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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9452

FusionGeneSummary for DCTN1_WDR54

check button Fusion gene summary
Fusion gene informationFusion gene name: DCTN1_WDR54
Fusion gene ID: 9452
HgeneTgene
Gene symbol

DCTN1

WDR54

Gene ID

1639

84058

Gene namedynactin subunit 1WD repeat domain 54
SynonymsDAP-150|DP-150|P135-
Cytomap

2p13.1

2p13.1

Type of geneprotein-codingprotein-coding
Descriptiondynactin subunit 1150 kDa dynein-associated polypeptidedynactin 1 (p150, glued homolog, Drosophila)WD repeat-containing protein 54
Modification date2018051920180519
UniProtAcc

Q14203

Q9H977

Ensembl transtripts involved in fusion geneENST00000394003, ENST00000361874, 
ENST00000407639, ENST00000409438, 
ENST00000409240, ENST00000409868, 
ENST00000409567, ENST00000495643, 
ENST00000461531, ENST00000409791, 
ENST00000348227, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DCTN1 [Title/Abstract] AND WDR54 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCTN1

GO:0031116

positive regulation of microtubule polymerization

23874158

HgeneDCTN1

GO:0090063

positive regulation of microtubule nucleation

23874158


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-SH-A7BD-01ADCTN1chr2

74618921

-WDR54chr2

74649997

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000394003ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000394003ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000394003ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000361874ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000361874ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000361874ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000407639ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000407639ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000407639ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000409438ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000409438ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000409438ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+
5UTR-3UTRENST00000409240ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
5UTR-3UTRENST00000409240ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
5UTR-3UTRENST00000409240ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+
5UTR-3UTRENST00000409868ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
5UTR-3UTRENST00000409868ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
5UTR-3UTRENST00000409868ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000409567ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000409567ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000409567ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000495643ENST00000461531DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000495643ENST00000409791DCTN1chr2

74618921

-WDR54chr2

74649997

+
intron-3UTRENST00000495643ENST00000348227DCTN1chr2

74618921

-WDR54chr2

74649997

+

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FusionProtFeatures for DCTN1_WDR54


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCTN1

Q14203

WDR54

Q9H977


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCTN1_WDR54


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCTN1_WDR54


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCTN1HAP1, GSTK1, BZW1, AKTIP, RFXANK, BBS4, VIM, DYNC1H1, DST, PLK1, KIF11, PAFAH1B1, RAB6A, GRB2, EPB41, SPTBN1, STAT1, FBXL5, MED14, DISC1, DTNBP1, DYNC1I1, NEK2, KIAA0408, CDC37, AKT1, PFDN1, PPP1CA, KIAA0368, CUL3, DYNLL1, DCTN1, DCTN2, SAP30BP, POLR2B, MCM3, RNF168, FLNC, MCCC1, RANBP9, STRN4, RBL2, SMURF1, PEX14, ZNF512B, BBS1, FBXW4, MTERF1, LGR4, BICD2, DYNC1LI1, MAPT, MOV10, NXF1, CAPZA2, ACTR1B, CYFIP1, ACTR1A, CAPZB, CC2D1B, CCAR1, DCTN4, DNAJA2, DYNC1I2, PSMB6, PSMD11, SF3A3, SF3B3, EIF2A, PACSIN3, POP1, NTRK1, HSPB2, CEP170, NIN, ACTR10, AGK, AURKB, BTF3, BTF3L4, KNSTRN, TMEM256, CAMSAP2, CCNB1, CKAP2, CKAP2L, CLASP1, CLTC, CPVL, DCLK1, DCTN3, DCTN6, DNM2, EBNA1BP2, EML1, EML4, ERLIN2, FDXR, GPATCH1, GTSE1, HAUS8, HMMR, HYOU1, IGF2BP2, IPO7, IPO9, CEP170B, KIF2A, LASP1, LONP1, LUZP1, MAP1LC3B, MAP1S, MAP2, MAP7, MAP7D1, MAP7D2, MAP7D3, MAP9, MAPRE1, MAPRE2, MAPRE3, MTUS1, NAP1L1, NAP1L4, NMT1, NNT, NUBP2, PLEKHA5, PSMD14, PSMD7, RAB2A, RAB35, RAB8A, SDHC, SKA2, SKA3, SPAG5, SRSF2, EMC3, TRIM36, TSFM, UQCRC1, ZC3H15, ZNF622, ABRACL, ANXA1, ARHGEF2, HYPK, CAMSAP1, CC2D1A, CCDC124, CEP41, CEP44, CHTOP, CLASP2, CLIP1, DCDC2, DCLK2, DCTN5, DLGAP5, DVL1, FAM83D, GAS2L3, GPX1, HAUS4, HAUS6, HAUS7, CFAP97, KIF14, KIF2C, LSM14B, LTV1, MARK2, STK26, MTPN, NAA10, NAA15, NACA, NDC80, NDUFA5, NEBL, NEDD1, NPLOC4, PAPOLG, PDZD11, PRC1, SKA1, SLAIN2, SPC24, SRP9, SUPT16H, TBCEL, TDRD3, TSR1, TTF2, TTK, UPF1, YTHDC2, YTHDF1, YTHDF2, ZC2HC1A, DYNLT1, MYO19, SEC16A, TRIM29, IRF3, SNW1, DCDC5, MYO6, DUSP12, DUSP13, KLHL2, MIPEP, RIC8A, DSTYK, C1orf106, PDGFD, RPS19BP1, C16orf45, ACTA2, CAPZA1, NINL, AHI1, CAMK2A, CYLD, TRIM25, UBE2A, HEY1, BRCA1, TES, WWC1WDR54RBPMS, MEMO1, DOK3, STAC3, FLYWCH2, OSCP1, XPO1, DUSP8, BCL7A, GYG2, TKT, GMEB1, APEX2, USP16, MAPK8IP3, DMD, SCGB1D1, BCL7C, MTMR14, PAPL, BOC, NAGPA, CLEC3A, LCN15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCTN1_WDR54


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCTN1_WDR54


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCTN1C1868594Perry Syndrome6CTD_human;ORPHANET;UNIPROT
HgeneDCTN1C1843315Neuronopathy, Distal Hereditary Motor, Type Viib5CTD_human;UNIPROT
HgeneDCTN1C1862939AMYOTROPHIC LATERAL SCLEROSIS 12CTD_human;UNIPROT
HgeneDCTN1C0242422Parkinsonian Disorders1CTD_human;HPO
HgeneDCTN1C0525045Mood Disorders1CTD_human
HgeneDCTN1C3203358Hypoventilation1CTD_human;HPO