCTGCTGGGCGGGCCAGGAGCCTGCTTCAGTGTGAGCGAGGTGGATGATATTATAGCTGAAG GGTCCCTCCTGGTCACCCTCATCTCAGCCTAGGTCACCAGGATGTCTGAGAGGGGTGGGTGCATGGGACGGGCGTGGCCAGTCTCAGGTG AGGTTTGGGCCCAGACCTCGTTGGAGTCCCAGACGTTGCCAGGCTGTTGGAAAATTGCCTTGTTCCTGTGATGCCTGGGAGTTAGGTGGG |
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FusionGenePPI for DDA1_TMEM38A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DDA1 | COPS6, DDB1, CUL4A, AMBRA1, VPRBP, DCAF17, DDB2, DCAF11, ANKFY1, LTA4H, ASNS, FKBP4, LARS, PGK1, TARS, ECHS1, PA2G4, HADHA, SHMT2, ETFA, COPA, PRKDC, CBR1, FARSB, SRM, LAP3, DCAF5, WDTC1, SEPT9, NANS, ESD, CAND1, WARS, PRKAA1, IDH3A, MCM2, ALDH7A1, ADSL, ALDH9A1, NAMPT, GMPS, EIF5, COPB2, HADHB, TRPC4AP, ELAVL1, UBE2E3, DET1, COPS3, COPS5, RBX1, CUL4B, RFWD2, COPS2, COPS4, COPS7A, COPS7B, COPS8, PWP1, DCAF12, ERCC8, DCAF6, DCAF10, DTL, DCAF8, DCAF15, DCAF16, TOR1AIP2, TUBG1, AGTRAP, CMTM5, UBE2E1, UBE2E2, MRPS11, LNX2, LLGL2, WSB2, RFPL4B, CFAP20, DCAF7 | TMEM38A | ARRB2, NCEH1, PCP2, DOK2, HSD3B2, OXLD1, LZTFL1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DDA1_TMEM38A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDA1_TMEM38A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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