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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9458

FusionGeneSummary for DCTN2_NAV3

check button Fusion gene summary
Fusion gene informationFusion gene name: DCTN2_NAV3
Fusion gene ID: 9458
HgeneTgene
Gene symbol

DCTN2

NAV3

Gene ID

10540

89795

Gene namedynactin subunit 2neuron navigator 3
SynonymsDCTN50|DYNAMITIN|HEL-S-77|RBP50POMFIL1|STEERIN3|unc53H3
Cytomap

12q13.3

12q21.2

Type of geneprotein-codingprotein-coding
Descriptiondynactin subunit 250 kDa dynein-associated polypeptidedynactin 2 (p50)dynactin complex 50 kDa subunitepididymis secretory protein Li 77p50 dynamitinneuron navigator 3pore membrane and/or filament interacting like protein 1unc-53 homolog 3
Modification date2018052320180523
UniProtAcc

Q13561

Q8IVL0

Ensembl transtripts involved in fusion geneENST00000548249, ENST00000537439, 
ENST00000434715, ENST00000543672, 
ENST00000551400, 		ENST00000536525, 
ENST00000397909, ENST00000228327, 
ENST00000266692, ENST00000552300, 
ENST00000541270, 
Fusion gene scores* DoF score10 X 5 X 5=25015 X 13 X 4=780
# samples 911
** MAII scorelog2(9/250*10)=-1.47393118833241
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/780*10)=-2.82597060022495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCTN2 [Title/Abstract] AND NAV3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A23R-01ADCTN2chr12

57939811

-NAV3chr12

78522486

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000548249ENST00000536525DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000548249ENST00000397909DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000548249ENST00000228327DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000548249ENST00000266692DCTN2chr12

57939811

-NAV3chr12

78522486

+
5CDS-intronENST00000548249ENST00000552300DCTN2chr12

57939811

-NAV3chr12

78522486

+
5CDS-intronENST00000548249ENST00000541270DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000537439ENST00000536525DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000537439ENST00000397909DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000537439ENST00000228327DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000537439ENST00000266692DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-intronENST00000537439ENST00000552300DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-intronENST00000537439ENST00000541270DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000434715ENST00000536525DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000434715ENST00000397909DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000434715ENST00000228327DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000434715ENST00000266692DCTN2chr12

57939811

-NAV3chr12

78522486

+
5CDS-intronENST00000434715ENST00000552300DCTN2chr12

57939811

-NAV3chr12

78522486

+
5CDS-intronENST00000434715ENST00000541270DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000543672ENST00000536525DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000543672ENST00000397909DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000543672ENST00000228327DCTN2chr12

57939811

-NAV3chr12

78522486

+
Frame-shiftENST00000543672ENST00000266692DCTN2chr12

57939811

-NAV3chr12

78522486

+
5CDS-intronENST00000543672ENST00000552300DCTN2chr12

57939811

-NAV3chr12

78522486

+
5CDS-intronENST00000543672ENST00000541270DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000551400ENST00000536525DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000551400ENST00000397909DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000551400ENST00000228327DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-3CDSENST00000551400ENST00000266692DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-intronENST00000551400ENST00000552300DCTN2chr12

57939811

-NAV3chr12

78522486

+
intron-intronENST00000551400ENST00000541270DCTN2chr12

57939811

-NAV3chr12

78522486

+

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FusionProtFeatures for DCTN2_NAV3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCTN2

Q13561

NAV3

Q8IVL0

Modulates cytoplasmic dynein binding to an organelle,and plays a role in prometaphase chromosome alignment and spindleorganization during mitosis. Involved in anchoring microtubules tocentrosomes. May play a role in synapse formation during braindevelopment. May regulate IL2 production by T-cells. May be involvedin neuron regeneration. {ECO:0000269|PubMed:16166283}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCTN2_NAV3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCTN2_NAV3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCTN2GADD45A, GOLM1, GNAO1, PAFAH1B1, BICD2, MARCKSL1, CALM1, HGS, EGFR, GRB2, UBC, DISC1, MAPK6, CUL3, EMILIN1, NDEL1, KCNA5, ACTR1A, DCTN3, DCTN1, ACTR1B, MCM4, MCM7, PSMC4, POLR2A, PSMD1, RANBP9, STRN4, DYNLRB1, POLR2D, PSMC2, SNRPA1, HSP90AB1, PSMD4, MCM6, TPM4, SMURF1, KPNA2, ACTR10, DCTN4, FLNB, LEO1, LMNB1, NUP43, RABEP1, SEH1L, DYNC1I1, KIFC3, DCTN2, BLOC1S6, HAUS1, CCDC172, NXF1, CSPP1, CAPZA2, EXD2, CCDC138, DCTN5, DCTN6, FBXO28, KLHL2, C17orf59, TRMT1L, TRIM11, ARMC1, CAPZB, CCAR1, PSMA2, PSMA5, PSMB6, SHMT2, DYNC1H1, MCFD2, PSMA1, PSMC1, SMARCC1, SMARCC2, NTRK1, MED4, CEP44, NIN, SCLT1, DBN1, MAPRE1, MYO19, MYO18A, SNW1, CDC5L, MYO6, DUSP13, DUSP19, DUSP28, DEFB127, MIS18A, PDGFD, RPS19BP1, C1orf106, RIC8A, UQCRH, CAPZA1, VTI1B, NINL, CAMK2A, AHI1, CYLD, DNM1L, CCND2NAV3APC, TFAP4, MAPRE1, TRIO, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCTN2_NAV3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCTN2_NAV3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNAV3C0007134Renal Cell Carcinoma1CTD_human
TgeneNAV3C0027412Opioid-Related Disorders1CTD_human