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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9486

FusionGeneSummary for DCXR_SIRT7

check button Fusion gene summary
Fusion gene informationFusion gene name: DCXR_SIRT7
Fusion gene ID: 9486
HgeneTgene
Gene symbol

DCXR

SIRT7

Gene ID

51181

51547

Gene namedicarbonyl and L-xylulose reductasesirtuin 7
SynonymsDCR|HCR2|HCRII|KIDCR|P34H|PNTSU|SDR20C1|XRSIR2L7
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
DescriptionL-xylulose reductasecarbonyl reductase 2carbonyl reductase IIdicarbonyl/L-xylulose reductasekidney dicarbonyl reductaseshort chain dehydrogenase/reductase family 20C member 1sperm surface protein P34HNAD-dependent protein deacetylase sirtuin-7NAD-dependent deacetylase sirtuin-7SIR2-like protein 7regulatory protein SIR2 homolog 7silent mating type information regulation 2, S.cerevisiae, homolog 7sir2-related protein type 7sirtuin type 7
Modification date2018052320180519
UniProtAcc

Q7Z4W1

Q9NRC8

Ensembl transtripts involved in fusion geneENST00000306869, ENST00000584318, 
ENST00000328666, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 42
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: DCXR [Title/Abstract] AND SIRT7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCXR

GO:0005997

xylulose metabolic process

11882650

HgeneDCXR

GO:0006006

glucose metabolic process

11882650

HgeneDCXR

GO:0051289

protein homotetramerization

11882650

HgeneDCXR

GO:0055114

oxidation-reduction process

19442656

TgeneSIRT7

GO:0000122

negative regulation of transcription by RNA polymerase II

22722849

TgeneSIRT7

GO:0070932

histone H3 deacetylation

22722849


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-GJ-A6C0-01ADCXRchr17

79994597

-SIRT7chr17

79873557

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000306869ENST00000328666DCXRchr17

79994597

-SIRT7chr17

79873557

-
5UTR-3CDSENST00000584318ENST00000328666DCXRchr17

79994597

-SIRT7chr17

79873557

-

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FusionProtFeatures for DCXR_SIRT7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCXR

Q7Z4W1

SIRT7

Q9NRC8

Catalyzes the NADPH-dependent reduction of severalpentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism.May play a role in the water absorption and cellularosmoregulation in the proximal renal tubules by producing xylitol,an osmolyte, thereby preventing osmolytic stress from occurring inthe renal tubules. NAD-dependent protein deacetylase that specificallymediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). Incontrast to other histone deacetylases, displays selectivity for asingle histone mark, H3K18Ac, directly linked to control of geneexpression. H3K18Ac is mainly present around the transcriptionstart site of genes and has been linked to activation of nuclearhormone receptors. SIRT7 thereby acts as a transcriptionrepressor. Moreover, H3K18 hypoacetylation has been reported as amarker of malignancy in various cancers and seems to maintain thetransformed phenotype of cancer cells. These data suggest thatSIRT7 may play a key role in oncogenic transformation bysuppresses expression of tumor suppressor genes by locus-specificdeacetylation of H3K18Ac at promoter regions. Also required torestore the transcription of ribosomal RNA (rRNA) at the exit frommitosis: promotes the association of RNA polymerase I with therDNA promoter region and coding region. Stimulates transcriptionactivity of the RNA polymerase I complex. May also deacetylatep53/TP53 and promotes cell survival, however such data needadditional confirmation. {ECO:0000269|PubMed:16618798,ECO:0000269|PubMed:19174463, ECO:0000269|PubMed:22722849}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCXRchr17:79994597chr17:79873557ENST00000306869-4811_40116245Nucleotide bindingNADP
TgeneSIRT7chr17:79994597chr17:79873557ENST00000328666-210167_170112401Nucleotide bindingNAD
TgeneSIRT7chr17:79994597chr17:79873557ENST00000328666-210268_270112401Nucleotide bindingNAD
TgeneSIRT7chr17:79994597chr17:79873557ENST00000328666-210297_299112401Nucleotide bindingNAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSIRT7chr17:79994597chr17:79873557ENST00000328666-2108_74112401Compositional biasNote=Arg-rich
TgeneSIRT7chr17:79994597chr17:79873557ENST00000328666-21090_331112401DomainDeacetylase sirtuin-type
TgeneSIRT7chr17:79994597chr17:79873557ENST00000328666-210107_126112401Nucleotide bindingNAD


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FusionGeneSequence for DCXR_SIRT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DCXR_ENST00000306869_chr17_79994597_-_SIRT7_ENST00000328666_chr17_79873557_-_405aa
MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQ
PFLEVTKEAFDRSFEVNLRAVIQVSQAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRS
GLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILC
LGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGEEGSHS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DCXR_ENST00000306869_chr17_79994597_-_SIRT7_ENST00000328666_chr17_79873557_-_1215nt
ATGGAGCTGTTCCTCGCGGGCCGCCGGGTGCTGGTCACCGGGGCAGGCAAAGGTATAGGGCGCGGCACGGTCCAGGCGCTGCACGCGACG
GGCGCGCGGGTGGTGGCTGTGAGCCGGACTCAGGCGGATCTTGACAGCCTTGTCCGCGAGTGCCCGGGGATAGAACCCGTGTGCGTGGAC
CTGGGTGACTGGGAGGCCACCGAGCGGGCGCTGGGCAGCGTGGGCCCCGTGGACCTGCTGGTGAACAACGCCGCTGTCGCCCTGCTGCAG
CCCTTCCTGGAGGTCACCAAGGAGGCCTTTGACAGATCCTTTGAGGTGAACCTGCGTGCGGTCATCCAGGTGTCGCAGGCAGCGTCTATC
CCAGACTACCGGGGCCCTAATGGAGTGTGGACACTGCTTCAGAAAGGGAGAAGCGTTAGTGCTGCCGACCTGAGCGAGGCCGAGCCAACC
CTCACCCACATGAGCATCACCCGTCTGCATGAGCAGAAGCTGGTGCAGCATGTGGTGTCTCAGAACTGTGACGGGCTCCACCTGAGGAGT
GGGCTGCCGCGCACGGCCATCTCCGAGCTCCACGGGAACATGTACATTGAAGTCTGTACCTCCTGCGTTCCCAACAGGGAGTACGTGCGG
GTGTTCGATGTGACGGAGCGCACTGCCCTCCACAGACACCAGACAGGCCGGACCTGCCACAAGTGTGGGACCCAGCTGCGGGACACCATT
GTGCACTTTGGGGAGAGGGGGACGTTGGGGCAGCCTTTGAACTGGGAAGCGGCGACCGAGGCTGCCAGCAGAGCAGACACCATCCTGTGT
CTAGGGTCCAGCCTGAAGGTTCTAAAGAAGTACCCACGCCTCTGGTGCATGACCAAGCCCCCTAGCCGGCGGCCGAAGCTTTACATCGTG
AACCTGCAGTGGACCCCGAAGGATGACTGGGCTGCCCTGAAGCTACATGGGAAGTGTGATGACGTCATGCGGCTCCTCATGGCCGAGCTG
GGCTTGGAGATCCCCGCCTATAGCAGGTGGCAGGATCCCATTTTCTCACTGGCGACTCCCCTGCGTGCTGGTGAAGAAGGCAGCCACAGT
CGGAAGTCGCTGTGCAGAAGCAGAGAGGAGGCCCCGCCTGGGGACCGGGGTGCACCGCTTAGCTCGGCCCCCATCCTAGGGGGCTGGTTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_DCXR_ENST00000306869_chr17_79994597_-_SIRT7_ENST00000328666_chr17_79873557_-_1742nt
