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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9437

FusionGeneSummary for DCP2_IL17B

check button Fusion gene summary
Fusion gene informationFusion gene name: DCP2_IL17B
Fusion gene ID: 9437
HgeneTgene
Gene symbol

DCP2

IL17B

Gene ID

167227

27190

Gene namedecapping mRNA 2interleukin 17B
SynonymsNUDT20IL-17B|IL-20|NIRF|ZCYTO7
Cytomap

5q22.2

5q32

Type of geneprotein-codingprotein-coding
Descriptionm7GpppN-mRNA hydrolaseDCP2 decapping enzyme homologhDpcmRNA-decapping enzyme 2nudix (nucleoside diphosphate linked moiety X)-type motif 20interleukin-17Bcytokine-like protein ZCYTO7interleukin 20interleukin-17 betaneuronal interleukin-17 related factor
Modification date2018052320180519
UniProtAcc

Q8IU60

Q9UHF5

Ensembl transtripts involved in fusion geneENST00000515408, ENST00000389063, 
ENST00000543319, ENST00000504961, 
ENST00000505432, ENST00000261796, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 1 X 3=9
# samples 83
** MAII scorelog2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCP2 [Title/Abstract] AND IL17B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCP2

GO:0006402

mRNA catabolic process

21070968


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-P6-A5OF-01ADCP2chr5

112328467

+IL17Bchr5

148756588

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000515408ENST00000505432DCP2chr5

112328467

+IL17Bchr5

148756588

-
5CDS-5UTRENST00000515408ENST00000261796DCP2chr5

112328467

+IL17Bchr5

148756588

-
5CDS-5UTRENST00000389063ENST00000505432DCP2chr5

112328467

+IL17Bchr5

148756588

-
5CDS-5UTRENST00000389063ENST00000261796DCP2chr5

112328467

+IL17Bchr5

148756588

-
5UTR-5UTRENST00000543319ENST00000505432DCP2chr5

112328467

+IL17Bchr5

148756588

-
5UTR-5UTRENST00000543319ENST00000261796DCP2chr5

112328467

+IL17Bchr5

148756588

-
intron-5UTRENST00000504961ENST00000505432DCP2chr5

112328467

+IL17Bchr5

148756588

-
intron-5UTRENST00000504961ENST00000261796DCP2chr5

112328467

+IL17Bchr5

148756588

-

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FusionProtFeatures for DCP2_IL17B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCP2

Q8IU60

IL17B

Q9UHF5

Decapping metalloenzyme that catalyzes the cleavage ofthe cap structure on mRNAs (PubMed:12417715, PubMed:12218187,PubMed:12923261, PubMed:21070968). Removes the 7-methyl guaninecap structure from mRNA molecules, yielding a 5'-phosphorylatedmRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261,PubMed:21070968). Necessary for the degradation of mRNAs, both innormal mRNA turnover and in nonsense-mediated mRNA decay(PubMed:14527413). Plays a role in replication-dependent histonemRNA degradation (PubMed:18172165). Has higher activity towardsmRNAs that lack a poly(A) tail (PubMed:21070968). Has no activitytowards a cap structure lacking an RNA moiety (PubMed:21070968).Blocks autophagy in nutrient-rich conditions by repressing theexpression of ATG-related genes through degration of theirtranscripts (PubMed:26098573). {ECO:0000269|PubMed:12218187,ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012,ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413,ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968,ECO:0000269|PubMed:26098573}. Stimulates the release of tumor necrosis factor alphaand IL-1-beta from the monocytic cell line THP-1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCP2_IL17B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCP2_IL17B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCP2PSMB1, UPF1, UPF2, UPF3A, DCP1A, EDC4, ELAVL1, TRIM21, ZFP36, EDC3, DCP1B, MMS19, POLA2, NAGK, ABCE1, ANGEL2, AP1M1, ARMCX5, CAPN2, DARS2, EIF5A, ELP3, FANCD2, FBXO3, GARS, GFPT1, GFPT2, GGCX, GGT7, GLUD1, GTPBP2, IDE, IKBKAP, INTS7, PFKM, PGM3, PHKB, POLD3, QPCTL, SFXN2, SLC25A10, SQSTM1, TARS, TRMT2A, TRRAP, FAM96B, NXPH3, SPACA1, COLEC10, PCBP3, TUBB8, EEF1A2, GAPDHS, GBAS, CRKL, PPP1R35, MTOR, ZFP36L1, F9, LRRC32, CHRM3, PDCD1IL17BENO2, IL17RB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCP2_IL17B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCP2_IL17B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource