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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9438

FusionGeneSummary for DCP2_REEP5

check button Fusion gene summary
Fusion gene informationFusion gene name: DCP2_REEP5
Fusion gene ID: 9438
HgeneTgene
Gene symbol

DCP2

REEP5

Gene ID

167227

7905

Gene namedecapping mRNA 2receptor accessory protein 5
SynonymsNUDT20C5orf18|D5S346|DP1|TB2|YOP1|Yip2e
Cytomap

5q22.2

5q22.2

Type of geneprotein-codingprotein-coding
Descriptionm7GpppN-mRNA hydrolaseDCP2 decapping enzyme homologhDpcmRNA-decapping enzyme 2nudix (nucleoside diphosphate linked moiety X)-type motif 20receptor expression-enhancing protein 5deleted in polyposis 1polyposis coli region hypothetical protein DP1polyposis locus protein 1
Modification date2018052320180519
UniProtAcc

Q8IU60

Q00765

Ensembl transtripts involved in fusion geneENST00000515408, ENST00000389063, 
ENST00000543319, ENST00000504961, 
ENST00000379638, ENST00000513339, 
ENST00000545426, ENST00000474542, 
ENST00000504247, 
Fusion gene scores* DoF score6 X 5 X 5=1502 X 2 X 2=8
# samples 83
** MAII scorelog2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: DCP2 [Title/Abstract] AND REEP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCP2

GO:0006402

mRNA catabolic process

21070968


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AQ-A54O-01ADCP2chr5

112312683

+REEP5chr5

112238215

-
TCGALDBRCATCGA-E9-A1NA-01ADCP2chr5

112312683

+REEP5chr5

112256953

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000515408ENST00000379638DCP2chr5

112312683

+REEP5chr5

112238215

-
In-frameENST00000515408ENST00000513339DCP2chr5

112312683

+REEP5chr5

112238215

-
Frame-shiftENST00000515408ENST00000545426DCP2chr5

112312683

+REEP5chr5

112238215

-
5CDS-5UTRENST00000515408ENST00000474542DCP2chr5

112312683

+REEP5chr5

112238215

-
5CDS-intronENST00000515408ENST00000504247DCP2chr5

112312683

+REEP5chr5

112238215

-
In-frameENST00000389063ENST00000379638DCP2chr5

112312683

+REEP5chr5

112238215

-
In-frameENST00000389063ENST00000513339DCP2chr5

112312683

+REEP5chr5

112238215

-
Frame-shiftENST00000389063ENST00000545426DCP2chr5

112312683

+REEP5chr5

112238215

-
5CDS-5UTRENST00000389063ENST00000474542DCP2chr5

112312683

+REEP5chr5

112238215

-
5CDS-intronENST00000389063ENST00000504247DCP2chr5

112312683

+REEP5chr5

112238215

-
5UTR-3CDSENST00000543319ENST00000379638DCP2chr5

112312683

+REEP5chr5

112238215

-
5UTR-3CDSENST00000543319ENST00000513339DCP2chr5

112312683

+REEP5chr5

112238215

-
5UTR-3CDSENST00000543319ENST00000545426DCP2chr5

112312683

+REEP5chr5

112238215

-
5UTR-5UTRENST00000543319ENST00000474542DCP2chr5

112312683

+REEP5chr5

112238215

-
5UTR-intronENST00000543319ENST00000504247DCP2chr5

112312683

+REEP5chr5

112238215

-
3UTR-3CDSENST00000504961ENST00000379638DCP2chr5

112312683

+REEP5chr5

112238215

-
3UTR-3CDSENST00000504961ENST00000513339DCP2chr5

112312683

+REEP5chr5

112238215

-
3UTR-3CDSENST00000504961ENST00000545426DCP2chr5

112312683

+REEP5chr5

112238215

-
3UTR-5UTRENST00000504961ENST00000474542DCP2chr5

112312683

+REEP5chr5

112238215

-
3UTR-intronENST00000504961ENST00000504247DCP2chr5

112312683

+REEP5chr5

112238215

-
Frame-shiftENST00000515408ENST00000379638DCP2chr5

112312683

+REEP5chr5

112256953

-
Frame-shiftENST00000515408ENST00000513339DCP2chr5

112312683

+REEP5chr5

112256953

-
Frame-shiftENST00000515408ENST00000545426DCP2chr5

112312683

+REEP5chr5

112256953

-
5CDS-5UTRENST00000515408ENST00000474542DCP2chr5

112312683

+REEP5chr5

112256953

-
5CDS-5UTRENST00000515408ENST00000504247DCP2chr5

112312683

+REEP5chr5

112256953

-
Frame-shiftENST00000389063ENST00000379638DCP2chr5

112312683

+REEP5chr5

112256953

-
Frame-shiftENST00000389063ENST00000513339DCP2chr5

112312683

+REEP5chr5

112256953

-
Frame-shiftENST00000389063ENST00000545426DCP2chr5

112312683

+REEP5chr5

112256953

-
5CDS-5UTRENST00000389063ENST00000474542DCP2chr5

112312683

+REEP5chr5

112256953

-
5CDS-5UTRENST00000389063ENST00000504247DCP2chr5

112312683

+REEP5chr5

112256953

-
5UTR-3CDSENST00000543319ENST00000379638DCP2chr5

112312683

+REEP5chr5

112256953

-
5UTR-3CDSENST00000543319ENST00000513339DCP2chr5

112312683

+REEP5chr5

112256953

-
5UTR-3CDSENST00000543319ENST00000545426DCP2chr5

112312683

+REEP5chr5

112256953

-
5UTR-5UTRENST00000543319ENST00000474542DCP2chr5

112312683

+REEP5chr5

112256953

-
5UTR-5UTRENST00000543319ENST00000504247DCP2chr5

112312683

+REEP5chr5

112256953

-
3UTR-3CDSENST00000504961ENST00000379638DCP2chr5

112312683

+REEP5chr5

112256953

-
3UTR-3CDSENST00000504961ENST00000513339DCP2chr5

112312683

+REEP5chr5

112256953

-
3UTR-3CDSENST00000504961ENST00000545426DCP2chr5

112312683

+REEP5chr5

112256953

-
3UTR-5UTRENST00000504961ENST00000474542DCP2chr5

112312683

+REEP5chr5

112256953

-
3UTR-5UTRENST00000504961ENST00000504247DCP2chr5

112312683

+REEP5chr5

112256953

-

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FusionProtFeatures for DCP2_REEP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCP2

Q8IU60

REEP5

Q00765

Decapping metalloenzyme that catalyzes the cleavage ofthe cap structure on mRNAs (PubMed:12417715, PubMed:12218187,PubMed:12923261, PubMed:21070968). Removes the 7-methyl guaninecap structure from mRNA molecules, yielding a 5'-phosphorylatedmRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261,PubMed:21070968). Necessary for the degradation of mRNAs, both innormal mRNA turnover and in nonsense-mediated mRNA decay(PubMed:14527413). Plays a role in replication-dependent histonemRNA degradation (PubMed:18172165). Has higher activity towardsmRNAs that lack a poly(A) tail (PubMed:21070968). Has no activitytowards a cap structure lacking an RNA moiety (PubMed:21070968).Blocks autophagy in nutrient-rich conditions by repressing theexpression of ATG-related genes through degration of theirtranscripts (PubMed:26098573). {ECO:0000269|PubMed:12218187,ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012,ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413,ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968,ECO:0000269|PubMed:26098573}. May promote functional cell surface expression ofolfactory receptors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneREEP5chr5:112312683chr5:112238215ENST00000379638-1590_11070190TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCP2chr5:112312683chr5:112238215ENST00000389063+11195_22617421DomainNudix hydrolase
HgeneDCP2chr5:112312683chr5:112238215ENST00000515408+11095_22617386DomainNudix hydrolase
HgeneDCP2chr5:112312683chr5:112238215ENST00000389063+111129_15017421MotifNote=Nudix box
HgeneDCP2chr5:112312683chr5:112238215ENST00000515408+110129_15017386MotifNote=Nudix box
TgeneREEP5chr5:112312683chr5:112238215ENST00000379638-1535_5570190TransmembraneHelical


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FusionGeneSequence for DCP2_REEP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCP2_REEP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCP2PSMB1, UPF1, UPF2, UPF3A, DCP1A, EDC4, ELAVL1, TRIM21, ZFP36, EDC3, DCP1B, MMS19, POLA2, NAGK, ABCE1, ANGEL2, AP1M1, ARMCX5, CAPN2, DARS2, EIF5A, ELP3, FANCD2, FBXO3, GARS, GFPT1, GFPT2, GGCX, GGT7, GLUD1, GTPBP2, IDE, IKBKAP, INTS7, PFKM, PGM3, PHKB, POLD3, QPCTL, SFXN2, SLC25A10, SQSTM1, TARS, TRMT2A, TRRAP, FAM96B, NXPH3, SPACA1, COLEC10, PCBP3, TUBB8, EEF1A2, GAPDHS, GBAS, CRKL, PPP1R35, MTOR, ZFP36L1, F9, LRRC32, CHRM3, PDCD1REEP5RABAC1, NUDT3, RGS2, VKORC1, ARFGAP1, GTF2H1, RAB5B, SGCZ, ATP1B3, GDE1, GPR52, ZDHHC7, GPR84, TNFRSF10B, LPAR1, FAM134C, DHCR24, KLRF1, CLEC5A, TCTN3, ACSL3, GALNT2, SMARCA4, ZMYM3, MED17, SCAMP2, DNAJC8, KDM2A, CNOT1, ATP6V0A2, MCAT, BRD7, DERL2, GOLT1B, IMPACT, DOCK6, MTHFSD, PSRC1, USMG5, REEP6, SCAMP4, DGKH, MFN2, TMEM68, FAM210B, GALNT16, TMUB2, SOGA3, PLSCR1, GALNT7, NCAM1, TMEM128, C4orf32, RNFT1, PLP1, SCAMP1, C10orf35, FPR2, PRAF2, ABCC4, KDSR, IFNA21, LITAF, C3AR1, TM4SF18, EBP, ATP6V0E1, TMPPE, GPR107, FAM3C, TSPAN11, AKAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCP2_REEP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCP2_REEP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneREEP5C0008370Cholestasis1CTD_human
TgeneREEP5C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneREEP5C0041696Unipolar Depression1PSYGENET
TgeneREEP5C1269683Major Depressive Disorder1PSYGENET
TgeneREEP5C4277682Chemical and Drug Induced Liver Injury1CTD_human