AGAGCTTCAAGTTCCGCAGCCCCAGTGCGGAGGGCGGAGACTGCGCCGACATGGAGCTGTTCCTCGCGGGCCGCCGGGTGCTGGTCACCG
GGGCAGGCAAAGGTATAGGGCGCGGCACGGTCCAGGCGCTGCACGCGACGGGCGCGCGGGTGGTGGCTGTGAGCCGGACTCAGGCGGATC
TTGACAGCCTTGTCCGCGAGTGCCCGGGGATAGAACCCGTGTGCGTGGACCTGGGTGACTGGGAGGCCACCGAGCGGGCGCTGGGCAGCG
TGGGCCCCGTGGACCTGCTGGTGAACAACGCCGCTGTCGCCCTGCTGCAGCCCTTCCTGGAGGTCACCAAGGAGGCCTTTGACAGATCCT
TTGAGGTGAACCTGCGTGCGGTCATCCAGGTGTCGCAGGCAGCGTCTATCCCAGACTACCGGGGCCCTAATGGAGTGTGGACACTGCTTC
AGAAAGGGAGAAGCGTTAGTGCTGCCGACCTGAGCGAGGCCGAGCCAACCCTCACCCACATGAGCATCACCCGTCTGCATGAGCAGAAGC
TGGTGCAGCATGTGGTGTCTCAGAACTGTGACGGGCTCCACCTGAGGAGTGGGCTGCCGCGCACGGCCATCTCCGAGCTCCACGGGAACA
TGTACATTGAAGTCTGTACCTCCTGCGTTCCCAACAGGGAGTACGTGCGGGTGTTCGATGTGACGGAGCGCACTGCCCTCCACAGACACC
AGACAGGCCGGACCTGCCACAAGTGTGGGACCCAGCTGCGGGACACCATTGTGCACTTTGGGGAGAGGGGGACGTTGGGGCAGCCTTTGA
ACTGGGAAGCGGCGACCGAGGCTGCCAGCAGAGCAGACACCATCCTGTGTCTAGGGTCCAGCCTGAAGGTTCTAAAGAAGTACCCACGCC
TCTGGTGCATGACCAAGCCCCCTAGCCGGCGGCCGAAGCTTTACATCGTGAACCTGCAGTGGACCCCGAAGGATGACTGGGCTGCCCTGA
AGCTACATGGGAAGTGTGATGACGTCATGCGGCTCCTCATGGCCGAGCTGGGCTTGGAGATCCCCGCCTATAGCAGGTGGCAGGATCCCA
TTTTCTCACTGGCGACTCCCCTGCGTGCTGGTGAAGAAGGCAGCCACAGTCGGAAGTCGCTGTGCAGAAGCAGAGAGGAGGCCCCGCCTG
GGGACCGGGGTGCACCGCTTAGCTCGGCCCCCATCCTAGGGGGCTGGTTTGGCAGGGGCTGCACAAAACGCACAAAAAGGAAGAAAGTGA
CGTAATCACGTGCTCGATGAAGAACAGTTGGCACTTTGCAGATGGCCAGTGTCACGGTGAAGGCTGGGTTGCCCCCACGGGTCTAGGGAG
AACGAACTCTTTGGGGATGACATTTTCACCGTGACATTTTTAGCCATTTGTCCTTGAGGAAGCCCCTTGCACTGCTGCGGTTGTACCCTG
ATACGGCCTGGCCATCGAGGACACCTGCCCATCCGGCCTCTGTGTCAAGAGGTGGCAGCCGCACCTTTCTGTGAGAACGGAACTCGGGTT
ATTTCAGCCCCGGCCTGCAGAGTGGAAGCGCCCAGCGGCCTTTCCTCGCTCACCAGGCCAGTCTCAGGGCCTCACCGTATTTCTACTACT
ACTTAATGAAAAAGTGTGAACTTTATAGAATCCTCTCTGTACTGGATGTGCGGCAGAGGGGTGGCTCCGAGCCTCGGCTCTATGCAGACC


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FusionGenePPI for DCXR_SIRT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCXRDMWD, APP, CRADD, DCXR, ABCE1, DEF6, SPHK1, C11orf54, CAB39, CAB39L, C4orf33, CRYZ, GPI, PIR, GOT1, ASB6, TRIM25SIRT7MAGED1, UBTF, POLR1A, HIST1H4A, HIST1H3A, HIST2H2BE, HIST2H2AC, NR0B2, MYBBP1A, FLNA, MKI67, FASN, PRKDC, MYH9, USP9X, DYNC1H1, EPPK1, DSP, SNRNP200, CLTC, PRPF8, PLEC, PDCD11, TUBA1C, DDX21, HEATR1, TUBB4A, NUMA1, FLNB, RANBP2, SPTAN1, ACTN4, TLN1, VCP, SPTBN1, PABPC1, HNRNPUL1, UTP20, MYH10, NOP2, UPF1, TPR, GCN1L1, SEC16A, FLNC, IQGAP1, UBR4, RPL4, CAD, PRRC2C, MDN1, GANAB, ACTN1, PDIA4, SF3B1, PABPC4, HIST1H2BL, DHX30, POLR2A, HUWE1, NCL, HYOU1, LMNA, KPNB1, HIST1H2BJ, RPLP0, DDB1, MOV10, CCT2, ACIN1, ACLY, CNOT1, BAZ1B, HSPA9, RRP12, NAT10, ATP1A1, RPL6, DHX15, GNB2L1, CCT3, FTSJ3, RSL1D1, RPL3, NUP205, MDC1, NOP58, YTHDC2, COPA, EIF4A1, XRCC6, BMS1, TBL3, EIF4G1, HSPA2, PELP1, HIST1H1E, RPL5, ATP2A2, SON, WDR36, GTPBP4, NUP214, EDC4, RBM28, IGF2BP3, LRPPRC, DDX27, NVL, PES1, SF3B2, H2AFX, HNRNPF, PHIP, MYO1B, MYH14, URB1, CEBPZ, CHD4, SYNCRIP, RBMX, SND1, ZFR, HNRNPA3, UTP14A, SMCHD1, CCT5, GTF3C1, DDX18, AHNAK, RPSA, YLPM1, RPL7A, RPS4X, UBR5, ACACA, MYO1C, SUGP2, WDR3, RPS2, PRRC2A, TRIP12, NOL6, NES, SUPT6H, ILF2, NUP153, CKAP5, LARP1, PWP2, NUP155, DDX24, FN1, NOC2L, BOP1, NUP210, FBL, CCAR2, ZNF638, FAM120A, MACF1, HERC2, HELZ, DOCK7, ANKHD1, TAF15, XRN2, UGGT1, RPL7, SFPQ, XRCC5, KIAA0020, DICER1, TEX10, SPEN, NOL11, HSPA4, SERBP1, RAD50, GNL3, TOP1, HIST1H1D, FUS, SUPT5H, MCM6, FRYL, SRRM2, WDR46, DNTTIP2, RPS3A, HADHA, NIFK, PFKP, NPEPPS, STRBP, TJP1, MAP1B, LAS1L, LMNB2, ASCC3, ZC3HAV1, WDR75, U2SURP, HDLBP, MCM5, NUP160, AHCTF1, NKRF, RPL10A, ELAVL1, P4HB, IMMT, RPL14, PGK1, KIAA1429, XPO1, NOP14, HP1BP3, SKIV2L2, AARS, CPSF1, HELZ2, BRIX1, DHX57, NOC3L, EXOSC10, NUP133, GAPVD1, SMARCA4, HCFC1, ANKRD17, URB2, FAM208B, COPB1, PSMD1, RPS6, PSMD2, GDI2, BIRC6, TP53BP1, KMT2A, RANGAP1, EBNA1BP2, RRP1B, NDUFS1, NUP93, NPM1, MCM4, XRN1, TRRAP, RSF1, RIF1, WDR43, IGF2BP2, EIF3L, SRSF4, FMR1, CANX, RAI1, FXR2, MSN, ATAD2, USP7, TJP2, IGF2R, DDX54, DDX10, PNN, RPLP2, RPL30, G3BP1, ZNF512, RPS5, RPL15, CALR, CKB, CUL9, NIPBL, KRI1, NARS, NCBP1, CSE1L, CHD1, COIL, EIF4G3, GEMIN5, XPO5, EIF3D, NUP107, SMARCC2, TUFM, SF3A1, GTF2I, THOC2, ATXN2L, EPB41L2, SART1, SLTM, RPS14, RPS7, SRSF3, RPS16, MSH6, DNMT1, MYCBP2, CHD8, SBF1, BYSL, MPHOSPH10, ZSWIM8, PRRC2B, RPS15, COPG1, RPL9, PPP1CA, ALYREF, COPB2, RPL23A, PFAS, NSUN2, DST, LCP1, GNL2, BLM, ZNF318, SYNE2, SCAF11, ANXA1, ATAD3A, RPL8, PPP1CC, RBM15, ATIC, IPO5, UBAP2L, BAZ2A, PHF3, DDX31, PCM1, NUP98, UTP6, KIAA0368, PPM1G, RPL10, TP53, PRPF6, SERPINH1, PPP1CB, RPL19, SMC4, CUL4B, RBM39, KIF14, PPP6R3, COPG2, UTRN, UTP18, GEMIN4, WDR12, SMU1, ACTR3, CEP170, RPS12, SART3, NUP88, TPP2, AP2B1, CSDE1, ALDH18A1, KIF5B, DDX42, KHSRP, NEFM, HECTD1, HERC5, OASL, CIRH1A, TSR1, UTP15, RBM25, POP1, ZC3H11A, SEC24C, RPN2, IKBKAP, MTHFD1L, PPP2R1A, RPL18A, RPL26, GART, ABCF1, U2AF2, DHX8, DDX52, SRSF5, NOC4L, RPL21, AP1B1, NUP188, STAU1, FXR1, RNH1, VDAC1, PRMT5, DPYSL2, TNKS1BP1, CHD2, RBM34, MRTO4, NEFL, STOML2, INA, PRDX4, GFPT1, IRS4, RRS1, USP47, DHX37, CTCF, SNX9, SMARCA2, BPTF, ACSL3, WDR18, KIF1A, TTC37, KARS, NOL10, FSCN1, INCENP, PRPF40A, NXF1, SNW1, EIF5B, AATF, PLOD1, SOGA1, MCM3AP, PRPF4B, EIF6, RRP1, KIF23, CAPRIN1, RPS19, DNAJA1, XAB2, CHERP, RTCB, SEC23A, EPB41L3, RRP9, ZC3H14, NF1, DDX56, ESF1, CCDC86, RPS10, GLYR1, SRP68, RPS26, MYEF2, GSTP1, ZMYM3, SDHA, LTA4H, IPO7, STAG2, HIST1H1A, RCL1, CENPF, ZCCHC3, COL5A1, DCAF13, CTNNA1, USP24, MLLT4, KRR1, NSA2, SRPK1, CSNK2A1, GLTSCR2, MTA2, AQR, RPS23, TCOF1, PAICS, PSMC2, DHX38, PBRM1, TNPO1, VCL, ADNP, ARF3, REXO4, DHX36, CUL7, MED12, MYO5A, ITPR3, DIDO1, RPL38, PWP1, SRP72, NOL9, GTF3C3, SEC13, PTCD3, MTOR, CBX3, PHRF1, INTS1, RPS24, POGZ, CRNKL1, WARS, CAPN1, DDX46, SSB, ACAT1, FANCI, PSMC3, MRE11A, GDI1, RBBP4, SLC25A13, RPF2, RRP7A, PUM1, ZC3H18, DIEXF, CHD7, MYO1D, USP34, ACTR2, TCF20, CSNK2A2, SPTBN2, SRRM1, PARN, CPSF3, SKIV2L, PSMD12, SNRNP70, MAK16, ZC3H13, OSBPL8, MAP4, IPO4, POLRMT, NCAPD2, NOLC1, RBBP7, PDS5A, IMPDH2, DHX16, HK1, OAT, LONP1, WHSC1, RPLP1, NSD1, RRP8, DDX20, GIGYF2, ABCE1, LARP7, KDM1A, RBM6, SMARCC1, ANXA6, EIF3I, ATAD2B, EIF3E, SEC23B, POLDIP3, LARP4B, LARP4, CGN, PREP, DNM2, PUF60, PYGB, FUBP3, IARS2, USP5, DLD, RAD21, PNP, PDCD6IP, H1FX, ZBTB11, ZCCHC8, USP11, IK, ASNS, UBE2O, SYMPK, RECQL, NCKAP1, HDAC2, DLAT, CLUH, ANKRD28, NUFIP2, WDR6, RNPEP, RFC1, DDX51, PGAM5, NNT, RCC2, ME2, PSMC5, DDX23, FKBP4, ZCCHC6, ANKRD52, POLE, NLE1, PDS5B, NAP1L1, EWSR1, CCAR1, LRRC47, TTF1, ANAPC1, POLA1, UQCRC2, SPAG9, XPOT, PDHA1, PGAM1, PCNT, PRKRA, ARID1A, MSH2, SRSF2, GMPS, UQCRC1, BEND3, KIF4A, TTLL12, PYGL, CAP1, SURF6, PNPT1, ANXA11, ARHGDIA, MVP, ATM, NAA15, DIS3, S100A8, TGM3, FH, XPO7, LTF, APP, VPRBP, POLH, AURKA, KBTBD7, MDM2, SIRT1, PSME2, CDK9, FOXO1, ELK4, COPS4, UBE2R2, WDR77, DCAF11, DCAF5, DCAF7, COPS5, CUL4A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCXR_SIRT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDCXRQ7Z4W1DB02325Isopropyl AlcoholL-xylulose reductasesmall moleculeapproved|investigational

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RelatedDiseases for DCXR_SIRT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCXRC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneDCXRC0028754Obesity1CTD_human
HgeneDCXRC0033578Prostatic Neoplasms1CTD_human
HgeneDCXRC0268162Pentosuria1CTD_human;ORPHANET
TgeneSIRT7C0015695Fatty Liver1CTD_human
TgeneSIRT7C0036421Systemic Scleroderma1CTD_human