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Fusion gene ID: 9443 |
FusionGeneSummary for DCPS_TIRAP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DCPS_TIRAP | Fusion gene ID: 9443 | Hgene | Tgene | Gene symbol | DCPS | TIRAP | Gene ID | 28960 | 114609 |
| Gene name | decapping enzyme, scavenger | TIR domain containing adaptor protein | |
| Synonyms | ARS|DCS1|HINT-5|HINT5|HSL1|HSPC015 | BACTS1|Mal|MyD88-2|wyatt | |
| Cytomap | 11q24.2 | 11q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | m7GpppX diphosphatase5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatasedecapping scavenger enzymeheat shock-like protein 1hint-related 7meGMP-directed hydrolasehistidine triad nucleotide-binding protein 5histidine triad protein member 5ho | toll/interleukin-1 receptor domain-containing adapter proteinMyD88 adapter-like proteinToll-like receptor adaptor proteinadapter protein wyattadaptor protein Wyatttoll-interleukin 1 receptor (TIR) domain containing adaptor protein | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q96C86 | P58753 | |
| Ensembl transtripts involved in fusion gene | ENST00000263579, ENST00000530860, | ENST00000392679, ENST00000467006, ENST00000392678, ENST00000392680, | |
| Fusion gene scores | * DoF score | 4 X 2 X 3=24 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DCPS [Title/Abstract] AND TIRAP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DCPS | GO:0036245 | cellular response to menadione | 16140270 |
| Hgene | DCPS | GO:0043069 | negative regulation of programmed cell death | 16140270 |
| Hgene | DCPS | GO:0045292 | mRNA cis splicing, via spliceosome | 18426921 |
| Tgene | TIRAP | GO:0032496 | response to lipopolysaccharide | 11544529 |
| Tgene | TIRAP | GO:0032738 | positive regulation of interleukin-15 production | 18583567 |
| Tgene | TIRAP | GO:0035665 | TIRAP-dependent toll-like receptor 4 signaling pathway | 11544529 |
| Tgene | TIRAP | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15294994 |
| Tgene | TIRAP | GO:0090073 | positive regulation of protein homodimerization activity | 12062447 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A195-06A | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000263579 | ENST00000392679 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| 5CDS-3UTR | ENST00000263579 | ENST00000467006 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| 5CDS-5UTR | ENST00000263579 | ENST00000392678 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| 5CDS-5UTR | ENST00000263579 | ENST00000392680 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-5UTR | ENST00000530860 | ENST00000392679 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-3UTR | ENST00000530860 | ENST00000467006 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-5UTR | ENST00000530860 | ENST00000392678 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
| intron-5UTR | ENST00000530860 | ENST00000392680 | DCPS | chr11 | 126176639 | + | TIRAP | chr11 | 126160357 | + |
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FusionProtFeatures for DCPS_TIRAP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DCPS | TIRAP |
| Decapping scavenger enzyme that catalyzes the cleavageof a residual cap structure following the degradation of mRNAs bythe 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes capanalog structures like 7-methylguanosine nucleoside triphosphate(m7GpppG) with up to 10 nucleotide substrates (small cappedoligoribonucleotides) and specifically releases 5'-phosphorylatedRNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleavescap analog structures like tri-methyl guanosine nucleosidetriphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does nothydrolyze unmethylated cap analog (GpppG) and shows no decappingactivity on intact m7GpppG-capped mRNA molecules longer than 25nucleotides. Does not hydrolyze 7-methylguanosine diphosphate(m7GDP) to m7GMP (PubMed:22985415). May also play a role in the5'->3 mRNA decay pathway; m7GDP, the downstream product releasedby the 5'->3' mRNA mediated decapping activity, may be alsoconverted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG andstrongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.{ECO:0000269|PubMed:11747811, ECO:0000269|PubMed:12198172,ECO:0000269|PubMed:12871939, ECO:0000269|PubMed:14523240,ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:15383679,ECO:0000269|PubMed:15769464, ECO:0000269|PubMed:16140270,ECO:0000269|PubMed:18426921, ECO:0000269|PubMed:22985415}. | Adapter involved in TLR2 and TLR4 signaling pathways inthe innate immune response. Acts via IRAK2 and TRAF-6, leading tothe activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resultingin cytokine secretion and the inflammatory response. Positivelyregulates the production of TNF-alpha and interleukin-6.{ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DCPS_TIRAP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DCPS_TIRAP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DCPS | GPC5, CDC27, CSNK2A2, CHST4, YWHAQ, ACO1, ASNS, CAMK1D, CAPNS1, NAE1, PCYT2, RAP1GDS1, TUFM, UBA3, ECHS1, GAPDH, GINS3, GINS4, GSS, HSPA5, MSN, PDCD10, PDHA1, PFAS, PPP1R2, PPP5C, VCL, XPO1, ANAPC4, ENO1, FZR1, CA14, AP1G1, AP1M1, PNKP, FLNB, NTRK1, CDC20 | TIRAP | TLR4, MYD88, TIRAP, IRAK2, TRAF6, MAP3K7, IL1RAP, RNF216, TLR2, IRAK4, IRAK1, NF1, ARAF, CCDC47, JAK1, PDS5A, LTN1, RPTOR, SAMHD1, SNRNP200, STAT3, TAB2, UBR1, UBR2, CASP1, SOCS1, BTK, TICAM2, KAT2A, APP, MPP3, PCNA, TAB1, TNFSF9, CAMK2D, CAMK2G, DHPS, NTMT1, BTBD9, KLHL24, TEP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DCPS_TIRAP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCPS_TIRAP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DCPS | C4085595 | AL-RAQAD SYNDROME | 1 | UNIPROT |
| Tgene | TIRAP | C0004610 | Bacteremia | 1 | CTD_human |
| Tgene | TIRAP | C0024530 | Malaria | 1 | CTD_human |
| Tgene | TIRAP | C0032269 | Pneumococcal Infections | 1 | CTD_human |
| Tgene | TIRAP | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | TIRAP | C0041296 | Tuberculosis | 1 | CTD_human |
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