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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9429

FusionGeneSummary for DCN_MAGI1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCN_MAGI1
Fusion gene ID: 9429
HgeneTgene
Gene symbol

DCN

MAGI1

Gene ID

1634

154043

Gene namedecorinCNKSR family member 3
SynonymsCSCD|DSPG2|PG40|PGII|PGS2|SLRR1BCNK3|CNK3/IPCEF1|MAGI1
Cytomap

12q21.33

6q25.2

Type of geneprotein-codingprotein-coding
Descriptiondecorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1Bconnector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1
Modification date2018052220180522
UniProtAcc

P07585

Q96QZ7

Ensembl transtripts involved in fusion geneENST00000052754, ENST00000425043, 
ENST00000393155, ENST00000228329, 
ENST00000303320, ENST00000552962, 
ENST00000441303, ENST00000420120, 
ENST00000547568, ENST00000456569, 
ENST00000546370, ENST00000546745, 
ENST00000550099, ENST00000551354, 
ENST00000548768, 
ENST00000330909, 
ENST00000402939, ENST00000483466, 
ENST00000497477, ENST00000470990, 
Fusion gene scores* DoF score5 X 5 X 1=2511 X 11 X 2=242
# samples 512
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/242*10)=-1.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCN [Title/Abstract] AND MAGI1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCN

GO:0010508

positive regulation of autophagy

23798385

HgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

HgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

HgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

HgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

HgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA736813DCNchr12

91571449

-MAGI1chr3

65352758

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000052754ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000052754ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000052754ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000052754ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000052754ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000425043ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000425043ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000425043ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000425043ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000425043ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000393155ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000393155ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000393155ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000393155ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000393155ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000228329ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000228329ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000228329ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000228329ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000228329ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000303320ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000303320ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000303320ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000303320ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000303320ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000552962ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000552962ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000552962ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000552962ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000552962ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000441303ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000441303ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000441303ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000441303ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000441303ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000420120ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000420120ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000420120ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000420120ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000420120ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000547568ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000547568ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000547568ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000547568ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000547568ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000456569ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000456569ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000456569ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000456569ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000456569ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546370ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546370ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546370ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546370ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546370ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546745ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546745ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546745ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546745ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000546745ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000550099ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000550099ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000550099ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000550099ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000550099ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000551354ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000551354ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000551354ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000551354ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000551354ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000548768ENST00000330909DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000548768ENST00000402939DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000548768ENST00000483466DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000548768ENST00000497477DCNchr12

91571449

-MAGI1chr3

65352758

+
intron-intronENST00000548768ENST00000470990DCNchr12

91571449

-MAGI1chr3

65352758

+

Top

FusionProtFeatures for DCN_MAGI1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCN

P07585

MAGI1

Q96QZ7

May affect the rate of fibrils formation. May play a role as scaffolding protein at cell-celljunctions. May regulate acid-induced ASIC3 currents by modulatingits expression at the cell surface (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DCN_MAGI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DCN_MAGI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DCN_MAGI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDCNP07585DB03754TromethamineDecorinsmall moleculeapproved

Top

RelatedDiseases for DCN_MAGI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCNC0014170Endometrial Neoplasms1CTD_human
HgeneDCNC0016059Fibrosis1CTD_human
HgeneDCNC0027707Nephritis, Interstitial1CTD_human
HgeneDCNC0151744Myocardial Ischemia1CTD_human
HgeneDCNC0238288Muscular Dystrophy, Facioscapulohumeral1CTD_human
TgeneMAGI1C0005586Bipolar Disorder2PSYGENET
TgeneMAGI1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneMAGI1C0036341Schizophrenia1PSYGENET
TgeneMAGI1C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET