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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9455

FusionGeneSummary for DCTN2_DENND3

check button Fusion gene summary
Fusion gene informationFusion gene name: DCTN2_DENND3
Fusion gene ID: 9455
HgeneTgene
Gene symbol

DCTN2

DENND3

Gene ID

10540

22898

Gene namedynactin subunit 2DENN domain containing 3
SynonymsDCTN50|DYNAMITIN|HEL-S-77|RBP50-
Cytomap

12q13.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptiondynactin subunit 250 kDa dynein-associated polypeptidedynactin 2 (p50)dynactin complex 50 kDa subunitepididymis secretory protein Li 77p50 dynamitinDENN domain-containing protein 3DENN/MADD domain containing 3
Modification date2018052320180519
UniProtAcc

Q13561

A2RUS2

Ensembl transtripts involved in fusion geneENST00000548249, ENST00000537439, 
ENST00000434715, ENST00000543672, 
ENST00000551400, 		ENST00000518347, 
ENST00000424248, ENST00000262585, 
ENST00000519811, ENST00000518806, 
ENST00000523308, 
Fusion gene scores* DoF score10 X 5 X 5=2505 X 5 X 5=125
# samples 96
** MAII scorelog2(9/250*10)=-1.47393118833241
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCTN2 [Title/Abstract] AND DENND3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-P5-A72U-01ADCTN2chr12

57925798

-DENND3chr8

142160933

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000548249ENST00000518347DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000548249ENST00000424248DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000548249ENST00000262585DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000548249ENST00000519811DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000548249ENST00000518806DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000548249ENST00000523308DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000537439ENST00000518347DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000537439ENST00000424248DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000537439ENST00000262585DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000537439ENST00000519811DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000537439ENST00000518806DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000537439ENST00000523308DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000434715ENST00000518347DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000434715ENST00000424248DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000434715ENST00000262585DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000434715ENST00000519811DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000434715ENST00000518806DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000434715ENST00000523308DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000543672ENST00000518347DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000543672ENST00000424248DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000543672ENST00000262585DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000543672ENST00000519811DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000543672ENST00000518806DCTN2chr12

57925798

-DENND3chr8

142160933

+
5CDS-intronENST00000543672ENST00000523308DCTN2chr12

57925798

-DENND3chr8

142160933

+
intron-intronENST00000551400ENST00000518347DCTN2chr12

57925798

-DENND3chr8

142160933

+
intron-intronENST00000551400ENST00000424248DCTN2chr12

57925798

-DENND3chr8

142160933

+
intron-intronENST00000551400ENST00000262585DCTN2chr12

57925798

-DENND3chr8

142160933

+
intron-intronENST00000551400ENST00000519811DCTN2chr12

57925798

-DENND3chr8

142160933

+
intron-intronENST00000551400ENST00000518806DCTN2chr12

57925798

-DENND3chr8

142160933

+
intron-intronENST00000551400ENST00000523308DCTN2chr12

57925798

-DENND3chr8

142160933

+

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FusionProtFeatures for DCTN2_DENND3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCTN2

Q13561

DENND3

A2RUS2

Modulates cytoplasmic dynein binding to an organelle,and plays a role in prometaphase chromosome alignment and spindleorganization during mitosis. Involved in anchoring microtubules tocentrosomes. May play a role in synapse formation during braindevelopment. Guanine nucleotide exchange factor (GEF) activatingRAB12. Promotes the exchange of GDP to GTP, converting inactiveGDP-bound RAB12 into its active GTP-bound form (PubMed:20937701).Regulates autophagy in response to starvation through RAB12activation. Starvation leads to ULK1/2-dependent phosphorylationof Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3adapter proteins and leads to up-regulation of GEF activitytowards RAB12 (By similarity). Also plays a role in proteintransport from recycling endosomes to lysosomes, regulating, forinstance, the degradation of the transferrin receptor and of theamino acid transporter PAT4 (PubMed:20937701). Starvation alsoinduces phosphorylation at Tyr-858, which leads to up-regulatedGEF activity and initiates autophagy (By similarity).{ECO:0000250|UniProtKB:A2RT67, ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCTN2_DENND3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCTN2_DENND3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCTN2GADD45A, GOLM1, GNAO1, PAFAH1B1, BICD2, MARCKSL1, CALM1, HGS, EGFR, GRB2, UBC, DISC1, MAPK6, CUL3, EMILIN1, NDEL1, KCNA5, ACTR1A, DCTN3, DCTN1, ACTR1B, MCM4, MCM7, PSMC4, POLR2A, PSMD1, RANBP9, STRN4, DYNLRB1, POLR2D, PSMC2, SNRPA1, HSP90AB1, PSMD4, MCM6, TPM4, SMURF1, KPNA2, ACTR10, DCTN4, FLNB, LEO1, LMNB1, NUP43, RABEP1, SEH1L, DYNC1I1, KIFC3, DCTN2, BLOC1S6, HAUS1, CCDC172, NXF1, CSPP1, CAPZA2, EXD2, CCDC138, DCTN5, DCTN6, FBXO28, KLHL2, C17orf59, TRMT1L, TRIM11, ARMC1, CAPZB, CCAR1, PSMA2, PSMA5, PSMB6, SHMT2, DYNC1H1, MCFD2, PSMA1, PSMC1, SMARCC1, SMARCC2, NTRK1, MED4, CEP44, NIN, SCLT1, DBN1, MAPRE1, MYO19, MYO18A, SNW1, CDC5L, MYO6, DUSP13, DUSP19, DUSP28, DEFB127, MIS18A, PDGFD, RPS19BP1, C1orf106, RIC8A, UQCRH, CAPZA1, VTI1B, NINL, CAMK2A, AHI1, CYLD, DNM1L, CCND2DENND3CBR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCTN2_DENND3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCTN2_DENND3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource