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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9470

FusionGeneSummary for DCUN1D2_ATP11A

check button Fusion gene summary
Fusion gene informationFusion gene name: DCUN1D2_ATP11A
Fusion gene ID: 9470
HgeneTgene
Gene symbol

DCUN1D2

ATP11A

Gene ID

55208

23250

Gene namedefective in cullin neddylation 1 domain containing 2ATPase phospholipid transporting 11A
SynonymsC13orf17ATPIH|ATPIS
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
DescriptionDCN1-like protein 2DCN1, defective in cullin neddylation 1, domain containing 2DCUN1 domain-containing protein 2defective in cullin neddylation protein 1-like protein 2probable phospholipid-transporting ATPase IHATPase, class VI, type 11AP4-ATPase flippase complex alpha subunit ATP11Aphospholipid-translocating ATPasepotential phospholipid-transporting ATPase IH
Modification date2018052320180523
UniProtAcc

Q6PH85

P98196

Ensembl transtripts involved in fusion geneENST00000332592, ENST00000478244, 
ENST00000375399, ENST00000460318, 
ENST00000283558, ENST00000375630, 
ENST00000487903, ENST00000375645, 
ENST00000419448, 
Fusion gene scores* DoF score3 X 3 X 3=2711 X 10 X 4=440
# samples 313
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(13/440*10)=-1.7589919004962
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCUN1D2 [Title/Abstract] AND ATP11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-KF-A41W-01ADCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000332592ENST00000283558DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-3CDSENST00000332592ENST00000375630DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-3CDSENST00000332592ENST00000487903DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-3CDSENST00000332592ENST00000375645DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-intronENST00000332592ENST00000419448DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000478244ENST00000283558DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000478244ENST00000375630DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000478244ENST00000487903DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000478244ENST00000375645DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
5CDS-intronENST00000478244ENST00000419448DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000375399ENST00000283558DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000375399ENST00000375630DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000375399ENST00000487903DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
Frame-shiftENST00000375399ENST00000375645DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
5CDS-intronENST00000375399ENST00000419448DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-3CDSENST00000460318ENST00000283558DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-3CDSENST00000460318ENST00000375630DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-3CDSENST00000460318ENST00000487903DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-3CDSENST00000460318ENST00000375645DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+
intron-intronENST00000460318ENST00000419448DCUN1D2chr13

114134890

-ATP11Achr13

113439449

+

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FusionProtFeatures for DCUN1D2_ATP11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCUN1D2

Q6PH85

ATP11A

P98196

Potently stimulates the neddylation of cullin componentsof SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play anessential role in the regulation of SCF-type complexes activity.{ECO:0000269|PubMed:23201271}. Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules (Probable). May be involved in the uptake offarnesyltransferase inhibitor drugs, such as lonafarnib.{ECO:0000269|PubMed:15860663, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCUN1D2_ATP11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCUN1D2_ATP11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCUN1D2DCUN1D1, APP, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, UBE2F, UBE2M, MAP3K1, CAND1, RBX1, RNF7, TCEB2ATP11ATMEM30A, NPDC1, PICK1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCUN1D2_ATP11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCUN1D2_ATP11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATP11AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET